Sex-determining region Y box-containing genes are transcription factors with roles in multiple biological processes, including cell differentiation, proliferation, and apoptosis.Sex-determining region Y box-containing...Sex-determining region Y box-containing genes are transcription factors with roles in multiple biological processes, including cell differentiation, proliferation, and apoptosis.Sex-determining region Y box-containing genes have also been shown to act as regulators and biomarkers in the progression of many different cancers, including gynecological cancers such as ovarian, cervical,and endometrial cancer.In this review, we summarize the contrasting regulatory roles of Sex-determining region Y box-containing genes in different gynecological cancers, as promotors with high expression levels or as suppressors with low expression levels.Expression levels of Sex-determining region Y box-containing genes were also identified as biomarkers of clinical features, including International Federation of Gynecology and Obstetrics stage, histopathologic grade together with disease-free survival, and treatment efficacy in patients with gynecological cancers.An understanding of the mechanisms whereby Sex-determining region Y box-containing genes regulate the progression of gynecological cancers will aid in the development of novel diagnostic and therapeutic strategies, while analysis of Sex-determining region Y box-containing expression levels will help to predict the prognosis of patients with gynecological cancers.展开更多
目的 探讨胃泌素17(gastrin-17,G-17)、性别决定区Y框蛋白2(sex-determining region Y box protein-2,SOX-2)、热休克蛋白70(heat shock protein 70,HSP70)在幽门螺杆菌(helicobacter pylori, Hp)感染胃炎中的表达及意义。方法 选取慢...目的 探讨胃泌素17(gastrin-17,G-17)、性别决定区Y框蛋白2(sex-determining region Y box protein-2,SOX-2)、热休克蛋白70(heat shock protein 70,HSP70)在幽门螺杆菌(helicobacter pylori, Hp)感染胃炎中的表达及意义。方法 选取慢性胃炎患者90例,根据是否合并Hp感染将其分为Hp阳性组和Hp阴性组,每组45例。比较2组一般资料,G-17、HSP70水平及SOX-2、HSP70表达情况。分析Hp阳性患者G-17、SOX-2、HSP70与各指标的相关性;多因素Logistic回归分析影响Hp感染胃炎的危险因素。结果 Hp阳性组共餐饮食方式比例、临床症状积分高于Hp阴性组,胃蛋白酶原Ⅰ(pepsinogenⅠ,PG-Ⅰ)、胃蛋白酶原Ⅱ(pepsinogenⅡ,PG-Ⅱ)水平低于Hp阴性组(P<0.05)。Hp阳性组G-17水平低于Hp阴性组,HSP70水平及SOX-2阳性、HSP70阳性表达率高于Hp阴性组(P<0.05)。Hp阳性患者中,G-17与PG-Ⅰ、PG-Ⅱ呈正相关,与临床症状积分呈负相关,SOX-2、HSP70与PG-Ⅰ、PG-Ⅱ呈负相关,与临床症状积分呈正相关(P<0.05)。Logistic回归分析结果显示,饮食方式、PG-Ⅱ、G-17、SOX-2、HSP70是影响Hp感染胃炎患者的危险因素(P<0.05)。结论 G-17在Hp感染胃炎患者中水平较低,SOX-2、HSP70阳性表达较高,饮食方式、PG-Ⅱ、G-17、SOX-2、HSP70是影响Hp感染胃炎患者的危险因素。展开更多
基金supported by grants from the National Natural Science Foundation of China (Grant No.81572568 and 81272863)
文摘Sex-determining region Y box-containing genes are transcription factors with roles in multiple biological processes, including cell differentiation, proliferation, and apoptosis.Sex-determining region Y box-containing genes have also been shown to act as regulators and biomarkers in the progression of many different cancers, including gynecological cancers such as ovarian, cervical,and endometrial cancer.In this review, we summarize the contrasting regulatory roles of Sex-determining region Y box-containing genes in different gynecological cancers, as promotors with high expression levels or as suppressors with low expression levels.Expression levels of Sex-determining region Y box-containing genes were also identified as biomarkers of clinical features, including International Federation of Gynecology and Obstetrics stage, histopathologic grade together with disease-free survival, and treatment efficacy in patients with gynecological cancers.An understanding of the mechanisms whereby Sex-determining region Y box-containing genes regulate the progression of gynecological cancers will aid in the development of novel diagnostic and therapeutic strategies, while analysis of Sex-determining region Y box-containing expression levels will help to predict the prognosis of patients with gynecological cancers.
文摘目的 探讨胃泌素17(gastrin-17,G-17)、性别决定区Y框蛋白2(sex-determining region Y box protein-2,SOX-2)、热休克蛋白70(heat shock protein 70,HSP70)在幽门螺杆菌(helicobacter pylori, Hp)感染胃炎中的表达及意义。方法 选取慢性胃炎患者90例,根据是否合并Hp感染将其分为Hp阳性组和Hp阴性组,每组45例。比较2组一般资料,G-17、HSP70水平及SOX-2、HSP70表达情况。分析Hp阳性患者G-17、SOX-2、HSP70与各指标的相关性;多因素Logistic回归分析影响Hp感染胃炎的危险因素。结果 Hp阳性组共餐饮食方式比例、临床症状积分高于Hp阴性组,胃蛋白酶原Ⅰ(pepsinogenⅠ,PG-Ⅰ)、胃蛋白酶原Ⅱ(pepsinogenⅡ,PG-Ⅱ)水平低于Hp阴性组(P<0.05)。Hp阳性组G-17水平低于Hp阴性组,HSP70水平及SOX-2阳性、HSP70阳性表达率高于Hp阴性组(P<0.05)。Hp阳性患者中,G-17与PG-Ⅰ、PG-Ⅱ呈正相关,与临床症状积分呈负相关,SOX-2、HSP70与PG-Ⅰ、PG-Ⅱ呈负相关,与临床症状积分呈正相关(P<0.05)。Logistic回归分析结果显示,饮食方式、PG-Ⅱ、G-17、SOX-2、HSP70是影响Hp感染胃炎患者的危险因素(P<0.05)。结论 G-17在Hp感染胃炎患者中水平较低,SOX-2、HSP70阳性表达较高,饮食方式、PG-Ⅱ、G-17、SOX-2、HSP70是影响Hp感染胃炎患者的危险因素。
