A Simple One-Step System Enhances the Availability of High-Quality Sperm for Assisted Reproductive Procedures

Over the last forty years, in vitro fertilization, which has expanded to assisted reproductive technologies (ART), has gone from an experimental procedure to the mainstay of infertility treatment. A technique that once made news with each birth is now responsible for 2% - 3% of the babies born in several nations of the world. This has happened due to significant advances in hormone therapies, culture techniques, and the specialization of equipment designed to support oocytes and embryos. However, for all the advances made to support female fertility, little has changed in male treatment since the advent of intracytoplasmic sperm injection in the early 1990’s. Recently, a number of authors have documented problems with sperm preparation techniques. Some report DNA damage, others membrane and organelle issues, all of which potentially hamper fertilization rates and possibly take-home baby rates. Further, as the clinical workload of ART has increased and staffing shortages have become critical, all labs are looking for simpler, more efficient ways to perform job functions. This study describes a simple, one-step method for preparing semen samples for ART. This new technique minimizes excessive manipulation of the sample compared to current standards and is less likely to cause cell damage. Preliminary results suggest a significant enhancement in recovered sample motility and an optimal sample for ART procedures with minimal sample manipulation.

Identification of time-varying system and energy-based optimization of adaptive control in seismically excited structure

The combination of structural health monitoring and vibration control is of great importance to provide components of smart structures.While synthetic algorithms have been proposed,adaptive control that is compatible with changing conditions still needs to be used,and time-varying systems are required to be simultaneously estimated with the application of adaptive control.In this research,the identification of structural time-varying dynamic characteristics and optimized simple adaptive control are integrated.First,reduced variations of physical parameters are estimated online using the multiple forgetting factor recursive least squares(MFRLS)method.Then,the energy from the structural vibration is simultaneously specified to optimize the control force with the identified parameters to be operational.Optimization is also performed based on the probability density function of the energy under the seismic excitation at any time.Finally,the optimal control force is obtained by the simple adaptive control(SAC)algorithm and energy coefficient.A numerical example and benchmark structure are employed to investigate the efficiency of the proposed approach.The simulation results revealed the effectiveness of the integrated online identification and optimal adaptive control in systems.

Simple and effective method for treating severe adult skeletal class II malocclusion: A case report

BACKGROUND Severe skeletal class II malocclusion is the indication for combined orthodontic and orthognathic treatment.CASE SUMMARY A woman with a chief complaint of a protruding chin and an inability to close her lips requested orthodontic camouflage.The treatment plan consisted of extracting the right upper third molar,right lower third molar,left lower second molar,and left upper third molar and moving the maxillary dentition distally using a convenient method involving microimplant nail anchors,push springs,long arm traction hooks,and elastic traction chains.After 52 months of treatment,her overbite and overjet were normal,and her facial profile was favorable.CONCLUSION This method can be used for distal movement of the maxillary dentition and to correct severe skeletal class II malocclusion in adults.

An Affordable and Easily Accessible Approach for Acrylonitrile Monomer Purification through a Simple Column Technique

This manuscript presents a dataset detailing a method for purifying monomers. Purification plays a crucial role in every chemical process, as it leads to an improvement in product quality through the removal of impurities. The primary method for monomer purification, like acrylonitrile (AN), is the distillation technique. However, this technique is unsafe and hard to set up or handle. A straightforward, risk-free, low-cost method like the column technique resolves these issues. A simple column technique demonstrated the successful execution of purifying AN. Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) analyses confirmed that AN was successfully purified, with purity reaching 99.8%. FTIR spectra revealed changes in the position and intensity of the stretching vibration peaks after purification. Also, the functional groups of the inhibitor monomethyl ether of hydroquinone (MeHQ) were undetected after purification. Furthermore, after purification, NMR spectra revealed the absence of aromatic protons and carbons associated with MeHQ. In conclusion, the column technique is a successful and inexpensive way to purify AN monomers. This makes it useful for a wide range of applications, especially in polymerization reactions where MeHQ needs to be removed to prevent self-polymerization during the initiation process.

Heat Kernel Estimates on Simple Random Walks and On-Diagonal Upper Bounds

We primarily provide several estimates for the heat kernel defined on the 2-dimensional simple random walk. Additionally, we offer an estimate for the heat kernel on high-dimensional random walks, demonstrating that the heat kernel in higher dimensions converges rapidly. We also compute the constants involved in the estimate for the 1-dimensional heat kernel. Furthermore, we discuss the general case of on-diagonal estimates for the heat kernel.

Life′s Simple 7干预减轻Her⁃2阳性乳腺癌患者化疗相关心血管系统损害的研究

目的探讨Life′s Simple 7(LS7)干预减轻Her⁃2阳性乳腺癌患者根治术后化疗相关心血管系统损害的作用。方法将120例Her⁃2阳性并接受标准化乳腺癌化疗的患者随机等量分为对照组及LS7组,对照组为标准化疗方案,LS7组为对照组基础上给予LS7干预12个月,后续通过比较两组治疗前后心血管系统损伤程度、焦虑、抑郁及生活质量等指标评价其对心血管系统损害的改善作用。结果相较于对照组,LS7组LS7总评分及7项心血管健康指标均优于对照组(P<0.05),LS7组LVEF较高(P<0.05)、NT⁃proBNP较低(P<0.05),焦虑和抑郁评分较低(P<0.05)、生活质量评分较高(P<0.05)。结论LS7干预可显著减轻Her⁃2阳性乳腺癌化疗相关心血管系统损害并改善乳腺癌患者的心理状况和生活质量,值得在临床推广。

A Simple Jerky Dynamics,Genesio System

The third order explicit autonomous differential equations named as jerk equations represent an interesting subclass of dynamical systems that can exhibit many major features of the regular and chaotic motion. In this paper, we show that an algebraically simple system, the Genesio system can be recast into a jerky dynamics and its jerk equation can be derived from one-dimensional Newtonian equation. We also investigate the global dynamical properties of the corresponding jerk system.

COHERENT, REGULAR AND SIMPLE SYSTEMS IN ZERO DECOMPOSITIONS OF PARTIAL DIFFERENTIAL SYSTEMS

This paper studies triangular differential systems arising from various decompositions of partial differential polynomial systems. In theoretical aspects, we emphasizeon translating differential problems into purely algebraic ones. Rosenfeld’s lemma is extended to a more general setting; relations between passivity and coherence are clarified;regular systems and simple systems are generalized and proposed, respectively. In algorithmic aspects, we review the Ritt-Wu and Seidenberg algorithms, and outline a methodfor decomposing a differential polynomial system into simple ones. Some applications arealso discussed.

Zone inhomogeneity with the random asymmetric simple exclusion process in a one-lane system

In this paper we use theoretical analysis and extensive simulations to study zone inhomogeneity with the random asymmetric simple exclusion process （ASEP）. In the inhomogeneous zone, the hopping probability is less than 1. Two typical lattice geometries are investigated here. In case A, the lattice includes two equal segments. The hopping probability in the left segment is equal to 1, and in the right segment it is equal to p, which is less than 1. In case B, there are three equal segments in the system; the hopping probabilities in the left and right segments are equal to 1, and in the middle segment it is equal to p, which is less than 1. Through theoretical analysis, we can discover the effect on these systems when p is changed.

Application of Simple Adaptive Control to Water Hydraulic Servo Cylinder System

Although conventional model reference adaptive control （MRAC） achieves good tracking performance for cylinder control, the controller structure is much more complicated and has less robustness to disturbance in real applications. This paper discusses the use of simple adaptive control （SAC） for positioning a water hydraulic servo cylinder system. Compared with MRAC, SAC has a simpler and lower order structure, i.e., higher feasibility. The control performance of SAC is examined and evaluated on a water hydraulic servo cylinder system. With the recent increased concerns over global environmental problems, the water hydraulic technique using pure tap water as a pressure medium has become a new drive source comparable to electric, oil hydraulic, and pneumatic drive systems. This technique is also preferred because of its high power density, high safety against fire hazards in production plants, and easy availability. However, the main problems for precise control in a water hydraulic system are steady state errors and overshoot due to its large friction torque and considerable leakage flow. MRAC has been already applied to compensate for these effects, and better control performances have been obtained. However, there have been no reports on the application of SAC for water hydraulics. To make clear the merits of SAC, the tracking control performance and robustness are discussed based on experimental results. SAC is confirmed to give better tracking performance compared with PI control, and a control precision comparable to MRAC （within 10 μm of the reference position） and higher robustness to parameter change, despite the simple controller. The research results ensure a wider application of simple adaptive control in real mechanical systems.

Simple waves for two-dimensional compressible pseudo-steady Euler system

A simple wave is defined as a flow in a region whose image is a curve in the phase space. It is well known that ＂the theory of simple waves is fundamental in building up the solutions of flow problems out of elementary flow patterns＂ see Courant and Friedrichs＇s chassical book ＂Supersonic Flow and Shock Waves＂. This paper mainly concerned with the geometric construction of simple waves for the 2D pseudo-steady compressible Euler system. Based on the geometric interpretation, the expansion or compression simple wave flow construction around a pseudo-stream line with a bend part are constructed. It is a building block that appears in the global solution to four contact discontinuities Riemann problems.

Simple shear extrusion versus equal channel angular pressing:A comparative study on the microstructure and mechanical properties of an Mg alloy

Two severe plastic deformation(SPD)techniques of simple shear extrusion(SSE)and equal channel angular pressing(ECAP)were employed to process an extruded Mg-6Gd-3Y-1.5Ag(wt%)alloy at 553 K for 1,2,4 and 6 passes.The microstructural evolutions were studied by electron back scattered diffraction(EBSD)analysis and transmission electron microscopy(TEM).The initial grain size of 7.5μm in the extruded alloy was reduced to about 1.3μm after 6 SPD passes.Discontinuous dynamic recrystallization was suggested to be operative in both SSE and ECAP,with also a potential contribution of continuous dynamic recrystallization at the early stages of deformation.The difference in the shear strain paths of the two SPD techniques caused different progression rate of dynamic recrystallization(DRX),so that the alloys processed by ECAP exhibited higher fractions of recrystallization and high angle grain boundaries(HAGBs).It was revealed that crystallographic texture was also significantly influenced by the difference in the strain paths of the two SPD methods,where dissimilar basal plane texture components were obtained.The compression tests,performed along extrusion direction(ED),indicated that the compressive yield stress(CYS)and ultimate compressive strength(UCS)of the alloys after both SEE and ECAP augmented continuously by increasing the number of passes.ECAP-processed alloys had lower values of CYS and UCS compared to their counterparts processed by SSE.This difference in the mechanical responses was attributed to the different configurations of basal planes with respect to the loading direction(ED)of each SPD technique.

GLOBAL SIMPLE WAVE SOLUTIONS TO A KIND OF TWO DIMENSIONAL HYPERBOLIC SYSTEM OF CONSERVATION LAWS

This paper is concerned with the simple waves of a kind of two dimensional hyperbolic system of conservation laws,which can be obtained from the two dimensional relativistic membrane equation in Minkowski space.Using wave decomposition method,we get that a flow adjacent to a nonconstant state can be a global simple wave.Furthermore,the flow is covered by three families of characteristics,in which the first family of characteristics is straight and the others are curved,which is different to the almost related results.

成年人Life's Simple 7和非酒精性脂肪性肝病之间的关联

目的探究成年人中Life's Simple 7与非酒精性脂肪性肝病(NAFLD)之间的关联。方法数据来自2017-2018年国家健康和营养检查调查(NHANES)中招募的成年人。排除HBsAg阳性、抗-HCV阳性和大量饮酒后,通过肝脏振动控制瞬时弹性成像(VCTE)对NAFLD进行诊断。参考既往的研究计算Life's Simple 7,0~8分为低分组(inadequate),9~10分为平均组(average),11~14分为优秀组(optimal)。进行多因素Logistic回归分析相关性。结果分析了2376名参与者的数据。NAFLD的总患病率为42.0%,在inadequate、average和optimal评分类别中的患病率分别为62.5%、33.4%和10.8%(P<0.001)。多因素Logistics回归分析,调整了年龄、性别、种族和贫困收入比率(PIR)后显示Life's Simple 7得分越高,NAFLD患病风险降低。跟inadequate组对比,average组OR值为0.31(95%CI:0.23-0.42),optimal组的OR值为0.08(95%CI:0.05-0.13)。根据分层分析,这种关联在不同年龄、性别、种族和经济群体中是相似的。结论越高的Life's Simple 7评分与越低的NAFLD患病率相关。拥有理想的心血管健康指标可能有利于降低普通成年人NAFLD的患病率。

Efficacy of Simple Assessment System of Oocyte Maturity in IVF-ET Cycles

Objective To establish and evaluate the efficacy of the simple assessment system of oocyte maturity. Methods A total of 251 couples were enrolled in this study and female patients were divided into two groups. In group Ⅰ, oocytes were inseminated at 6 h after ovum pick-up. In group Ⅱ, oocyte maturity was rapidly categorized by simple assessment system. Mature oocytes were inseminated at 3-4 h after ovum pick-up when oocyte-corona complexes （OCC） exhibited clear thick ring-like halo （RLH） and expanded cumulus cells （CC） or 5-6 h when OCC exhibited RLH and a few clumped and/or dark CC, respectively. Intermediate oocytes were inseminated at 7-8 h when RLH was not found around the OCC and CC were compacted and clumped and/or dark. Results Normal fertilization rate was higher in group Ⅱ （76.5%） than that in group Ⅰ （58.0%） （P〈0.001）. However, abnormal fertilization rate was higher in group Ⅰ（11.3%） than that in group 11 （3.6%） （P〈0.001）. The cleavage （82.6% vs 90.0%）, chemical pregnancy （4. 8% vs 3.9%）, twin pregnancy （6. 7% vs 3.9%） and implantation rate （8.4% vs 10.6%） had no statistically differences between group I and Ⅱ. Rate of clinical and singleton pregnancy was higher in groupⅡ （35.3% and 31.4%） than those in group Ⅰ （24.8% and 18.2%） （P〈0.05）. Conclusion This simple assessment system is useful and effective for evaluation and categorization of the oocyte maturity with better reproductive outcomes.

A web product data management system based on Simple Object Access Protocol

A new web product data management architecture is presented. The three-tier web architecture and Simple Object Access Protocol (SOAP) are combined to build the web-based product data management (PDM) system which includes three tiers: the user services tier, the business services tier, and the data services tier. The client service component uses the server-side technology, and Extensible Markup Language (XML) web service which uses SOAP as the communication protocol is chosen as the business service component. To illustrate how to build a web-based PDM system using the proposed architecture, a case PDM system which included three logical tires was built. To use the security and central management features of the database, a stored procedure was recommended in the data services tier. The business object was implemented as an XML web service so that client could use standard internet protocols to communicate with the business object from any platform. In order to satisfy users using all sorts of browser, the server-side technology and Microsoft ASP.NET was used to create the dynamic user interface.

基于Simple Seasonal模型上网电量和厂用电量的发电量预测

近年来,预测发电量统计引起国家电网的高度关注。供电企业对发电量进行预测,不仅能满足社会用电要求,还能提高企业的竞争力。文章以辽宁省的两个火电厂为例,采用Simple Seasonal模型预测未来1个月的上网电量和厂用电量,进而统计发电量的预测值。在确保电网安全前提下,不仅可以保障电力供应平稳有序,最大限度减少因无序用电带来的损失,还可以为节约用电开辟一条新的道路。

基于SIMPLE药学服务模式的药物指导在呼吸内科慢性病患者用药管理中的效果评估

对基于SIMPLE药学服务模式的药物指导应用于呼吸内科慢性病患者用药管理中的应用效果进行评估。方法 自我院2021年8月~2022年8月间收治的呼吸内科慢性病患者中随机抽选本次研究对象,筛选后符合相关标准的共计108例,组织患者集中抽签,分别设置红色球54颗,黄色球54颗,抽到红色球的患者进入研究组,抽到黄色球的患者进入对照组,由此每组可均分54例。对照组患者接受常规药学服务模式下的药物指导,研究组患者则基于SIMPLE药物服务模式进行药物指导,对两种模式取得的临床效果展开对比。结果 干预进行至第3个月与第6个月时,所有患者在吸入装置使用方面的评分较前有所改善,但研究组患者的评分更高(P<0.05);干预进行至第3个月与第6个月时,所有患者的肺功能指标逐渐好转,对比研究组与对照组数据,发现研究组更具优势(P<0.05);干预结束时,研究组患者在安全用药方面的评价明显高于对照组,各维度评分均表现出显著差异(P<0.05);干预期间,研究组患者更少出现不良反应,组间数据对比:研究组(3.70%)vs对照组(20.37%)有明显优势(P<0.05)。结论 基于SIMPLE药学服务模式的药学指导能够规范呼吸内科慢性病患者的用药行为,提升其吸入装置使用能力,改善患者的临床症状,有较高的临床应用价值。

Symmetry phases of asymmetric simple exclusion processes on two lanes with an intersection

This paper studies two-lane asymmetric simple exclusion processes(ASEPs)with an intersection.In the upstream segments of the intersection,one particle can move to the next site with rate 1 if the site is empty,and the other particle can move forward with rate p in the sites of downstream segments.The parameter p can represent the rate of slowing of motion,and the parameter is introduced to investigate spontaneous symmetry breaking(SSB)phenomenon.Extensive Monte Carlo simulations are carried out.It is shown that three symmetric phases exist and the SSB does not exist in the system.Simple mean field approach in which correlation of sites is ignored is firstly adopted to analyze the system,and the system is divided into four independent segments.It is found that the analytical results deviate from the simulation ones,especially when p is small.In addition,the inexsitence of SSB can only be explained qualitatively.Motivated by this,we carry out the cluster mean field analysis in which correlation of five sites is considered.It is shown that densities of the two upstream segments are equal,which demonstrates that the SSB does not exist.It is also shown that,as expected,the cluster mean field analysis performs much better than the simple mean field analysis.

PD-like finite time controller with simple structure for satellite attitude control

A finite time controller with PD-like structure for satellite attitude control is proposed in this paper.The controller is constructed with simple structure based on standard PD controller.The fractional order term is designed hence system could both have strong robustness and finite time convergence rate,and the advantage of finite time control and PD control is combined in this paper.System convergence rate is discussed by Lyapunov method,and the constraint on control parameters is given by implementing the coupled term of angular velocity and attitude quaternion.Moreover,the accuracy at steady stage depending on control parameters is given hence system could converge to this field within finite time.System stability and performance is demonstrated by numerical simulation results.