In order to solve the problems of rotor overvoltage,overcurrent and DC side voltage rise caused by grid voltage drops,a coordinated control strategy based on symmetrical and asymmetrical low voltage ride through of ro...In order to solve the problems of rotor overvoltage,overcurrent and DC side voltage rise caused by grid voltage drops,a coordinated control strategy based on symmetrical and asymmetrical low voltage ride through of rotor side converter of the doubly-fed generator is proposed.When the power grid voltage drops symmetrically,the generator approximate equation under steady-state conditions is no longer applicable.Considering the dynamic process of stator current excitation,according to the change of stator flux and the depth of voltage drop,the system can dynamically provide reactive power support for parallel nodes and suppress the rise of DC side voltage and rotor over-current.When the grid voltage drops asymmetrically,the positive and negative sequence components are separated in the rotating coordinate system.The doubly fed generator model is established to suppress the rotor positive sequence current and negative sequence current respectively.At the same time,the output voltage limit of the converter is discussed,and the reference value is adjusted within the allowable output voltage range.In order to adapt to the occurrence of different types of power grid faults and complex operating conditions,a fast switching module of fault type detection and rotor control mode is designed to detect the type of power grid faults and voltage drop depth in real time and switch the rotor side control mode dynamically.Finally,the simulation model of the doubly fed wind turbine is constructed in Matlab/Simulink.The simulation results verify that the proposed control strategy can improve the low-voltage ride through performance of the system when dealing with the symmetrical and asymmetric voltage drop of the power grid and identify the power grid fault type and provide the correct control strategy.展开更多
Gob-side entry driving can increase coal recovery ratio, and it is implied in many coal mines. Based on geological condition of 10416 working face tailentry in Yangliu Coal Mine, the surrounding rock deformation chara...Gob-side entry driving can increase coal recovery ratio, and it is implied in many coal mines. Based on geological condition of 10416 working face tailentry in Yangliu Coal Mine, the surrounding rock deformation characteristics of gob-side entry driving with narrow coal pillar is analysed, reasonable size of coal pillar and reasonable roadway excavation time after mining are achieved. Surrounding rock control technology and effective roadway side sealing technology are proposed and are taken into field practice. The results showed that a safer and more efficient mining of working face can be achieved. In addition, results of this paper also have important theoretical significance and valuable reference for surrounding rock control technology of gob-side entry driving with narrow coal pillar under special geological condition.展开更多
The effect of reinforcing roof, sides and floor corners to control floor heave of extraction opening was analyzed, It was proved by engineering practice and numerical simulation that reinforcing any part of surroundin...The effect of reinforcing roof, sides and floor corners to control floor heave of extraction opening was analyzed, It was proved by engineering practice and numerical simulation that reinforcing any part of surrounding rock have certainly control effect for floor heave, in the basis of this, the new way that roof, sides and floor corners were rein-forced to control floor heave was put forward. Contrasting control result of reinforcing floor with this, it is determined that reinforcing is more suitable to control floor heave of extrac-tion opening than reinforcing floor when advancing abutment pressure is in some range.展开更多
Strong asymmetrical vortices appear on the leeward of slender body at high angles of attack, which has very unfavorable effect on the stability and control of the aircraft. A method is developed to control the side fo...Strong asymmetrical vortices appear on the leeward of slender body at high angles of attack, which has very unfavorable effect on the stability and control of the aircraft. A method is developed to control the side force of slender body at high angles of attack, and is verified in wind tunnel. A thin-film triangular self-excited oscillation flag is fixed at the tip of the slender body model whose semi-apex angle is 10°. Side force is approximately linearly proportional to roll-setting angle of self-excited oscillation flag at high angles of attack, and the slop of fitting straight line obtained by the least square method is -0.158. The linear relationship between side force and roU-setting angle provides convenience for developing side force control law of slender body at high angles of attack. Experimental data shows that the side force coefficients vary linearly with roll-setting angles when a specific plastic self-excited oscillation flag is used as the control flag. The range of side force coefficient and roll-setting angle are, respectively, -3.2 to 3.0 and -20° to 20°. The device is simple, effective, and is of great potential in engineering application.展开更多
In allusion to the problems of complex stress distribution in the surrounding rock and deformation failure laws, as well as the difficulty in roadway supporting of the gob-side entry driving in the island coal face, 2...In allusion to the problems of complex stress distribution in the surrounding rock and deformation failure laws, as well as the difficulty in roadway supporting of the gob-side entry driving in the island coal face, 2107 face in Chengjiao Colliery is researched as an engineering case. Through physical mechanical test of rock, theoretical and numerical simulation analyses of rock, the analysis model of the roadway overlying strata structure was established, and its parameters quantified. To reveal the deformation law of the surrounding rock, the stability of the overlying strata structure was studied before, during and after the roadway driving. According to the field conditions, the stress distribution in coal pillar was quantified, and the surrounding rock deformation feature studied with different widths of the pillars in gob-side entry driving. Finally, the pillar width of 4 m was considered as the most reasonable. The research results show that there is great difference in support conditions among roadway roof, entity coal side and narrow pillar side. Besides, the asymmetric control technique for support of the surrounding rock was proposed. The asymmetric control technique was proved to be reasonable by field monitoring, support by bolt-net, steel ladder and steel wire truss used in narrow pillar side.展开更多
This paper addresses the principle and control topology of active pow er filter( APF). The control strategy of direct pow er control based on DC side is introduced,and the control output is implemented by using the pr...This paper addresses the principle and control topology of active pow er filter( APF). The control strategy of direct pow er control based on DC side is introduced,and the control output is implemented by using the principle of hysteresis control.The active pow er filter can effectively control the pow er system harmonics,improve the quality of electricity and purify pow er grid. The experimental results are provided to illustrate that the direct pow er control based on DC side has the advantages of simple structure,stable DC output voltage and fast dynamic response.展开更多
Nowadays renewable energy has become a trend for energy production but its variable nature has made balancing of demand and supply of the power grid difficult. Dynamic demand management using smart appliances is propo...Nowadays renewable energy has become a trend for energy production but its variable nature has made balancing of demand and supply of the power grid difficult. Dynamic demand management using smart appliances is proposed to serve as a way that part of the regulation burden of balancing demand and supply is shifted to the demand side. However, if all appliances respond to the same frequency deviation, they may start to synchronize, causing large power overshoots and instability of the power grid. Therefore, the idea of implementing randomness into the frequency control of the appliances is proposed and this is what we call a stochastic approach. Simulators are built from scratch to model both scenarios. The effect of synchronization is analyzed and the parameters that can affect the synchronization are investigated. It has been found that the larger the contribution from the smart appliances to the power grid, the easier and faster the synchronization takes place. The stochastic approach solves the problem of synchronization and averages out the large power overshoot. However, the overall performance of stochastic operations is unacceptable due to the randomness in the operation though the mean and variance are as expected. More advanced feedback policies and schemes may be designed to achieve a better performance.展开更多
Considering the situation that it is difficult to control the stability of narrow coal pillar in gob-side entry driving under unstable overlying strata, the finite difference numerical simulation method was adopted to...Considering the situation that it is difficult to control the stability of narrow coal pillar in gob-side entry driving under unstable overlying strata, the finite difference numerical simulation method was adopted to analyze the inner stress distribution and its evolution regularity, as well as the deformation characteristics of narrow coal pillar in gob-side entry driving, in the whole process from entry driving of last working face to the present working face mining. A new method of narrow coal pillar control based on the triune coupling support technique (TCST), which includes that high-strength prestressed thread steel bolt is used to strain the coal on the goaf side, and that short bolt to control the integrity of global displacement zone in coal pillar on the entry side, and that long grouting cable to fix anchor point to constrain the bed separation between global displacement zone and fixed zone, is thereby generated and applied to the field production. The result indicates that after entry excavating along the gob under unstable overlying strata, the supporting structure left on the gob side of narrow coal pillar is basically invalid to maintain the coal-pillar stability, and the large deformation of the pillar on the gob side is evident. Except for the significant dynamic pressure appearing in the coal mining of last working face and overlying strata stabilizing process, the stress variation inside the coal pillar in other stages are rather steady, however, the stress expansion is obvious and the coal pillar continues to deform. Once the gob-side entry driving is completed, a global displacement zone on the entry side appears in the shallow part of the pillar, whereas, a relatively steady fixed zone staying almost still in gob-side entry driving and present working face mining is found in the deep part of the pillar. The application of TCST can not only avoid the failure of pillar supporting structure, but exert the supporting capacity of the bolting structure left in the pillar of last sublevel entry, thus to jointly maintain the stability of coal pillar.展开更多
Direct wind power purchase for large industrial users is a meaningful way to improve wind power consumption and decrease industrial production costs.Short-term wind power fluctuations may lead to large-scale wind powe...Direct wind power purchase for large industrial users is a meaningful way to improve wind power consumption and decrease industrial production costs.Short-term wind power fluctuations may lead to large-scale wind power curtailment problems.To promote use of wind energy,a demand side control method is proposed based on output regulator theory for a grid-connected industrial microgrid with electrolytic aluminum loads to continuously track and respond to wind power fluctuations.The control model of the EALs and the dominant frequencies of the wind power fluctuation signals are analyzed and incorporated into the demand side control plant.The feedback control signals with active power deviations on the tie-line are used to design the demand side controller.Simulations are conducted for an actual industrial microgrid to validate the feasibility and effectiveness of the proposed method.The results demonstrate that the proposed controller based on output regulator theory is able to effectively track wind power fluctuations.展开更多
This paper develops a new method to deal with the robust H-infinity control problem for a class of uncertain switched nonlinear systems by using integral sliding mode control.A robust H-infinity integral sliding surfa...This paper develops a new method to deal with the robust H-infinity control problem for a class of uncertain switched nonlinear systems by using integral sliding mode control.A robust H-infinity integral sliding surface is constructed such that the sliding mode is robust stable with a prescribed disturbance attenuation level γ for a class of switching signals with average dwell time.Furthermore,variable structure controllers are designed to maintain the state of switched system on the sliding surface from the initial time.A numerical example is given to illustrate the effectiveness of the proposed method.展开更多
目的探讨特瑞普利单抗联合FOLFOX方案治疗进展期胃癌的效果及其免疫调节机制。方法选取2021年6月至2023年6月驻马店市中心医院收治的97例进展期胃癌患者纳入研究,按随机数表法分为观察组49例和对照组48例,其中对照组采用FOLFOX方案治疗...目的探讨特瑞普利单抗联合FOLFOX方案治疗进展期胃癌的效果及其免疫调节机制。方法选取2021年6月至2023年6月驻马店市中心医院收治的97例进展期胃癌患者纳入研究,按随机数表法分为观察组49例和对照组48例,其中对照组采用FOLFOX方案治疗者,观察组采用FOLFOX方案+特瑞普利单抗治疗,21 d为一个疗程,持续治疗6个疗程。比较两组患者治疗6个疗程后的治疗效果,以及治疗前、治疗3个疗程和6个疗程后的程序性细胞死亡受体-1(PD-1)/程序性细胞死亡配体-1(PD-L1)信号通路(PD-1蛋白、PD-1 m RNA、PD-L1蛋白、PD-L1 m RNA)、血管新生指标[低氧诱导因子1α(HIF-1α)、血管内皮生长因子(VEGF)、促血管生成素-2(Ang-2)、环氧合酶-2(COX-2)],同时比较两组患者治疗期间的毒副反应以及随访6个月的生存率。结果治疗6个疗程后,观察组患者的疾病控制率为63.27%,明显高于对照组的41.67%,差异有统计学意义(P<0.05)。治疗3个疗程、6个疗程后,观察组患者的PD-1蛋白分别为5.83±1.12、5.77±1.26,明显低于对照组的6.84±1.25、7.11±1.36,PD-1m RNA分别为6.12±1.33、6.01±1.34,明显低于对照组的6.91±1.34、7.20±1.30,PD-L1蛋白分别为6.30±1.05、6.19±1.11,明显低于对照组的7.02±1.33、6.88±1.40,PD-1 mRNA分别为6.41±1.24、6.33±1.25,明显低于对照组的7.19±1.36、7.10±1.38,差异有统计学意义(P<0.05)。治疗3个疗程、6个疗程后,观察组患者的VEGF分别为(224.46±25.25)ng/mL、(150.10±14.14)ng/mL,明显低于对照组的(279.79±30.44)ng/mL、(191.65±16.63)ng/mL,HIF-1α分别为(135.51±16.67)μg/L、(100.10±12.28)μg/L,明显低于对照组的(175.53±18.48)μg/L、(153.53±14.88)μg/L,Ang-2分别为(68.98±7.36)ng/mL、(46.68±5.13)ng/mL,明显低于对照组的(75.51±7.95)ng/mL、(56.64±6.11)ng/mL,COX-2分别为(31.48±4.12)ng/mL、(20.24±3.38)ng/mL,明显低于对照组的(36.64±4.20)ng/mL、(25.74±3.59)ng/mL;差异均有统计学意义(P<0.05)。两组患者治疗6个疗程后的毒副反应发生率与随访期间生存率比较差异均无统计学意义(P>0.05)。结论特瑞普利单抗联合FOLFOX方案治疗进展期胃癌,可阻断PD-1/PD-L1信号通路,增强肿瘤控制效果,且具有较好的安全性。展开更多
Realizing of weld penetration control in gas tungsten arc welding requires establishment of a model describing the relationship between the front-side geometrical parameters of weld pool and the back-side weld width w...Realizing of weld penetration control in gas tungsten arc welding requires establishment of a model describing the relationship between the front-side geometrical parameters of weld pool and the back-side weld width with sufficient accuracy. A neural network model is developed to attain this aim. Welding experiments are conducted to obtain the training data set (including 973 groups of geometrical parameters of the weld pool and back-side weld width) and the verifying data set (108 groups). Two data sets are used for training and verifying the neural network, respectively. The testing results show that the model has sufficient accuracy and can meet the requirements of weld penetration control.展开更多
A series of plane-strain physical model experiments are carried out to study the spatiotemporal evolution rule of rocks fracture surrounding gob-side roadway, which is subjected to the pressure induced by the mining p...A series of plane-strain physical model experiments are carried out to study the spatiotemporal evolution rule of rocks fracture surrounding gob-side roadway, which is subjected to the pressure induced by the mining process. The digital photogrammetry technology and large deformation analysis method are applied to measure the deformation and fracture of surrounding rocks. The experimental results indicate that the deformation and fracture of coal pillars are the cause to the instability and failure of the surrounding rocks. The spatiotemporal evolution rule of the rock deformation and fracture surrounding gob-side roadway is obtained. The coal pillar and the roof near coal pillar should be strengthened in support design. The engineering application results also can provide a useful guide that the combined support with wire meshes, beam, anchor bolt and cable is an effective method.展开更多
Nonlinear control methods are presented based on theory of sliding mode control (SMC) or variable structure control (VSC) for application to active automobile suspensions. Requirements of reducing manufacturing cost a...Nonlinear control methods are presented based on theory of sliding mode control (SMC) or variable structure control (VSC) for application to active automobile suspensions. Requirements of reducing manufacturing cost and energy consumption of the active suspension system may be satisfied by reasonable design of the sliding surface and hydraulic servo system. Emphasis is placed on the study of the discrete sliding mode control method (DSMC) applicable for a new sort of speed on off solenoid valves of anti dust capability and low price. Robustness and effectiveness of the feedback linearized controller in typical road conditions are demonstrated by numerical results for a quarter car suspension model.展开更多
基金The authors highly acknowledge the technology financial assistance provided by Jiangsu Frontier Electric Technology Co.,Ltd.(KJ202003).
文摘In order to solve the problems of rotor overvoltage,overcurrent and DC side voltage rise caused by grid voltage drops,a coordinated control strategy based on symmetrical and asymmetrical low voltage ride through of rotor side converter of the doubly-fed generator is proposed.When the power grid voltage drops symmetrically,the generator approximate equation under steady-state conditions is no longer applicable.Considering the dynamic process of stator current excitation,according to the change of stator flux and the depth of voltage drop,the system can dynamically provide reactive power support for parallel nodes and suppress the rise of DC side voltage and rotor over-current.When the grid voltage drops asymmetrically,the positive and negative sequence components are separated in the rotating coordinate system.The doubly fed generator model is established to suppress the rotor positive sequence current and negative sequence current respectively.At the same time,the output voltage limit of the converter is discussed,and the reference value is adjusted within the allowable output voltage range.In order to adapt to the occurrence of different types of power grid faults and complex operating conditions,a fast switching module of fault type detection and rotor control mode is designed to detect the type of power grid faults and voltage drop depth in real time and switch the rotor side control mode dynamically.Finally,the simulation model of the doubly fed wind turbine is constructed in Matlab/Simulink.The simulation results verify that the proposed control strategy can improve the low-voltage ride through performance of the system when dealing with the symmetrical and asymmetric voltage drop of the power grid and identify the power grid fault type and provide the correct control strategy.
基金Financial support for this work was provided by the National Natural Science Foundation of China(Nos.51474005,51004002)
文摘Gob-side entry driving can increase coal recovery ratio, and it is implied in many coal mines. Based on geological condition of 10416 working face tailentry in Yangliu Coal Mine, the surrounding rock deformation characteristics of gob-side entry driving with narrow coal pillar is analysed, reasonable size of coal pillar and reasonable roadway excavation time after mining are achieved. Surrounding rock control technology and effective roadway side sealing technology are proposed and are taken into field practice. The results showed that a safer and more efficient mining of working face can be achieved. In addition, results of this paper also have important theoretical significance and valuable reference for surrounding rock control technology of gob-side entry driving with narrow coal pillar under special geological condition.
基金Supported by the Natural Science Foundation Project of Hunan(01JJY3020)
文摘The effect of reinforcing roof, sides and floor corners to control floor heave of extraction opening was analyzed, It was proved by engineering practice and numerical simulation that reinforcing any part of surrounding rock have certainly control effect for floor heave, in the basis of this, the new way that roof, sides and floor corners were rein-forced to control floor heave was put forward. Contrasting control result of reinforcing floor with this, it is determined that reinforcing is more suitable to control floor heave of extrac-tion opening than reinforcing floor when advancing abutment pressure is in some range.
基金supported by the ‘‘National Natural Science Foundation-Outstanding Youth Foundation’’
文摘Strong asymmetrical vortices appear on the leeward of slender body at high angles of attack, which has very unfavorable effect on the stability and control of the aircraft. A method is developed to control the side force of slender body at high angles of attack, and is verified in wind tunnel. A thin-film triangular self-excited oscillation flag is fixed at the tip of the slender body model whose semi-apex angle is 10°. Side force is approximately linearly proportional to roll-setting angle of self-excited oscillation flag at high angles of attack, and the slop of fitting straight line obtained by the least square method is -0.158. The linear relationship between side force and roU-setting angle provides convenience for developing side force control law of slender body at high angles of attack. Experimental data shows that the side force coefficients vary linearly with roll-setting angles when a specific plastic self-excited oscillation flag is used as the control flag. The range of side force coefficient and roll-setting angle are, respectively, -3.2 to 3.0 and -20° to 20°. The device is simple, effective, and is of great potential in engineering application.
文摘In allusion to the problems of complex stress distribution in the surrounding rock and deformation failure laws, as well as the difficulty in roadway supporting of the gob-side entry driving in the island coal face, 2107 face in Chengjiao Colliery is researched as an engineering case. Through physical mechanical test of rock, theoretical and numerical simulation analyses of rock, the analysis model of the roadway overlying strata structure was established, and its parameters quantified. To reveal the deformation law of the surrounding rock, the stability of the overlying strata structure was studied before, during and after the roadway driving. According to the field conditions, the stress distribution in coal pillar was quantified, and the surrounding rock deformation feature studied with different widths of the pillars in gob-side entry driving. Finally, the pillar width of 4 m was considered as the most reasonable. The research results show that there is great difference in support conditions among roadway roof, entity coal side and narrow pillar side. Besides, the asymmetric control technique for support of the surrounding rock was proposed. The asymmetric control technique was proved to be reasonable by field monitoring, support by bolt-net, steel ladder and steel wire truss used in narrow pillar side.
文摘This paper addresses the principle and control topology of active pow er filter( APF). The control strategy of direct pow er control based on DC side is introduced,and the control output is implemented by using the principle of hysteresis control.The active pow er filter can effectively control the pow er system harmonics,improve the quality of electricity and purify pow er grid. The experimental results are provided to illustrate that the direct pow er control based on DC side has the advantages of simple structure,stable DC output voltage and fast dynamic response.
文摘Nowadays renewable energy has become a trend for energy production but its variable nature has made balancing of demand and supply of the power grid difficult. Dynamic demand management using smart appliances is proposed to serve as a way that part of the regulation burden of balancing demand and supply is shifted to the demand side. However, if all appliances respond to the same frequency deviation, they may start to synchronize, causing large power overshoots and instability of the power grid. Therefore, the idea of implementing randomness into the frequency control of the appliances is proposed and this is what we call a stochastic approach. Simulators are built from scratch to model both scenarios. The effect of synchronization is analyzed and the parameters that can affect the synchronization are investigated. It has been found that the larger the contribution from the smart appliances to the power grid, the easier and faster the synchronization takes place. The stochastic approach solves the problem of synchronization and averages out the large power overshoot. However, the overall performance of stochastic operations is unacceptable due to the randomness in the operation though the mean and variance are as expected. More advanced feedback policies and schemes may be designed to achieve a better performance.
基金supports from the National High Technology Research and Development Program of China (No. 2012AA062101)the Program for New Century Excellent Talents in University of Ministry of Education of China (No. NCET-10-0770)+1 种基金the Program Granted for Scientific Innovation Research of College Graduate in Jiangsu Province (No. CXZZ11-0309)the Priority Academic Program Development of Jiangsu Higher Education Institutions (No. SZBF2011-6-B35)
文摘Considering the situation that it is difficult to control the stability of narrow coal pillar in gob-side entry driving under unstable overlying strata, the finite difference numerical simulation method was adopted to analyze the inner stress distribution and its evolution regularity, as well as the deformation characteristics of narrow coal pillar in gob-side entry driving, in the whole process from entry driving of last working face to the present working face mining. A new method of narrow coal pillar control based on the triune coupling support technique (TCST), which includes that high-strength prestressed thread steel bolt is used to strain the coal on the goaf side, and that short bolt to control the integrity of global displacement zone in coal pillar on the entry side, and that long grouting cable to fix anchor point to constrain the bed separation between global displacement zone and fixed zone, is thereby generated and applied to the field production. The result indicates that after entry excavating along the gob under unstable overlying strata, the supporting structure left on the gob side of narrow coal pillar is basically invalid to maintain the coal-pillar stability, and the large deformation of the pillar on the gob side is evident. Except for the significant dynamic pressure appearing in the coal mining of last working face and overlying strata stabilizing process, the stress variation inside the coal pillar in other stages are rather steady, however, the stress expansion is obvious and the coal pillar continues to deform. Once the gob-side entry driving is completed, a global displacement zone on the entry side appears in the shallow part of the pillar, whereas, a relatively steady fixed zone staying almost still in gob-side entry driving and present working face mining is found in the deep part of the pillar. The application of TCST can not only avoid the failure of pillar supporting structure, but exert the supporting capacity of the bolting structure left in the pillar of last sublevel entry, thus to jointly maintain the stability of coal pillar.
基金supported by Science and Technology Project of State Grid Corporation of China (5100-202199286A-0-0-00).
文摘Direct wind power purchase for large industrial users is a meaningful way to improve wind power consumption and decrease industrial production costs.Short-term wind power fluctuations may lead to large-scale wind power curtailment problems.To promote use of wind energy,a demand side control method is proposed based on output regulator theory for a grid-connected industrial microgrid with electrolytic aluminum loads to continuously track and respond to wind power fluctuations.The control model of the EALs and the dominant frequencies of the wind power fluctuation signals are analyzed and incorporated into the demand side control plant.The feedback control signals with active power deviations on the tie-line are used to design the demand side controller.Simulations are conducted for an actual industrial microgrid to validate the feasibility and effectiveness of the proposed method.The results demonstrate that the proposed controller based on output regulator theory is able to effectively track wind power fluctuations.
基金supported by the National Natural Science Foundation of China(No.60874024,60574013)
文摘This paper develops a new method to deal with the robust H-infinity control problem for a class of uncertain switched nonlinear systems by using integral sliding mode control.A robust H-infinity integral sliding surface is constructed such that the sliding mode is robust stable with a prescribed disturbance attenuation level γ for a class of switching signals with average dwell time.Furthermore,variable structure controllers are designed to maintain the state of switched system on the sliding surface from the initial time.A numerical example is given to illustrate the effectiveness of the proposed method.
文摘目的探讨特瑞普利单抗联合FOLFOX方案治疗进展期胃癌的效果及其免疫调节机制。方法选取2021年6月至2023年6月驻马店市中心医院收治的97例进展期胃癌患者纳入研究,按随机数表法分为观察组49例和对照组48例,其中对照组采用FOLFOX方案治疗者,观察组采用FOLFOX方案+特瑞普利单抗治疗,21 d为一个疗程,持续治疗6个疗程。比较两组患者治疗6个疗程后的治疗效果,以及治疗前、治疗3个疗程和6个疗程后的程序性细胞死亡受体-1(PD-1)/程序性细胞死亡配体-1(PD-L1)信号通路(PD-1蛋白、PD-1 m RNA、PD-L1蛋白、PD-L1 m RNA)、血管新生指标[低氧诱导因子1α(HIF-1α)、血管内皮生长因子(VEGF)、促血管生成素-2(Ang-2)、环氧合酶-2(COX-2)],同时比较两组患者治疗期间的毒副反应以及随访6个月的生存率。结果治疗6个疗程后,观察组患者的疾病控制率为63.27%,明显高于对照组的41.67%,差异有统计学意义(P<0.05)。治疗3个疗程、6个疗程后,观察组患者的PD-1蛋白分别为5.83±1.12、5.77±1.26,明显低于对照组的6.84±1.25、7.11±1.36,PD-1m RNA分别为6.12±1.33、6.01±1.34,明显低于对照组的6.91±1.34、7.20±1.30,PD-L1蛋白分别为6.30±1.05、6.19±1.11,明显低于对照组的7.02±1.33、6.88±1.40,PD-1 mRNA分别为6.41±1.24、6.33±1.25,明显低于对照组的7.19±1.36、7.10±1.38,差异有统计学意义(P<0.05)。治疗3个疗程、6个疗程后,观察组患者的VEGF分别为(224.46±25.25)ng/mL、(150.10±14.14)ng/mL,明显低于对照组的(279.79±30.44)ng/mL、(191.65±16.63)ng/mL,HIF-1α分别为(135.51±16.67)μg/L、(100.10±12.28)μg/L,明显低于对照组的(175.53±18.48)μg/L、(153.53±14.88)μg/L,Ang-2分别为(68.98±7.36)ng/mL、(46.68±5.13)ng/mL,明显低于对照组的(75.51±7.95)ng/mL、(56.64±6.11)ng/mL,COX-2分别为(31.48±4.12)ng/mL、(20.24±3.38)ng/mL,明显低于对照组的(36.64±4.20)ng/mL、(25.74±3.59)ng/mL;差异均有统计学意义(P<0.05)。两组患者治疗6个疗程后的毒副反应发生率与随访期间生存率比较差异均无统计学意义(P>0.05)。结论特瑞普利单抗联合FOLFOX方案治疗进展期胃癌,可阻断PD-1/PD-L1信号通路,增强肿瘤控制效果,且具有较好的安全性。
基金the Shandong Provincial Natural Science Foundation of China (No. Z2003F05 ).
文摘Realizing of weld penetration control in gas tungsten arc welding requires establishment of a model describing the relationship between the front-side geometrical parameters of weld pool and the back-side weld width with sufficient accuracy. A neural network model is developed to attain this aim. Welding experiments are conducted to obtain the training data set (including 973 groups of geometrical parameters of the weld pool and back-side weld width) and the verifying data set (108 groups). Two data sets are used for training and verifying the neural network, respectively. The testing results show that the model has sufficient accuracy and can meet the requirements of weld penetration control.
基金supported by the National Natural Science Foundation of China (No. 51174197)the Major State Basic Research Development Program of China (No. 2014CB046905)+1 种基金State Key Laboratory for Geo Mechanics and Deep Underground Engineering (CUMT) (No. SKLGDUEK1503)the ‘Qing Lan’ Project of Jiangsu Province
文摘A series of plane-strain physical model experiments are carried out to study the spatiotemporal evolution rule of rocks fracture surrounding gob-side roadway, which is subjected to the pressure induced by the mining process. The digital photogrammetry technology and large deformation analysis method are applied to measure the deformation and fracture of surrounding rocks. The experimental results indicate that the deformation and fracture of coal pillars are the cause to the instability and failure of the surrounding rocks. The spatiotemporal evolution rule of the rock deformation and fracture surrounding gob-side roadway is obtained. The coal pillar and the roof near coal pillar should be strengthened in support design. The engineering application results also can provide a useful guide that the combined support with wire meshes, beam, anchor bolt and cable is an effective method.
文摘Nonlinear control methods are presented based on theory of sliding mode control (SMC) or variable structure control (VSC) for application to active automobile suspensions. Requirements of reducing manufacturing cost and energy consumption of the active suspension system may be satisfied by reasonable design of the sliding surface and hydraulic servo system. Emphasis is placed on the study of the discrete sliding mode control method (DSMC) applicable for a new sort of speed on off solenoid valves of anti dust capability and low price. Robustness and effectiveness of the feedback linearized controller in typical road conditions are demonstrated by numerical results for a quarter car suspension model.