Clinical Observation on Effect of Xuesaitong Injection (血塞通注射液) as Auxiliary Treatment of Severe Craniocerebral Injury

Objective To evaluate the effect of Xuesai-tong injection (XSTI, 血塞通注射液 , a preparation of Panax Notoginseng) as auxilliary treatment of severe craniocerebral injury. Methods Eighty-seven patients with severe craniocerebral injury were selected and randomly divided into the treated group (n=44) and the control group (n = 43), they were treated with conventional treatment, and XSTI was given additionally to the treated group. Intracranial pressure (ICP) and Glasgow coma score (GCS) of all patients were measuredafter 1 or 2-week treatment, and Glasgow outcome scale (GOS) of them was determined 3 months later. Then the therapeutic effect in the two groups were compared. Results After treatment, the ICP was lower, GCS higher and GOS better in the treated group than those in the control group significantly, all showing statistical significance (P<0.05). Conclusion XSTI has marked clinical therapeutic effect in treating patients with severe craniocerebral injury.Original article on CJITWM (Chin) 2004 ;23 (3): 213

The treatment of severe open Pilon fractures

Objective To discuss the operative methods,timing and outcomes of severe open Pilon fractures.Methods From April 2003 to July 2008,21 patients with open Pilon fractures were admitted.All the patients were type C fracture according to

Successful Treatment with Integrated Chinese and Western Medicine for Severe Overdose of Amlodipine:A Case Report

Introduction Amlodipine is a dihydropyridine calcium channel blocker （CCB） that inhibits calcium influx into cardiac, vascular smooth muscle cells, and pancreatic beta cells, leading to dilation of arteries and arterioles and reduction in insulin secretion. Oral administration of amlodipine is absorbed slowly but almost completely, with a hiah oral bioavailabilitv up to 60%-80%.

A hospital outbreak of severe acute respiratory syndrome in Guangzhou,China

Objective To describe a hospital outbreak of severe acute respiratory syndrome (SARS) and summarize its clinical features and therapeutic approaches.Methods The outbreak started with a SARS patient from the community, and a total of 96 people (76 women and 20 men, mean age (29. 5±10. 3) years, 93. 8% of whom were health care workers) who had exposure to this source patient became infected in a short time. Clinical data in this cohort were collected prospectively as they were identified.Results (1) The incubation period ranged from 1 to 20 (mean: 5. 9±3. 5) days. The duration of hospitalization was (17. 2±8. 0) days. (2) The initial temperature was (38. 3±0. 6)℃, while the highest was (39. 2 ±0. 6)℃( P<0. 001), with fever duration of (9. 0±4. 2) days. (3) Other most common symptoms included fatigue (93. 8%), cough (85. 4%), mild sputum production (66. 7%), chills (55.2%), headache (39.6%), general malaise (35.4%) and myalgia (21.9%). (4) The radiographic changes were predominantly bilateral in the middle or lower lung zones. The number of affected lung fields was 1. 2±0. 8 on presentation, which increased to 2. 9 ?1. 4 after admission (P<0. 001). The interval from the beginning of fever to the onset of abnormal chest radiographs was (3. 5±2. 3) days, which increased in size, extent, and severity to the maximum (6. 7±3. 5) days later. The time before the lung opacities were basically absorbed was (14.9±7.8) days. (5) Leukopenia was observed in 67. 7% of this cohort. The time between the onset of fever and leukopenia was (4. 4±2. 3) days, with the lowest white blood cell count of (2. 80±0. 72)×10~9/L (6) The lowest arterial oxygen saturation was (94.8±3.1 )% with supplementary oxygen. (7) Antibiotical therapies included tetracyclines ( 91. 0%), aminoglycosides ( 83. 3%), quinolones (79. 2%); 18. 8% of the patients received a combination of tetracyclines and aminoglycosides, while 11. 5% received a combination of tetracyclines and quinolones, and 63. 5% received a combination of tetracyclines, aminoglycosides and quinolones. Vancomycin was used in 13. 5% of the patients. (8) 68. 8% of the patients were treated with methylprednisolones for a mean interval of (4. 9±2. 4) days. The initial dose was (67. 3±28. 2) mg/d and the maximal dose was (82. 4 ±30. 5) mg/d. (9) Human y-globulin, interferon-α, antiviral drugs (oral ribavirin or oseltamivir) were used respectively in 68.6%, 46.9% and 92.7% of the patients. (10) Ninety-five patients (99.0%) had a complete clinical recovery, and only 1 patient (1.0%) died. Conclusions SARS appears to be quickly infectious and potentially lethal among health care workers, characterized by acute onset and rapid progression, and mostly bilateral lung involvement on chest radiographs. Proper administration of glucocorticosteroids seems to be of some benefits. Antibiotics, human y-globulin, interferon-α, and antiviral drugs, although empirically, might be useful to shorten the clinical course.

Tailoring Microstructure and Tribological Properties of Cold Deformed TiZrAlV Alloy by Thermal Treatment

Microstructure evolution and tribological properties of a new Ti Zr Al V alloy have been investigated in the present study. Various microstructures, i.e., equiaxed grain structure, dual-phase lamella structure, and heterogeneous lamellar structure, have been successfully prepared, and the effect of the microstructure on tribological properties was explored by means of cold severe plastic deformation combined with subsequent recrystallization annealing and aging treatments. The special heterogeneous lamellar-structured alloy exhibits a high ultimate tensile strength（~1545 MPa）,reasonable ductility（~7.9%）, and excellent wear resistance as compared with the equiaxed grain-structured and dualphase lamella-structured alloy. The present study demonstrates an alternative route for enhancing the tribological properties of alloys with heterogeneous lamellar structure.