Many safety-critical applications that utilize the global navigation satellite system (GNSS) demand highly accurate positioning information, as well as highly integrity and reliability. Due to GNSS signals are easily ...Many safety-critical applications that utilize the global navigation satellite system (GNSS) demand highly accurate positioning information, as well as highly integrity and reliability. Due to GNSS signals are easily distorted by the interferences or disturbances, the signal quality monitoring (SQM) is necessary to detect the presence of dangerous signal distortions. In this paper, we developed an SQM software for binary offset carrier (BOC) modulated navigation signals. Firstly, the models of BOC signal with ideal and distortion are presented respectively. Then the architecture of SQM software is proposed. Moreover, the effect of the white gaussian noise (WGN) and the front-end filter on the correlation peak of the receiver is analyzed. Finally, the biases induced by the signal distortion are evaluated. The experiments simulate the relationships between the code phase shift and the normalized correlation value in the case of the signal digital distortion and the analog distortion. The simulation results demonstrate that the proposed SQM method can effectively monitor the signal distortion and accurately estimate the correlation peak deviation caused by the distortion.展开更多
Dissemination of information to citizens is a relevant component of governance. Expectedly, viewers tuned to broadcast stations within and outside their localities, expecting their receivers to faithfully reproduce th...Dissemination of information to citizens is a relevant component of governance. Expectedly, viewers tuned to broadcast stations within and outside their localities, expecting their receivers to faithfully reproduce the exact features of the transmitted signal. Akpabuyo is a dense forest zone near the creeks leading to the Atlantic ocean in Cross River State, Nigeria. The location has distinct environmental characteristics that made Akpabuyo Area Council, a challenging location to propagate electromagnetic waves;and therefore recipe for further investigation. Radio frequency analyzer, with 24 channels spectrum, ranging between 46 - 870 MHz (model: RO.VE.R.-“DLM3-T”) was deployed to capture signals from terrestrial television stations (TV). CATV measured signal of TV stations in dB, dBμV and dBmV. Its frequency ranged from 40 - 860 MHz;while varying from channel 1 to channel 69. Measurements taken from Akpabuyo L.G.A. showed the following results: the signal strength received from VHF Channel 11 ranged from 20 dBμV to 49 dBμV. From recorded empirical statistics from the study, 50% of the area received signal from this station above 30 dBμV, while other regions had signals below this value;representing the fringe zone of the frequency. The results obtained from the study relatively showed acceptance with Egli’s model. The study recorded a steady fluctuation between 17 dBμV and 19 dBμV from both propagating stations. However, Channel 27 signal at 519 MHz, had very weak signal coverage in Akpabuyo Local Government Area;with signal strength dropped to as low as 13 dB in many parts of the rural area. The study discovered that the state’s broadcasting stations, both at UHF and VHF channels did not transmit successfully across this densely forest (rural) location. Remedial measures such as installing Repeater stations at different locations as signal booster were recommended.展开更多
A common practice adopted for the pseudorange bias estimation and calibration assumes that Global Navigation Satellite System satellite-dependent pseudorange biases vary gently over time.Whereupon satellite pseudorang...A common practice adopted for the pseudorange bias estimation and calibration assumes that Global Navigation Satellite System satellite-dependent pseudorange biases vary gently over time.Whereupon satellite pseudorange biases are routinely estimated and provided as the products with low temporal resolution,e.g.,hourly or daily,by the agencies.The story sounds unquestionably perfect under the acquainted assumption.To validate the inadequacy of the above hypothesis we herein present an approach to the estimate the BeiDou Navigation Satellite System(BDS)pseudorange biases with high temporal resolution.Its feasibility,affecting factors,and necessity are discussed.Concretely,the Geometry-Free function models are first constructed to retrieve the linear combination of the pseudorange biases;then the pseudorange Observable-specific Signal Bias(OSB)values with respect to baseline frequencies(e.g.,BDS C2I/C6I)are estimated along with the ionosphere modeling;subsequently,all multi-frequency pseudorange OSBs are determined by using the ionospheric information with constraint conditions;finally,the possible Differential Code Bias sets are attainable with the estimated pseudorange OSBs.Using the observation data of four months when the estimated BDS pseudorange biases are stable,their reliability is demonstrated with the stability at the level of sub-nanosecond and the BeiDou-3 Navigation Satellite System(BDS-3)values more stable than that of BeiDou-2 Navigation Satellite System(BDS-2).The comparison between the estimated pseudorange biases and the Chinese Academy of Sciences products reveals that the accuracy of the estimated pseudorange biases is 0.2–0.4 ns.Moreover,the large magnitude of the short-term pseudorange bias variation in the tens of nanoseconds for the BDS-2 and BDS-3 are found in years 2021 and 2022,which are affected by two types of the satellite flex power for the BDS-2 and BDS-3,respectively.We stress that it’s necessary to estimate the BDS pseudorange biases with high temporal resolution in the case of the satellite flex power and the products currently provided by the agencies cannot reflect the true quantity under the circumstance.展开更多
The conventional test-per-scan built-in self-test （BIST） scheme needs a number of shift cycles followed by one capture cycle. Fault effects received by the scan flipflops are shifted out while shifting in the next t...The conventional test-per-scan built-in self-test （BIST） scheme needs a number of shift cycles followed by one capture cycle. Fault effects received by the scan flipflops are shifted out while shifting in the next test vector like scan testing. Unlike deterministic testing, it is unnecessary to apply a complete test vector to the scan chains. A new scan-based BIST scheme is proposed by properly controlling the test signals of the scan chains. Different biased random values are assigned to the test signals of scan flip-flops in separate scan chains. Capture cycles can be inserted at any clock cycle if necessary. A new testability estimation procedure according to the proposed testing scheme is presented. A greedy procedure is proposed to select a weight for each scan chain. Experimental results show that the proposed method can improve test effectiveness of scan-based BIST greatly, and most circuits can obtain complete fault coverage or very close to complete fault coverage.展开更多
In the last few years, there have been important new insights into the structural biology of G-protein coupled receptors. It is now known that allosteric binding sites are involved in the affinity and selec- tivity of...In the last few years, there have been important new insights into the structural biology of G-protein coupled receptors. It is now known that allosteric binding sites are involved in the affinity and selec- tivity of ligands for G-protein coupled receptors, and that signaling by these receptors involves both G-protein dependent and independent pathways. The present review outlines the physiological and pharmacological implications of this perspective for the design of new drugs to treat disorders of the central nervous system. Specifically, new possibilities are explored in relation to allosteric and or- thosteric binding sites on dopamine receptors for the treatment of Parkinson＇s disease, and on muscarinic receptors for Alzheimer＇s disease. Future research can seek to identify ligands that can bind to more than one site on the same receptor, or simultaneously bind to two receptors and form a dimer. For example, the design of bivalent drugs that can reach homo/hetero-dimers of D2 dopa- mine receptor holds promise as a relevant therapeutic strategy for Parkinson＇s disease. Regarding the treatment of Alzheimer＇s disease, the design of dualsteric ligands for mono-oligomeric mus- carinic receptors could increase therapeutic effectiveness by generating potent compounds that could activate more than one signaling pathway.展开更多
The two ubiquitous, outside the retina, G protein-coupled receptor(GPCR)adapter proteins, β-arrestin-1 and-2(also known as arrestin-2 and-3,respectively), have three major functions in cells: GPCR desensitization, i....The two ubiquitous, outside the retina, G protein-coupled receptor(GPCR)adapter proteins, β-arrestin-1 and-2(also known as arrestin-2 and-3,respectively), have three major functions in cells: GPCR desensitization, i.e.,receptor decoupling from G-proteins; GPCR internalization via clathrin-coated pits; and signal transduction independently of or in parallel to G-proteins. Bothβ-arrestins are expressed in the heart and regulate a large number of cardiac GPCRs. The latter constitute the single most commonly targeted receptor class by Food and Drug Administration-approved cardiovascular drugs, with about onethird of all currently used in the clinic medications affecting GPCR function.Since β-arrestin-1 and-2 play important roles in signaling and function of several GPCRs, in particular of adrenergic receptors and angiotensin II type 1 receptors,in cardiac myocytes, they have been a major focus of cardiac biology research in recent years. Perhaps the most significant realization coming out of their studies is that these two GPCR adapter proteins, initially thought of as functionally interchangeable, actually exert diametrically opposite effects in the mammalian myocardium. Specifically, the most abundant of the two β-arrestin-1 exerts overall detrimental effects on the heart, such as negative inotropy and promotion of adverse remodeling post-myocardial infarction(MI). In contrast, β-arrestin-2 is overall beneficial for the myocardium, as it has anti-apoptotic and antiinflammatory effects that result in attenuation of post-MI adverse remodeling,while promoting cardiac contractile function. Thus, design of novel cardiac GPCRligands that preferentially activate β-arrestin-2 over β-arrestin-1 has the potential of generating novel cardiovascular therapeutics for heart failure and other heart diseases.展开更多
基金supported by the National Natural Science Foundation of China(61771393 61571368)
文摘Many safety-critical applications that utilize the global navigation satellite system (GNSS) demand highly accurate positioning information, as well as highly integrity and reliability. Due to GNSS signals are easily distorted by the interferences or disturbances, the signal quality monitoring (SQM) is necessary to detect the presence of dangerous signal distortions. In this paper, we developed an SQM software for binary offset carrier (BOC) modulated navigation signals. Firstly, the models of BOC signal with ideal and distortion are presented respectively. Then the architecture of SQM software is proposed. Moreover, the effect of the white gaussian noise (WGN) and the front-end filter on the correlation peak of the receiver is analyzed. Finally, the biases induced by the signal distortion are evaluated. The experiments simulate the relationships between the code phase shift and the normalized correlation value in the case of the signal digital distortion and the analog distortion. The simulation results demonstrate that the proposed SQM method can effectively monitor the signal distortion and accurately estimate the correlation peak deviation caused by the distortion.
文摘Dissemination of information to citizens is a relevant component of governance. Expectedly, viewers tuned to broadcast stations within and outside their localities, expecting their receivers to faithfully reproduce the exact features of the transmitted signal. Akpabuyo is a dense forest zone near the creeks leading to the Atlantic ocean in Cross River State, Nigeria. The location has distinct environmental characteristics that made Akpabuyo Area Council, a challenging location to propagate electromagnetic waves;and therefore recipe for further investigation. Radio frequency analyzer, with 24 channels spectrum, ranging between 46 - 870 MHz (model: RO.VE.R.-“DLM3-T”) was deployed to capture signals from terrestrial television stations (TV). CATV measured signal of TV stations in dB, dBμV and dBmV. Its frequency ranged from 40 - 860 MHz;while varying from channel 1 to channel 69. Measurements taken from Akpabuyo L.G.A. showed the following results: the signal strength received from VHF Channel 11 ranged from 20 dBμV to 49 dBμV. From recorded empirical statistics from the study, 50% of the area received signal from this station above 30 dBμV, while other regions had signals below this value;representing the fringe zone of the frequency. The results obtained from the study relatively showed acceptance with Egli’s model. The study recorded a steady fluctuation between 17 dBμV and 19 dBμV from both propagating stations. However, Channel 27 signal at 519 MHz, had very weak signal coverage in Akpabuyo Local Government Area;with signal strength dropped to as low as 13 dB in many parts of the rural area. The study discovered that the state’s broadcasting stations, both at UHF and VHF channels did not transmit successfully across this densely forest (rural) location. Remedial measures such as installing Repeater stations at different locations as signal booster were recommended.
文摘A common practice adopted for the pseudorange bias estimation and calibration assumes that Global Navigation Satellite System satellite-dependent pseudorange biases vary gently over time.Whereupon satellite pseudorange biases are routinely estimated and provided as the products with low temporal resolution,e.g.,hourly or daily,by the agencies.The story sounds unquestionably perfect under the acquainted assumption.To validate the inadequacy of the above hypothesis we herein present an approach to the estimate the BeiDou Navigation Satellite System(BDS)pseudorange biases with high temporal resolution.Its feasibility,affecting factors,and necessity are discussed.Concretely,the Geometry-Free function models are first constructed to retrieve the linear combination of the pseudorange biases;then the pseudorange Observable-specific Signal Bias(OSB)values with respect to baseline frequencies(e.g.,BDS C2I/C6I)are estimated along with the ionosphere modeling;subsequently,all multi-frequency pseudorange OSBs are determined by using the ionospheric information with constraint conditions;finally,the possible Differential Code Bias sets are attainable with the estimated pseudorange OSBs.Using the observation data of four months when the estimated BDS pseudorange biases are stable,their reliability is demonstrated with the stability at the level of sub-nanosecond and the BeiDou-3 Navigation Satellite System(BDS-3)values more stable than that of BeiDou-2 Navigation Satellite System(BDS-2).The comparison between the estimated pseudorange biases and the Chinese Academy of Sciences products reveals that the accuracy of the estimated pseudorange biases is 0.2–0.4 ns.Moreover,the large magnitude of the short-term pseudorange bias variation in the tens of nanoseconds for the BDS-2 and BDS-3 are found in years 2021 and 2022,which are affected by two types of the satellite flex power for the BDS-2 and BDS-3,respectively.We stress that it’s necessary to estimate the BDS pseudorange biases with high temporal resolution in the case of the satellite flex power and the products currently provided by the agencies cannot reflect the true quantity under the circumstance.
基金the National Natural Science Foundation of China (Grant Nos.60373009 and 60425203)
文摘The conventional test-per-scan built-in self-test （BIST） scheme needs a number of shift cycles followed by one capture cycle. Fault effects received by the scan flipflops are shifted out while shifting in the next test vector like scan testing. Unlike deterministic testing, it is unnecessary to apply a complete test vector to the scan chains. A new scan-based BIST scheme is proposed by properly controlling the test signals of the scan chains. Different biased random values are assigned to the test signals of scan flip-flops in separate scan chains. Capture cycles can be inserted at any clock cycle if necessary. A new testability estimation procedure according to the proposed testing scheme is presented. A greedy procedure is proposed to select a weight for each scan chain. Experimental results show that the proposed method can improve test effectiveness of scan-based BIST greatly, and most circuits can obtain complete fault coverage or very close to complete fault coverage.
基金supported by SIP-IPN,CONACYT (CB-168116)FIS/IMSS (FIS/IMSS/PROT/G11-2/1013)
文摘In the last few years, there have been important new insights into the structural biology of G-protein coupled receptors. It is now known that allosteric binding sites are involved in the affinity and selec- tivity of ligands for G-protein coupled receptors, and that signaling by these receptors involves both G-protein dependent and independent pathways. The present review outlines the physiological and pharmacological implications of this perspective for the design of new drugs to treat disorders of the central nervous system. Specifically, new possibilities are explored in relation to allosteric and or- thosteric binding sites on dopamine receptors for the treatment of Parkinson＇s disease, and on muscarinic receptors for Alzheimer＇s disease. Future research can seek to identify ligands that can bind to more than one site on the same receptor, or simultaneously bind to two receptors and form a dimer. For example, the design of bivalent drugs that can reach homo/hetero-dimers of D2 dopa- mine receptor holds promise as a relevant therapeutic strategy for Parkinson＇s disease. Regarding the treatment of Alzheimer＇s disease, the design of dualsteric ligands for mono-oligomeric mus- carinic receptors could increase therapeutic effectiveness by generating potent compounds that could activate more than one signaling pathway.
基金a NSU’s President’s Faculty Research and Development Grant(PFRDG)
文摘The two ubiquitous, outside the retina, G protein-coupled receptor(GPCR)adapter proteins, β-arrestin-1 and-2(also known as arrestin-2 and-3,respectively), have three major functions in cells: GPCR desensitization, i.e.,receptor decoupling from G-proteins; GPCR internalization via clathrin-coated pits; and signal transduction independently of or in parallel to G-proteins. Bothβ-arrestins are expressed in the heart and regulate a large number of cardiac GPCRs. The latter constitute the single most commonly targeted receptor class by Food and Drug Administration-approved cardiovascular drugs, with about onethird of all currently used in the clinic medications affecting GPCR function.Since β-arrestin-1 and-2 play important roles in signaling and function of several GPCRs, in particular of adrenergic receptors and angiotensin II type 1 receptors,in cardiac myocytes, they have been a major focus of cardiac biology research in recent years. Perhaps the most significant realization coming out of their studies is that these two GPCR adapter proteins, initially thought of as functionally interchangeable, actually exert diametrically opposite effects in the mammalian myocardium. Specifically, the most abundant of the two β-arrestin-1 exerts overall detrimental effects on the heart, such as negative inotropy and promotion of adverse remodeling post-myocardial infarction(MI). In contrast, β-arrestin-2 is overall beneficial for the myocardium, as it has anti-apoptotic and antiinflammatory effects that result in attenuation of post-MI adverse remodeling,while promoting cardiac contractile function. Thus, design of novel cardiac GPCRligands that preferentially activate β-arrestin-2 over β-arrestin-1 has the potential of generating novel cardiovascular therapeutics for heart failure and other heart diseases.
