This study was undertaken to dissect quantitative trait loci (QTLs) controlling yield traits on the short arm of rice chromosome 6. A residual heterozygous line that carries a heterozygous segment extending from RM5...This study was undertaken to dissect quantitative trait loci (QTLs) controlling yield traits on the short arm of rice chromosome 6. A residual heterozygous line that carries a heterozygous segment extending from RM587 to RM19784 on the short arm of rice chromosome 6 was selected from an F7 population of the indica rice cross Zhenshan 97B/Milyang 46. An F2:3 population consisting of 221 lines was derived and grown in two trial sites. Six yield traits including number of panicles per plant, number of filled grains per panicle, total number of spikelets per panicle, spikelet fertility, 1 000-grain weight, and grain yield per plant were measured. An SSR marker linkage map was constructed and employed to determine QTLs for yield traits with Windows QTL Cartographer 2.5. QTLs were detected in the target interval for all the traits analyzed except NP, with phenotypic variance explained by a single QTL ranging between 6.3% and 35.2%. Most of the QTLs for yield components acted as additive QTLs, while the three QTLs for grain yield had dominance degrees of 1.65, 0.84, and -0.42, respectively. It was indicated that three or more QTLs for yield traits were located in the target region. The genetic action mode, the direction of the QTL effect, and the magnitude of the QTL effect varied among different QTLs for a given trait, and among QTLs for different traits that were located in the same interval.展开更多
A rice residual heterozygous line (RHL) carrying a heterozygous segment extending from RM111 to RM19784 on the short arm of rice chromosome 6 was selected from a RHL-derived population used previously. The resultant...A rice residual heterozygous line (RHL) carrying a heterozygous segment extending from RM111 to RM19784 on the short arm of rice chromosome 6 was selected from a RHL-derived population used previously. The resultant F2:3 population was used to detect quantitative trait loci (QTLs) for three yield traits, the number of spikelets per panicle (NSP), the number of grains per panicle (NGP) and grain yield per plant (GY). Two QTLs for NSP, one QTL for NGP and one QTL for GY were detected, all of which were partially dominant and had the enhancing alleles from the maternal line Zhenshan 97B. Analysis based on the genotypic groups of the markers closely linked to the two QTLs for NSP indicated that they did not interact with each other. Two F2 populations and two near isogenic line (NIL) sets segregating in two sub-regions of interval RM111-RM19784 were developed. The two QTLs for NSP were validated, of which one had major effect and was co-segregated with heading date gene Hdl, and the other had smaller effect and was located in an upper region linked to Hdl. The two regions also showed significant effects on the number of filled grain and grain yield, although the effect on the number of filled grain was less consistent.展开更多
Background:Vestibular symptoms on sitting-up are frequent on patients seen by vestibular specialists.Recently,a benign paroxysmal positional vertigo(BPPV)variant which elicits vestibular symptoms with oculomotor evide...Background:Vestibular symptoms on sitting-up are frequent on patients seen by vestibular specialists.Recently,a benign paroxysmal positional vertigo(BPPV)variant which elicits vestibular symptoms with oculomotor evidence of posterior semicircular canal(P-SCC)cupula stimulation on sitting-up was described and named sitting-up vertigo BPPV.A periampullar restricted P-SCC canalolithiasis was proposed as a causal mechanism.Objective:To describe new mechanisms of action for the sitting-up vertigo BPPV variant.Methods:Eighteen patients with sitting-up vertigo BPPV were examined with a pre-established set of positional maneuvers and follow-up until they resolved their symptoms and clinical findings.Results:All patients showed up-beating torsional nystagmus(UBTN)and vestibular symptoms on coming up from either Dix-Hallpike(DHM)or straight head-hanging maneuver.Sixteen out of 18 patients presented a sustained UBTN with an ipsitorsional component to the tested side on half-Hallpike maneuver(HH).A slower persistent contratorsional down-beating nystagmus was found in eleven out18 patients tested on nose down position(ND).Conclusions:Persistent direction changing positional nystagmus on HH and ND positions indicative of PSCC heavy cupula was found in 11 patients.A sustained UBTN on HH with the absence of findings on ND,which is suggestive of the presence of P-SCC short arm canalolithiasis,was found on 5 patients.All patients were treated with canalith repositioning maneuvers without success,but they resolved their findings by means of Brandt-Daroff exercises.We propose P-SCC heavy cupula and P-SCC short arm canalolithiasis as two new putative mechanisms for the sitting-up vertigo BPPV variant.展开更多
BACKGROUND Distal radius fractures(DRFs)are a common challenge in orthopaedic trauma care,yet for those fractures that are treated nonoperatively,strong evidence to guide cast treatment is still lacking.AIM To compare...BACKGROUND Distal radius fractures(DRFs)are a common challenge in orthopaedic trauma care,yet for those fractures that are treated nonoperatively,strong evidence to guide cast treatment is still lacking.AIM To compare the efficacy of below elbow cast(BEC)and above elbow cast(AEC)in maintaining reduction of manipulated DRFs.METHODS We conducted a prospective,monocentric,randomized,parallel-group,open label,blinded,noninferiority trial comparing the efficacy of BEC and AEC in the nonoperative treatment of DRFs.Two hundred and eighty patients>18 years of age diagnosed with DRFs were successfully randomized and included for analysis over a 3-year period.Noninferiority thresholds were defined as a 2 mm difference for radial length(RL),a 3°difference for radial inclination(RI),and volar tilt(VT).The trial is registered at Clinicaltrials.gov(NCT03468023).RESULTS One hundred and forty-three patients were treated with BEC,and 137 were treated with AEC.The mean time of immobilization was 33 d.The mean loss of RL,RI,and VT was 1.59 mm,2.83°,and 4.11°for BEC and 1.63 mm,2.54°,and VT loss were respectively 0.04 mm(95%CI:-0.36-0.44),-0.29°(95%CI:-1.03-0.45),and 0.59°(95%CI:-1.39-2.57),and they were all below the prefixed noninferiority thresholds.The rate of loss of reduction was similar.CONCLUSION BEC performs as well as AEC in maintaining the reduction of a manipulated DRF.Being more comfortable to patients,BEC may be preferable for nonoperative treatment of DRFs.展开更多
模块化多电平换流器的固态变压器(modular multilevel converter based solid state transformer,MMC-SST)由于具备多电压等级、多电压形态的端口,在交直流混合配电网中得到广泛关注。传统的输入串联输出并联(inputseriesoutput paralle...模块化多电平换流器的固态变压器(modular multilevel converter based solid state transformer,MMC-SST)由于具备多电压等级、多电压形态的端口,在交直流混合配电网中得到广泛关注。传统的输入串联输出并联(inputseriesoutput parallel,ISOP)型MMC-SST具有较高的功率密度,但是在中压直流(medium voltage DC,MVDC)端口短路故障情况下无法持续向低压侧供电;双向有源全桥变换器(dualactive bridge,DAB)型MMC-SST则存在功率密度低、成本高等问题,并且传统的半桥结构的DAB型MMC-SST在MVDC端口短路故障情况下同样无法持续向低压侧供电。文章提出了一种子模块桥臂复用(arm integrated submodule,AISM)型MMC-SST拓扑,在不改变MMC-SST端口电气特性的情况下,在有效减少开关器件数量的同时,还使得SST具备中压直流端口短路故障下的不间断运行能力,进而提升SST的功率密度和供电可靠性。针对文中提出的AISM型MMCSST拓扑,该文还提出了一种针对输入级MMC的混频调制方法,基于共模、差模解耦原理,实现输入级MMC桥臂电压的高频分量和低频分量的解耦。通过理论分析与仿真模拟,验证了所提拓扑及控制方法的可行性。展开更多
基金supported by the Zhejiang Natural Science Foundation(Y304446)the National 863 Program of China(2006AA10Z1E8)the Chinese Super Rice Breeding Program(200606).
文摘This study was undertaken to dissect quantitative trait loci (QTLs) controlling yield traits on the short arm of rice chromosome 6. A residual heterozygous line that carries a heterozygous segment extending from RM587 to RM19784 on the short arm of rice chromosome 6 was selected from an F7 population of the indica rice cross Zhenshan 97B/Milyang 46. An F2:3 population consisting of 221 lines was derived and grown in two trial sites. Six yield traits including number of panicles per plant, number of filled grains per panicle, total number of spikelets per panicle, spikelet fertility, 1 000-grain weight, and grain yield per plant were measured. An SSR marker linkage map was constructed and employed to determine QTLs for yield traits with Windows QTL Cartographer 2.5. QTLs were detected in the target interval for all the traits analyzed except NP, with phenotypic variance explained by a single QTL ranging between 6.3% and 35.2%. Most of the QTLs for yield components acted as additive QTLs, while the three QTLs for grain yield had dominance degrees of 1.65, 0.84, and -0.42, respectively. It was indicated that three or more QTLs for yield traits were located in the target region. The genetic action mode, the direction of the QTL effect, and the magnitude of the QTL effect varied among different QTLs for a given trait, and among QTLs for different traits that were located in the same interval.
基金supported by the Chinese Super Rice Research Program(200906)the High-Yielding Transgenic Program,China(2008ZX08001-004)the National Natural Science Foundation of China(30571062)
文摘A rice residual heterozygous line (RHL) carrying a heterozygous segment extending from RM111 to RM19784 on the short arm of rice chromosome 6 was selected from a RHL-derived population used previously. The resultant F2:3 population was used to detect quantitative trait loci (QTLs) for three yield traits, the number of spikelets per panicle (NSP), the number of grains per panicle (NGP) and grain yield per plant (GY). Two QTLs for NSP, one QTL for NGP and one QTL for GY were detected, all of which were partially dominant and had the enhancing alleles from the maternal line Zhenshan 97B. Analysis based on the genotypic groups of the markers closely linked to the two QTLs for NSP indicated that they did not interact with each other. Two F2 populations and two near isogenic line (NIL) sets segregating in two sub-regions of interval RM111-RM19784 were developed. The two QTLs for NSP were validated, of which one had major effect and was co-segregated with heading date gene Hdl, and the other had smaller effect and was located in an upper region linked to Hdl. The two regions also showed significant effects on the number of filled grain and grain yield, although the effect on the number of filled grain was less consistent.
文摘Background:Vestibular symptoms on sitting-up are frequent on patients seen by vestibular specialists.Recently,a benign paroxysmal positional vertigo(BPPV)variant which elicits vestibular symptoms with oculomotor evidence of posterior semicircular canal(P-SCC)cupula stimulation on sitting-up was described and named sitting-up vertigo BPPV.A periampullar restricted P-SCC canalolithiasis was proposed as a causal mechanism.Objective:To describe new mechanisms of action for the sitting-up vertigo BPPV variant.Methods:Eighteen patients with sitting-up vertigo BPPV were examined with a pre-established set of positional maneuvers and follow-up until they resolved their symptoms and clinical findings.Results:All patients showed up-beating torsional nystagmus(UBTN)and vestibular symptoms on coming up from either Dix-Hallpike(DHM)or straight head-hanging maneuver.Sixteen out of 18 patients presented a sustained UBTN with an ipsitorsional component to the tested side on half-Hallpike maneuver(HH).A slower persistent contratorsional down-beating nystagmus was found in eleven out18 patients tested on nose down position(ND).Conclusions:Persistent direction changing positional nystagmus on HH and ND positions indicative of PSCC heavy cupula was found in 11 patients.A sustained UBTN on HH with the absence of findings on ND,which is suggestive of the presence of P-SCC short arm canalolithiasis,was found on 5 patients.All patients were treated with canalith repositioning maneuvers without success,but they resolved their findings by means of Brandt-Daroff exercises.We propose P-SCC heavy cupula and P-SCC short arm canalolithiasis as two new putative mechanisms for the sitting-up vertigo BPPV variant.
文摘BACKGROUND Distal radius fractures(DRFs)are a common challenge in orthopaedic trauma care,yet for those fractures that are treated nonoperatively,strong evidence to guide cast treatment is still lacking.AIM To compare the efficacy of below elbow cast(BEC)and above elbow cast(AEC)in maintaining reduction of manipulated DRFs.METHODS We conducted a prospective,monocentric,randomized,parallel-group,open label,blinded,noninferiority trial comparing the efficacy of BEC and AEC in the nonoperative treatment of DRFs.Two hundred and eighty patients>18 years of age diagnosed with DRFs were successfully randomized and included for analysis over a 3-year period.Noninferiority thresholds were defined as a 2 mm difference for radial length(RL),a 3°difference for radial inclination(RI),and volar tilt(VT).The trial is registered at Clinicaltrials.gov(NCT03468023).RESULTS One hundred and forty-three patients were treated with BEC,and 137 were treated with AEC.The mean time of immobilization was 33 d.The mean loss of RL,RI,and VT was 1.59 mm,2.83°,and 4.11°for BEC and 1.63 mm,2.54°,and VT loss were respectively 0.04 mm(95%CI:-0.36-0.44),-0.29°(95%CI:-1.03-0.45),and 0.59°(95%CI:-1.39-2.57),and they were all below the prefixed noninferiority thresholds.The rate of loss of reduction was similar.CONCLUSION BEC performs as well as AEC in maintaining the reduction of a manipulated DRF.Being more comfortable to patients,BEC may be preferable for nonoperative treatment of DRFs.
文摘模块化多电平换流器的固态变压器(modular multilevel converter based solid state transformer,MMC-SST)由于具备多电压等级、多电压形态的端口,在交直流混合配电网中得到广泛关注。传统的输入串联输出并联(inputseriesoutput parallel,ISOP)型MMC-SST具有较高的功率密度,但是在中压直流(medium voltage DC,MVDC)端口短路故障情况下无法持续向低压侧供电;双向有源全桥变换器(dualactive bridge,DAB)型MMC-SST则存在功率密度低、成本高等问题,并且传统的半桥结构的DAB型MMC-SST在MVDC端口短路故障情况下同样无法持续向低压侧供电。文章提出了一种子模块桥臂复用(arm integrated submodule,AISM)型MMC-SST拓扑,在不改变MMC-SST端口电气特性的情况下,在有效减少开关器件数量的同时,还使得SST具备中压直流端口短路故障下的不间断运行能力,进而提升SST的功率密度和供电可靠性。针对文中提出的AISM型MMCSST拓扑,该文还提出了一种针对输入级MMC的混频调制方法,基于共模、差模解耦原理,实现输入级MMC桥臂电压的高频分量和低频分量的解耦。通过理论分析与仿真模拟,验证了所提拓扑及控制方法的可行性。