The human pregnane X receptor(hPXR) plays a critical role in the metabolism, transport and clearance of xenobiotics in the liver and intestine. The hPXR can be activated by a structurally diverse of drugs to initiat...The human pregnane X receptor(hPXR) plays a critical role in the metabolism, transport and clearance of xenobiotics in the liver and intestine. The hPXR can be activated by a structurally diverse of drugs to initiate clinically relevant drug-drug interactions. In this article, in silico investigation was performed on a structurally diverse set of drugs to identify critical structural features greatly related to their agonist activity towards h PXR. Heuristic method(HM)-Best Subset Modeling(BSM) and HM-Polynomial Neural Networks(PNN) were utilized to develop the linear and non-linear quantitative structure-activity relationship models. The applicability domain(AD) of the models was assessed by Williams plot. Statistically reliable models with good predictive power and explain were achieved(for HM-BSM, r^2=0.881, q^2_(LOO)=0.797, q^2_(EXT)=0.674; for HM-PNN, r^2=0.882, q^2_(LOO)=0.856, q^2_(EXT)=0.655). The developed models indicated that molecular aromatic and electric property, molecular weight and complexity may govern agonist activity of a structurally diverse set of drugs to h PXR.展开更多
The properties of 1(1/2)-spectrum are proved and the performances are an- alyzed. By means of the spectrum, the basic frequency component of the harmonic signals can be enhanced. Gaussian color noise and symetrical di...The properties of 1(1/2)-spectrum are proved and the performances are an- alyzed. By means of the spectrum, the basic frequency component of the harmonic signals can be enhanced. Gaussian color noise and symetrical distribution noise can be canceled. And non-quadratic phase coupling harmonic components in harmonic signal can be reduced. The ship radiated-noise is analyzed and its 7 features are extracted by the spectrum. By means of B-P artificial neural network, three type ships are classified according to extracted features. The classification results about the three type ships A, B and C are 90%, 91.3% and 85.7%. respectively.展开更多
基金supported by grants from the Natural Science Research Project of Institution of Higher Education of Jiangsu Province(No.11KJB180006)National Natural Science Foundation of China(No.21277074 and No.81302458)
文摘The human pregnane X receptor(hPXR) plays a critical role in the metabolism, transport and clearance of xenobiotics in the liver and intestine. The hPXR can be activated by a structurally diverse of drugs to initiate clinically relevant drug-drug interactions. In this article, in silico investigation was performed on a structurally diverse set of drugs to identify critical structural features greatly related to their agonist activity towards h PXR. Heuristic method(HM)-Best Subset Modeling(BSM) and HM-Polynomial Neural Networks(PNN) were utilized to develop the linear and non-linear quantitative structure-activity relationship models. The applicability domain(AD) of the models was assessed by Williams plot. Statistically reliable models with good predictive power and explain were achieved(for HM-BSM, r^2=0.881, q^2_(LOO)=0.797, q^2_(EXT)=0.674; for HM-PNN, r^2=0.882, q^2_(LOO)=0.856, q^2_(EXT)=0.655). The developed models indicated that molecular aromatic and electric property, molecular weight and complexity may govern agonist activity of a structurally diverse set of drugs to h PXR.
文摘The properties of 1(1/2)-spectrum are proved and the performances are an- alyzed. By means of the spectrum, the basic frequency component of the harmonic signals can be enhanced. Gaussian color noise and symetrical distribution noise can be canceled. And non-quadratic phase coupling harmonic components in harmonic signal can be reduced. The ship radiated-noise is analyzed and its 7 features are extracted by the spectrum. By means of B-P artificial neural network, three type ships are classified according to extracted features. The classification results about the three type ships A, B and C are 90%, 91.3% and 85.7%. respectively.