New solutions for combatting implant bacterial infection based on silver nano-dispersed and gallium incorporated phosphate bioactive glass sputtered films:A preliminary study

Ag/Ga were incorporated into resorbable orthopaedic phosphate bioactive glasses(PBG,containing P,Ca,Mg,Na,and Fe)thin films to demonstrate their potential to limit growth of Staphylococcus aureus and Escherichia coli in post-operative prosthetic implantation.Dual target consecutive co-sputtering was uniquely employed to produce a 46 nm Ag:PBG composite observed by high resolution TEM to consist of uniformly dispersed~5 nm metallic Ag nano-particles in a glass matrix.Ga^(3+)was integrated into a phosphate glass preform target which was magnetron sputtered to film thicknesses of~400 or 1400 nm.All coatings exhibited high surface energy of 75.4-77.3 mN/m,attributed to the presence of hydrolytic P-O-P structural surface bonds.Degradation profiles obtained in deionized water,nutrient broth and cell culture medium showed varying ion release profiles,whereby Ga release was measured in 1400 nm coating by ICP-MS to be~6,27,and 4 ppm respectively,fully dissolving by 24 h.Solubility of Ag nanoparticles was only observed in nutrient broth(~9 ppm by 24 h).Quantification of colony forming units after 24 h showed encouraging antibacterial efficacy towards both S.aureus(4-log reduction for Ag:PBG and 6-log reduction for Ga-PBG≈1400 nm)and E.coli(5-log reduction for all physical vapour deposited layers)strains.Human Hs27 fibroblast and mesenchymal stem cell line in vitro tests indicated good cytocompatibility for all sputtered layers,with a marginal cell proliferation inertia in the case of the Ag:PBG composite thin film.The study therefore highlights the(i)significant manufacturing development via the controlled inclusion of metallic nanoparticles into a PBG glass matrix by dual consecutive target co-sputtering and(ii)potential of PBG resorbable thin-film structures to incorporate and release cytocompatible/antibacterial oxides.Both architectures showed prospective bio-functional performance for a future generation of endo-osseous implant-type coatings.

抗菌陶瓷釉面砖的制备及其性能研究

通过在釉中引入磷酸银抗菌剂 ,研制了低温两次快烧抗菌陶瓷釉面砖。用正交实验法优选出抗菌釉面砖的坯体配方、釉料配方及烧成温度制度 ,研究了Ag3PO4及烧成温度对抗菌效果及白度的影响 ,探讨了银挥发量和Ag+在釉层中的径向分布与烧成温度的关系。结果表明 ,基釉中加入 2 %Ag3PO4及烧成温度为 10 5 0℃的抗菌釉面砖可获得较好的抗菌效果和釉面质量 。

抗菌搪瓷及其性能的研究

在搪瓷面釉中引入磷酸银抗菌剂,研制出了抗菌搪瓷。在确定了抗菌搪瓷的底釉和面釉的配方及其烧成温度制度的基础上,主要研究了烧成温度对银挥发量的影响,并对在不同的烧成温度下,Ag+在釉层中的径向分布情况进行了分析。结果表明:制备抗菌搪瓷时,在面釉中加入1.5%Ag3PO4、烧成温度为940℃时即获得良好的抗菌效果、釉面质量及抗菌耐久性。

无机抗菌硼酸盐玻璃材料的研究

采用高温熔融法 ,在硼酸盐玻璃的配合料中引入抗菌剂磷酸银 ,一次烧制而成制得抗菌玻璃材料 ,并对硼酸盐玻璃的抗菌性能和缓释性能进行了分析。结果表明 :制备抗菌硼酸盐玻璃时 ,合适的银含量为 1.5 %～ 2 .0 % ,处理温度在 110 0～ 14 0 0℃即获得良好的抗菌效果和缓释性。

无机抗菌磷酸盐玻璃及其性能的研究

采用高温熔融法,在磷酸盐玻璃的配合料中引入抗菌剂硝酸银,一次烧制而成制得抗菌玻璃材料,对磷酸盐玻璃的抗菌性能和缓释性能进行分析。结果表明:制备抗菌磷酸盐玻璃时,合适的银质量分数为1.5%～2.0%,处理温度在1200～1350℃,即获得良好的抗菌效果和缓释性。

无机抗菌磷酸盐玻璃及其性能的研究

采用高温熔融法，在磷酸盐玻璃的配合料中引入抗菌剂硝酸银，一次熔化制得抗菌玻璃材料。通过对磷酸盐玻璃的抗菌性能和缓释性能分析，结果表明：制备抗菌磷酸盐玻璃，合适的银含量为1．5％～2．0％（质量），处理温度在1200～1350℃，即可获得良好的抗菌效果和缓释性。

载硼酸盐系无机抗菌玻璃及其性能研究

采用高温熔融法,在硼酸盐玻璃的配合料中引入抗菌剂磷酸银,一次烧制而成制得抗菌玻璃材料。通过对硼酸盐玻璃的抗菌性能和缓释性能分析,结果表明:制备抗菌硼酸盐玻璃时,合适的银含量为1.5%-2.0%(Wt),处理温度在1100℃-1400℃即获得良好的抗菌效果和缓释性。

载银磷酸盐玻璃的缓释及抗菌性能研究进展

载银磷酸盐玻璃是一种新型抗菌材料。通常磷酸盐玻璃的化学性质不稳定,在水中可溶且溶解速率可调。银离子具有优良的抗菌性能,载银磷酸盐玻璃由于其缓释性和抗菌性,在诸多领域具有潜在的应用前景。综述了近年来该材料的研究成果,概述了其合成方法,总结了其结构和性能,及其在水处理剂、洗衣机、肥料、塑料和医学实践等领域的应用进展,并对其未来的发展作出了展望。