The Qingsong Garment Co. Ltd in Inner Mongolia was founded in 1988 by five enterprises from the Mainland, Japan and Hongkong. The company has introduced the world’s advanced equipment, adopted the Japanese CAD clothi...The Qingsong Garment Co. Ltd in Inner Mongolia was founded in 1988 by five enterprises from the Mainland, Japan and Hongkong. The company has introduced the world’s advanced equipment, adopted the Japanese CAD clothing design system and invited foreign experts to give technological instruction展开更多
Objective:It is well known that stress plays a critical role in immune response and susceptibility to diseases.Among many stressors,restraint stress has been shown to suppress immune function and increase susceptibili...Objective:It is well known that stress plays a critical role in immune response and susceptibility to diseases.Among many stressors,restraint stress has been shown to suppress immune function and increase susceptibility to infections.In this study,we employed a restraint-mouse model to investigate the effect and preliminary mechanism of ShiQi herbal tea(SQHT),a traditional Chinese medicine,on H1N1 virus infection.Methods:Mice were exposed to restraint stress and infected with H1N1 influenza virus by intranasal inoculation.SQHT(936 and 1872 mg/kg/d)was orally administrated to mice for 7 days from the first day of restraint stress.The survival rate of mice in each group was monitored daily for 21 days.Histopathological changes,inflammatory cells infiltration,and virus titer in lungs were examined.For the study of mechanisms,we investigated whether SQHT could promote interferon-β(IFN-β)generation and interferon stimulated genes(ISG)expression.Results:Our results suggested that SQHT(936 mg/kg/d)significantly reduced H1N1-induced mortality,the level of complement C5a and lung tissue inflammation,and viral replication in restraint-stressed mice.Further results revealed that in restraint-stressed mice model,SQHT(936 mg/kg/d)administration markedly improved IFN-βgeneration,and increased MX1 and IFITM3 gene expression.Conclusion:Our study demonstrates that SQHT reduces restraint stress-induced susceptibility to H1N1 infection via improving IFN-βantiviral pathway,which provides a certain basis for the clinical use of SQHT to treat H1N1 infection.展开更多
Yang Shiqi, leader of the Taige Style in early Ming Dynasty, is a follower of Ouyang Xiu in literary writing which is predominantly on the interpretation and exposition of the Way of Nature. But Yang is better at writ...Yang Shiqi, leader of the Taige Style in early Ming Dynasty, is a follower of Ouyang Xiu in literary writing which is predominantly on the interpretation and exposition of the Way of Nature. But Yang is better at writing travel notes and biographies. His poetry consists of two styles, the archaic, which imitates Han and Wei, and the contemporary, which imitates High Tang and is the better of the two. Yang’s literary creation provides a model for the Taige Style, and has a significant influence on its establishment.展开更多
文摘The Qingsong Garment Co. Ltd in Inner Mongolia was founded in 1988 by five enterprises from the Mainland, Japan and Hongkong. The company has introduced the world’s advanced equipment, adopted the Japanese CAD clothing design system and invited foreign experts to give technological instruction
基金This work was financially supported,in part,by Science and Technology Project of Zhongshan(2013A3FC0253)Scientific Research Team Training Project in University of Electronic Science and Technology of China,Zhongshan Institute(No.412YT02)Natural Science Foundation of Guangdong Province-the Ph.D.Startup and Vertical Collaboration Project(2018030310186).
文摘Objective:It is well known that stress plays a critical role in immune response and susceptibility to diseases.Among many stressors,restraint stress has been shown to suppress immune function and increase susceptibility to infections.In this study,we employed a restraint-mouse model to investigate the effect and preliminary mechanism of ShiQi herbal tea(SQHT),a traditional Chinese medicine,on H1N1 virus infection.Methods:Mice were exposed to restraint stress and infected with H1N1 influenza virus by intranasal inoculation.SQHT(936 and 1872 mg/kg/d)was orally administrated to mice for 7 days from the first day of restraint stress.The survival rate of mice in each group was monitored daily for 21 days.Histopathological changes,inflammatory cells infiltration,and virus titer in lungs were examined.For the study of mechanisms,we investigated whether SQHT could promote interferon-β(IFN-β)generation and interferon stimulated genes(ISG)expression.Results:Our results suggested that SQHT(936 mg/kg/d)significantly reduced H1N1-induced mortality,the level of complement C5a and lung tissue inflammation,and viral replication in restraint-stressed mice.Further results revealed that in restraint-stressed mice model,SQHT(936 mg/kg/d)administration markedly improved IFN-βgeneration,and increased MX1 and IFITM3 gene expression.Conclusion:Our study demonstrates that SQHT reduces restraint stress-induced susceptibility to H1N1 infection via improving IFN-βantiviral pathway,which provides a certain basis for the clinical use of SQHT to treat H1N1 infection.
文摘Yang Shiqi, leader of the Taige Style in early Ming Dynasty, is a follower of Ouyang Xiu in literary writing which is predominantly on the interpretation and exposition of the Way of Nature. But Yang is better at writing travel notes and biographies. His poetry consists of two styles, the archaic, which imitates Han and Wei, and the contemporary, which imitates High Tang and is the better of the two. Yang’s literary creation provides a model for the Taige Style, and has a significant influence on its establishment.
