运用象数形神气理论辨治黄褐斑

黄褐斑是一种慢性、难治性、损容性、色素沉着性皮肤病,其发病影响因素多,病机复杂。“取象运数,形神一体,气为一元”是中医学在长期的临床实践中形成的相对稳定的抽象化思维体系,对黄褐斑的认识更加全面。在象数形神气的理论指导下,黄褐斑的临床诊疗将脏腑、气血、阴阳、寒热、经络相联系,依据疾病征象多维辨证,形神同治,内外一气,整体调节,辨证论治,以提高临床疗效,减少疾病复发;重视心理干预,缓解患者的紧张、焦虑情绪,善用调理情志,不拘泥于一方一药。

基于皮腠神气变生理论指导的综合疗法治疗带状疱疹相关性疼痛的临床研究

目的探讨基于皮腠神气变生理论指导下的中医综合疗法治疗带状疱疹相关性疼痛的临床疗效。方法利用随机数字表法将我院收治的208例带状疱疹相关性疼痛患者分为观察组和对照组各104例,2组在心理治疗基础上对照组给予普瑞巴林,观察组给予中医综合疗法,14 d为1个疗程,治疗1个疗程后评价2组患者临床疗效。分别与治疗前后采用视觉模拟评分(VAS)、疼痛分级指数(PRI)及现有疼痛强度(PPI)评价疼痛;采用入睡时间评分、睡眠质量评分、睡眠时间评分、睡眠障碍评分及睡眠效率评分评价睡眠质量;观察治疗后血清白细胞介素(IL)-6、干扰素(IFN)-γ、超敏C反应蛋白(hs-CRP)及肿瘤坏死因子(TNF)-α炎性因子表达及CD4^+/CD8^+、CD8^+、CD3^+免疫指标。结果治疗后,观察组有效率显著高于对照组(P<0.05);观察组VAS、PRI及PPI评分均显著低于对照组(P<0.05);入睡时间评分、睡眠质量评分、睡眠时间评分、睡眠障碍评分及睡眠效率评分均显著低于对照组(P<0.05)。观察组治疗后IL-6、IFN-γ、hs-CRP及TNF-α均明显低于对照组,且CD4^+/CD8^+、CD8^+、CD4^+及CD3^+改善程度均明显优于对照组(P<0.05)。结论基于皮腠神气变生理论指导下的中医综合疗法治疗带状疱疹相关性疼痛疗效较好,值得开展进一步研究。

“神气饮”抗焦虑作用的研究

当今生活节奏加快，人在精神上、心理上常存在某种不平衡，烦躁、沮丧、紧张和情绪及精神失常正困扰着越来越多的现代人；人长期的在精神紧张状态下，其自身的免疫功能降低，易导致早衰和疾病的发生；进入更年期的中老年人或多或少都具有更年期综合症的临床表现；患有心血...

初论中医神气生命观

在解读《内经》的基础上,探讨中医学神、神明、心藏神的经典含义,提出"神气生命观"的论点,认为中医理论中的"神"是表明以气为根据的生命特征,而神的运动即气的运动在于升降出入及循环运转,此即气机,亦称神机。

文论范畴的生命体验——刘大櫆“神气”说的时空美学阐释

"神气"作为古代文论的范畴,具有一种生命存在和自由的时空美学向度。刘大櫆思想中无论是"神气"本身含义,还是"神"和"气"之间的关系,乃至具有"神气"的"十二贵",都让人清晰地感觉出"神气"背后蕴含着的无限的空间感和流动的时间感。这种时空感在刘大櫆"神气"说中集中地从本体层和表征层体现出来——"神"具有一种生命的时空本体性质,而"气"是这种时空本体的表征和体现。

刘大木魁神气音节说在桐城文论中的地位

“文气”说是古代文学创作论的基石,刘大木魁的神气音节说是对“文气”说的发展,刘大木魁的贡献主要表现在两个方面:一为贯气,认为在行文中气要一脉相贯,不可以断断续续,不相衔接;二为鼓气,认为气以壮势为美。刘大木魁的神气音节说抓住了散文创作的艺术特点,使桐城文派得以发展壮大,屹立于清代文坛。

刘大櫆“神气说”批判——兼论其散文艺术风格

"神"是一篇文章的灵魂,"气"是一篇文章的生命。刘大櫆"神气"说传承了中国古典文论"文气""神韵"说之内质。"神气、字句、音节"的文本解读方式,寄寓了清晰的结构层次意识。丰富多样的散文艺术风格为其理论作了明确的实证注解。

王者风范 气贯长虹——论毛泽东诗词的“精神气”

毛泽东诗词是毛泽东思想、毛泽东精神的形象化、艺术化、诗化。毛泽东精神博大精深，可以从各种不同的角度去概括他的特质。用台湾学者龚忠武概括的七气，即骨气、志气、勇气、才气、土气、正气、王气等，从七个方面论述了毛泽东诗词的精神气，以为这种“精神气”是实现国家富强、民族振兴、人民幸福的社会主义的“中国梦”必不可少的。

Clinical Study on Treatment of Primary Hepatocellular Carcinoma by Shenqi Mixture (参芪合剂) Combined with Microwave Coagulation

Objective: To observe the short￣term efficacy and safety of Shenqi mixture (参芪合剂, SQM) combined with microwave coagulation in treating primary hepatocellular carcinoma (HCC).Methods: Seventy-two patients with primary HCC of stage Ⅱ-Ⅲ, Karnofsky scoring ≥50 scores and predicted survival period ≥3 months were selected and randomly assigned into two groups, the treated group and the control group, 36 in each. Microwave therapy was applied to both groups by double leads, 60 W, 800 sec once a week for two weeks. To the treated group, SQM was given additionally through oral intake of 20 ml, three times a day for 1 month. The changes in tumor size, main symptoms, serum level of alpha-fetoprotein (AFP), immune function and adverse reaction were observed after treatment and the immune parameters of the patients were compared with 30 healthy persons in the normal control group. Results: (1) In the SQM treated group, after treatment 3 patients got completely remitted (CR), 24 partial remitted (PR), 4 unchanged (NC) and 5 progressively deteriorated (PD), the effective rate being 75.00%; while in the control group, 1 got CR, 19 PR, 9 NC and 7 PD, the effective rate being 55.56%. Comparison of the effective rate between the two groups showed significant difference (P<0.05). (2) AFP level decreased after treatment in both groups, but the decrement in the treated group was significantly higher than that in the control group (P<0.01). (3) After treatment, in the treated group, CD3+, CD4+, CD4+/CD8+ and NK activity were improved, Karnofsky scores increased and liver function bettered, with these improvements significantly superior to those in the control group (P<0.01). (4) The improvement in symptoms such as hepatic region pain, fever, weakness, poor appetite and jaundice in the treated group after treatment was also superior to that in the control group (P<0.01). (5)The 12-month, 18-month and 24-month survival rates were higher and the recurrence rate was lower in the treated group than those in the control group, showing significant difference (P<0.05). Conclusion: Combined therapy with SQM and microwave coagulation could not only kill the tumor and residue tumor cells to prevent recurrence, but also enhance the cellular immunity of organism. It is one of the effective therapies for patients with middle-advanced hepatocarcinoma, who have lost the chance of surgical operation. It could improve clinical symptoms, elevate the quality of life, prolong the survival period of patients, but shows no evident adverse reaction.

Preli minary Study on Treat ment of Partial Androgen Deficiencyin Aging Males with Jingui Shenqi Pill (金匮肾气丸)

Objective： To observe the efficacy and safety of Jingui Shengqi Pill （金匮肾气丸, JSP） in treating partial androgen deficiency in aging males （PADAM）, and to explore the new approach in improving the quality of life in PADAM patients. Methods： Forty patients with PADAM were treated with JSP, the efficacy was evaluated with international index of erectile function （IIEF） scoring, PADAM questionnaire scoring, hormone, prostatic specific antigen （PSA）, etc., and the data before treatment were compared with those after treatment in the same group. Results： After 3 months of treatment, PADAM scoring and IIEF scoring were all significantly improved. Symptoms regarding physical ability, vasomotion, and psychical and mental condition all got improved more markedly than symptoms regarding sexual hypofunction. The serum level of testosterone was 3.85±0.36 before treatment and 5.02±0.83 after treatmnet （P〈0.05）; luteinizing hormone of 7.33±2.14 and 4.84±1.43 （P〈0.01）, follicule-stimulating hormone of 10.22±4.48 and 6.47±3.28 （P〈0.01）, respectively. The level of PSA failed to change significantly （1.94±0.55 and 2.06±0.47, P〉0.05）. Conclusion： JSP is effective and safe in treating PADAM, the mechanism of it is different from supplementing extrinsic androgen. It may have produced the effect by means of favorably regulating the condition of sex hormone to improve the balance of pituitary-sex gland axis, so it has more extensive clinical application.

Chinese Medicine Formula “Shenqi San” Extract Inhibits Proliferation of Human Lung Adenocarcinoma A549 Cells via Inducing Apoptosis

The main purpose of this study was to investigate the active components of the Chinese medicine formula Shenqi San（SS） by high performance liquid chromatography with diode array detector and electrospray ionization-hybrid quadrupole time-of-flight mass spectrum（HPLC-DADESI-QTOF-MS）, and demonstrate the anticancer mechanism of SS on human lung adenocarcinoma A549 cells by evaluating the cell proliferation and apoptosis induction. The chloroform extraction of SS（CE-SS） was extracted from SS, while HPLC-DAD-ESI-QTOF-MS assay was performed to identify components of CE-SS. MTT assay was used to quantify the proliferation of A549 cells with the treatment of CE-SS. Apoptosis analysis was carried out by detecting phosphatidylserine（PS） externalization using the Annexin V-FITC Apoptosis Detection Kit and the stained cells were analyzed with a flow cytometer. DAPI staining assay was carried out to observe morphological characteristics of apoptotic cells. Western blotting was used to detect the expression of important signaling proteins including caspase-3,-8,-9, p53, Bax and Bcl-2. Eight compounds were identified through HPLC-DAD-ESI-QTOF-MS analysis and 3-pyridine carboxylic acid, barbatin C, scutebarbatine F and barbatine D might be the main compounds responsible for the antitumor effect of CE-SS. CE-SS suppressed the proliferation of lung cancer A549 cells in a time-and dose-dependent manner. By Annexin V-FITC/PI double staining, we found that treatment with CE-SS induced apoptosis in A549 cells. After 24-h exposure to CE-SS, the expression of cleaved-caspase-9, cleaved-caspase-8 and cleaved-caspase-3 protein was activated, the expression of p53 protein increased while the ratio of Bax/Bcl-2 also increased. This study identified the eight compounds of CE-SS, and demonstrated their anticancer effect on human lung adenocarcinoma A549 cells via induction of apoptosis.

自拟神气汤在慢性疲劳综合征中的应用(80例)

目的:观察神气汤加减治疗慢性疲劳综合征的临床疗效。方法:采用回顾性病例系列的设计方法,选取2016年1月至2017年5月在北京中医医院顺义医院治未病科及体检中心、高才达名医工作室就诊的慢性疲劳综合征气阴两虚型患者80例,给予神气汤治疗,口服,2次/d,200 m L/d,共30 d。门诊随访观察,根据疗效标准评价治疗效果。结果:患者服用神气汤4、6、8周的总有效率分别为83%、88%、91%。结论:神气汤能够调整患者机体气阴两虚,改善慢性疲劳综合征的乏力症状,提高患者生命质量,且未发现不良反应。

基于AHP-CRITIC混合加权法的正交试验优选神气汤提取工艺

目的优选神气汤的提取工艺。方法以加水倍量、提取时间、提取次数为考察因素,以AHP-CRITIC混合加权法确定神气汤中多糖含量,以及党参炔苷、毛蕊花糖苷、松脂醇二葡萄苷、马钱苷、五味子醇甲的提取率及干膏得率的权重系数,以综合评分为评价指标,采用L9(34)正交试验优选最佳提取工艺。结果神气汤最佳提取工艺为,药材加6倍量水,提取3次,每次30 min。结论AHP-CRITIC混合加权法结合正交试验优选的神气汤提取工艺稳定、可行,可为后期工业化生产提供参考。

Clinical Effects of Shenqi Fuzheng Injection in the Neoadjuvant Chemotherapy for Local Advanced Breast Cancer and the Effects on T-lymphocyte Subsets

Objective： To evaluate clinical effects of Shenqi Fuzheng Injection （参芪抉正注射液） in the neoadjuvant chemotherapy for local advanced breast cancer and the effects on T-lymphocyte subsets. Methods： During the period from 2000 to 2005, 126 patients with local advanced breast cancer were treated with the neoadjuvant chemotherapy. They were randomly divided into the following two groups： a control group of 61 cases treated by chemotherapy alone and a study group of 65 cases treated by chemotherapy plus Shenqi Fuzheng Injection, All the cases of both groups were given the CEF （CTX 500 mg/m^2, d1, 8; EP140 mg/m^2, d1, 8; and 5-Fu 500 mg/m^2, d1,8） regimen. The clinical effects, the effects on T-lymphocyte subgroup and NK cells, and the toxic side effects were observed. Results： All the patients completed two cycles of the chemotherapy, and the efficacy and the toxic side effects were evaluated. For the primary tumor in the breast, the total effective rate was 69.2% （45/65） in the study group and 49.2% （30/61） in the control group with a statistically significant difference in the intergroup comparison （x^2=5.251, P=0.022, 〈 0.05）. There was no progression of the disease in both the groups, and there were no grade IV toxic side effects in the two groups. The major toxic responses were myelosuppression and gastrointestinal reaction, which were milder in the study group than the control group, and with a shorter recovery course in the former than the latter. Besides, an obvious rise of the T-lymphocyte subgroup and NK cells was found in the study group after the neoadjuvant chemotherapy, with a very significant difference from the controls （P〈0.01）. Conclusions： Shenqi Fuzheng Injection can improve and regulate immune function of the patients with local advanced breast cancer given the neoadjuvant chemotherapy, and therefore it can enhance the curative effect and reduce the side effect as well.

Shenqi Fuzheng Injection Ameliorates Radiation-induced Brain Injury

Shenqi Fuzheng injection(SFI)has been confirmed to be able to alleviate brain injury in mice.This study examined the brain-protective effect of SFI on patients after cranial radiation.Lung cancer patients with brain metastasis were randomly assigned to two groups.The SFI group received cranial radiation in combination with SFI.The control group received cranial radiation alone.The changes in cognitive function were evaluated pre- and post-radiation against the Mini-Mental State Exam(MMSE),Montreal Cognitive Assessement(MoCA),Zung Self-Rating Depression Scale(SDS)and Zung Self-Rating Anxiety Scale(SAS).The changes in inflammatory factors,such as TGF-β1,TNF-α and IL-10,were also detected before,during and after radiation(15Gy/5F).The results showed that 6 months after cranial radiation,the total scores on the MMSE and MoCA scales of the patients decreased,especially memory ability.The control group experienced a more evident decline,the memory ability being the greatest.TGF-β1 and TNF-α increased shortly after radiation and decreased one month later,and the change was more conspicuous in SFI group than in control group.IL-10 increased after radiation and stayed at a high level one month later in both groups,the level being higher in the SFI group than in the control group.Our study indicated that cognitive functions,especially memory ability,were impaired after cranial radiation.SFI could alleviate radiation-induced brain injury by regulating inflammatory factors.

Meta-analysis of Shenqi Fuzheng Injection Combined with Chemotherapy in Treatment of Colorectal Cancer

[Objectives] To make a systematic evaluation of the clinical efficacy and safety of Shenqi Fuzheng Injection in the treatment of colorectal cancer. [Methods] Databases,such as China National Knowledge Infrastructure( CNKI),Wanfang,China biomedical literature service system( CBM),CQVIP,Medline,and Cochrane,were searched for the time before April 2017. The randomized controlled trial( RCT) that met the inclusion criteria was screened. Then,quality evaluation was made based on the modified Jadad scale. Data were extracted and meta-analysis was made with the aid of Review Manager 5. 3. [Results] Finally,21 papers met the inclusion criteria,including 2 high quality papers. The average Jadad score was 2. 5 points,1 589 patients were included. Meta-analysis results showed that the intervention of the experimental group could improve the quality of life[OR = 3. 32,95% CI( 2. 33,4. 74),P < 0. 000 01]; improve the short-term efficacy[OR =1. 68,95% CI( 1. 26,2. 24),P =0. 000 4]; reduce the incidence of adverse chemotherapy reactions such as reducing the gastrointestinal reactions[OR = 0. 33,95% CI( 0. 25,0. 43),P < 0. 000 01],reducing myelosuppressive reactions[OR = 0. 33,95% CI( 0. 24,0. 46),P < 0. 000 01]; improve the immune functions,such as increasing CD4/CD8 cell ratio[WMD = 1. 19,95% CI( 0. 24,0. 41),( P <0. 000 01) ],and increasing the number of NK cells[WMD =1. 72,95% CI( 5. 62,14. 30),( P <0. 000 01) ]. [Conclusions]The clinical effect of Shenqi Fuzheng Injection in the treatment of colorectal cancer is better than that of chemotherapy alone,but it needs more highquality RCTs to improve the level of research.

从神气相关探讨功能性胃肠病诊治

神、气学说是人与自然的辩证哲学思想,神、气互生互用、对立统一,反映微观及宏观的生命现象。从神、气相关认识功能性胃肠病,气的失常是病机共性,神病及气、气病及神的神气共病是疾病本质。神气同调治疗功能性胃肠病,调节脏腑之气的升降平衡、出入有序,恢复气、血、精、津液的代谢及转化,安藏五神,滋养元神。内外合治,运用针刺、艾灸等外治方法,遵循四时八节、五运六气的客观规律,实现人与自然的神气和谐。

Neuroprotective effect of Shenqi Fuzheng injection pretreatment in aged rats with cerebral ischemia/reperfusion injury

Shenqi Fuzheng injection is extracted from the Chinese herbs Radix Astragali and Radix Codonopsis. The aim of the present study was to investigate the neuroprotective effects of Shenqi Fuzheng injection in cerebral ischemia and reperfusion. Aged rats（20–22 months） were divided into three groups： sham, model, and treatment. Shenqi Fuzheng injection or saline（40 m L/kg） was injected into the tail vein daily for 1 week, after which a cerebral ischemia/reperfusion injury model was established. Compared with model rats that received saline, rats in the treatment group had smaller infarct volumes, lower brain water and malondialdehyde content, lower brain Ca2＋ levels, lower activities of serum lactate dehydrogenase and creatine kinase, and higher superoxide dismutase activity. In addition, the treatment group showed less damage to the brain tissue ultrastructure and better neurological function. Our findings indicate that Shenqi Fuzheng injection exerts neuroprotective effects in aged rats with cerebral ischemia/reperfusion injury, and that the underlying mechanism relies on oxygen free radical scavenging and inhibition of brain Ca2＋ accumulation.

Clinical Observation on Effect of Shenqi Fuzheng(参芪扶正)Injection Combined with Chemotherapy in Treating Post-operational Patients with Colorectal Carcinoma

Chemotherapy(CT)is the most impor-tant therapeutic means in treating post-oper-ational patients with colorectal carcinoma(CA),but its efficacy is often affected bythe toxic side-effects of CT agents.TCMcould reinforce body resistance and tonifythe qi,alleviate the toxic side-effects of CT,thus strengthening the efficacy of organismagainst tumor.Shenqi Fuzheng(参芪扶正,

神气汤对慢性疲劳综合征大鼠免疫功能的影响

目的:探讨神气汤对慢性疲劳综合征(CFS)大鼠免疫功能的影响及其作用机制。方法:将40只健康雌性SD大鼠随机分为正常组、模型组、帕罗西汀组和神气汤组,每组各10只。除正常组外,其余各组制备CFS模型,模型制备成功后模型组不给药、帕罗西汀组和神气汤组灌胃相应的药物。检测各组大鼠旷场实验评分、免疫器官指数及血清免疫球蛋白G(IgG)、免疫球蛋白A(IgA)的表达水平。结果:正常组大鼠在整个实验过程中未见明显异常;模型组大鼠对外界的适应能力减弱,如懒动、烦躁易怒等;神气汤组、帕罗西汀组大鼠的皮毛脱落状况较给药前好转,大便成形、情绪正常。与正常组比较,模型组大鼠水平运动次数、垂直运动次数、胸腺指数、脾脏指数及IgA、IgG均减少(P<0.05),中央格停留时间增加(P<0.05)。与模型组比较,神气汤组、帕罗西汀组水平运动次数、垂直运动次数、胸腺指数、脾脏指数及IgA、IgG均增加(P<0.05),中央格停留时间减少(P<0.05)。与帕罗西汀组比较,神气汤组IgG、IgA增加(P<0.05)。结论:神气汤能够提高CFS大鼠的免疫器官指数,上调IgG、IgA的表达,改善大鼠的免疫水平,治疗CFS。