Clinical efficacy of intradermal type Ⅰ collagen injections in treating skin photoaging in patients from high-altitude areas

BACKGROUND Photoaging,a result of chronic sun exposure,leads to skin damage and pigmentation changes.Traditional treatments may have limitations in high-altitude areas like Yunnan Province.Intradermal Col Ⅰ injections stimulate collagen production,potentially improving skin quality.This study aims to assess the efficacy and safety of this treatment for photoaging.AIM To evaluate the efficacy and safety of intradermal typeΙcollagen(ColΙ)injection for treating photoaging.METHODS This prospective,self-controlled study investigated the impact of intradermal injections of ColΙon skin photodamage in 20 patients from the Yunnan Province.Total six treatment sessions were conducted every 4 wk±3 d.Before and after each treatment,facial skin characteristics were quantified using a VISIA skin detector.Skin thickness data were assessed using the ultrasound probes of the Dermalab skin detector.The Face-Q scale was used for subjective evaluation of the treatment effect by the patients.RESULTS The skin thickness of the right cheek consistently increased after each treatment session compared with baseline.The skin thickness of the left cheek significantly increased after the third through sixth treatment sessions compared with baseline.The skin thickness of the right zygomatic region increased after the second to sixth treatment sessions,whereas that of the left zygomatic region showed a significant increase after the fourth through sixth treatment sessions.The skin thickness of both temporal regions significantly increased after the fifth and sixth treatment sessions compared with baseline(P<0.05).These findings were also supported by skin ultrasound images.The feature count for the red areas and wrinkle feature count decreased following the treatment(P<0.05).VISIA assessments also revealed a decrease in the red areas after treatment.The Face-QSatisfaction with Facial Appearance Overall and Face-Q-Satisfaction with Skin scores significantly increased after each treatment session.The overall appearance of the patients improved after treatment.CONCLUSION Intradermal ColΙinjection improves photoaging,with higher patient satisfaction and fewer adverse reactions,and could be an effective treatment method for populations residing in high-altitude areas.

Effects of the Reynolds number on the mean skin friction decomposition in turbulent channel flows

As the Reynolds number increases, the skin friction has been identified as the dominant drag in many practical applications. In the present paper, the effects of the Reynolds number on the mean skin friction decomposition in turbulent channel flows up to Reτ= 5 200 are investigated based on two different methods, i.e., the FukagataIwamoto-Kasagi(FIK) identity(FUKAGATA, K., IWAMOTO, K., and KASAGI, N.Contribution of Reynolds stress distribution to the skin friction in wall-bounded flows.Physics of Fluids, 14(11), L73–L76(2002)) and the Renard-Deck(RD) identity(DECK,S., RENARD, N., LARAUFIE, R., and WEISS, P.′E. Large-scale contribution to mean wall shear stress in high-Reynolds-number flat-plate boundary layers up to Reθ= 13 650.Journal of Fluid Mechanics, 743, 202–248(2014)). The direct numerical simulation(DNS) data provided by Lee and Moser(LEE, M. and MOSER, R. D. Direct numerical simulation of turbulent channel flow up to Reτ≈ 5 200. Journal of Fluid Mechanics,774, 395–415(2015)) are used. For these two skin friction decomposition methods, their decomposed constituents are discussed and compared for different Reynolds numbers.The integrands of the decomposed constituents are locally analyzed across the boundary layer to assess the actions associated with the inhomogeneity and multi-scale nature of turbulent motion. The scaling of the decomposed constituents and their integrands are presented. In addition, the boundary layer is divided into three sub-regions to evaluate the contributive proportion of each sub-region with an increase in the Reynolds number.

Investigation of turbulence and skin friction modification in particle-laden channel flow using lattice Boltzmann method

Interaction between turbulence and particles is investigated in a channel flow. The fluid motion is calculated using direct numerical simulation(DNS) with a lattice Boltzmann(LB) method, and particles are tracked in a Lagrangian framework through the action of force imposed by the fluid. The particle diameter is smaller than the Kolmogorov length scale, and the point force is used to represent the feedback force of particles on the turbulence. The effects of particles on the turbulence and skin friction coefficient are examined with different particle inertias and mass loadings. Inertial particles suppress intensities of the spanwise and wall-normal components of velocity, and the Reynolds shear stress. It is also found that, relative to the reference particle-free flow,the overall mean skin-friction coefficient is reduced by particles. Changes of near wall turbulent structures such as longer and more regular streamwise low-speed streaks and less ejections and sweeps are the manifestation of drag reduction.

Influence of Error-prone Channel on the Performance of IEEE 802.11 WLAN Utilizing RTS/CTS Handshaking

A comprehensive study was presented for WLAN 802.11b using error-prone channel. It was theoretically and numerically evaluated the performance of three different network sizes with the bit rates that available in 802.11b protocol. Results show that throughput does not change with the size of the network for wide range of bit error rates (BERs) and the channel bit rates play a significant role in the main characteristics of the network. A comprehensive explanation has given for the phenomenon of the packet delay suppression at relatively high level of BERs in view of the size of the networks and the BERs. The effect length of the transmitting packets is also investigated.

Effects of Outdoor Thermal Environment upon the Human Responses

In a summer outdoor space, the influence of short-wave length solar radiation on the human body is strongly apparent, heat is retained in the body, and the risk of heat disorders such as heat stroke increases. To avoid this, it is essential to seek shade to avoid the influence of short-wave length solar radiation. In addition, natural ground surfaces such as green spaces and water surfaces are useful in reducing the air temperature. It is indispensable to consider climate mitigation effect of outdoor space. The purpose of this study is to clarify the influence of the thermal environment of an outdoor space on the human body in rural and suburban regions where paddy fields remain. Subject experiments were conducted to examine the relationship between the thermal environment evaluation index enhanced conduction-corrected modified effective temperature (ETFe) in an outdoor space and the physiological and psychological responses of the human body. Experiment sites were selected with consideration for the natural ground surface such as bare ground where the surface is gravel or soil;paved ground such as concrete, asphalt or blocks;green areas covered in plants;and water surfaces, as well as the sky factor due to buildings or trees etc. and the proportion of the solid angle of components of greenery and water etc. comprising the solid angle of the total celestial sphere. A ground surface feature with a high heat capacity may promote sensation of hot and deteriorate the thermal sensation. A landscape of thick vegetation with a high green factor may have a strong feeling of confinement, which can make it somewhat hot and somewhat uncomfortable thermal environment due to the sense of stagnation. Compared with the urban environment, it is conceivable that the difference in the perceptual environment, whereby it is subconsciously assumed to be a comfortable thermal environment, had an effect in the rural and suburban regional environment, resulting in an ETFe lower than the upper limit of comfort in a summer urban environment.

Research Progress on Causes and Pathogenesis of Sensitive Skin

The causes and pathogenesis of sensitive skin are relatively complex.Herein,the causes and pathogenesis of sensitive skin are summarized based on previous research results.The causes of sensitive skin mainly include various external factors,internal factors,and other dermatological factors.The mechanisms are complex,including skin barrier function injury,changes in epidermal microbial status,abnormal sensory nerve fiber function,activation of TRPV1 channel,neurovascular-immune-inflammatory pathway,transcriptome,etc.Sensitive skin is often induced by multiple mechanisms.The analysis and discussion of the causes and mechanisms of sensitive skin will be helpful to guide clinical practice.

Baicalein and Salvia officinalis Extract Upregulate Transglutaminase 1 mRNA Expression via the Activation of Transient Receptor Potential Channel V4

Background: It is important to maintain skin homeostasis for cosmetic and medical reasons. Many ceramide-related ingredients and cosmetics have been developed to improve the skin barrier function and skin hydration. Similar to extracellular lipids, the cornified envelope, which is a structure formed beneath the plasma membrane, contributes to the skin barrier function as a scaffold for extracellular lipids. Therefore, in this study, we focused on transglutaminase 1 (TGM1) which is the key enzyme for formation of the cornified envelope Objective: The objectives of this study were to identify compounds that could upregulate the expression of TGM1 and evaluate their underlying action mechanisms. Methods: Expression of the transient receptor potential channel vanilloid subfamily member 4 (TRPV4) at the mRNA and protein levels was estimated by PCR and western blotting. Effects of baicalein and Salvia officinalis (SO) extract on TGM1 mRNA expression were measured by PCR. The involvement of TRPV4 in TGM1 mRNA expression was evaluated by the inhibition and silencing of TRPV4. Results: TRPV4 was expressed in both basal cell-like HaCaT cells and suprabasal cell-like HaCaT cells. Baicalein and SO extract upregulated TGM1 mRNA expression in basal cell-like HaCaT cells. However, inhibition and silencing of TRPV4 abrogated the effects of baicalein and SO extract. Conclusion: Baicalein and SO extract upregulated the expression of TGM1 mRNA via the activation of TRPV4, suggesting that it may improve the skin barrier function by enhancing cornified envelope formation.

自体刃厚头皮回植修复中厚供皮区创面的安全有效性

背景:大面积深度烧伤创面愈合后多伴瘢痕增生,需要移植中厚皮进行修复,所取中厚皮片一般达到真皮乳头层以下,若处理不当容易出现供区皮创面愈合延迟、溃破和愈合后疼痛瘙痒等并发症,因此,供皮区创面修复应得到重视。目的:分析自体头皮修复深度烧伤和瘢痕患者供皮区的安全性和实用性。方法:选择2021年1月至2023年9月郑州市第一人民医院烧伤科收治的60例深度烧伤和瘢痕增生患者作为研究对象,均进行中厚皮移植修复,取皮部位为患者自身腿部或背部中厚皮,采用随机数字表法分为研究组(30例)、对照组(30例),研究组采用自体刃厚头皮回植修复中厚皮供皮区,对照组采用吸水敷料修复中厚皮供皮区。对比两组术后6 d的中厚皮供皮区创面愈合率、创面完全上皮化时间,术后3,6 d供皮区换药疼痛评分,以及术后6个月中厚皮供皮区瘢痕增生情况。结果与结论:①研究组中厚皮供皮区创面上皮化时间短于对照组(P<0.05),中厚皮供皮区创面愈合率高于对照组(P<0.05),术后3,6 d的中厚皮供皮区换药疼痛评分均低于对照组(P<0.05),术后6个月的中厚皮供皮区瘢痕增生率、瘢痕评分及瘙痒评分均低于对照组(P<0.05);②结果表明,自体头皮修复中厚皮供皮区具有加快创面愈合和减轻瘢痕增生的优点。

低频脉冲磁场慢性暴露对健康成年股四头肌收缩力及形态的影响

背景:目前已有关于低频脉冲磁场对骨骼肌结构形态影响研究发现了骨骼肌质量变化,但对接受慢性暴露后的形态变化未见相关研究。目的:观察低频脉冲磁场慢性暴露对腿部股四头肌最大自主收缩力与形态指标的影响,为使用该技术作为肌肉功能改善策略提供组织形态变化的参考依据。方法:招募普通健康受试者70名,随机分为接受磁场刺激的试验组与进行假治疗的对照组,每组35名,试验时长共计4周,试验组受试者每隔48 h进行1次15 min的低频脉冲磁刺激干预,对照组进行假治疗,干预间隔与时长与试验组一致,干预4周后观察不同组别受试者股四头肌最大自主收缩力值变化,利用B型超声影像作为评估手段,观察肌肉厚度、肌肉横截面积及羽状角指标的变化。结果与结论:①经过4周的低频脉冲磁场慢性暴露,68名受试者完成试验,试验组受试者股四头肌最大自主收缩力测试值显著增长(P=0.000),提升幅度显著高于对照组(P=0.008);②试验组受试者的肌肉形态3项指标均显著高于试验前测(P=0.000),而对照组肌肉厚度指标呈显著性下降(P=0.020),羽状角无显著性变化,横截面积显著性提升(P=0.000);③组间对比发现,试验组关于肌肉形态的肌肉厚度(P=0.012)、羽状角(P=0.003)及横截面积(P=0.049)3项指标均显著高于对照组;④上述数据证实,健康成年受试者经过4周的低频脉冲磁场慢性暴露,股四头肌的最大自主收缩力显著提升,同时观察到试验组的肌肉厚度、横截面积及羽状角3项肌肉形态指标的显著增长,对使用该技术作为肌肉改善的运动替代与医疗策略提供了肌组织形态改善的支持依据。

一种改进的MIMO-OFDM系统频域信道估计和跟踪方案

深入研究了MIMO-OFDM系统中的频域信道估计和跟踪算法.在分析比较了现有频域信道估计算法的基础上,提出了一种有效的改进频域信道估计和跟踪方案.该方案利用基于正交训练符号的算法求得初始信道估计值,利用信道估计和信号检测的联合迭代算法来跟踪随时间变化的信道参数.在典型的室内传输环境下对三种频域信道估计和跟踪方案进行了仿真比较,结果表明,本文所提方案在较低的迭代次数下就可以带来明显的性能改善.

基于OFDMA-WLAN系统的上行MAC协议研究

基于OFDMA-WLAN系统提出了一种改进的上行MAC协议,用以提高IEEE802.11无线局域网(Wireless Local Area Network,WLAN)在大量站点(stations,STAs)存在时的信道利用率和吞吐量。在OFDMA-WLAN系统存在多个子信道时,该协议使多个STA同时在时域与频域上按照CSMA/CA方式发送信道接入的请求帧,在不需要额外增加信道与射频的基础上,解决了随机接入带来的静默问题。数值分析结果表明,与现有的基于OFDMA的上行MAC协议FICA相比,本协议较好地提高了系统的信道利用率和吞吐量。

Rainfall-runoff simulation and flood forecasting for Huaihe Basin

The main purpose of this study was to forecast the inflow to Hongze Lake using the Xin＇anjiang rainfall-runoff model. The upper area of Hongze Lake in the Huaihe Basin was divided into 23 sub-basins, including the surface of Hongze Lake. The influence of reservoirs and gates on flood forecasting was considered in a practical and simple way. With a one-day time step, the linear and non-linear Muskingum method was used for channel flood routing, and the least-square regression model was used for real-time correction in flood forecasting. Representative historical data were collected for the model calibration. The hydrological model parameters for each sub-basin were calibrated individually, so the parameters of the Xin＇anjiang model were different for different sub-basins. This flood forecasting system was used in the real-time simulation of the large flood in 2005 and the results are satisfactory when compared with measured data from the flood.

Performance analysis of an iSCSI-based unified storage network

In this paper, we introduced a novel storage architecture 'Unified Storage Network', which merges NAC( Network Attached Channel) and SAN( Storage Area Network) , and provides the file I/O services as NAS devices and provides the block I/O services as SAN. To overcome the drawbacks from FC, we employ iSCSI to implement the USN( Unified Storage Network) . To evaluate whether iSCSI is more suitable for implementing the USN, we analyze iSCSI protocol and compare it with FC protocol from several components of a network protocol which impact the performance of the network. From the analysis and comparison, we can conclude that the iSCSI is more suitable for implementing the storage network than the FC under condition of the wide-area network. At last, we designed two groups of experiments carefully.

Seismic sedimentology of conglomeratic sandbodies in lower third member of Shahejie Formation (Palaeogene) in Shengtuo area, East China

The sand-conglomerate fans are the major depositional systems in the lower third member of Shahejie Formation in Shengtuo area, which formed in the deep lacustrine environment characterized by steep slope gradient, near sources and intensive tectonic activity. This work was focused on the sedimentary feature of the glutenite segment to conduct the seismic sedimentology research. The near-shore subaqueous fans and its relative gravity channel and slump turbidite fan depositions were identified according to observation and description of cores combining with the numerous data of seismic and logging. Then, the depositional model was built depending on the analysis of palaeogeomorphology. The seismic attributes which are related to the hydrocarbon but relative independent were chosen to conduct the analysis, the reservoir area of the glutenite segment was found performing a distribution where the amplitude value is relatively higher, and finally the RMS amplitude attribute was chosen to conduct the attribute predicting. At the same time, the horizontal distribution of the sedimentary facies was analyzed qualitatively. At last, the sparse spike inversion method was used to conduct the acoustic impedance inversion, and the inversion result can distinguish glutenite reservoir which is greater than 5 m. This method quantitatively characterizes the distribution area of the favorable reservoir sand.

Modeling and Simulation of P-Aloha,CSMA /CA and MACAW Protocols for Underwater Acoustic Channel

Medium access control( MAC) protocol of underwater acoustic communication network is a key technology for underwater acoustic networks( UANs). Most of the MAC protocols for wireless terrestrial communication networks have been designed with negligible propagation delay. If it is deployed directly in an underwater environment,the UANs will perform inefficiently. In this paper,the characteristics of underwater acoustic channel are modeled and simulated by using the OPNET simulation tool,which are the speed of sound, propagation loss, and four sources for ambient noise: the turbulence,shipping,wind driven waves and thermal noise. The performance of pure Aloha( P-Aloha),carrier sense multiple access with collision avoidance( CSMA / CA) and multiple access collision avoidance for wireless local area network( MACAW) protocols in underwater acoustic channel environment are evaluated. The different performance of protocols in underwater environment is compared in the simulation.

Progress in Sediment Research of TGP

Sediment research of TGP has been carried out for more than 40 years since 1958.This paper briefly describes the sediment research work of Yangtze River Scientific Research Institute in the reservoir area and damsite area of TGP in recent years.The research results demonstrate that sediment from Jinsha river and Jialing river reaches 83% of the total sediment at TGP.The completion of Xiluodu,Xiangjiaba and Tingzikou reservoirs will postpone the initial sediment balance time in TGP reservoir. In initial operation period of the project,the sediment in approach channels of the navigation structures can be cleared by machinery,in future period,the sediment outside the entrances of the upper and lower approach channels still need to be cleared by machinery while the sediment within the approach channel should be cleared by joint measures of flushing and mechanical dredging.

Cutaneous sensory nerve as a substitute for auditory nerve in solving deaf-mutes' hearing problem: an innovation in multi-channel-array skin-hearing technology

The current use of hearing aids and artificial cochleas for deaf-mute individuals depends on their auditory nerve. Skin-hearing technology, a patented system developed by our group, uses a cutaneous sensory nerve to substitute for the auditory nerve to help deaf-mutes to hear sound. This paper introduces a new solution, multi-channel-array skin-hearing technology, to solve the problem of speech discrimination. Based on the filtering principle of hair cells, external voice sig- nals at different frequencies are converted to current signals at corresponding frequencies using electronic multi-channel bandpass filtering technology. Different positions on the skin can be stimulated by the electrode array, allowing the perception and discrimination of external speech signals to be determined by the skin response to the current signals. Through voice frequen- cy analysis, the frequency range of the band-pass filter can also be determined. These findings demonstrate that the sensory nerves in the skin can help to transfer the voice signal and to dis- tinguish the speech signal, suggesting that the skin sensory nerves are good candidates for the replacement of the auditory nerve in addressing deaf-mutes＇ hearing problems. Scientific hearing experiments can be more safely performed on the skin. Compared with the artificial cochlea, multi-channel-array skin-hearing aids have lower operation risk in use, are cheaper and are more easily popularized.

Overall Planning of Tour Routes: A Case Study of Tour Route Planning in Panzhihua City

Taking overall planning of tour routes as the guiding concept of regional tourism development,one core,three subjects,three sections and three levels in the overall planning of tour routes were explored. Range,planning principle,optimized layout of travel channels,construction of tourist towns,construction of scenic areas,construction of highway landscapes along travel channels,construction of tourist distribution centers in the overall planning of tourist routes for Panzhihua City,Sichuan Province were elaborated. Signifi cance of the overall planning of tour routes was summarized.

Partially Overlapping Channel Assignment Using Bonded and Non-Bonded Channels in IEEE 802.11n WLAN

Nowadays,wireless local area network(WLAN)has become prevalent Internet access due to its low-cost gadgets,flexible coverage and hasslefree simple wireless installation.WLAN facilitates wireless Internet services to users with mobile devices like smart phones,tablets,and laptops through deployment of multiple access points(APs)in a network field.Every AP operates on a frequency band called channel.Popular wireless standard such as IEEE 802.11n has a limited number of channels where frequency spectrum of adjacent channels overlaps partially with each other.In a crowded environment,users may experience poor Internet services due to channel collision i.e.,interference from surrounding APs that affects the performance of the WLAN system.Therefore,it becomes a challenge to maintain expected performance in a crowded environment.A mathematical model of throughput considering interferences from surrounding APs can play an important role to set up a WLAN system properly.While set up,assignment of channels considering interference can maximize network performance.In this paper,we investigate the signal propagation of APs under interference of partially overlapping channels for both bonded and non-bonded channels.Then,a throughput estimation model is proposed using difference of operating channels and received signal strength indicator(RSSI).Then,a channel assignment algorithm is introduced using proposed throughput estimation model.Finally,the efficiency of the proposal is verified by numerical experiments using simulator.The results show that the proposal selects the best channel combination of bonded and non-bonded channels that maximize the performance.

Synchronization in Wireless Networks for Practical MIMO-OFDM Systems

In this paper a frequency offset estimation technique for Wireless Local Area and Wireless Metropolitan Ar- ea Networks is presented. For frequency offset estimation, we have applied a low-complexity frequency offset estimator for simple AWGN channels to fading channels for MIMO-OFDM systems. Simulation results have shown that the performance of the proposed estimator is better than the low complexity frequency offset estimator designed for AWGN channels.