BACKGROUND Postoperative pain management and cognitive function preservation are crucial for patients undergoing thoracoscopic surgery for lung cancer(LC).This is achieved using either a thoracic paravertebral block(T...BACKGROUND Postoperative pain management and cognitive function preservation are crucial for patients undergoing thoracoscopic surgery for lung cancer(LC).This is achieved using either a thoracic paravertebral block(TPVB)or sufentanil(SUF)-based multimodal analgesia.However,the efficacy and impact of their combined use on postoperative pain and postoperative cognitive dysfunction(POCD)remain unclear.AIM To explore the analgesic effect and the influence on POCD of TPVB combined with SUF-based multimodal analgesia in patients undergoing thoracoscopic radical resection for LC to help optimize postoperative pain management and improve patient outcomes.METHODS This retrospective analysis included 107 patients undergoing thoracoscopic radical resection for LC at The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital between May 2021 and January 2023.Patients receiving SUF-based multimodal analgesia(n=50)and patients receiving TPVB+SUF-based multimodal analgesia(n=57)were assigned to the control group and TPVB group,respectively.We compared the Ramsay Sedation Scale and visual analog scale(VAS)scores at rest and with cough between the two groups at 2,12,and 24 h after surgery.Serum levels of epinephrine(E),angio-tensin Ⅱ(Ang Ⅱ),norepinephrine(NE),superoxide dismutase(SOD),vascular endothelial growth factor(VEGF),transforming growth factor-β1(TGF-β1),tumor necrosis factor-α(TNF-α),and S-100 calcium-binding proteinβ(S-100β)were measured before and 24 h after surgery.The Mini-Mental State Examination(MMSE)was administered 1 day before surgery and at 3 and 5 days after surgery,and the occurrence of POCD was monitored for 5 days after surgery.Adverse reactions were also recorded.RESULTS There were no significant time point,between-group,and interaction effects in Ramsay sedation scores between the two groups(P>0.05).Significantly,there were notable time point effects,between-group differences,and interaction effects observed in VAS scores both at rest and with cough(P<0.05).The VAS scores at rest and with cough at 12 and 24 h after surgery were lower than those at 2 h after surgery and gradually decreased as postoperative time increased(P<0.05).The TPVB group had lower VAS scores than the control group at 2,12,and 24 h after surgery(P<0.05).The MMSE scores at postoperative days 1 and 3 were markedly higher in the TPVB group than in the control group(P<0.05).The incidence of POCD was significantly lower in the TPVB group than in the control group within 5 days after surgery(P<0.05).Both groups had elevated serum E,Ang Ⅱ,and NE and decreased serum SOD levels at 24 h after surgery compared with the preoperative levels,with better indices in the TPVB group(P<0.05).Marked elevations in serum levels of VEGF,TGF-β1,TNF-α,and S-100β were observed in both groups at 24 h after surgery,with lower levels in the TPVB group than in the control group(P<0.05).CONCLUSION TPVB combined with SUF-based multimodal analgesia further relieves pain in patients undergoing thoracoscopic radical surgery for LC,enhances analgesic effects,reduces postoperative stress response,and inhibits postoperative increases in serum VEGF,TGF-β1,TNF-α,and S-100β levels.This scheme also reduced POCD and had a high safety profile.展开更多
目的探讨不同切口手术联合加速康复外科(enhanced recovery after surgery,ERAS)理念指导下的呼吸功能训练在肺癌患者中的应用效果。方法选择2020年1月至2022年12月在苏州大学附属太仓医院择期行肺癌根治术的患者200例,随机分为4组,每...目的探讨不同切口手术联合加速康复外科(enhanced recovery after surgery,ERAS)理念指导下的呼吸功能训练在肺癌患者中的应用效果。方法选择2020年1月至2022年12月在苏州大学附属太仓医院择期行肺癌根治术的患者200例,随机分为4组,每组50例。A组接受单孔胸腔镜手术,术前ERAS宣教,呼吸训练器和常规呼吸功能训练;B组接受腋下肌肉非损伤性小切口手术,术前ERAS宣教,呼吸训练器和常规呼吸功能训练;C组接受腋下肌肉非损伤性小切口手术,术前常规宣教和常规呼吸功能训练;D组接受单孔胸腔镜手术,术前常规宣教和常规呼吸功能训练。比较4组患者术后恢复情况及术后疼痛评分。结果与其他3组相比,A组患者肺部并发症发生率降低,下床时间更早,置管时间、住院时间均缩短(P<0.05);与B组、C组相比,A组患者术后疼痛显著减轻(P<0.05)。与C组相比,B组患者肺部并发症发生率降低,下床时间、置管时间、住院时间缩短(P<0.05)。手术切口相同组间的术后疼痛差异无统计学意义。结论单孔胸腔镜肺癌手术联合ERAS理念指导下的呼吸功能训练可明显降低患者术后肺部并发症发生率,减轻术后疼痛,加速康复。展开更多
文摘BACKGROUND Postoperative pain management and cognitive function preservation are crucial for patients undergoing thoracoscopic surgery for lung cancer(LC).This is achieved using either a thoracic paravertebral block(TPVB)or sufentanil(SUF)-based multimodal analgesia.However,the efficacy and impact of their combined use on postoperative pain and postoperative cognitive dysfunction(POCD)remain unclear.AIM To explore the analgesic effect and the influence on POCD of TPVB combined with SUF-based multimodal analgesia in patients undergoing thoracoscopic radical resection for LC to help optimize postoperative pain management and improve patient outcomes.METHODS This retrospective analysis included 107 patients undergoing thoracoscopic radical resection for LC at The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital between May 2021 and January 2023.Patients receiving SUF-based multimodal analgesia(n=50)and patients receiving TPVB+SUF-based multimodal analgesia(n=57)were assigned to the control group and TPVB group,respectively.We compared the Ramsay Sedation Scale and visual analog scale(VAS)scores at rest and with cough between the two groups at 2,12,and 24 h after surgery.Serum levels of epinephrine(E),angio-tensin Ⅱ(Ang Ⅱ),norepinephrine(NE),superoxide dismutase(SOD),vascular endothelial growth factor(VEGF),transforming growth factor-β1(TGF-β1),tumor necrosis factor-α(TNF-α),and S-100 calcium-binding proteinβ(S-100β)were measured before and 24 h after surgery.The Mini-Mental State Examination(MMSE)was administered 1 day before surgery and at 3 and 5 days after surgery,and the occurrence of POCD was monitored for 5 days after surgery.Adverse reactions were also recorded.RESULTS There were no significant time point,between-group,and interaction effects in Ramsay sedation scores between the two groups(P>0.05).Significantly,there were notable time point effects,between-group differences,and interaction effects observed in VAS scores both at rest and with cough(P<0.05).The VAS scores at rest and with cough at 12 and 24 h after surgery were lower than those at 2 h after surgery and gradually decreased as postoperative time increased(P<0.05).The TPVB group had lower VAS scores than the control group at 2,12,and 24 h after surgery(P<0.05).The MMSE scores at postoperative days 1 and 3 were markedly higher in the TPVB group than in the control group(P<0.05).The incidence of POCD was significantly lower in the TPVB group than in the control group within 5 days after surgery(P<0.05).Both groups had elevated serum E,Ang Ⅱ,and NE and decreased serum SOD levels at 24 h after surgery compared with the preoperative levels,with better indices in the TPVB group(P<0.05).Marked elevations in serum levels of VEGF,TGF-β1,TNF-α,and S-100β were observed in both groups at 24 h after surgery,with lower levels in the TPVB group than in the control group(P<0.05).CONCLUSION TPVB combined with SUF-based multimodal analgesia further relieves pain in patients undergoing thoracoscopic radical surgery for LC,enhances analgesic effects,reduces postoperative stress response,and inhibits postoperative increases in serum VEGF,TGF-β1,TNF-α,and S-100β levels.This scheme also reduced POCD and had a high safety profile.
文摘目的探讨不同切口手术联合加速康复外科(enhanced recovery after surgery,ERAS)理念指导下的呼吸功能训练在肺癌患者中的应用效果。方法选择2020年1月至2022年12月在苏州大学附属太仓医院择期行肺癌根治术的患者200例,随机分为4组,每组50例。A组接受单孔胸腔镜手术,术前ERAS宣教,呼吸训练器和常规呼吸功能训练;B组接受腋下肌肉非损伤性小切口手术,术前ERAS宣教,呼吸训练器和常规呼吸功能训练;C组接受腋下肌肉非损伤性小切口手术,术前常规宣教和常规呼吸功能训练;D组接受单孔胸腔镜手术,术前常规宣教和常规呼吸功能训练。比较4组患者术后恢复情况及术后疼痛评分。结果与其他3组相比,A组患者肺部并发症发生率降低,下床时间更早,置管时间、住院时间均缩短(P<0.05);与B组、C组相比,A组患者术后疼痛显著减轻(P<0.05)。与C组相比,B组患者肺部并发症发生率降低,下床时间、置管时间、住院时间缩短(P<0.05)。手术切口相同组间的术后疼痛差异无统计学意义。结论单孔胸腔镜肺癌手术联合ERAS理念指导下的呼吸功能训练可明显降低患者术后肺部并发症发生率,减轻术后疼痛,加速康复。
