In cases of auricular surgery, postoperative dressings are thought to be important for keeping auricular contour and in helping to prevent from dressing failures due to edema or subcutaneous hematoma, which may result...In cases of auricular surgery, postoperative dressings are thought to be important for keeping auricular contour and in helping to prevent from dressing failures due to edema or subcutaneous hematoma, which may result in fibrous or cartilaginous proliferation. However, it is often difficult to achieve success with standard dressings because of the complicated shape of the auricle. We used 2-octyl-cyanoacrylate skin adhesive to dress the auricle after different types of auricular procedures (five cases of cryptotia, two of prominent ear, two of severe auricular laceration, two of skin grafting and one of flap repair of the partial auricle defect). The 2-octyl-cyanoacrlaate skin adhesive was applied to the suture line and the operated and peripheral areas for wider coverage. No dressing materials were placed over the surface. In all cases, the desired outcome was achieved, without subcutaneous hematoma, wound dehiscence, and wound infection. Contact dermatitis caused by the skin adhesive was not observed in any of the cases. Dressing and splinting after auricular surgery can be simply and successfully achieved using 2-octyl-cyanoacrylate skin adhesive. There is no need for more complicated dressings and post-surgical dressing changes, resulting in higher patient satisfaction.展开更多
For improved wound healing,antimicrobial adhesives are one path forward.However,with the current challenge of bacterial resistance,it is essential to choose the included drug carefully.Octenidine is an obvious choice ...For improved wound healing,antimicrobial adhesives are one path forward.However,with the current challenge of bacterial resistance,it is essential to choose the included drug carefully.Octenidine is an obvious choice due to its broad antimicrobial efficacy and no reported bacterial resistance.In its pure form,octenidine complexes efficiently with the platinum catalyst in the silicone composition,inhibiting the targeted hydrosilyla-tion reaction and hindering curing.This obstacle is overcome by screening octenidine with cyclodextrins in homogeneously dispersed glycerol droplets,suppressing Pt inhibition in the silicone phase.Curing efficiency is demonstrated using rheol-ogy,which shows that it is possible to incorporate one wt%of octenidine into glycerol–silicone adhesives in the presence of(2-hydroxypropyl)-β-cyclodextrin without affecting the adhe-sives’mechanical properties.The interaction between octeni-dine and(2-hydroxypropyl)-β-cyclodextrin through an inclusion complex is confirmed by ROESY spectroscopy.Despite this screening,octenidine is still released efficiently from the glycerol–silicone adhesives upon contact with water,and the resulting antimicrobial action is subsequently demonstrated.This new technology constitutes a simple and efficient method for preparing wound care adhesives that actively inhibit the growth of four bacteria strains and one fungus.展开更多
文摘In cases of auricular surgery, postoperative dressings are thought to be important for keeping auricular contour and in helping to prevent from dressing failures due to edema or subcutaneous hematoma, which may result in fibrous or cartilaginous proliferation. However, it is often difficult to achieve success with standard dressings because of the complicated shape of the auricle. We used 2-octyl-cyanoacrylate skin adhesive to dress the auricle after different types of auricular procedures (five cases of cryptotia, two of prominent ear, two of severe auricular laceration, two of skin grafting and one of flap repair of the partial auricle defect). The 2-octyl-cyanoacrlaate skin adhesive was applied to the suture line and the operated and peripheral areas for wider coverage. No dressing materials were placed over the surface. In all cases, the desired outcome was achieved, without subcutaneous hematoma, wound dehiscence, and wound infection. Contact dermatitis caused by the skin adhesive was not observed in any of the cases. Dressing and splinting after auricular surgery can be simply and successfully achieved using 2-octyl-cyanoacrylate skin adhesive. There is no need for more complicated dressings and post-surgical dressing changes, resulting in higher patient satisfaction.
文摘For improved wound healing,antimicrobial adhesives are one path forward.However,with the current challenge of bacterial resistance,it is essential to choose the included drug carefully.Octenidine is an obvious choice due to its broad antimicrobial efficacy and no reported bacterial resistance.In its pure form,octenidine complexes efficiently with the platinum catalyst in the silicone composition,inhibiting the targeted hydrosilyla-tion reaction and hindering curing.This obstacle is overcome by screening octenidine with cyclodextrins in homogeneously dispersed glycerol droplets,suppressing Pt inhibition in the silicone phase.Curing efficiency is demonstrated using rheol-ogy,which shows that it is possible to incorporate one wt%of octenidine into glycerol–silicone adhesives in the presence of(2-hydroxypropyl)-β-cyclodextrin without affecting the adhe-sives’mechanical properties.The interaction between octeni-dine and(2-hydroxypropyl)-β-cyclodextrin through an inclusion complex is confirmed by ROESY spectroscopy.Despite this screening,octenidine is still released efficiently from the glycerol–silicone adhesives upon contact with water,and the resulting antimicrobial action is subsequently demonstrated.This new technology constitutes a simple and efficient method for preparing wound care adhesives that actively inhibit the growth of four bacteria strains and one fungus.
