Architecture of Intelligent Grouping and Resource Sharing Standard

The Intelligent Grouping and Resource Sharing (IGRS) standard is set to enable intelligent grouping, resource sharing and services collaboration among information devices. An IGRS system adopts open architecture, that is, the devices abide by the IGRS standard are interoperable with devices following other standards such as Universal Plug and Play (UPnP). The IGRS supports multiple application frameworks and special applications. Developers can use an IGRS media application framework with various media format standards, such as AVS and MPEG-2, to develop multimedia applications. Applied among computers, consumer electronics, and communication devices, the IGRS standard can realize resource sharing and services collaboration in a certain range of wired or wireless network domain.

Implementing ISO9000 Standard Conscientiously to Win a Share of World Market Steadily

The CMC Bearing Co. Ltd. In Yantai,Shandong Province, is a joint venture invested by China National Machinery Import and Export Corporation with a registered capital of RMB61.50 million. It mainly produces conical ball bearings, about 90 percent of which are exported to the United States, Korea, Austria,Turkey and Brazil. It is the first enterprise of its kind in China to acquire the certificate of ISO9000 standard. During the past few years, the company,guided by the policy of achieving economic results by management, and taking the world market as its target, has made much headway with growing earnings of foreign exchange from its exports. In 1995, it earned US$813,600 and in 1996, the figure rose to US$5.9336 million. In 1997, from January to August, it earned US$6.032 million,scoring a historical high. So far, its conical ball bearings make up 40 percent of the total exported to the United States from China. To implement the ISO9000 standard and guarantee the high quality of products by way of

Towards efficiency in rare disease research： what is distinctive and important？

Characterized by their low prevalence, rare diseases are often chronically debilitating or life threatening. Despite their low prevalence, the aggregate number of individuals suffering from a rare disease is estimated to be nearly 400 million worldwide.Over the past decades, efforts from researchers, clinicians, and pharmaceutical industries have been focused on both the diagnosis and therapy of rare diseases. However, because of the lack of data and medical records for individual rare diseases and the high cost of orphan drug development, only limited progress has been achieved. In recent years, the rapid development of next-generation sequencing(NGS)-based technologies, as well as the popularity of precision medicine has facilitated a better understanding of rare diseases and their molecular etiology. As a result, molecular subclassification can be identified within each disease more clearly, significantly improving diagnostic accuracy. However, providing appropriate care for patients with rare diseases is still an enormous challenge. In this review, we provide a brief introduction to the challenges of rare disease research and make suggestions on where and how our efforts should be focused.