期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Mechanopathology of red blood cell diseases—Why mechanics matters 被引量:1
1
作者 Chwee Teck Lim 《Theoretical & Applied Mechanics Letters》 CAS 2011年第1期1-6,共6页
During the onset of a disease a cell may experience alterations in both the composition and organization of its cellular and molecular structures.These alterations may eventually lead to changes in its geometrical and... During the onset of a disease a cell may experience alterations in both the composition and organization of its cellular and molecular structures.These alterations may eventually lead to changes in its geometrical and mechanical properties such as cell size and shape,deformability and adhesion.As such,knowing how diseased cells respond to mechanical forces can reveal ways by which they differ from healthy ones.Here,we will present biomechanistic insights into red blood cell related diseases that manifest mechanical property changes and how they directly contribute to the pathophysiology of diseases.By conducting cell and molecular mechanics studies,not only can we elucidate changes in the structure-property-function relationship of diseased cells,we can also exploit the new knowledge gained to develop biomechanics based devices that may better detect and diagnose these diseases as well as help identify important biomechanical targets for possible therapeutic interventions. 展开更多
关键词 human diseases PATHOPHYSIOLOGY cell mechanics single molecule biomechanics
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部