In this paper,what causes the setting-on place of woven fabrics without adopting tension compensation is explained by means of experimental methods.Owing to that the main shaft speed and the beating speed of reed can ...In this paper,what causes the setting-on place of woven fabrics without adopting tension compensation is explained by means of experimental methods.Owing to that the main shaft speed and the beating speed of reed can not attain the normal values at setting-on,the warp tension and the beating force of the reed can neither reach the normal level.Therefore,the relative slippage movement of the weft against the warp during beating will be less,while the common movement of the weft together with the warp will be bigger than those at nor-mal running.As a result,the setting-on place is展开更多
Presents the fin-propeller test set-up to solve the problem of roll stabilization with ships in full speed range, withwhich, tests were run in water rank for acquisition of data, and concludes from data acquired that ...Presents the fin-propeller test set-up to solve the problem of roll stabilization with ships in full speed range, withwhich, tests were run in water rank for acquisition of data, and concludes from data acquired that the fin-propeller test set-up produces more lift than simple fin, and provides lateral thrust as well, and it is therefore an effective roll stabilization devicefor ships in full speed range.展开更多
目的:探讨内质网氧化还原酶-1α(endoplasmic reticulum oxidoreductin 1α,ERO1α)在同型半胱氨酸(homocysteine,Hcy)诱导的肝细胞内质网应激(endoplasmic reticulum stress,ERS)中的作用及机制.方法:培养人肝细胞,用Hcy(100μmol/L)干...目的:探讨内质网氧化还原酶-1α(endoplasmic reticulum oxidoreductin 1α,ERO1α)在同型半胱氨酸(homocysteine,Hcy)诱导的肝细胞内质网应激(endoplasmic reticulum stress,ERS)中的作用及机制.方法:培养人肝细胞,用Hcy(100μmol/L)干预,同时设对照组,使用酶联免疫法(ELISA)检测ERS相关蛋白葡萄糖调节蛋白78(glucoseregulated protein 78,GRP78)、X盒结合蛋白-1(X-box binding protein-1,XBP-1)、内质网类似激酶(protein kinase RNA-like endoplasmic r e t i c u l u m k i n a s e,P E R K)及激活转录因子6(activating transcription factor 6,ATF6)的水平;用不同浓度Hcy(0、50、100、200、500μmol/L)和100μmol/L Hcy+叶酸+维生素B12(VB12)干预,运用实时定量PCR和Western blot检测ERO1αm RNA和蛋白水平;构建ERO1α基因重组质粒和RNA干扰片段并感染肝细胞,检测ERO1αm RNA和蛋白表达变化;采用ELISA法检测其对ERS相关蛋白的调控作用.结果:与对照组比较,Hcy组GRP78、ATF6、P E R K、X B P-1水平升高(P<0.01,P<0.01,P<0.05,P<0.01);不同浓度Hcy干预后,肝细胞内ERO1αm RNA及蛋白水平呈下降趋势,且随着Hcy浓度的增加而减少(P<0.01),呈剂量依赖关系;将ERO1α重组质粒转染肝细胞后,ERO1αm RNA及蛋白表达明显增加(P<0.01);将三个不同的ERO1αsi RNA片段转染肝细胞后,ERO1αm RNA及蛋白表达降低(P<0.01),其中si RNA2作用最明显(P<0.01);与Hcy组相比,Hcy+p ERO1α组GRP78、XBP-1、PERK及ATF6均明显降低(P<0.01),而Hcy+si RNA2组均明显升高(P<0.01).结论:Hcy可能通过下调ERO1α引起肝细胞GRP78-XBP-1/PERK/ATF6表达增加促进ERS发生.展开更多
Based on the theory of stability of the liquid metal under the action of surface tension,a physical mod- el is established for the mechanisms of the bead formation deferct' humping', which is generated durin...Based on the theory of stability of the liquid metal under the action of surface tension,a physical mod- el is established for the mechanisms of the bead formation deferct' humping', which is generated during high - speed welding.A boundary function is introduced to correct the model,theoretical results got by the model correspond well with the experimental phenomena. A two - dimensional conducting model is adoopted in the simulation of the temperature field during high - speed welding.Finally, the factors acting upon the stability of liquid metal are analyzed.展开更多
This study focused on the development of a new low viscosity automatic transmission fluid(ATF) with enhanced friction durability to meet the needs of new step type automatic transmissions.Recent high fuel prices encou...This study focused on the development of a new low viscosity automatic transmission fluid(ATF) with enhanced friction durability to meet the needs of new step type automatic transmissions.Recent high fuel prices encourage increased efficiency in the driveline,including the transmission.Reduction in fluid viscosity and wider use of slip control in torque converter clutches are two ways to practically improve fuel efficiency.Increased torque and more shifting is seen with a variety of new transmission hardware platforms,such as wet starting clutches,dual clutches and seven-or eight-speed ATs.This suggests the need for enhanced levels of friction durability from the ATF.The new challenge from this hardware for the ATF formulator lies in the need to simultaneously meet the wear,friction durability and torque capacity requirements at low viscosity in a cost-effective manner.This report introduced a new low viscosity fluid that represents a different commercial ATF formulation style.The new chemistry employs a low viscosity for increased fuel economy,while easily doubling the friction durability of current conventional ATFs and offering higher torque and better EP.展开更多
Wnt signaling directs cell-fate choices during embryonic development and tissue tumorigenesis. T cell fac-tor 4 (TCF4) plays a pivotal role in the Wnt signaling path-way. We demonstrate that a specific protein-protein...Wnt signaling directs cell-fate choices during embryonic development and tissue tumorigenesis. T cell fac-tor 4 (TCF4) plays a pivotal role in the Wnt signaling path-way. We demonstrate that a specific protein-protein interac-tion occurs between TCF4 and ATF5 (activating transcrip-tion factor 5) —— a new member of cAMP response element binding protein (CREB) with the yeast two-hybrid system. The N-terminal and DNA binding domain of TCF4 (TCF4ND, 1—495 aa) and the C-terminal spanning bZIP domain of ATF5 (162—282 aa) were found to be responsible for the interaction, and the C-terminal of ATF5 (ATF5/C) showed a much stronger interaction with TCF4ND than the full-length of ATF5 by detecting the b-gal activity. Further-more, overexpression of ATF5/C enhanced transcriptional activation by TCF4 proteins in luciferase assay by transient transfection. Taken together, these data suggest that ATF5 may function as a co-activator to potentiate the ability of TCF4 to activate transcription.展开更多
文摘In this paper,what causes the setting-on place of woven fabrics without adopting tension compensation is explained by means of experimental methods.Owing to that the main shaft speed and the beating speed of reed can not attain the normal values at setting-on,the warp tension and the beating force of the reed can neither reach the normal level.Therefore,the relative slippage movement of the weft against the warp during beating will be less,while the common movement of the weft together with the warp will be bigger than those at nor-mal running.As a result,the setting-on place is
文摘Presents the fin-propeller test set-up to solve the problem of roll stabilization with ships in full speed range, withwhich, tests were run in water rank for acquisition of data, and concludes from data acquired that the fin-propeller test set-up produces more lift than simple fin, and provides lateral thrust as well, and it is therefore an effective roll stabilization devicefor ships in full speed range.
文摘目的:探讨内质网氧化还原酶-1α(endoplasmic reticulum oxidoreductin 1α,ERO1α)在同型半胱氨酸(homocysteine,Hcy)诱导的肝细胞内质网应激(endoplasmic reticulum stress,ERS)中的作用及机制.方法:培养人肝细胞,用Hcy(100μmol/L)干预,同时设对照组,使用酶联免疫法(ELISA)检测ERS相关蛋白葡萄糖调节蛋白78(glucoseregulated protein 78,GRP78)、X盒结合蛋白-1(X-box binding protein-1,XBP-1)、内质网类似激酶(protein kinase RNA-like endoplasmic r e t i c u l u m k i n a s e,P E R K)及激活转录因子6(activating transcription factor 6,ATF6)的水平;用不同浓度Hcy(0、50、100、200、500μmol/L)和100μmol/L Hcy+叶酸+维生素B12(VB12)干预,运用实时定量PCR和Western blot检测ERO1αm RNA和蛋白水平;构建ERO1α基因重组质粒和RNA干扰片段并感染肝细胞,检测ERO1αm RNA和蛋白表达变化;采用ELISA法检测其对ERS相关蛋白的调控作用.结果:与对照组比较,Hcy组GRP78、ATF6、P E R K、X B P-1水平升高(P<0.01,P<0.01,P<0.05,P<0.01);不同浓度Hcy干预后,肝细胞内ERO1αm RNA及蛋白水平呈下降趋势,且随着Hcy浓度的增加而减少(P<0.01),呈剂量依赖关系;将ERO1α重组质粒转染肝细胞后,ERO1αm RNA及蛋白表达明显增加(P<0.01);将三个不同的ERO1αsi RNA片段转染肝细胞后,ERO1αm RNA及蛋白表达降低(P<0.01),其中si RNA2作用最明显(P<0.01);与Hcy组相比,Hcy+p ERO1α组GRP78、XBP-1、PERK及ATF6均明显降低(P<0.01),而Hcy+si RNA2组均明显升高(P<0.01).结论:Hcy可能通过下调ERO1α引起肝细胞GRP78-XBP-1/PERK/ATF6表达增加促进ERS发生.
文摘Based on the theory of stability of the liquid metal under the action of surface tension,a physical mod- el is established for the mechanisms of the bead formation deferct' humping', which is generated during high - speed welding.A boundary function is introduced to correct the model,theoretical results got by the model correspond well with the experimental phenomena. A two - dimensional conducting model is adoopted in the simulation of the temperature field during high - speed welding.Finally, the factors acting upon the stability of liquid metal are analyzed.
文摘This study focused on the development of a new low viscosity automatic transmission fluid(ATF) with enhanced friction durability to meet the needs of new step type automatic transmissions.Recent high fuel prices encourage increased efficiency in the driveline,including the transmission.Reduction in fluid viscosity and wider use of slip control in torque converter clutches are two ways to practically improve fuel efficiency.Increased torque and more shifting is seen with a variety of new transmission hardware platforms,such as wet starting clutches,dual clutches and seven-or eight-speed ATs.This suggests the need for enhanced levels of friction durability from the ATF.The new challenge from this hardware for the ATF formulator lies in the need to simultaneously meet the wear,friction durability and torque capacity requirements at low viscosity in a cost-effective manner.This report introduced a new low viscosity fluid that represents a different commercial ATF formulation style.The new chemistry employs a low viscosity for increased fuel economy,while easily doubling the friction durability of current conventional ATFs and offering higher torque and better EP.
基金supported by the National Natural Science Foundation of China(Grant Nos.30070703 and 39970369).
文摘Wnt signaling directs cell-fate choices during embryonic development and tissue tumorigenesis. T cell fac-tor 4 (TCF4) plays a pivotal role in the Wnt signaling path-way. We demonstrate that a specific protein-protein interac-tion occurs between TCF4 and ATF5 (activating transcrip-tion factor 5) —— a new member of cAMP response element binding protein (CREB) with the yeast two-hybrid system. The N-terminal and DNA binding domain of TCF4 (TCF4ND, 1—495 aa) and the C-terminal spanning bZIP domain of ATF5 (162—282 aa) were found to be responsible for the interaction, and the C-terminal of ATF5 (ATF5/C) showed a much stronger interaction with TCF4ND than the full-length of ATF5 by detecting the b-gal activity. Further-more, overexpression of ATF5/C enhanced transcriptional activation by TCF4 proteins in luciferase assay by transient transfection. Taken together, these data suggest that ATF5 may function as a co-activator to potentiate the ability of TCF4 to activate transcription.
