目的采用两样本孟德尔随机化(MR)探讨417种循环代谢产物与吉兰-巴雷综合征(GBS)风险的因果关系。方法通过MRC IEU OpenGWAS项目获得3个循环代谢产物全基因组关联研究(GWAS)数据,分别为“met-a”“met-c”和“met-d”。GBS相关的单核苷...目的采用两样本孟德尔随机化(MR)探讨417种循环代谢产物与吉兰-巴雷综合征(GBS)风险的因果关系。方法通过MRC IEU OpenGWAS项目获得3个循环代谢产物全基因组关联研究(GWAS)数据,分别为“met-a”“met-c”和“met-d”。GBS相关的单核苷酸多态性位点(SNPs)数据来源于芬兰生物银行数据库,表型代码为“finn-b-G6_GUILBAR”。将来自GWAS的与循环代谢产物密切相关的遗传变异数据(SNPs)作为工具变量(IVs),与来自芬兰的GBS GWAS数据进行双样本MR分析,主要采用随机效应模型的逆方差加权(IVW)方法,根据效应指标优势比(OR)和95%CI评估结果。使用留一法、异质性检验、水平基因多效性检验验证结果的稳定性和可靠性。结果共5种循环代谢产物具有与GBS因果关系的提示性证据。其中,肌酐(OR=2.924,95%CI:1.194~7.163,P=0.019)、谷氨酰胺(OR=1.902,95%CI:1.007~3.592,P=0.048)、异戊酰基肉碱(OR=140.767,95%CI:3.510~5645.336,P=0.009)的循环水平与GBS风险较高有关。相反,基因预测葡萄糖(OR=0.308,95%CI:0.010~0.981,P=0.046)、X-11491(OR=0.069,95%CI:0.007~0.707,P=0.024)的循环水平与GBS风险呈负相关。结论肌酐、谷氨酰胺、异戊酰基肉碱、葡萄糖、X-11491可能与GBS有因果关系。展开更多
We present seeing measurements of the Guoshoujing Telescope （formerly named the Large Sky Area Multi-Object Fiber Spectroscopic Telescope- LAMOST） site at Xinglong station during the period from 2007 March 12 to Apr...We present seeing measurements of the Guoshoujing Telescope （formerly named the Large Sky Area Multi-Object Fiber Spectroscopic Telescope- LAMOST） site at Xinglong station during the period from 2007 March 12 to April 25. The measurements were carried out with the Differential Image Motion Monitor （DIMM）, and a total of 9259 data sets was obtained. The median seeing was measured to be 1.1″, with 25% being better than 0.8″and 75% better than 1.5″. The experiment shows that the DIMM exposure time has significant effects on the results of seeing measurements. An SBIG Polaris seeing monitor, which had been planned to be installed on the LAMOST site for long-term monitoring, was also employed during the DIMM observations. The results show that the SBIG seeing monitor is easily affected by gusty wind, resulting in larger seeing values. Considering the previous seeing measurements at Xinglong station over the last 15 yr, we conclude that an acceptable seeing condition at Xinglong station is around 1″-2″.展开更多
文摘目的采用两样本孟德尔随机化(MR)探讨417种循环代谢产物与吉兰-巴雷综合征(GBS)风险的因果关系。方法通过MRC IEU OpenGWAS项目获得3个循环代谢产物全基因组关联研究(GWAS)数据,分别为“met-a”“met-c”和“met-d”。GBS相关的单核苷酸多态性位点(SNPs)数据来源于芬兰生物银行数据库,表型代码为“finn-b-G6_GUILBAR”。将来自GWAS的与循环代谢产物密切相关的遗传变异数据(SNPs)作为工具变量(IVs),与来自芬兰的GBS GWAS数据进行双样本MR分析,主要采用随机效应模型的逆方差加权(IVW)方法,根据效应指标优势比(OR)和95%CI评估结果。使用留一法、异质性检验、水平基因多效性检验验证结果的稳定性和可靠性。结果共5种循环代谢产物具有与GBS因果关系的提示性证据。其中,肌酐(OR=2.924,95%CI:1.194~7.163,P=0.019)、谷氨酰胺(OR=1.902,95%CI:1.007~3.592,P=0.048)、异戊酰基肉碱(OR=140.767,95%CI:3.510~5645.336,P=0.009)的循环水平与GBS风险较高有关。相反,基因预测葡萄糖(OR=0.308,95%CI:0.010~0.981,P=0.046)、X-11491(OR=0.069,95%CI:0.007~0.707,P=0.024)的循环水平与GBS风险呈负相关。结论肌酐、谷氨酰胺、异戊酰基肉碱、葡萄糖、X-11491可能与GBS有因果关系。
基金supported by the National Natural Science Foundation of China(Grant Nos.10903014 and10778709)supported by the Young Researcher Grant of National Astronomical Observatories,Chinese Academy of Sciences
文摘We present seeing measurements of the Guoshoujing Telescope （formerly named the Large Sky Area Multi-Object Fiber Spectroscopic Telescope- LAMOST） site at Xinglong station during the period from 2007 March 12 to April 25. The measurements were carried out with the Differential Image Motion Monitor （DIMM）, and a total of 9259 data sets was obtained. The median seeing was measured to be 1.1″, with 25% being better than 0.8″and 75% better than 1.5″. The experiment shows that the DIMM exposure time has significant effects on the results of seeing measurements. An SBIG Polaris seeing monitor, which had been planned to be installed on the LAMOST site for long-term monitoring, was also employed during the DIMM observations. The results show that the SBIG seeing monitor is easily affected by gusty wind, resulting in larger seeing values. Considering the previous seeing measurements at Xinglong station over the last 15 yr, we conclude that an acceptable seeing condition at Xinglong station is around 1″-2″.
