期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Synthesis and biological evaluation of nitric oxide-releasing sixalkoxyl biphenyl derivatives as anticancer agents 被引量:5
1
作者 Xiang Wen Kong Yi Hua Zhang +3 位作者 Li Dai Hui Ji Yi Sheng Lai Si Xun Peng 《Chinese Chemical Letters》 SCIE CAS CSCD 2008年第2期149-152,共4页
A series of novel nitric oxide-donating sixalkoxyl biphenyl derivatives (14a-1) were synthesized by coupling furoxan with alkoxyl biphenyl skeleton using amino acids as the spacers, and their cytotoxicity against He... A series of novel nitric oxide-donating sixalkoxyl biphenyl derivatives (14a-1) were synthesized by coupling furoxan with alkoxyl biphenyl skeleton using amino acids as the spacers, and their cytotoxicity against HepG2 cells in vitro were evaluated by MTT method. It was found that 14c, 14d, 14f, 14i, 14j and 14k showed more potent cytotoxic activities than control 5-fluorouracil. NO release assay of target compounds indicated that the maximum amount of NO released by most active compounds 14c and 14j was about 6 × 10^-2 μmol/L, whereas 14a and 14h with very weak activity only released NO of 1 × 10^-2 μmol/L. 展开更多
关键词 Nitric oxide-donating sixalkoxyl biphenyl derivatives FUROXAN CYTOTOXICITY
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部