To well understand the effect of garment pressure on skin blood flow(SBF) at lower limb,external pressures of various magnitudes were exerted on lower limb in supine or sitting postures respectively using sphygmomanom...To well understand the effect of garment pressure on skin blood flow(SBF) at lower limb,external pressures of various magnitudes were exerted on lower limb in supine or sitting postures respectively using sphygmomanometer.Five male subjects volunteered to participate in this study.An alternating pressure loading protocol between non-pressure and pressure was employed.The SBF was observed by laser flowmeter.No matter the subjects being sitting or supine,SBF obviously increased under low pressure;as the pressure increasing,it turned to decrease.Moreover,while lying supine,SBF turned to decrease under lower pressure than sitting;SBF at calf turned to decrease under lower pressure than at ankle.It was also confirmed that the increment of SBF was obviously higher when the pressure of the same magnitudes was exerted at ankle than at calf.The pressure around 5.32 kPa was confirmed to be a crucial value to SBF.The findings will be helpful in design and application of tight-fit garments.展开更多
Purpose: The purpose of this study was to investigate the effects of Micro Vibrational therapy (MVT) on muscle stiffness and blood flow in the skin before and after Micro Vibrational therapy in healthy subjects in ord...Purpose: The purpose of this study was to investigate the effects of Micro Vibrational therapy (MVT) on muscle stiffness and blood flow in the skin before and after Micro Vibrational therapy in healthy subjects in order to scientifically verify the effects of MVT. Methods: Micro Vibrational therapy is nurse care use in Japan. It was performed on the backs of 30 subjects (8 males and 22 females) in their 20 s to 50 s according to the eligibility criteria. The resting state before implementation was set as the baseline for the control group, and after 30 seconds of MVT was set as the intervention group. The effects of the MVT were statistically analyzed by these factors and subjective sensation by Visual Analog Scale. Results: The muscle hardness of the area where the MVT was applied for 30 seconds decreased to 29.54 (SD 5.04) after the application, compared to 30.45 (SD 5.05) before. A corresponding t-test showed a significant difference (p = 0.019). Skin blood flow increased from a median of 0.76 (variance 0.062) before to a median of 0.86 (variance 0.16) after the procedure. The Wilcoxon rank test showed a significant difference (p = 0.000). Circulatory response was confirmed by SBP, DBP, and HR. SBP of 108.6 mmHg (SD 14.8) before the study decreased to 105.7 mmHg (SD 15.0) after the study, and DBP of 65.6 mmHg (SD 11.1) before the study decreased to 62.7 mmHg (SD 11.8) after the study. HR decreased from 71.6 beats per minute (SD 10.3) before to 69.2 beats per minute (SD 11.7) after. There was a significant difference in all cardiovascular indices (p < 0.05). VAS (pain, stiffness, and fatigue) was significantly decreased after MVT (p < 0.05). Conclusion: Micro Vibrational therapy tended to decrease muscle hardness and increase skin blood flow even in the short time of 30 seconds. The results suggest that local vibration stimulation is not likely to cause a sudden increase in blood pressure or pulse rate fluctuation. These results suggest that hand vibration nursing care may be applicable to acute patients with unstable circulatory conditions.展开更多
The aim of this study was to clarify the response of sympathetic activity to antihypertensive drugs using a mental stress test in hypertensive patients and to determine the effects of antihypertensive drugs on the sym...The aim of this study was to clarify the response of sympathetic activity to antihypertensive drugs using a mental stress test in hypertensive patients and to determine the effects of antihypertensive drugs on the sympathetic activitymediated hemodynamic response to mental stress. Hypertensive patients were divided into three groups according to the type of drug(s) being taken: a calcium antagonist group, an angiotensin II receptor blocker group, and a combination therapy group of calcium antagonists and angiotensin II receptor blockers. The Stroop color-word conflict test was applied as a mental stress test and hemodynamic responses to mental stress were measured, including blood pressure, pulse rate, and skin blood flow. Elevation of blood pressure by mental stress was suppressed in the combination therapy group compared with the calcium antagonist group. Reduction of skin blood flow by mental stress was suppressed in both the angiotensin II blocker group and the combination therapy group compared with the calcium antagonist group. In conclusion, skin blood flow can be a useful tool to evaluate sympathetic activity and combination therapy with calcium antagonists and angiotensin II receptor blockers were the most useful therapy for suppressing the hemodynamic response to mental stress.展开更多
Nicotinamide adenine dinucleotide (NADH/NAD+) is involved in important biochemical reactions in human metabolism, including participation in energy production by mitochondria. The changes in fluorescence intensity as ...Nicotinamide adenine dinucleotide (NADH/NAD+) is involved in important biochemical reactions in human metabolism, including participation in energy production by mitochondria. The changes in fluorescence intensity as a function of time in response to blocking and releasing of blood flow in a forearm are used as a measure of oxygen transport with blood to the tissue, which directly correlates with the skin microcirculation status. In this paper, a non-invasive dynamic monitoring system based on blood flow-mediated skin fluorescence (FMSF) technology is developed to monitor the NADH fluorescence intensity of skin tissue during the process of blocking reactive hyperemia. Simultaneously, laser speckle contrast imaging (LSCI) and laser Doppler flowmetry (LDF) were used to observe blood flow, blood oxygen saturation (SOt2) and relative amount of hemoglobin (rHb) during the measurement process, which helped to explore NADH dynamics relevant physiological changes. A variety of parameters have been derived to describe NADH fluorescence curve based on the FMSF device. The experimental results are conducive to understanding the NADH measurement and the physiological processes related to it, which help FMSF to be a great avenue for in vivo physiological, clinical and pharmacological research on mitochondrial metabolism.展开更多
We aimed to assess the impact of consuming two Zespri Hayward green kiwifruit a day on 11 healthy women subjects over a period of 4 consecutive weeks. We analyzed the effects of kiwifruit consumption on intestinal, ab...We aimed to assess the impact of consuming two Zespri Hayward green kiwifruit a day on 11 healthy women subjects over a period of 4 consecutive weeks. We analyzed the effects of kiwifruit consumption on intestinal, abdominal, and bowel movement related discomfort, bowel movement frequency, peripheral blood flow, skin health, and autonomic nervous system activity. This study was a randomized control trial, consisting of a four-week intervention period. Participants were divided to ensure equal age distributions and then randomly placed into two intervention groups: a kiwifruit consumption group (n = 11) and a control group (no kiwifruit consumption) (n = 5). The kiwifruit consumption group was instructed to consume two kiwifruit a day during the 4-week intervention period, while subjects in the control group were instructed not to consume kiwifruit for the duration of the study. Besides a restriction from eating yogurt and other fruits, subjects were requested to eat their meals as per usual. The results of this study showed a significant decrease in intestinal, abdominal, and bowel movement discomfort, and a significant increase in bowel movement frequency, at 4 weeks of kiwifruit consumption compared to before consumption. In addition, subjects in the kiwifruit consumption group experienced a significant increase in blood flow, particularly in the index and middle finger at 2 and 4 weeks of kiwifruit consumption. Furthermore, subjects in the kiwifruit consumption group experienced a significant increase in skin brightness at 4 weeks of kiwifruit consumption compared to before consumption. The results of this study suggest that kiwifruit appears to be a delicious and safe option for intestinal, abdominal, and bowel movement discomfort interventions for healthy women. In addition, kiwifruit may aid in increasing bowel movement frequency, peripheral blood flow, and brightness of skin among healthy women as well.展开更多
This study investigated the effects of clothing fabric on human skin microcirculation.Once skin is covered with a clothing fabric,human sensations,namely,coolness,warmth,softness,and roughness,are aroused immediately,...This study investigated the effects of clothing fabric on human skin microcirculation.Once skin is covered with a clothing fabric,human sensations,namely,coolness,warmth,softness,and roughness,are aroused immediately,and the cutaneous microcirculation may be changed consequently.Since the complex relationships of the human skin,the environment,and the clothing,there is few publication focusing on the physiological responses of the skin to the fabrics.In this paper,a Laser Doppler Flowmetry(LDF)was used to test the dynamic responses of the skin blood flow when the fabric was placed on the skin.Effects of different fabrics on the skin blood flux were investigated.The results show that cold stimulation of fabric has remarkable influences on the skin blood flux,and the surface properties of fabric are of importance to affect the human skin blood flow.展开更多
OBJECTIVE： This study aims to investigate the relationship between major signal points （MaSPs） of the lower extremities used in court-type Thai traditional massage （CTTM） and the corresponding underlying anatomic...OBJECTIVE： This study aims to investigate the relationship between major signal points （MaSPs） of the lower extremities used in court-type Thai traditional massage （CTTM） and the corresponding underlying anatomical structures, as well as to determine the short-term changes in blood flow and skin temperature of volunteers experiencing CTTM. METHODS： MaSPs were identified and marked on cadavers before acrylic color was injected. The underlying structures marked with acrylic colors were observed and the anatomical structures were determined. Then, pressure was applied to each MaSP in human volunteers （lateral side of leg and medial side of leg） and blood flow on right dorsalis pedis artery was measured using duplex ultrasound while skin temperature changes were monitored using an infrared themographic camera. RESULTS： Short-term changes in the blood flow parameters, volume flow and average velocity, compared to baseline （P 〈 0.05）, were observed on MaSP of the lower extremity, ML4. Changes in the peak systolic velocity of the area ML5 were also observed relative to baseline. The skin temperature of two different MaSPs on the lateral side of leg （LL4 and LL5） and four on the medial side of leg （ML2, ML3, ML4 and ML5） was significantly increased （P 〈 0.05） at 1 rain after pressure application. CONCLUSION： This study established the clear correlation between the location of MaSP, as defined in CTTM, and the underlying anatomical structures. The effect of massage can stimulate skin blood flow because results showed increased skin temperature and blood flow characteristics. While these results were statistically significant, they may not be clinically relevant, as the present study focused on the immediate physiological effect of manipulation, rather than treatment effects. Thus, this study will serve as baseline data for further clinical studies in CTTM展开更多
基金Research and Development of High Performance Foundation Wear,ChinaPriority Academic Program Development of Jiangsu Higher Education Institutions(PAPD),China
文摘To well understand the effect of garment pressure on skin blood flow(SBF) at lower limb,external pressures of various magnitudes were exerted on lower limb in supine or sitting postures respectively using sphygmomanometer.Five male subjects volunteered to participate in this study.An alternating pressure loading protocol between non-pressure and pressure was employed.The SBF was observed by laser flowmeter.No matter the subjects being sitting or supine,SBF obviously increased under low pressure;as the pressure increasing,it turned to decrease.Moreover,while lying supine,SBF turned to decrease under lower pressure than sitting;SBF at calf turned to decrease under lower pressure than at ankle.It was also confirmed that the increment of SBF was obviously higher when the pressure of the same magnitudes was exerted at ankle than at calf.The pressure around 5.32 kPa was confirmed to be a crucial value to SBF.The findings will be helpful in design and application of tight-fit garments.
文摘Purpose: The purpose of this study was to investigate the effects of Micro Vibrational therapy (MVT) on muscle stiffness and blood flow in the skin before and after Micro Vibrational therapy in healthy subjects in order to scientifically verify the effects of MVT. Methods: Micro Vibrational therapy is nurse care use in Japan. It was performed on the backs of 30 subjects (8 males and 22 females) in their 20 s to 50 s according to the eligibility criteria. The resting state before implementation was set as the baseline for the control group, and after 30 seconds of MVT was set as the intervention group. The effects of the MVT were statistically analyzed by these factors and subjective sensation by Visual Analog Scale. Results: The muscle hardness of the area where the MVT was applied for 30 seconds decreased to 29.54 (SD 5.04) after the application, compared to 30.45 (SD 5.05) before. A corresponding t-test showed a significant difference (p = 0.019). Skin blood flow increased from a median of 0.76 (variance 0.062) before to a median of 0.86 (variance 0.16) after the procedure. The Wilcoxon rank test showed a significant difference (p = 0.000). Circulatory response was confirmed by SBP, DBP, and HR. SBP of 108.6 mmHg (SD 14.8) before the study decreased to 105.7 mmHg (SD 15.0) after the study, and DBP of 65.6 mmHg (SD 11.1) before the study decreased to 62.7 mmHg (SD 11.8) after the study. HR decreased from 71.6 beats per minute (SD 10.3) before to 69.2 beats per minute (SD 11.7) after. There was a significant difference in all cardiovascular indices (p < 0.05). VAS (pain, stiffness, and fatigue) was significantly decreased after MVT (p < 0.05). Conclusion: Micro Vibrational therapy tended to decrease muscle hardness and increase skin blood flow even in the short time of 30 seconds. The results suggest that local vibration stimulation is not likely to cause a sudden increase in blood pressure or pulse rate fluctuation. These results suggest that hand vibration nursing care may be applicable to acute patients with unstable circulatory conditions.
文摘The aim of this study was to clarify the response of sympathetic activity to antihypertensive drugs using a mental stress test in hypertensive patients and to determine the effects of antihypertensive drugs on the sympathetic activitymediated hemodynamic response to mental stress. Hypertensive patients were divided into three groups according to the type of drug(s) being taken: a calcium antagonist group, an angiotensin II receptor blocker group, and a combination therapy group of calcium antagonists and angiotensin II receptor blockers. The Stroop color-word conflict test was applied as a mental stress test and hemodynamic responses to mental stress were measured, including blood pressure, pulse rate, and skin blood flow. Elevation of blood pressure by mental stress was suppressed in the combination therapy group compared with the calcium antagonist group. Reduction of skin blood flow by mental stress was suppressed in both the angiotensin II blocker group and the combination therapy group compared with the calcium antagonist group. In conclusion, skin blood flow can be a useful tool to evaluate sympathetic activity and combination therapy with calcium antagonists and angiotensin II receptor blockers were the most useful therapy for suppressing the hemodynamic response to mental stress.
文摘Nicotinamide adenine dinucleotide (NADH/NAD+) is involved in important biochemical reactions in human metabolism, including participation in energy production by mitochondria. The changes in fluorescence intensity as a function of time in response to blocking and releasing of blood flow in a forearm are used as a measure of oxygen transport with blood to the tissue, which directly correlates with the skin microcirculation status. In this paper, a non-invasive dynamic monitoring system based on blood flow-mediated skin fluorescence (FMSF) technology is developed to monitor the NADH fluorescence intensity of skin tissue during the process of blocking reactive hyperemia. Simultaneously, laser speckle contrast imaging (LSCI) and laser Doppler flowmetry (LDF) were used to observe blood flow, blood oxygen saturation (SOt2) and relative amount of hemoglobin (rHb) during the measurement process, which helped to explore NADH dynamics relevant physiological changes. A variety of parameters have been derived to describe NADH fluorescence curve based on the FMSF device. The experimental results are conducive to understanding the NADH measurement and the physiological processes related to it, which help FMSF to be a great avenue for in vivo physiological, clinical and pharmacological research on mitochondrial metabolism.
文摘We aimed to assess the impact of consuming two Zespri Hayward green kiwifruit a day on 11 healthy women subjects over a period of 4 consecutive weeks. We analyzed the effects of kiwifruit consumption on intestinal, abdominal, and bowel movement related discomfort, bowel movement frequency, peripheral blood flow, skin health, and autonomic nervous system activity. This study was a randomized control trial, consisting of a four-week intervention period. Participants were divided to ensure equal age distributions and then randomly placed into two intervention groups: a kiwifruit consumption group (n = 11) and a control group (no kiwifruit consumption) (n = 5). The kiwifruit consumption group was instructed to consume two kiwifruit a day during the 4-week intervention period, while subjects in the control group were instructed not to consume kiwifruit for the duration of the study. Besides a restriction from eating yogurt and other fruits, subjects were requested to eat their meals as per usual. The results of this study showed a significant decrease in intestinal, abdominal, and bowel movement discomfort, and a significant increase in bowel movement frequency, at 4 weeks of kiwifruit consumption compared to before consumption. In addition, subjects in the kiwifruit consumption group experienced a significant increase in blood flow, particularly in the index and middle finger at 2 and 4 weeks of kiwifruit consumption. Furthermore, subjects in the kiwifruit consumption group experienced a significant increase in skin brightness at 4 weeks of kiwifruit consumption compared to before consumption. The results of this study suggest that kiwifruit appears to be a delicious and safe option for intestinal, abdominal, and bowel movement discomfort interventions for healthy women. In addition, kiwifruit may aid in increasing bowel movement frequency, peripheral blood flow, and brightness of skin among healthy women as well.
基金Key Science and Technology Project of Tianjin Municipal Science and Technology Commission,China(No.09JCZDJC24400)
文摘This study investigated the effects of clothing fabric on human skin microcirculation.Once skin is covered with a clothing fabric,human sensations,namely,coolness,warmth,softness,and roughness,are aroused immediately,and the cutaneous microcirculation may be changed consequently.Since the complex relationships of the human skin,the environment,and the clothing,there is few publication focusing on the physiological responses of the skin to the fabrics.In this paper,a Laser Doppler Flowmetry(LDF)was used to test the dynamic responses of the skin blood flow when the fabric was placed on the skin.Effects of different fabrics on the skin blood flux were investigated.The results show that cold stimulation of fabric has remarkable influences on the skin blood flux,and the surface properties of fabric are of importance to affect the human skin blood flow.
基金supported by the Siriraj Research Fund(No.R015631018)
文摘OBJECTIVE： This study aims to investigate the relationship between major signal points （MaSPs） of the lower extremities used in court-type Thai traditional massage （CTTM） and the corresponding underlying anatomical structures, as well as to determine the short-term changes in blood flow and skin temperature of volunteers experiencing CTTM. METHODS： MaSPs were identified and marked on cadavers before acrylic color was injected. The underlying structures marked with acrylic colors were observed and the anatomical structures were determined. Then, pressure was applied to each MaSP in human volunteers （lateral side of leg and medial side of leg） and blood flow on right dorsalis pedis artery was measured using duplex ultrasound while skin temperature changes were monitored using an infrared themographic camera. RESULTS： Short-term changes in the blood flow parameters, volume flow and average velocity, compared to baseline （P 〈 0.05）, were observed on MaSP of the lower extremity, ML4. Changes in the peak systolic velocity of the area ML5 were also observed relative to baseline. The skin temperature of two different MaSPs on the lateral side of leg （LL4 and LL5） and four on the medial side of leg （ML2, ML3, ML4 and ML5） was significantly increased （P 〈 0.05） at 1 rain after pressure application. CONCLUSION： This study established the clear correlation between the location of MaSP, as defined in CTTM, and the underlying anatomical structures. The effect of massage can stimulate skin blood flow because results showed increased skin temperature and blood flow characteristics. While these results were statistically significant, they may not be clinically relevant, as the present study focused on the immediate physiological effect of manipulation, rather than treatment effects. Thus, this study will serve as baseline data for further clinical studies in CTTM
