Micro- injury （exercise-induced muscle damage, EIMD） will cause a temporary decline in muscle function, if not handled properly, it could cause more serious injury or overtraining, and even lead to the end of the at...Micro- injury （exercise-induced muscle damage, EIMD） will cause a temporary decline in muscle function, if not handled properly, it could cause more serious injury or overtraining, and even lead to the end of the athletes ＇ sports life. However, some studies have shown that an appropriate period of eccentric exercise training resulted in EIMD while promoted heart muscle fiber hypertrophy and corresponding muscle growth faster than exercise training, and there are the typical ＂ repetitive training effect＂ , ie after a period of the EIMD recovery, the muscle＇ s injury or delayed onset muscle soreness （DOMS） caused by the same movement is significantly reduced. So its deep study could help to guide the athlete to avoid or mitigate the negative effects which brought by EIMD, while could help to further clarify the process of the body to adapt to exercise training or mechanism.展开更多
Acute interruption of arterial blood flow to the extremities is often associated with significant morbidity and mortality. Broad spectrum mitogenic and non mitogenic activities of FGFs inspired us to study its protect...Acute interruption of arterial blood flow to the extremities is often associated with significant morbidity and mortality. Broad spectrum mitogenic and non mitogenic activities of FGFs inspired us to study its protecting effects on tissue injuries in ischemia reperfusion condition. We found that systemic administration of aFGF after reperfusion onset prevented severe skeletal muscle injuries. In rats treated with aKGF, the tissue edema was reduced significantly, the tissue viability was increased, and the muscle fibers contained more succinate dehydrogenase (SDH) and adenosine triphosphatasc (ATPase). The pathological results supported the concept of improved prevention with aFGF treatment. The possible tissue protection by aFGF may come from its ability to regulate the concentration of evtra- and intracellular calcium ion. Besides, it may moderate other Ca2+ dependent enzyme conversion processes. Also, it may take part in the vascular tone regulation under ischemia and reperfusion conditions. These results suggest further study of tissue ischemia prevention with FGF and its possible mechanisms in the future.展开更多
文摘Micro- injury （exercise-induced muscle damage, EIMD） will cause a temporary decline in muscle function, if not handled properly, it could cause more serious injury or overtraining, and even lead to the end of the athletes ＇ sports life. However, some studies have shown that an appropriate period of eccentric exercise training resulted in EIMD while promoted heart muscle fiber hypertrophy and corresponding muscle growth faster than exercise training, and there are the typical ＂ repetitive training effect＂ , ie after a period of the EIMD recovery, the muscle＇ s injury or delayed onset muscle soreness （DOMS） caused by the same movement is significantly reduced. So its deep study could help to guide the athlete to avoid or mitigate the negative effects which brought by EIMD, while could help to further clarify the process of the body to adapt to exercise training or mechanism.
文摘Acute interruption of arterial blood flow to the extremities is often associated with significant morbidity and mortality. Broad spectrum mitogenic and non mitogenic activities of FGFs inspired us to study its protecting effects on tissue injuries in ischemia reperfusion condition. We found that systemic administration of aFGF after reperfusion onset prevented severe skeletal muscle injuries. In rats treated with aKGF, the tissue edema was reduced significantly, the tissue viability was increased, and the muscle fibers contained more succinate dehydrogenase (SDH) and adenosine triphosphatasc (ATPase). The pathological results supported the concept of improved prevention with aFGF treatment. The possible tissue protection by aFGF may come from its ability to regulate the concentration of evtra- and intracellular calcium ion. Besides, it may moderate other Ca2+ dependent enzyme conversion processes. Also, it may take part in the vascular tone regulation under ischemia and reperfusion conditions. These results suggest further study of tissue ischemia prevention with FGF and its possible mechanisms in the future.
