In the wave of big data,can traditional medicine for the diagnosis and treatment of skeletal disorders be given a new lease of life?

In recent years,big data has become a buzzword in the internet sector,gradually being used in various industries and fields,and has already yielded considerable benefits in e-commerce.In the past few years,big data has become increasingly important in healthcare based on the massive volume of clinical data and the increasing demand for personalized medicine.Traditional medicine,one of humanity’s fabulous creations,has also contributed actively to preventing and controlling new epidemics.With the development of the Internet,AI,cloud computing,the Internet of Things,and other high technologies in recent years,new vitality has been injected into the development of traditional medicine.It has also provided strong support for conventional medicine to play a more excellent value.Traditional medicine is now flourishing and gradually moving into the era of big data.Recently,there has been an increasing number of medical studies related to big data,but more studies are focused on cancer survival and cancer metastasis,which may be related to the fact that there are more free databases related to oncology,similar to the studies on big data related to skeletal diseases,but there are not many studies on the linkage between traditional medicine and big data for skeletal diseases.So,how will the field of big data and traditional medicine combine and diagnose or treat skeletal-related diseases in the future?How can traditional medicine in skeletal disorders ride the current fast-growing big data train?Will big data bring a new lease of life to traditional medicine in skeletal disorders?This review intends to systematically elaborate on the current and future research in the direction of big data in relation to diagnosing and treating skeletal diseases in traditional medicine.

Wnt signaling:Essential roles in osteoblast differentiation,bone metabolism and therapeutic implications for bone and skeletal disorders

Wnt signaling executes an indispensable performance in osteoblast differentiation,bone development,homeostasis,and remodeling.Wnt signals trigger the intracellular Wnt signaling cascade to initiate regulating the implication of b-catenin in the bone environment.Going through the novel discoveries done via high-throughput sequencing technologies on ge-netic mouse models,we highlighted the significant contribution of Wnt ligands,co-receptors,inhibitors,their related skeletal phenotypes in mouse models and the similar bone disorders clinically observed in human beings.Moreover,the crosstalk between Wnt signaling pathway and BMP,TGF-b,FGF,Hippo,Hedgehog,Notch and PDGF signaling pathways is thoroughly demonstrated to be the underlying gene regulatory network that orchestrates osteoblast dif-ferentiation and bone development.We also introspected the significance of Wnt signaling transduction in the reorganization of cellular metabolism by stimulating glycolysis,glutamine catabolism,and fatty acid oxidation in osteoblast-lineage cells that display an important reg-ulatory arbor in the cellular bioenergetics of the bone.Throughout this evaluation,most to date therapeutical approaches towards osteoporosis and other bone maladies found in human beings,are formulated with an aspiration to holistically revamp the present clinical applica-tions involving various monoclonal antibodies therapies that lack specificity,efficacy,and safety into more requisite advanced therapeutics that satisfy these three requirements for further clinical considerations.Conclusively,our review provides comprehensive scientific findings related to the fundamental significance of Wnt signaling cascades in skeletal system and the underlying gene regulatory network with other signaling pathways enlightening re-searchers with the possibility to further integrate the identified target molecules into thera-peutic strategies for skeletal disorders treatment in the clinic.