<span style="font-family:""><span style="font-family:Verdana;">The mixture of </span><i><span style="font-family:Verdana;">Erigeron floribundus</span...<span style="font-family:""><span style="font-family:Verdana;">The mixture of </span><i><span style="font-family:Verdana;">Erigeron floribundus</span></i><span style="font-family:Verdana;"> and </span><i><span style="font-family:Verdana;">Tragia benthamii</span></i><span style="font-family:Verdana;"> (AEMEFTB) is</span></span><span style="font-family:""> <span style="font-family:Verdana;">tra</span><span style="font-family:Verdana;">ditionally used against pelvic pain, dysmenorrhea and female sexual dysfunctions. In a recent study, we showed that the aqueous extract of the mixture of </span><span style="font-family:Verdana;">AEMEFTB suppresses the endometrium growth in rat</span></span><span style="font-family:Verdana;">s</span><span style="font-family:Verdana;"> with experimental</span><span style="font-family:""> </span><span style="font-family:Verdana;">en</span><span style="font-family:Verdana;">dometriosis. </span><span style="font-family:Verdana;">The </span><span style="font-family:""><span style="font-family:Verdana;">present study was aimed at investigating the effects of AEM</span><span style="font-family:Verdana;">EFTB on estrogen’s sensitive sexual organs growth and architecture. Imma</span><span style="font-family:Verdana;">ture gonado-intact female rats were randomly distributed into 7 groups of 5 ani</span><span style="font-family:Verdana;">mals each and daily treated during one week with either distilled water (10</span><span> </span><span style="font-family:Verdana;">ml/kg), refined palm oil (1</span></span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">ml/kg) or 17</span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">-estradiol (1</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">μg/day). Plant extract</span><span style="font-family:""><span style="font-family:Verdana;"> groups received aqueous extract of AEMEFTB at 130 or 260 mg/kg. The remaining groups were co-administered with 17</span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">-estradiol (1</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">μg) plus 130 or 260 mg/kg of the plant mixture. Moreover, thirty-five immature female rats were bilaterally ovariectomized, then left and treated as before. Five other females, </span><span style="font-family:Verdana;">considered as sham animals, orally received distilled water (10 ml/kg). The</span><span style="font-family:Verdana;"> body weight of each animal was recorded daily and at the end of the treatment (day 8), animals were</span><span style="font-family:Verdana;"> sacrificed under anesthesia</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> and </span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">vagina</span><span style="font-family:Verdana;">s</span><span style="font-family:Verdana;">, uterus</span><span style="font-family:Verdana;">es</span><span style="font-family:""> <span style="font-family:Verdana;">and ovaries (if any) </span><span style="font-family:Verdana;">were collected for analysis. Treatment with AEMEFTB did not affect the ova</span><span style="font-family:Verdana;">rian </span><span style="font-family:Verdana;">weight and architecture in gonado-intact immature female rats. However, a</span><span style="font-family:Verdana;"> moderate increase of the uterine weight was recorded in animals treated with plant </span><span style="font-family:Verdana;">mixture at </span></span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">high dose (260 mg/kg). On the contrary, a drop in the uterine</span><span style="font-family:""> </span><span style="font-family:Verdana;">growth index and total plasmatic proteins w</span><span style="font-family:Verdana;">as </span><span style="font-family:Verdana;">observed in immature females </span><span style="font-family:Verdana;">co-administered with the extract and estradiol. Results from this work showed</span><span style="font-family:""><span style="font-family:Verdana;"> that the mixture of </span><i><span style="font-family:Verdana;">Erigeron flori</span><span style="font-family:Verdana;">bundus</span></i><span><span style="font-family:Verdana;"> and </span><i><span style="font-family:Verdana;">Tragia benthamii </span></i><span style="font-family:Verdana;">possesses a weak but observable estro</span></span><span style="font-family:Verdana;">gen-mimetic potential.展开更多
Aim: To investigate the effects of crude garlic on adult male rat reproductive functions. Methods: Thirty male rats were divided into five groups: group 1 (untreated) and groups 2, 3, 4 and 5 were fed for 30 days...Aim: To investigate the effects of crude garlic on adult male rat reproductive functions. Methods: Thirty male rats were divided into five groups: group 1 (untreated) and groups 2, 3, 4 and 5 were fed for 30 days with 5%, 10%, 15% and 30% crude garlic, respectively. Testes and accessory organs were weighed and some markers were assessed. Light and electron microscopy observations were also performed. Results: A significant decrease was observed in the body weight of groups 4 (14%; P 〈 0.01) and 5 (20%; P 〈 0.01); of the prostate weight in group 5 (29.1%; P 〈 0.05) and of seminal vesicle weight in groups 3 (14.4%; P 〈 0.01), 4 (18.3%; P 〈 0.01) and 5 (27.3%; P 〈 0.01). In contrast, testis and epididymis weights were unchanged. In epididymis tissue, the alpha glucosidase activity and the spermatozoa density were unchanged. The treatment resulted in a significant decrease in testosterone serum levels in groups 3 (77.3%; P 〈 0.01), 4 (77.3%; P 〈 0.01) and 5 (90.9%; P 〈 0.01), associated with a significant increase in LH serum levels (P 〈 0.01). Testicular histology showed a dose-dependent increase in the percentage of empty seminiferous tubules. Moreover, testicular function was affected; a significant decrease in phosphatase acid activity (P 〈 0.01) and testosterone (P 〈 0.05) contents were observed. Conclusion: Crude garlic consumption during 1 month reduced testosterone secretion and altered spermatogenesis at 10%, 15% and 30% doses.展开更多
文摘<span style="font-family:""><span style="font-family:Verdana;">The mixture of </span><i><span style="font-family:Verdana;">Erigeron floribundus</span></i><span style="font-family:Verdana;"> and </span><i><span style="font-family:Verdana;">Tragia benthamii</span></i><span style="font-family:Verdana;"> (AEMEFTB) is</span></span><span style="font-family:""> <span style="font-family:Verdana;">tra</span><span style="font-family:Verdana;">ditionally used against pelvic pain, dysmenorrhea and female sexual dysfunctions. In a recent study, we showed that the aqueous extract of the mixture of </span><span style="font-family:Verdana;">AEMEFTB suppresses the endometrium growth in rat</span></span><span style="font-family:Verdana;">s</span><span style="font-family:Verdana;"> with experimental</span><span style="font-family:""> </span><span style="font-family:Verdana;">en</span><span style="font-family:Verdana;">dometriosis. </span><span style="font-family:Verdana;">The </span><span style="font-family:""><span style="font-family:Verdana;">present study was aimed at investigating the effects of AEM</span><span style="font-family:Verdana;">EFTB on estrogen’s sensitive sexual organs growth and architecture. Imma</span><span style="font-family:Verdana;">ture gonado-intact female rats were randomly distributed into 7 groups of 5 ani</span><span style="font-family:Verdana;">mals each and daily treated during one week with either distilled water (10</span><span> </span><span style="font-family:Verdana;">ml/kg), refined palm oil (1</span></span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">ml/kg) or 17</span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">-estradiol (1</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">μg/day). Plant extract</span><span style="font-family:""><span style="font-family:Verdana;"> groups received aqueous extract of AEMEFTB at 130 or 260 mg/kg. The remaining groups were co-administered with 17</span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">-estradiol (1</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">μg) plus 130 or 260 mg/kg of the plant mixture. Moreover, thirty-five immature female rats were bilaterally ovariectomized, then left and treated as before. Five other females, </span><span style="font-family:Verdana;">considered as sham animals, orally received distilled water (10 ml/kg). The</span><span style="font-family:Verdana;"> body weight of each animal was recorded daily and at the end of the treatment (day 8), animals were</span><span style="font-family:Verdana;"> sacrificed under anesthesia</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> and </span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">vagina</span><span style="font-family:Verdana;">s</span><span style="font-family:Verdana;">, uterus</span><span style="font-family:Verdana;">es</span><span style="font-family:""> <span style="font-family:Verdana;">and ovaries (if any) </span><span style="font-family:Verdana;">were collected for analysis. Treatment with AEMEFTB did not affect the ova</span><span style="font-family:Verdana;">rian </span><span style="font-family:Verdana;">weight and architecture in gonado-intact immature female rats. However, a</span><span style="font-family:Verdana;"> moderate increase of the uterine weight was recorded in animals treated with plant </span><span style="font-family:Verdana;">mixture at </span></span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">high dose (260 mg/kg). On the contrary, a drop in the uterine</span><span style="font-family:""> </span><span style="font-family:Verdana;">growth index and total plasmatic proteins w</span><span style="font-family:Verdana;">as </span><span style="font-family:Verdana;">observed in immature females </span><span style="font-family:Verdana;">co-administered with the extract and estradiol. Results from this work showed</span><span style="font-family:""><span style="font-family:Verdana;"> that the mixture of </span><i><span style="font-family:Verdana;">Erigeron flori</span><span style="font-family:Verdana;">bundus</span></i><span><span style="font-family:Verdana;"> and </span><i><span style="font-family:Verdana;">Tragia benthamii </span></i><span style="font-family:Verdana;">possesses a weak but observable estro</span></span><span style="font-family:Verdana;">gen-mimetic potential.
文摘Aim: To investigate the effects of crude garlic on adult male rat reproductive functions. Methods: Thirty male rats were divided into five groups: group 1 (untreated) and groups 2, 3, 4 and 5 were fed for 30 days with 5%, 10%, 15% and 30% crude garlic, respectively. Testes and accessory organs were weighed and some markers were assessed. Light and electron microscopy observations were also performed. Results: A significant decrease was observed in the body weight of groups 4 (14%; P 〈 0.01) and 5 (20%; P 〈 0.01); of the prostate weight in group 5 (29.1%; P 〈 0.05) and of seminal vesicle weight in groups 3 (14.4%; P 〈 0.01), 4 (18.3%; P 〈 0.01) and 5 (27.3%; P 〈 0.01). In contrast, testis and epididymis weights were unchanged. In epididymis tissue, the alpha glucosidase activity and the spermatozoa density were unchanged. The treatment resulted in a significant decrease in testosterone serum levels in groups 3 (77.3%; P 〈 0.01), 4 (77.3%; P 〈 0.01) and 5 (90.9%; P 〈 0.01), associated with a significant increase in LH serum levels (P 〈 0.01). Testicular histology showed a dose-dependent increase in the percentage of empty seminiferous tubules. Moreover, testicular function was affected; a significant decrease in phosphatase acid activity (P 〈 0.01) and testosterone (P 〈 0.05) contents were observed. Conclusion: Crude garlic consumption during 1 month reduced testosterone secretion and altered spermatogenesis at 10%, 15% and 30% doses.