<p align="left"> <span style="font-family:Verdana;">To investigate the relationship between muscle strength and sEMG of biceps brachii during elbow flexion by measuring the maximum musc...<p align="left"> <span style="font-family:Verdana;">To investigate the relationship between muscle strength and sEMG of biceps brachii during elbow flexion by measuring the maximum muscle strength and sEMG value of normal children and adults, and to analyze their sources, so as to lay a theoretical foundation for the method of motor program reconstruction to restore the function after brain injury, 30 healthy children aged 9 - 10 years and 30 adults aged 20 - 30 years were randomly selected. The muscle strength and sEMG of biceps brachii during elbow flexion were detected and recorded, and the data were statistically analyzed. The muscle strength of children was significantly lower than that of adults (P < 0.001), and the sEMG value of biceps brachii was significantly lower than that of adults (P < 0.001), but the sEMG value per kilogram force of children was significantly higher than that of adults (P < 0.01). The results show that there was a very significant difference in pull (efficiency) between adults and children when there was no significant difference in SEMG signal intensity. This is because although children’s central nervous system has matured, the muscle tissue has not been well trained, resulting in insufficient muscle strength. The muscle strength of adults is significantly higher than that of children, because they have been exercising for a long time after the development of the central nervous system. It is proved that sEMG signal is not produced by muscle contraction itself, but comes from the motor program signal of central nervous system which drives muscle contraction, and it is produced before muscle contraction.</span> </p>展开更多
【目的】对城市交叉口采用的左转非机动车信号灯设施进行交通安全性量化评估。【方法】提出一种基于拓展碰撞时间(extended time to collision,ETTC)指标的左转非机动车信号灯安全效应评估方法。针对现有的碰撞时间(time to collision,T...【目的】对城市交叉口采用的左转非机动车信号灯设施进行交通安全性量化评估。【方法】提出一种基于拓展碰撞时间(extended time to collision,ETTC)指标的左转非机动车信号灯安全效应评估方法。针对现有的碰撞时间(time to collision,TTC)指标不适于评估交叉口左转非机动车冲突的问题,考虑非机动车车辆尺寸与加速度对交通冲突的影响,采用拓展碰撞时间指标,评估交叉口非机动车交通冲突。收集长沙市4个信号交叉口的视频大数据,利用视频软件Tracker提取车辆微观轨迹后,开展案例分析。【结果】左转非机动车信号灯在时间上明确了非机动车的通行权,其设置能显著降低非机动车冲突率,在平峰、高峰时段非机动车冲突率分别降低了40.11%、25.27%。在直行相位末期、左转相位即将启亮时,设置组的左转非机动车在待行区等待,冲突率降为0;而对比组近50%的非机动车违规左转,冲突严重。设置左转非机动车信号灯的改善效果随非机动车流量的增大呈先增加后降低趋势,而随机动车流量的增大呈逐步波动下降趋势。【结论】本研究揭示了非机动车左转信号灯的设置对减少交叉口交通冲突的影响,可为城市交叉口非机动车交通安全管控提供有益参考。展开更多
本文提出一种跨被试的深度神经网络识别方法,应对运动想象脑电信号的非线性、非平稳特性.该方法首先计算协方差矩阵均值,将不同被试者样本集的协方差对齐至单位矩阵,提升样本的被试间泛化性.然后,将对齐后的样本输入至卷积神经网络中,...本文提出一种跨被试的深度神经网络识别方法,应对运动想象脑电信号的非线性、非平稳特性.该方法首先计算协方差矩阵均值,将不同被试者样本集的协方差对齐至单位矩阵,提升样本的被试间泛化性.然后,将对齐后的样本输入至卷积神经网络中,通过留一被试交叉验证法,构建跨被试的运动想象脑电信号识别方法.在BCI Competition IV dataset 2b公开数据集上进行实验,结果表明,新的方法在该数据集上取得了高的识别性能,且测试场景中的时间复杂度与现有方法相同.展开更多
为提高运动想象脑机接口识别准确率,结合共空间模式(common spatial pattern,CSP)和卷积神经网络(convolutional neural network,CNN)方法,提出一种改进滤波器组共空间模式(filter bank common spatial pattern,FBCSP)和CNN的算法,用于...为提高运动想象脑机接口识别准确率,结合共空间模式(common spatial pattern,CSP)和卷积神经网络(convolutional neural network,CNN)方法,提出一种改进滤波器组共空间模式(filter bank common spatial pattern,FBCSP)和CNN的算法,用于多分类运动想象脑电信号识别任务。信号预处理后,使用包含重叠频带的FBCSP计算空间投影矩阵,数据经过投影得到更有区分度的特征序列。然后将特征序列以二维排列方式输入搭建的CNN模型中进行分类。所提出方法在脑机接口竞赛数据集2a和Ⅲa上验证,并和其他文献方法对比。结果表明,本文方法一定程度上提高了运动想象脑电信号的分类准确率,为运动想象研究提供了一个有效办法。展开更多
背景:肌萎缩侧索硬化为一种进行性神经退行性疾病,常导致大脑和脊髓神经元死亡。肌萎缩侧索硬化发病机制极为复杂,难治率、死亡率高且目前其治疗药物仅有2种,因此开发新治疗方法以改善患者预后迫在眉睫。目的:综述中药及间充质干细胞调...背景:肌萎缩侧索硬化为一种进行性神经退行性疾病,常导致大脑和脊髓神经元死亡。肌萎缩侧索硬化发病机制极为复杂,难治率、死亡率高且目前其治疗药物仅有2种,因此开发新治疗方法以改善患者预后迫在眉睫。目的:综述中药及间充质干细胞调控免疫反应治疗肌萎缩侧索硬化的作用机制。方法:以“traditional Chinese medicine,mesenchymal stem cells,ALS,immune response”为英文检索词,以“中药,间充质干细胞,肌萎缩侧索硬化,免疫反应”为中文检索词,检索万方、中国知网、PubMed及Web of Science数据库2010-2023年的相关文献,最终纳入69篇文献进行综述分析。结果与结论:①中药调控免疫反应治疗肌萎缩侧索硬化可总结为5个机制:主要包括冰片和黄芪甲苷等中药促进闭锁小带蛋白1、闭合蛋白5表达重建血液中枢神经系统屏障完整性;复方扶芳藤合剂调节自然杀伤细胞表面受体分子抑制其自身毒性;半枝莲和广藿香等作用补体系统因子抑制其异常激活;雷公藤和钩藤等介导细胞外信号调节激酶1/2衰减诱导型一氧化氮合酶产生而抑制小胶质细胞活化;左归丸、栝蒌根等促进白细胞介素10表达调控T细胞改善免疫环境。②通过现有研究总结了间充质干细胞调控免疫反应治疗肌萎缩侧索硬化可总结为5个机制:减少水通道蛋白4表达和降低内皮型一氧化氮合酶信号传导等方面修复免疫屏障完整性;释放吲哚胺2,3-双加氧酶和前列腺素E2等因子抗自然杀伤细胞毒性;分泌因子H干扰转化酶活性抑制补体系统异常激活;调控CX3CL1/CX3CR1系统轴或分泌转化生长因子β等途径改变小胶质细胞表型抑制其活性;增加白细胞介素10表达或激活STATS磷酸化通路来恢复T细胞功能。③目前中药联合间充质干细胞治疗肌萎缩侧索硬化研究较少,已知的相关研究报道显示,肌萎灵注射液可促进干细胞增殖分化以及补阳还五汤联合骨髓间充质干细胞显著提高血脑屏障完整性,未来还需进一步探讨两者对难治性肌萎缩侧索硬化的协同治疗效果。展开更多
文摘<p align="left"> <span style="font-family:Verdana;">To investigate the relationship between muscle strength and sEMG of biceps brachii during elbow flexion by measuring the maximum muscle strength and sEMG value of normal children and adults, and to analyze their sources, so as to lay a theoretical foundation for the method of motor program reconstruction to restore the function after brain injury, 30 healthy children aged 9 - 10 years and 30 adults aged 20 - 30 years were randomly selected. The muscle strength and sEMG of biceps brachii during elbow flexion were detected and recorded, and the data were statistically analyzed. The muscle strength of children was significantly lower than that of adults (P < 0.001), and the sEMG value of biceps brachii was significantly lower than that of adults (P < 0.001), but the sEMG value per kilogram force of children was significantly higher than that of adults (P < 0.01). The results show that there was a very significant difference in pull (efficiency) between adults and children when there was no significant difference in SEMG signal intensity. This is because although children’s central nervous system has matured, the muscle tissue has not been well trained, resulting in insufficient muscle strength. The muscle strength of adults is significantly higher than that of children, because they have been exercising for a long time after the development of the central nervous system. It is proved that sEMG signal is not produced by muscle contraction itself, but comes from the motor program signal of central nervous system which drives muscle contraction, and it is produced before muscle contraction.</span> </p>
文摘【目的】对城市交叉口采用的左转非机动车信号灯设施进行交通安全性量化评估。【方法】提出一种基于拓展碰撞时间(extended time to collision,ETTC)指标的左转非机动车信号灯安全效应评估方法。针对现有的碰撞时间(time to collision,TTC)指标不适于评估交叉口左转非机动车冲突的问题,考虑非机动车车辆尺寸与加速度对交通冲突的影响,采用拓展碰撞时间指标,评估交叉口非机动车交通冲突。收集长沙市4个信号交叉口的视频大数据,利用视频软件Tracker提取车辆微观轨迹后,开展案例分析。【结果】左转非机动车信号灯在时间上明确了非机动车的通行权,其设置能显著降低非机动车冲突率,在平峰、高峰时段非机动车冲突率分别降低了40.11%、25.27%。在直行相位末期、左转相位即将启亮时,设置组的左转非机动车在待行区等待,冲突率降为0;而对比组近50%的非机动车违规左转,冲突严重。设置左转非机动车信号灯的改善效果随非机动车流量的增大呈先增加后降低趋势,而随机动车流量的增大呈逐步波动下降趋势。【结论】本研究揭示了非机动车左转信号灯的设置对减少交叉口交通冲突的影响,可为城市交叉口非机动车交通安全管控提供有益参考。
文摘本文提出一种跨被试的深度神经网络识别方法,应对运动想象脑电信号的非线性、非平稳特性.该方法首先计算协方差矩阵均值,将不同被试者样本集的协方差对齐至单位矩阵,提升样本的被试间泛化性.然后,将对齐后的样本输入至卷积神经网络中,通过留一被试交叉验证法,构建跨被试的运动想象脑电信号识别方法.在BCI Competition IV dataset 2b公开数据集上进行实验,结果表明,新的方法在该数据集上取得了高的识别性能,且测试场景中的时间复杂度与现有方法相同.
文摘为提高运动想象脑机接口识别准确率,结合共空间模式(common spatial pattern,CSP)和卷积神经网络(convolutional neural network,CNN)方法,提出一种改进滤波器组共空间模式(filter bank common spatial pattern,FBCSP)和CNN的算法,用于多分类运动想象脑电信号识别任务。信号预处理后,使用包含重叠频带的FBCSP计算空间投影矩阵,数据经过投影得到更有区分度的特征序列。然后将特征序列以二维排列方式输入搭建的CNN模型中进行分类。所提出方法在脑机接口竞赛数据集2a和Ⅲa上验证,并和其他文献方法对比。结果表明,本文方法一定程度上提高了运动想象脑电信号的分类准确率,为运动想象研究提供了一个有效办法。
文摘背景:肌萎缩侧索硬化为一种进行性神经退行性疾病,常导致大脑和脊髓神经元死亡。肌萎缩侧索硬化发病机制极为复杂,难治率、死亡率高且目前其治疗药物仅有2种,因此开发新治疗方法以改善患者预后迫在眉睫。目的:综述中药及间充质干细胞调控免疫反应治疗肌萎缩侧索硬化的作用机制。方法:以“traditional Chinese medicine,mesenchymal stem cells,ALS,immune response”为英文检索词,以“中药,间充质干细胞,肌萎缩侧索硬化,免疫反应”为中文检索词,检索万方、中国知网、PubMed及Web of Science数据库2010-2023年的相关文献,最终纳入69篇文献进行综述分析。结果与结论:①中药调控免疫反应治疗肌萎缩侧索硬化可总结为5个机制:主要包括冰片和黄芪甲苷等中药促进闭锁小带蛋白1、闭合蛋白5表达重建血液中枢神经系统屏障完整性;复方扶芳藤合剂调节自然杀伤细胞表面受体分子抑制其自身毒性;半枝莲和广藿香等作用补体系统因子抑制其异常激活;雷公藤和钩藤等介导细胞外信号调节激酶1/2衰减诱导型一氧化氮合酶产生而抑制小胶质细胞活化;左归丸、栝蒌根等促进白细胞介素10表达调控T细胞改善免疫环境。②通过现有研究总结了间充质干细胞调控免疫反应治疗肌萎缩侧索硬化可总结为5个机制:减少水通道蛋白4表达和降低内皮型一氧化氮合酶信号传导等方面修复免疫屏障完整性;释放吲哚胺2,3-双加氧酶和前列腺素E2等因子抗自然杀伤细胞毒性;分泌因子H干扰转化酶活性抑制补体系统异常激活;调控CX3CL1/CX3CR1系统轴或分泌转化生长因子β等途径改变小胶质细胞表型抑制其活性;增加白细胞介素10表达或激活STATS磷酸化通路来恢复T细胞功能。③目前中药联合间充质干细胞治疗肌萎缩侧索硬化研究较少,已知的相关研究报道显示,肌萎灵注射液可促进干细胞增殖分化以及补阳还五汤联合骨髓间充质干细胞显著提高血脑屏障完整性,未来还需进一步探讨两者对难治性肌萎缩侧索硬化的协同治疗效果。