Conventional frame-based image sensors suffer greatly from high energy consumption and latency.Mimicking neurobiological structures and functionalities of the retina provides a promising way to build a neuromorphic vi...Conventional frame-based image sensors suffer greatly from high energy consumption and latency.Mimicking neurobiological structures and functionalities of the retina provides a promising way to build a neuromorphic vision sensor with highly efficient image processing.In this review article,we will start with a brief introduction to explain the working mechanism and the challenges of conventional frame-based image sensors,and introduce the structure and functions of biological retina.In the main section,we will overview recent developments in neuromorphic vision sensors,including the silicon retina based on conventional Si CMOS digital technologies,and the neuromorphic vision sensors with the implementation of emerging devices.Finally,we will provide a brief outline of the prospects and outlook for the development of this field.展开更多
Background A satisfied glaucoma model is absent now.The aim of this study was to evaluate the effect of a combination of intracameral injection of silicone oil and electrocoagulation of corneal limbal vessels and epis...Background A satisfied glaucoma model is absent now.The aim of this study was to evaluate the effect of a combination of intracameral injection of silicone oil and electrocoagulation of corneal limbal vessels and episcleral veins in the rats to establish glaucoma model.Methods Operation was performed in each of the left eyes of 90 adult male rats.Right eyes were used as controls.Measurement of intraocular pressure （IOP） was performed with an applanation tonometer （Tong-Pen）.Retinal ganglion cells （RGCs） were retrogradely labeled by applying FluoroGold onto the bilateral superior colliculus.Results During the follow-up （24 weeks）,the lOP of the study eyes was significantly higher （P〈0.05） than the control eyes （at final examination,IOP of control eyes was （13.4±1.0） mmHg and lOP of study eyes was （16.1±1.8） mmHg）.Correspondingly,at 24 weeks after operation,the RGCs density of the study eyes （2286.11±290.45/mm^2） was significantly lower than the control eyes （2626.46±164.85/mm^2,P〈0.01）.In the operated eyes,histological examination showed excavation of optic disc and increased neuroglial cells in the optic nerve,reduced thickness of retina and diminution of retinal ganglion cells,and atrophy of ciliary body and iris.Notably,the anterior chamber angle of the operated eye remained open.Conclusions A combination of intracameral injection of silicone oil and electrocoagulation of comeal limbal vessels and episcleral veins may establish a reliable glaucoma model for further research.展开更多
基金Research Grant Council of Hong Kong(15205619)the Shenzhen Science and Technology Innovation Commission(JCYJ20180507183424383)National Natural Science Foundation of China(61851402).
文摘Conventional frame-based image sensors suffer greatly from high energy consumption and latency.Mimicking neurobiological structures and functionalities of the retina provides a promising way to build a neuromorphic vision sensor with highly efficient image processing.In this review article,we will start with a brief introduction to explain the working mechanism and the challenges of conventional frame-based image sensors,and introduce the structure and functions of biological retina.In the main section,we will overview recent developments in neuromorphic vision sensors,including the silicon retina based on conventional Si CMOS digital technologies,and the neuromorphic vision sensors with the implementation of emerging devices.Finally,we will provide a brief outline of the prospects and outlook for the development of this field.
基金This study was supported by grants from the National Natural Science Foundation of China （No. 30670514）, the Program of Beijing Education Commission （No. KM200910025007） and Beijing Novel Program （No. 2009B04）.
文摘Background A satisfied glaucoma model is absent now.The aim of this study was to evaluate the effect of a combination of intracameral injection of silicone oil and electrocoagulation of corneal limbal vessels and episcleral veins in the rats to establish glaucoma model.Methods Operation was performed in each of the left eyes of 90 adult male rats.Right eyes were used as controls.Measurement of intraocular pressure （IOP） was performed with an applanation tonometer （Tong-Pen）.Retinal ganglion cells （RGCs） were retrogradely labeled by applying FluoroGold onto the bilateral superior colliculus.Results During the follow-up （24 weeks）,the lOP of the study eyes was significantly higher （P〈0.05） than the control eyes （at final examination,IOP of control eyes was （13.4±1.0） mmHg and lOP of study eyes was （16.1±1.8） mmHg）.Correspondingly,at 24 weeks after operation,the RGCs density of the study eyes （2286.11±290.45/mm^2） was significantly lower than the control eyes （2626.46±164.85/mm^2,P〈0.01）.In the operated eyes,histological examination showed excavation of optic disc and increased neuroglial cells in the optic nerve,reduced thickness of retina and diminution of retinal ganglion cells,and atrophy of ciliary body and iris.Notably,the anterior chamber angle of the operated eye remained open.Conclusions A combination of intracameral injection of silicone oil and electrocoagulation of comeal limbal vessels and episcleral veins may establish a reliable glaucoma model for further research.
