In recent decades,the importance of surface acoustic waves,as a biocompatible tool to integrate with microfluidics,has been proven in various medical and biological applications.The numerical modeling of acoustic stre...In recent decades,the importance of surface acoustic waves,as a biocompatible tool to integrate with microfluidics,has been proven in various medical and biological applications.The numerical modeling of acoustic streaming caused by surface acoustic waves in microchannels requires the effect of viscosity to be considered in the equations which complicates the solution.In this paper,it is shown that the major contribution of viscosity and the horizontal component of actuation is concentrated in a narrow region alongside the actuation boundary.Since the inviscid equations are considerably easier to solve,a division into the viscous and inviscid domains would alleviate the computational load significantly.The particles'traces calculated by this approximation are excellently alongside their counterparts from the completely viscous model.It is also shown that the optimum thickness for the viscous strip is about 9-fold the acoustic boundary layer thickness for various flow patterns and amplitudes of actuation.展开更多
Even as gigahertz(GHz) acoustic streaming has developed into a multi-functional platform technology for biochemical applications, including ultrafast microfluidic mixing, microparticle operations, and cellar or vesicl...Even as gigahertz(GHz) acoustic streaming has developed into a multi-functional platform technology for biochemical applications, including ultrafast microfluidic mixing, microparticle operations, and cellar or vesicle surgery, its theoretical principles have yet to be established. This is because few studies have been conducted on the use of such high frequency acoustics in microscale fluids. Another difficulty is the lack of velocimetry methods for microscale and nanoscale fluidic streaming. In this work, we focus on the basic aspects of GHz acoustic streaming,including its micro-vortex generation principles, theoretical model, and experimental characterization technologies. We present details of a weak-coupled finite simulation that represents our current understanding of the GHz-acoustic-streaming phenomenon. Both our simulation and experimental results show that the GHzacoustic-induced interfacial body force plays a determinative role in vortex generation. We carefully studied changes in the formation of GHz acoustic streaming at different acoustic powers and flow rates. In particular,we developed a microfluidic-particle-image velocimetry method that enables the quantification of streaming at the microscale and even nanoscale. This work provides a full map of GHz acoustofluidics and highlights the way to further theoretical study of this topic.展开更多
This paper describes a new phenomenon of acoustic streaming which takes place when a Helmholtz resonator is excited by an inside sound source with resonant frequency,and takes the form of a strong turbulent jet.The fl...This paper describes a new phenomenon of acoustic streaming which takes place when a Helmholtz resonator is excited by an inside sound source with resonant frequency,and takes the form of a strong turbulent jet.The flow visualizations,hot wire and LDV measurements are combined to investigate the process of acoustic streaming.It is found that this kind of acoustic streaming results from the contribution of Reynolds stress.展开更多
Contactless acoustic manipulation of micro/nanoscale particles has attracted considerable attention owing to its near independence of the physical and chemical properties of the targets,making it universally applicabl...Contactless acoustic manipulation of micro/nanoscale particles has attracted considerable attention owing to its near independence of the physical and chemical properties of the targets,making it universally applicable to almost all biological systems.Thin-film bulk acoustic wave(BAW)resonators operating at gigahertz(GHz)frequencies have been demonstrated to generate localized high-speed microvortices through acoustic streaming effects.Benefitting from the strong drag forces of the high-speed vortices,BAW-enabled GHz acoustic streaming tweezers(AST)have been applied to the trapping and enrichment of particles ranging in size from micrometers to less than 100 nm.However,the behavior of particles in such 3D microvortex systems is still largely unknown.In this work,the particle behavior(trapping,enrichment,and separation)in GHz AST is studied by theoretical analyses,3D simulations,and microparticle tracking experiments.It is found that the particle motion in the vortices is determined mainly by the balance between the acoustic streaming drag force and the acoustic radiation force.This work can provide basic design principles for AST-based lab-on-a-chip systems for a variety of applications.展开更多
The blood–brain barrier(BBB)is a structural and functional barrier necessary for brain homeostasis,and it plays an important role in the realization of neural function and in protecting the brain from damage by circu...The blood–brain barrier(BBB)is a structural and functional barrier necessary for brain homeostasis,and it plays an important role in the realization of neural function and in protecting the brain from damage by circulating toxins and pathogens.However,the extremely dense BBB also severely limits the transport of molecules across it,which is a great hindrance to the diagnosis and treatment of central nervous system(CNS)diseases.This paper reports a new method for controllable opening of the BBB,based on the gigahertz acoustic streaming(AS)generated by a bulk acoustic wave resonant device.By adjusting the input power and working distance of the device,AS with tunable flow rate can be generated to disrupt tight junction proteins(TJs)between endothelial cells.The results obtained with this method show that the gigahertz AS promotes the penetration of dextran molecules with different molecular weights across the BBB.This work provides a new platform for studying the mechanical regulation of BBB by fluid shear forces and a new method for improving the efficiency of drug delivery.展开更多
This study experimentally investigated two-phase acoustic streaming and droplet properties of aerosols, which were generated by a dental ultrasonic scaler. The velocity field of acoustic streaming was measured using p...This study experimentally investigated two-phase acoustic streaming and droplet properties of aerosols, which were generated by a dental ultrasonic scaler. The velocity field of acoustic streaming was measured using particle image velocimetry with the generated liquid droplets as tracers, and the shadowgraph technique was adopted to measure the droplet diameter. In the PIV measurement of the gas-liquid two-phase flow, the injection of oil smoke substantially suppressed the number of invalid vectors. The acoustic streaming of the ultrasonic scaler showed maximum velocity at a region away from the scaler tip, and the maximum velocity increased with an increase in the liquid flow rate. The droplets of the ultrasonic scaler were generated by capillary waves and had a diameter on the order of tens of micrometers. These droplets effectively enhanced the velocity of the acoustic streaming in the two-phase case compared to the single-phase case without the droplets.展开更多
The ultrasonic melt treatment(UMT)is widely used in the fields of casting and metallurgy.However,there are certain drawbacks associated with the conventional process of single-source ultrasonic(SSU)treatment,such as t...The ultrasonic melt treatment(UMT)is widely used in the fields of casting and metallurgy.However,there are certain drawbacks associated with the conventional process of single-source ultrasonic(SSU)treatment,such as the fast attenuation of energy and limited range of effectiveness.In this study,the propagation models of SSU and four-source ultrasonic(FSU)in Al melt were respectively established,and the distribution patterns of acoustic and streaming field during the ultrasonic treatment process were investigated by numerical simulation and physical experiments.The simulated results show that the effective cavitation zone is mainly located in a small spherical region surrounding the end of ultrasonic horn during the SSU treatment process.When the FSU is applied,the effective cavitation zone is obviously expanded in the melt.It increases at first and then decreases with increasing the vibration-source spacing(Lv)from 30 mm to 100 mm.Especially,when the Lv is 80 mm,the area of effective cavitation zone reaches the largest,indicating the best effect of cavitation.Moreover,the acoustic streaming level and flow pattern in the melt also change with the increase of Lv.When the Lv is 80 mm,both the average flow rate and maximum flow rate of the melt reach the highest,and the flow structure is more stable and uniform,with the typical morphological characteristics of angular vortex,thus significantly expanding the range of acoustic streaming.The accuracy of the simulation results was verified by physical experiments of glycerol aqueous solution and tracer particles.展开更多
Rotational manipulation of massive particles and biolo gical samples is essential for the development of miniaturized lab-on-a-chip platforms in the fields of chemical,medical,and biological applications.In this paper...Rotational manipulation of massive particles and biolo gical samples is essential for the development of miniaturized lab-on-a-chip platforms in the fields of chemical,medical,and biological applications.In this paper,a device concept of a two-dimensional acoustofluidic chamber actuated by multiple nonlinear vibration sources is proposed.The functional chamber enables the generation of acoustic streaming vortices for potential applications that include strong mixing of multiphase flows and rotational manipulation of micro-/nano-scale objects without any rotating component.Using numerical simulations,we find that diversified acoustofluidic fields can be generated in the chamber under various actuations,and massive polystyrene beads inside can experience different acoustophoretic motions under the combined effect of an acoustic radiation force and acoustic streaming.Moreover,we investigate and clarify the effects of structural design on modulation of the acoustofluidic fields in the chamber.We believe the presented study could not only provide a promising potential tool for rotational acoustofluidic manipulation,but could also bring this community some useful design insights into the achievement of desired acoustofluidic fields for assorted microfluidic applications.展开更多
The speed of the streaming flow in the liquid layer loaded on a thin plate, in which Lamb waves are propagating, was calculated. The results are good agreement with Moroney's experiment
Large amplitude dust ion acoustic (DIA) solitons as well as double layers (DLs) are studied in a dusty plasma having a high-energy-tail electron distribution. The influence of electron deviation from the Maxwellia...Large amplitude dust ion acoustic (DIA) solitons as well as double layers (DLs) are studied in a dusty plasma having a high-energy-tail electron distribution. The influence of electron deviation from the Maxwellian distribution and ion streaming on the existence domain of solitons is discussed in the (M, f) space using the pseudo-potential approach. It is found that in the presence of streaming ions and for a fixed f, solitons may appear for larger values of M. This means that in the presence of ion streaming, high values of the Mach number are needed to have soliton. The DIA solitary waves profile is highly sensitive to the ion streaming speed. Their amplitude is found to decrease with an increase of the ion streaming speed. In addition, we find that the ion streaming effect may lead to the appearance of double layers. The results of this axticle should be useful in understanding the basic nonlinear features of DIA waves propagating in space dusty plasmas, especially those including a relative motion between species, such as comet tails and solar wind streams, etc.展开更多
文摘In recent decades,the importance of surface acoustic waves,as a biocompatible tool to integrate with microfluidics,has been proven in various medical and biological applications.The numerical modeling of acoustic streaming caused by surface acoustic waves in microchannels requires the effect of viscosity to be considered in the equations which complicates the solution.In this paper,it is shown that the major contribution of viscosity and the horizontal component of actuation is concentrated in a narrow region alongside the actuation boundary.Since the inviscid equations are considerably easier to solve,a division into the viscous and inviscid domains would alleviate the computational load significantly.The particles'traces calculated by this approximation are excellently alongside their counterparts from the completely viscous model.It is also shown that the optimum thickness for the viscous strip is about 9-fold the acoustic boundary layer thickness for various flow patterns and amplitudes of actuation.
基金financial support from the National Natural Science Foundation of China (Grant Nos. 91743110, 61674114, 21861132001)National Key R&D Program of China (Grant No. 2017YFF0204600)+2 种基金Tianjin Applied Basic Research and Advanced Technology (Grant No. 17JCJQJC43600)the Foundation for Talent Scientists of Nanchang Institute for Microtechnology of Tianjin Universitythe 111 Project (Grant No. B07014)
文摘Even as gigahertz(GHz) acoustic streaming has developed into a multi-functional platform technology for biochemical applications, including ultrafast microfluidic mixing, microparticle operations, and cellar or vesicle surgery, its theoretical principles have yet to be established. This is because few studies have been conducted on the use of such high frequency acoustics in microscale fluids. Another difficulty is the lack of velocimetry methods for microscale and nanoscale fluidic streaming. In this work, we focus on the basic aspects of GHz acoustic streaming,including its micro-vortex generation principles, theoretical model, and experimental characterization technologies. We present details of a weak-coupled finite simulation that represents our current understanding of the GHz-acoustic-streaming phenomenon. Both our simulation and experimental results show that the GHzacoustic-induced interfacial body force plays a determinative role in vortex generation. We carefully studied changes in the formation of GHz acoustic streaming at different acoustic powers and flow rates. In particular,we developed a microfluidic-particle-image velocimetry method that enables the quantification of streaming at the microscale and even nanoscale. This work provides a full map of GHz acoustofluidics and highlights the way to further theoretical study of this topic.
文摘This paper describes a new phenomenon of acoustic streaming which takes place when a Helmholtz resonator is excited by an inside sound source with resonant frequency,and takes the form of a strong turbulent jet.The flow visualizations,hot wire and LDV measurements are combined to investigate the process of acoustic streaming.It is found that this kind of acoustic streaming results from the contribution of Reynolds stress.
基金The authors gratefully acknowledge financial support from the National Key R&D Program of China(2018YFE0118700)the Natural Science Foundation of China(NSFC No.62174119)+1 种基金Tianjin Applied Basic Research and Advanced Technology(17JCJQJC43600)the 111 Project(B07014).
文摘Contactless acoustic manipulation of micro/nanoscale particles has attracted considerable attention owing to its near independence of the physical and chemical properties of the targets,making it universally applicable to almost all biological systems.Thin-film bulk acoustic wave(BAW)resonators operating at gigahertz(GHz)frequencies have been demonstrated to generate localized high-speed microvortices through acoustic streaming effects.Benefitting from the strong drag forces of the high-speed vortices,BAW-enabled GHz acoustic streaming tweezers(AST)have been applied to the trapping and enrichment of particles ranging in size from micrometers to less than 100 nm.However,the behavior of particles in such 3D microvortex systems is still largely unknown.In this work,the particle behavior(trapping,enrichment,and separation)in GHz AST is studied by theoretical analyses,3D simulations,and microparticle tracking experiments.It is found that the particle motion in the vortices is determined mainly by the balance between the acoustic streaming drag force and the acoustic radiation force.This work can provide basic design principles for AST-based lab-on-a-chip systems for a variety of applications.
基金financial support from the National Natural Science Foundation of China(Grant No.61971302)。
文摘The blood–brain barrier(BBB)is a structural and functional barrier necessary for brain homeostasis,and it plays an important role in the realization of neural function and in protecting the brain from damage by circulating toxins and pathogens.However,the extremely dense BBB also severely limits the transport of molecules across it,which is a great hindrance to the diagnosis and treatment of central nervous system(CNS)diseases.This paper reports a new method for controllable opening of the BBB,based on the gigahertz acoustic streaming(AS)generated by a bulk acoustic wave resonant device.By adjusting the input power and working distance of the device,AS with tunable flow rate can be generated to disrupt tight junction proteins(TJs)between endothelial cells.The results obtained with this method show that the gigahertz AS promotes the penetration of dextran molecules with different molecular weights across the BBB.This work provides a new platform for studying the mechanical regulation of BBB by fluid shear forces and a new method for improving the efficiency of drug delivery.
文摘This study experimentally investigated two-phase acoustic streaming and droplet properties of aerosols, which were generated by a dental ultrasonic scaler. The velocity field of acoustic streaming was measured using particle image velocimetry with the generated liquid droplets as tracers, and the shadowgraph technique was adopted to measure the droplet diameter. In the PIV measurement of the gas-liquid two-phase flow, the injection of oil smoke substantially suppressed the number of invalid vectors. The acoustic streaming of the ultrasonic scaler showed maximum velocity at a region away from the scaler tip, and the maximum velocity increased with an increase in the liquid flow rate. The droplets of the ultrasonic scaler were generated by capillary waves and had a diameter on the order of tens of micrometers. These droplets effectively enhanced the velocity of the acoustic streaming in the two-phase case compared to the single-phase case without the droplets.
基金This study was financially supported by the National Natural Science Foundation of China(Grant No.52071123)the Natural Science Foundation of Anhui Province(Grant No.2308085ME167)the Fundamental Research Funds for the Central Universities of China(Grant No.PA2022GDGP0029).
文摘The ultrasonic melt treatment(UMT)is widely used in the fields of casting and metallurgy.However,there are certain drawbacks associated with the conventional process of single-source ultrasonic(SSU)treatment,such as the fast attenuation of energy and limited range of effectiveness.In this study,the propagation models of SSU and four-source ultrasonic(FSU)in Al melt were respectively established,and the distribution patterns of acoustic and streaming field during the ultrasonic treatment process were investigated by numerical simulation and physical experiments.The simulated results show that the effective cavitation zone is mainly located in a small spherical region surrounding the end of ultrasonic horn during the SSU treatment process.When the FSU is applied,the effective cavitation zone is obviously expanded in the melt.It increases at first and then decreases with increasing the vibration-source spacing(Lv)from 30 mm to 100 mm.Especially,when the Lv is 80 mm,the area of effective cavitation zone reaches the largest,indicating the best effect of cavitation.Moreover,the acoustic streaming level and flow pattern in the melt also change with the increase of Lv.When the Lv is 80 mm,both the average flow rate and maximum flow rate of the melt reach the highest,and the flow structure is more stable and uniform,with the typical morphological characteristics of angular vortex,thus significantly expanding the range of acoustic streaming.The accuracy of the simulation results was verified by physical experiments of glycerol aqueous solution and tracer particles.
基金Project supported by the National Natural Science Foundation of China(Grant No.11904117)the IndustryUniversity-Research Collaboration Project of Jiangsu Province,China(Grant No.BY2019058)+1 种基金the Scientific Research Foundation of Huaiyin Institute of Technology(Grant No.Z301B19529)the Training Foundation of Postgraduate Supervisor(Grant No.Z206E20555)。
文摘Rotational manipulation of massive particles and biolo gical samples is essential for the development of miniaturized lab-on-a-chip platforms in the fields of chemical,medical,and biological applications.In this paper,a device concept of a two-dimensional acoustofluidic chamber actuated by multiple nonlinear vibration sources is proposed.The functional chamber enables the generation of acoustic streaming vortices for potential applications that include strong mixing of multiphase flows and rotational manipulation of micro-/nano-scale objects without any rotating component.Using numerical simulations,we find that diversified acoustofluidic fields can be generated in the chamber under various actuations,and massive polystyrene beads inside can experience different acoustophoretic motions under the combined effect of an acoustic radiation force and acoustic streaming.Moreover,we investigate and clarify the effects of structural design on modulation of the acoustofluidic fields in the chamber.We believe the presented study could not only provide a promising potential tool for rotational acoustofluidic manipulation,but could also bring this community some useful design insights into the achievement of desired acoustofluidic fields for assorted microfluidic applications.
文摘The speed of the streaming flow in the liquid layer loaded on a thin plate, in which Lamb waves are propagating, was calculated. The results are good agreement with Moroney's experiment
文摘Large amplitude dust ion acoustic (DIA) solitons as well as double layers (DLs) are studied in a dusty plasma having a high-energy-tail electron distribution. The influence of electron deviation from the Maxwellian distribution and ion streaming on the existence domain of solitons is discussed in the (M, f) space using the pseudo-potential approach. It is found that in the presence of streaming ions and for a fixed f, solitons may appear for larger values of M. This means that in the presence of ion streaming, high values of the Mach number are needed to have soliton. The DIA solitary waves profile is highly sensitive to the ion streaming speed. Their amplitude is found to decrease with an increase of the ion streaming speed. In addition, we find that the ion streaming effect may lead to the appearance of double layers. The results of this axticle should be useful in understanding the basic nonlinear features of DIA waves propagating in space dusty plasmas, especially those including a relative motion between species, such as comet tails and solar wind streams, etc.