Four-dimensional flow magnetic resonance imaging for noninvasive diagnosis of clinically significant portal hypertension and high-risk gastroesophageal varices in patients with cirrhosis

Introduction:Noninvasive diagnoses of clinically significant portal hypertension(CSPH)and high-risk gastroesophageal varices are clinically relevant but challenging.Four-dimensional(4D)flow magnetic resonance imaging(MRI)provides comprehensive flow information and is a promising alternative.This study evaluated the efficacy of 4D flow MRI as a noninvasive method for diagnosing CSPH and high-risk varices in patients with liver cirrhosis.Methods:This prospective study enrolled consecutive patients diagnosed with liver cirrhosis at a tertiary referral center between October 2020 and March 2021.Each participant underwent abdominal 4D flow MRI.Hemodynamic parameters within the portal vein,including the average and peak flow velocities,normalized flow volume(Q_(normal)),and regurgitant fraction(R%),were extracted and compared between healthy individuals and patients with CSPH and between participants with high-and low-risk varices.Subsequently,these parameters were incorporated into a logistic regression(LR)model refined using L1 regularization and validated using five-fold cross-validation.The diagnostic efficacy was evaluated using receiver operating characteristic(ROC)curves.Results:Eighty-two participants were enrolled(71 patients diagnosed with liver cirrhosis and 11 healthy individuals serving as controls).Among hemodynamic parameters,patients with CSPH exhibited a notable increase in Q_(normal)of 0.66±0.19 ml*m^(2)/[cycle*kg](P=0.001)and an R%of 1.98(2.05)(P=0.002).Similarly,patients with high-risk varices showed a higher Q_(normal)of 0.61±0.15 ml*m^(2)/[cycle*kg](P<0.001)and R%of 1.88(2.81)(P=0.006).ROC analysis revealed an area under the curve(AUC)for Q_(normal)of 0.93 and 0.91 for R%for diagnosing CSPH,while the LR model showcased a superior AUC of 0.95.For high-risk varices,Q_(normal)and R%showed AUC values of 0.75 and 0.70,respectively,whereas the LR model showed a higher AUC of 0.84.Conclusion:As a noninvasive imaging modality,4D flow MRI exhibits considerable potential for the diagnosis of CSPH and high-risk gastroesophageal varices;thus,it may minimize the reliance on invasive procedures in patients with cirrhosis.

A Timeless Tradition

The Spring Festival,also known as Chinese New Year,is the most important celebration in China.It is a cherished occasion for families to reunite,share festive meals,and honour the memory of their ancestors.The Spring Festival holds profound cultural,social,and historical significance.For the Chinese people,the Spring Festival is a celebration of their rich cultural heritage.

Immersing Into a Rich Tradition

The Spring Festival is the largest and most important festival in China and among Chinese communities worldwide.Having experienced the festival for six years in China,I have developed a deep appreciation for its cultural,social,and economic significance.

Long-Term Characterization of Sea Conditions in the East China Sea Using Significant Wave Height and Wind Speed

In this study, the statistical characterization of sea conditions in the East China Sea(ECS) is investigated by analyzing a significant wave height and wind speed data at a 6-hour interval for 30 years(1980–2009), which was simulated and computed using the WAVEWATCH Ⅲ(WW3) model. The monthly variations of these parameters showed that the significant wave height and wind speed have minimum values of 0.73 m and 5.15 ms^(-1) and 1.73 m and 8.24 ms^(-1) in the month of May and December, respectively. The annual, seasonal, and monthly mean sea state characterizations showed that the slight sea generally prevailed in the ECS and had nearly the highest occurrence in all seasons and months. Additionally, the moderate sea prevailed in the winter months of December and January, while the smooth(wavelets) sea prevailed in May. Furthermore, the spatial variation of sea states showed that the calm and smooth sea had the largest occurrences in the northern ECS. The slight sea occurred mostly(above 30%) in parts of the ECS and the surrounding locations, while higher occurrences of the rough and very rough seas were distributed in waters between the southwest ECS and the northeast South China Sea(SCS). The occurrences of the phenomenal sea conditions are insignificant and are distributed in the northwest Pacific and its upper region, which includes the Southern Kyushu-Palau Ridge and Ryukyu Trench.

The validation of HY-2 altimeter measurements of a significant wave height based on buoy data

HY-2 has been launched by China on August 16, 2011 which assembles multi-microwave remote sensing payloads in a body and has the ability of monitoring ocean dynamic environments. The HY-2 satellite data need to be calibrated and validated before being put into use. Based on the in-situ buoys from the Nation- al Data Buoy Center （NDBC）, Ku-band significant wave heights （SWH, hs） of HY-2 altimeter are validated. Eleven months of HY-2 altimeter Level 2 products data are chose from October 1, 2011 to August 29, 2012. Using NDBC 60 buoys yield 902 collocations for HY-2 by adopting collocation criteria of 30 min for tempo- ral window and 50 km for a spatial window. An overall RMS difference of the SWH between HY-2 and buoy data is 0.297 m. A correlation coefficient between these is 0.964. An ordinary least squares （OLS） regression is performed with the buoy data as an independent variable and the altimeter data as a dependent vari- able. The regression equation of hs is hs （HY-2）=0.891 × hs （NDBC）＋0.022. In addition, 2016 collocations are matched with temporal window of 30 rain at the crossing points of HY-2 and Jason-2 orbits. RMS difference of Ku-band SWH between the two data sets is 0.452 m.

The validation of the significant wave height product of HY-2altimeter–primary results

The HY-2 satellite was successfully launched on 16 August 2011. The HY-2 significant wave height （SWH） is validated by the data from the South China Sea （SCS） field experiment, National Data Buoy Center （NDBC/ buoys and Jason-1/2 altimeters, and is corrected using a linear regression with in-situ measurements. Com- pared with NDBC SWH, the HY-2 SWH show a RMS of 0.36 m, which is similar to Jason- 1 and Jason-2 SWH with the RMS of 0.35 m and 0.37 m respectively; the RMS of corrected HY-2 SWH is 0.27 m, similar to 0.27 m and 0.23 m of corrected Jason-1 and Jason-2 SWH. Therefore the accuracy of HY-2 SWH products is close to that of Jason-1/2 SWH, and the linear regression function derived can improve the accuracy of HY-2 SWH products.

Recent Significant Tornadoes in China

1.Introduction Compared with the United States,whose annual number of tornadoes can exceed 1000,the average number of tornadoes per year in China over the past half a century is estimated to be fewer than 100（Fan and Yu,2015）,even though both countries are located in a similar latitudinal zone of the Northern Hemisphere.

Validation of Chinese HY-2 satellite radar altimeter significant wave height

Chinese Haiyang-2（HY-2） satellite is the first Chinese marine dynamic environment satellite. The dual-frequency （Ku and C band） radar altimeter onboard HY-2 has been working effective to provide operational significant wave height （SWH） for more than three years （October 1, 2011 to present）.We validated along-track Ku-band SWH data of HY-2 satellite against National Data Buoy Center （NDBC） in-situ measurements over a time period of three years from October 1, 2011 to September 30, 2014, the root mean square error （RMSE） and mean bias of HY-2 SWH is 0.38 m and （-0.13±0.35） m, respectively. We also did cross validation against Jason-2 altimeter SWH data, the RMSE and the mean bias is 0.36m and （-0.22±0.28） m, respectively. In order to compare the statistical results between HY-2 and Jason-2 satellite SWH data, we validated the Jason-2 satellite radar altimeter along-track Ku-band SWH data against NDBC measurements using the same method. The results demonstrate the validation method in this study is scientific and the RMSE and mean bias of Jason-2 SWH data is 0.26 m and （0.00±0.26） m, respectively. We also validated both HY-2 and Jason-2 SWH data every month, the mean bias of Jason-2 SWH data almost equaled to zero all the time, while the mean bias of HY-2 SWH data was no less than -0.31m before April 2013 and dropped to zero after that time. These results indicate that the statistical results for HY-2 altimeter SWH are reliable and HY-2 altimeter along-track SWH data were steady and of high quality in the last three years. The results also indicate that HY-2 SWH data have greatly been improved and have the same accuracy with Jason-2 SWH data after April, 2013. SWH data provided by HY-2 satellite radar altimeter are useful and acceptable for ocean operational applications.

Estimating significant wave height from SAR imagery based on an SVM regression model

A new method for estimating significant wave height（SWH） from advanced synthetic aperture radar（ASAR） wave mode data based on a support vector machine（SVM） regression model is presented. The model is established based on a nonlinear relationship between σ0, the variance of the normalized SAR image, SAR image spectrum spectral decomposition parameters and ocean wave SWH. The feature parameters of the SAR images are the input parameters of the SVM regression model, and the SWH provided by the European Centre for Medium-range Weather Forecasts（ECMWF） is the output parameter. On the basis of ASAR matching data set, a particle swarm optimization（PSO） algorithm is used to optimize the input kernel parameters of the SVM regression model and to establish the SVM model. The SWH estimation results yielded by this model are compared with the ECMWF reanalysis data and the buoy data. The RMSE values of the SWH are 0.34 and 0.48 m, and the correlation coefficient is 0.94 and 0.81, respectively. The results show that the SVM regression model is an effective method for estimating the SWH from the SAR data. The advantage of this model is that SAR data may serve as an independent data source for retrieving the SWH, which can avoid the complicated solution process associated with wave spectra.

Risk factors for clinically significant macular edema in a multi-ethnics population with type 2 diabetes

·AIM:To determine the risk factors of clinically significant macular edema (CSME) in patients with non-proliferative diabetic retinopathy (NPDR) in a multi-ethnics Malaysian population. ·METHODS:We performed a case control study in which 150 patients with bilateral NPDR and CSME in either eye were compared to 150 patients with bilateral NPDR and no CSME in both eyes. CSME and NPDR were graded according to Early Treatment of Diabetic Retinopathy Study criteria. Student’s t-test, odds ratio and multiple logistic regression analysis were performed to analyze the duration of diabetes, body mass index (BMI), blood pressure(BP), total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL), triglycerides (TG), fasting blood glucose (FBG), HbA1c, full blood count, serum creatinine and proteinuria between the two groups. ·RESULTS:Both groups were matched in terms of age, gender and ethnicity. Duration of diabetes, total serum cholesterol, serum LDL, FBG, HbA1c and serum creatinine were significantly higher in the CSME group (P <0.05). The hemoglobin, packed cell volume were significantly lower in the CSME group (P <0.05). There was no significant difference for serum HDL, TG, BMI, systolic and diastolic BP. Multiple logistic regression analysis showed that total serum cholesterol and HbA1c had significantly high odds of developing CSME. ·CONCLUSION:HbA1c and total cholesterol are the two most important risk factors associated with CSME in patients with NPDR.

The seasonal variations in the significant wave height and sea surface wind speed of the China's seas

Long-term variations in a sea surface wind speed （WS） and a significant wave height （SWH） are associated with the global climate change, the prevention and mitigation of natural disasters, and an ocean resource exploitation, and other activities. The seasonal characteristics of the long-term trends in China＇s seas WS and SWH are determined based on 24 a （1988-2011） cross-calibrated, multi-platform （CCMP） wind data and 24 a hindcast wave data obtained with the WAVEWATCH-III （WW3） wave model forced by CCMP wind data. The results show the following. （1） For the past 24 a, the China＇s WS and SWH exhibit a significant increasing trend as a whole, of 3.38 cm/（s.a） in the WS, 1.3 cm/a in the SWH. （2） As a whole, the increasing trend of the China＇s seas WS and SWH is strongest in March-April-May （MAM） and December-January-February （DJF）, followed by June-July-August （JJA）, and smallest in September-October-November （SON）. （3） The areal extent of significant increases in the WS was largest in MAM, while the area decreased in JJA and DJF; the smallest area was apparent in SON. In contrast to the WS, almost all of China＇s seas exhibited a significant increase in SWH in MAM and DJF; the range was slightly smaller in JJA and SON. The WS and SWH in the Bohai Sea, the Yellow Sea, East China Sea, the Tsushima Strait, the Taiwan Strait, the northern South China Sea, the Beibu Gull and the Gulf of Thailand exhibited a significant increase in all seasons. （4） The variations in China＇s seas SWH and WS depended on the season. The areas with a strong increase usually appeared in DJF.

A newly developed ocean significant wave height retrieval method from Envisat ASAR wave mode imagery

The main objective of this paper is to propose a newly developed ocean Significant Wave Height (SWH) retrieval method from Envisat Advanced Synthetic Aperture Radar (ASAR) imagery. A series of wave mode imagery from January, April and May of 2011 are collocated with ERA-Interim reanalysis SWH data. Based on the matched datasets, a simplified empirical relationship between 22 types of SAR imagery parameters and SWH products is developed with the Genetic Algorithms Partial Least-Squares (GA-PLS) model. Two major features of the backscattering coefficient σ0 and the frequency parameter S10 are chosen as the optimal training feature subset of SWH retrieval by using cross validation. In addition, we also present a comparison of the retrieval results of the simplified empirical relationship with the collocated ERA-Interim data. The results show that the assessment index of the correlation coefficient, the bias, the root-mean-square error of cross validation (RMSECV) and the scattering index (SI) are 0.78, 0.07 m, 0.76 m and 0.5, respectively. In addition, the comparison of the retrieved SWH data between our simplifying model and the Jason-2 radar altimeter data is proposed in our study. Moreover, we also make a comparison of the retrieval of SWH data between our developed model and the well- known CWAVE_ENV model. The results show that satisfying retrieval results are acquired in the low-moderate sea state, but major bias appears in the high sea state, especially for SWH>5 m.

Comparative analysis of significant wave height between a new Southern Ocean buoy and satellite altimeter

In-situ observation is restricted by the strong wind and waves in the Southern Ocean.A Westerlies EnvironmentalMonitoring Buoy(WEMB)was firstly deployed in the Southern Ocean during China’s 35th Antarctic Expedition,facilitating further understanding of the oceanic environmental characteristics of this region.With the develop-ment of technology and the improvement of data processing methods,the accuracy of satellite altimeter productsis constantly improved,thus making it possible to inspect and evaluate the in-situ observation data.Based on theL3 products of multiple satellite altimeters,this paper analyzes and corrects the significant wave height(SWH)data of WEMB by means of data matching,error statistics,and linear least-squares fitting.Through this study,the authors obtained the following results.The effect of gravitational acceleration changes with latitude on SWHaccuracy is fairly small.Due to the low response of WEMB to high-frequency waves,there is a systematic devia-tion.A feasible correction method is therefore proposed to improve the SWH accuracy of WEMB.The temporalvariation of the corrected SWH is highly consistent with that of the 10 m wind during the observation period,and its average value reaches 3.8 m.

Validation of significant wave height retrieval from co-polarization Chinese Gaofen-3 SAR imagery using an improved algorithm

Chinese Gaofen-3（GF-3） is the first civilian satellite to carry C-band（5.3 GHz） synthetic aperture radar（SAR）.During the period of August 2016 to December 2017, 1 523 GF-3 SAR images acquired in quad-polarization（vertical-vertical（VV）, horizontal-horizontal（HH）, vertical-horizontal（VH）, and horizontal-vertical（HV）） mode were recorded, mostly around China＇s seas. In our previous study, the root mean square error（RMSE） of significant wave height（SWH） was found to be around 0.58 m when compared with retrieval results from a few GF-3 SAR images in co-polarization（VV and HH） with moored measurements by using an empirical algorithm CSARWAVE. We collected a number of sub-scenes from these 1 523 images in the co-polarization channel,which were collocated with wind and SWH data from the European Centre for Medium-Range Weather Forecasts（ECMWF） reanalysis field at a 0.125° grid. Through the collected dataset, an improved empirical wave retrieval algorithm for GF-3 SAR in co-polarization was tuned, herein denoted as CSARWAVE2. An additional 92 GF-3 SAR images were implemented in order to validate CSARWAVE2 against SWH from altimeter Jason-2, showing an about 0.52 m RMSE of SWH for co-polarization GF-3 SAR. Therefore, we conclude that the proposed empirical algorithm has a good performance for wave retrieval from GF-3 SAR images in co-polarization.

The Regions with the Most Significant Temperature Trends During the Last Century

Having analyzed a global grid temperature anomaly data set and some sea level pressure data during the last century, we found the following facts. Firstly, the annual temperature change with a warming trend of about 0.6°C/ 100 years in the tropical area over Indian to the western Pacific Oceans was most closely correlated to the global mean change. Therefore, the temperature change in this area might serve as an indi-cator of global mean change at annual and longer time scales. Secondly, a cooling of about -0.3°C/ 100 years occurred over the northern Atlantic. Thirdly, a two-wave pattern of temperature change, warming over northern Asia and northwestern America and cooling over the northern Atlantic and the northern Pa-cific, occurred during the last half century linked to strengthening westerlies over the northern Atlantic and the weakening Siberian High. Fourthly, a remarkable seasonal difference occurred over the Eurasian con-tinent, with cooling (warming) in winter (summer) during 1896–1945, and warming (cooling) in winter (summer) during 1946-1995. The corresponding variations of the North Atlantic Oscillation and the South-ern Oscillation were also discussed. Key words Temperature trend - Mann-Kendall’s Test - Significance - Regional difference - Correlation coefficient This study was supported by the Ministry of Science and Technology Projects G1999043400 and Na-tional Key Project- “Studies on Short-Term Climate Prediction System in China” under Grant No.96-908-01-04.

Quality evaluation and calibration of the SWIM significant wave height product with buoy data

The significant wave height(SWH)is one of the main parameters that describe wave characteristics and is widely used in wave research fields.Wave parameters measured by radar are influenced by the offshore distance and sea state.Validation and calibration are of great significance for radar data applications.The nadir beam of surface wave investigation and monitoring(SWIM)detects the global-ocean-surface SWH.To determine the product quality of SWIM SWH,this paper carried out time-space matching between SWIM and buoy data.The data qualities were evaluated under different offshore distances and sea states.An improved calibration method was proposed based on sea state segmentation,which considered the distribution of the point collocation numbers in various sea states.The results indicate that(1)the SWIM SWH accuracy at offshore distances greater than 50 km is higher than that at distances less than 50 km,with an root mean squared error(RMSE)of 0.2444 m,scatter index(SI)of 0.1156 and relative error(RE)of 9.97%at distances greater than 50 km and those of 0.4460 m,0.2230 and18.66%at distances less than 50 km.(2)SWIM SWH qualities are better in moderate and rough sea states with RMSEs of 0.2848 m and 0.3169 m but are worse in slight and very rough sea states.(3)The effect of the improved calibration method is superior to the traditional method in each sea state and overall data,and the RMSE of SWIM SWH is reduced from the raw 0.3135 m to 0.2859 m by the traditional method and 0.1982 m by the improved method.The influence of spatiotemporal window selection on data quality evaluation was analyzed in this paper.This paper provides references for SWIM SWH product applications.

China's Shale Gas Geological Investigation and Prospecting Have Made Significant Progress

Since 2015, the China Geological Survey has implemented a major program of ＂Geology Survey of Land Energy Mineral Resources＂. Till now, a total of billions of RMB have been invested and seven engineering projects have been established, all of which has greatly enhanced the geological survey and exploration of China＇s continental shale gas in an attempt to overcome the oil and gas shortage.

Study on Technologies for Information Monitoring and Quick Response of Agricultural Focuses and Significant Events

This article analyzed the importance of information monitoring and quick response on agricultural focuses and significant events, proposed the workflow and technical framework for information monitoring and quick response based on modern information technologies, and explained key technologies during implementation and the functional structure for prototype system of the technical support platform.

Laparoscopic liver resection for hepatocellular carcinoma complicated with significant portal hypertension:A propensity score-matched survival analysis

Background: Significant portal hypertension(SPH) is a relative contraindication for patients with resectable hepatocellular carcinoma(HCC). However, increasing evidence indicates that liver resection is feasible for HCC patients with SPH. Methods: HCC patients with cirrhosis who underwent laparoscopic liver resection(LLR) in two centers from January 2013 to April 2018 were included. Surgical and survival outcomes were analyzed to explore potential prognostic factors. Propensity score matching(PSM) analysis was performed to minimize bias. Results: A total of 165 patients were divided into two groups based on the presence(SPH, n = 76) or absence(non-SPH, n = 89) of SPH. Patients in the SPH group had longer operative time, more blood loss, and more advanced TNM stage than patients in the non-SPH group( P < 0.05). However, there were no significant differences in the postoperative 90-day mortality rate( n = 0), overall postoperative complications(47.4% vs. 41.6%, P = 0.455), Clavien-Dindo classification( P = 0.347), conversion to open surgery(9.2% vs. 6.7%, P = 0.557), or length of hospitalization(16 vs. 15 days, P = 0.203) between the SPH and non-SPH groups before PSM. Similar results were obtained after PSM. The 1-, 3-, and 5-year overall survival(OS) and recurrence-free survival rates in the SPH group were not significantly different from those in the non-SPH group both before and after PSM(log-rank P > 0.05). After PSM, alpha-fetoprotein(AFP) ≥ 400 μg/L [hazard ratio(HR) = 4.71, 95% confidence interval(CI): 2.69-8.25], ascites(HR = 2.18, 95% CI: 1.30-3.66), American Society of Anesthesiologists(ASA) classification(Ⅲ vs. Ⅱ)(HR = 2.13, 95% CI: 1.11-4.07) and tumor diameter > 5 cm(HR = 3.91, 95% CI: 2.02-7.56) independently predicted worse OS. Conclusions: LLR for patients with HCC complicated with SPH appears feasible at the price of increasing operative time and blood loss. AFP, ascites, ASA classification and tumor diameter may predict the prognosis of HCC complicated with SPH after LLR.

Calculation of Significant Wave Height Using the Linear Mean Square Estimation Method

Significant wave height is an important criterion in designing coastal and offshore structures.Based on the orthogonality principle, the linear mean square estimation method is applied to calculate significant wave height in this paper.Twenty-eight-year time series of wave data collected from three ocean buoys near San Francisco along the California coast are analyzed.It is proved theoretically that the computation error will be reduced by using as many measured data as possible for the calculation of significant wave height.Measured significant wave height at one buoy location is compared with the calculated value based on the data from two other adjacent buoys.The results indicate that the linear mean square estimation method can be well applied to the calculation and prediction of significant wave height in coastal regions.