Objective To explore the role of miR-202 in multiple myeloma(MM)cells,and study the regulation of miR-202 on drug sensitivity of MM cells.Methods miR-202 and BAFF mRNA levels were detected by real-time PCR.U266 cells ...Objective To explore the role of miR-202 in multiple myeloma(MM)cells,and study the regulation of miR-202 on drug sensitivity of MM cells.Methods miR-202 and BAFF mRNA levels were detected by real-time PCR.U266 cells were transfected with miR-202-mimics,miR-202-inhibitor,siB AFF and their negative controls.展开更多
The regional changes of daily temperature extremes in North China caused by ur- banization are studied further from observed facts and model estimates on the basis of ho- mogenized daily series of maximum and minimum ...The regional changes of daily temperature extremes in North China caused by ur- banization are studied further from observed facts and model estimates on the basis of ho- mogenized daily series of maximum and minimum temperature observations from 268 mete- orological stations, NCEP/DOE AMIP- Ⅱ reanalysis data （R-2）, and the data of simulations by regional climate model （RegCM3）. The observed facts of regional warming on long time scales are obtained by analyzing the indices of temperature extremes during two time periods of 1961-2010 and 1951-2010. For urbanization effect, the contributions to decreases in an- nual and winter diurnal temperature range （DTR） are 56.0% and 52.9%, respectively, and increases in the lowest minimum temperature （TNn） are 35.7% and 26.2% by comparison of urban and rural observations. Obtained by R-2 data with observations for contrast, on the other hand, increase in the number of annual warm nights （TN90p） contributed by urbaniza- tion is 60.9%. And observed facts of regional warming in daily temperature extremes are also reflected in the simulations, but what difference is urbanization progress at rural areas in North China would be prominent in the next few years relative to urban areas to some extent from model estimates.展开更多
文摘Objective To explore the role of miR-202 in multiple myeloma(MM)cells,and study the regulation of miR-202 on drug sensitivity of MM cells.Methods miR-202 and BAFF mRNA levels were detected by real-time PCR.U266 cells were transfected with miR-202-mimics,miR-202-inhibitor,siB AFF and their negative controls.
基金Urban Meteorological Research Fund of CMA,No.UMRF201009
文摘The regional changes of daily temperature extremes in North China caused by ur- banization are studied further from observed facts and model estimates on the basis of ho- mogenized daily series of maximum and minimum temperature observations from 268 mete- orological stations, NCEP/DOE AMIP- Ⅱ reanalysis data （R-2）, and the data of simulations by regional climate model （RegCM3）. The observed facts of regional warming on long time scales are obtained by analyzing the indices of temperature extremes during two time periods of 1961-2010 and 1951-2010. For urbanization effect, the contributions to decreases in an- nual and winter diurnal temperature range （DTR） are 56.0% and 52.9%, respectively, and increases in the lowest minimum temperature （TNn） are 35.7% and 26.2% by comparison of urban and rural observations. Obtained by R-2 data with observations for contrast, on the other hand, increase in the number of annual warm nights （TN90p） contributed by urbaniza- tion is 60.9%. And observed facts of regional warming in daily temperature extremes are also reflected in the simulations, but what difference is urbanization progress at rural areas in North China would be prominent in the next few years relative to urban areas to some extent from model estimates.
