腺癌多发转移合并Sister Mary Joseph结节

报告1例腺癌多发转移合并Sister Mary Joseph结节。患者男,49岁。脐部斑块、结节6个月,腰痛2个月。皮肤科检查:脐部一直径3.5 cm的淡红色浸润性斑块,表面可见多个直径1~5 mm淡红色丘疹、结节,簇集呈菜花样外观,质地坚韧,活动度差。CT检查示纵隔内淋巴结增大,腰3~腰5椎体等多处骨质破坏;锝亚甲基二膦酸盐(^(99m)Tc-MDP)全身骨显像示全身骨骼多处异常放射性浓聚灶。皮损组织病理检查:表皮大致正常,真皮全层致密增生的胶原束间肿瘤细胞呈单个或条索状、列兵样排列,部分肿瘤细胞核大、深染,有明显异形性。免疫组化:细胞角蛋白(CK)、CK7、绒毛蛋白(villin)均阳性表达。腰4椎体针吸组织病理检查符合转移性腺癌,免疫组化示CK及低分子质量细胞角蛋白(CAM)5.2均阳性表达。诊断:腺癌多发转移合并Sister Mary Joseph结节。治疗:患者拒绝接受治疗,随访至13个月时死亡。

Sister Mary Joseph's nodule as the first sign of pregnancy-associated gastric cancer:A case report

Sister Mary Joseph's nodule is an inconspicuous and uncommon clinical sign of advanced malignant disease, especially gastric cancer. Pregnancy-associated gastric cancer is an extremely rare condition and can be difficult to diagnose, due to the absence or misinterpretation of symptoms as pregnancy-related. Diagnostic aids, such as a basic chemistry panel and imaging techniques, may not show any abnormalities. We present a case of a 37-year-old pregnant patient whose umbilical nodule was the first presenting physical sign of gastric cancer, which had metastasized throughout the abdominal and pelvic regions.

Malignant peritoneal mesothelioma presenting umbilical hernia and Sister Mary Joseph's nodule

Malignant peritoneal mesothelioma is a rare aggres-sive tumor of the peritoneum. An increasing number of malignant mesothelioma cases have been reported in recent years. We report here a very rare case of malignant peritoneal mesothelioma with both umbilical hernia and umbilical metastasis which is also called Sister Mary Joseph's nodule. We performed laparoscopy which showed specific laparoscopic findings, and the pathological findings of the biopsy specimen led to the diagnosis. This case was associated with umbilical her-nia which could be induced by massive ascites. A newly developed abdominal hernia should be noted as a primary symptom of malignant peritoneal mesothelioma, as shown in the present case.

Sister Mary Joseph's nodule as a first sign of pancreatic cancer

Sister Mary Joseph's nodule(SMJN) refers to a metastatic tumor of the umbilicus.It is a rare entity which arises from a malignancy in the intra-abdominal cavity.We herein describe a patient who presented with SMJN as his first sign of pancreatic cancer.It is an even more unusual case of SMJN.We therefore,suggest that pancreatic cancer should be included in the differential diagnosis when an umbilical mass is found.With the progress made in surgical procedures and other modalities,an early diagnosis will dramatically improve the prognosis of the patients.

Long-term survival of the Sister Mary Joseph nodule originating from breast cancer:A case report

BACKGROUND A Sister Mary Joseph nodule(SMJN)is an uncommon cutaneous metastasis found in the umbilicus,indicating an advanced malignancy.SMJNs typically originate from intra-abdominal sources,rarely from breast cancer.Diagnosis suggests a poor prognosis with a median survival of approximately 8 mo after detection.Managing patients with SMJNs is challenging,as most receive limited palliative care only.The optimal strategy for long-term survival of these patients remains unclear.CASE SUMMARY A 58-year-old female,previously diagnosed with right breast cancer 17 years ago and underwent breast-conserving surgery,adjuvant radiotherapy,and endocrine therapy,presented with a 2-cm umbilical nodule.Thirteen years previously,metastases were detected in the right supraclavicular,infraclavicular,hilar,and mediastinal lymph nodes.An umbilical nodule emerged four years before the date of presentation,confirmed as a skin metastasis of primary breast cancer upon excisional biopsy.Despite initial removal,the nodule recurred and grew,leading to her referral to our hospital.The patient underwent extensive excision of the umbilical tumor and immediate abdominal wall reconstruction.Endocrine therapy was continued postoperatively.Five years later,no local recurrence was observed,and the patient continued to work full-time,achieving over 9 years of survival following SMJN diagnosis.CONCLUSION This case study aimed to identify the optimal strategy for achieving extended survival outcomes in patients with SMJN through comprehensive treatment.We presented a case of the longest survival in a patient after undergoing a multidisciplinary treatment regimen.Our findings underscore the significance of adopting a multimodal treatment approach comprising timely and wide excision along with adjunctive therapy.This approach can control the disease,prolong survival,and improve the quality of life in patients with SMJN.

Sister Mary Joseph结节一例

患者,男,54岁。脐部肿块3天。1年前确诊胃癌并行胃大部切除术-空肠吻合术。脐部肿物组织病理示:浸润性或转移性低分化腺癌,部分为印戒细胞癌。结合病史及免疫组化,符合胃来源。诊断为Sister Mary Joseph结节,给予手术切除。

右侧结肠癌伴Sister Mary Joseph’s结节及腹股沟淋巴结转移——一例报告及文献综述(英文)

Sister Mary Joseph’s结节(Sister Mary Joseph’s nodule,SMJN)是指腹腔内恶性肿瘤导致的脐部转移性结节,1949年由Hamilton Bailey命名以纪念St.Mary’s Hospital的护士Sister Joseph。SMJN并不多见,但个案报道屡屡见诸文献。这种脐部转移可以与腹腔内肿瘤同时出现或异时出现,是预后极差的表现。SMJN最常见原发肿瘤为胃癌及卵巢癌,结肠癌特别是右侧结肠癌引起的SMJN极其罕见。另外右侧结肠癌转移至腹股沟淋巴结未见文献报道。本文报道一例右侧结肠癌同时伴有SMJN及腹股沟淋巴结转移,并对相关文献进行综述。

Sister Mary Joseph结节

报告1例可能为胃癌转移的Sister Mary Joseph结节1例。患者男,44岁。脐部出现暗红色大小不等的结节7个月。皮损组织病理检查:真皮全层胶原束间散在呈腺样分化的肿瘤细胞,免疫组化染色:癌胚抗原(CEA)阳性、细胞角蛋白(CK)20阳性、CK7阳性、甲状腺转录因子(TTF)-1阴性。糖链抗原(CA)19-9、CA72-4、CA24-2均升高。腹部B超检查示:胃幽门部胃壁增生性病变,肝右叶多发偏强回声结节,腹水。

Sister Mary Joseph结节一例

患者,男,52岁。脐部结节8个月。脐部皮损组织病理诊断为皮肤转移性腺癌(Sister Mary Joseph结节),免疫组化染色:细胞角蛋白(CK)20阳性、CK7阴性、尾型同源框转录因子-2(CDX2)阳性。肺部CT示肺转移癌。诊断:Sister Mary Joseph结节。

Sister Mary Joseph’s nodule in endometrial carcinoma: A case report

BACKGROUND Sister Mary Joseph’s nodule(SMJN)is rare and may occur independently or simultaneously with malignant tumors in the abdominal cavity.It has a poor prognosis.Endometrial carcinoma is the most common malignant tumor in the upper segment of the female reproductive tract;however,it rarely occurs with SMJN.We here report a case of endometrial carcinoma with SMJN.CASE SUMMARY A 75-year-old woman was diagnosed with endometrial cancer>2 years ago.After multiple cycles of chemotherapy,an obvious but painless umbilical mass was detected 2 wk before admission.The patient did not undergo surgical treatment but received chemotherapy,which was different from previous chemotherapy,for three consecutive cycles after discovery of umbilical metastases.Currently,the umbilical metastatic tumor has reduced,and the quality of life of the patient has significantly improved.CONCLUSION Once the umbilical mass is found,the possibility of SMJN should be considered.We should also take into account the poor prognosis of endometrial carcinoma complicated with umbilical metastasis,especially in patients with advanced tumors,and it is important to choose an appropriate treatment.

结肠癌术后脐转移1例报告

结肠癌是我国常见的恶性肿瘤之一,发病率呈逐年上升趋势~[1],远处转移者约占50%~60%,其中不可切除的肝脏转移占80%~90%~[2-4],发生脐转移者极其罕见。结肠癌一旦出现脐转移,预后效果极差,临床上应高度重视。我院收治1例结肠癌脐转移患者,具体报告如下。1临床资料患者,王某某,女,69岁,2014年09月底出现便中带血,色暗红。

胃癌伴Sister Mary Joseph结节4例临床和病理分析

目的 探讨胃癌伴Sister Mary Joseph结节的临床和病理特点,以及其转移方式、治疗及预后。方法 对2011年1月-2020年12月就诊于第四军医大学西京皮肤医院的4例以脐部结节为首发皮肤表现的胃癌患者的临床和病理资料进行回顾性分析。结果 4例患者原发病均为胃癌,均经组织病理检查证实为皮肤转移癌,即Sister Mary Joseph结节。治疗原则均为尽量手术切除原发灶和转移灶后,辅以化学等药物治疗和放射治疗。随访4~13个月,4例患者均死亡。结论 Sister Mary Joseph结节一般为恶性肿瘤的晚期表现,常提示预后差,如果患者一般状况良好,应积极行手术切除肿瘤及术后放化疗等治疗方案。