Advanced Glycation End-Products (AGEs), play a crucial part in advancing the process of cellular skin aging and its link to chronological age was re-assessed. AGEs accumulation alters cell structure and function of mo...Advanced Glycation End-Products (AGEs), play a crucial part in advancing the process of cellular skin aging and its link to chronological age was re-assessed. AGEs accumulation alters cell structure and function of most types of skin cells, affecting skin’s mechanical and physiological properties, following the molecular transformations. Slowdown AGEs accumulation rate in skin, although a potent anti-aging strategy, is difficult and tricky. The lack of working methods for <span style="white-space:nowrap;"><i>In-Vitro</i></span> and <span style="white-space:nowrap;"><i>In-Vitro</i></span> measuring AGEs level complicates the evaluation and prediction of active ingredients’ ability to affect cellular AGEs accumulation. A two-step <span style="white-space:nowrap;"><i>In-Vitro</i></span> systematic screening method is proposed and three different cosmetic active ingredients were selected for its demonstration, using BSA-Glucose and Collagen-Glucose predicting models. Candidates’ effects on AGEs accumulation were evaluated as standalone, and when formulated in a blend. Additionally, the potency of non-invasive auto-fluorescence in-vivo measurement to detect AGEs levels among subjects of different ages was demonstrated. The results are presented in this work and the potential contribution of the proposed system to assist the desired inhibition of AGEs accumulation in skin is discussed.展开更多
Studies show that 235UO2F2 was chiefly localized in kidneys, then in skeleton and liver. Its radioactivity in skeleton rose steadily while the concentration in kidneys and liver droped. 235UO2F2 was difficult to pass ...Studies show that 235UO2F2 was chiefly localized in kidneys, then in skeleton and liver. Its radioactivity in skeleton rose steadily while the concentration in kidneys and liver droped. 235UO2F2 was difficult to pass through the blood- testes barrier. With 1 to 6 h contact period, only 1.4-1.6 % 235UO2F2 was found in the intact skin, but 41-54 % in the abrasive skin. The dynamic retention of 235UO2F2 through intact or abrasive skins was also dominantly localized in kidneys, skeleton and liver. Accumulation of insoluble 235U3O8 in gastrointestinal tract was well described by a double- exponential- term expression. Values of retention were estimated for fast component T1= 0.34 d, and for relatively long term component T2= 4.05 d.展开更多
Objective:To explore the role of endothelial biomarkers in predicting damp-heat syndrome in diabetic kidney disease(DKD).Methods:A total of 183 patients with DKD were divided into 3 groups:the early DKD group,establis...Objective:To explore the role of endothelial biomarkers in predicting damp-heat syndrome in diabetic kidney disease(DKD).Methods:A total of 183 patients with DKD were divided into 3 groups:the early DKD group,established DKD group,and advanced DKD group.All patients were classified according to traditional Chinese medicine(TCM)syndrome type,and clinical indexes were collected for statistical analysis.Results:A total of 183 DKD patients were included in this study.Fibroblast growth factor 23(FGF23),chitinase-3-like protein 1(CHI3L1),endocan,tumor necrosis factor receptor 1(TNFR1),secretory leukocyte protease inhibitor(SLPI),and vascular endothelial growth factor A(VEGF-A)were increased in advanced DKD.FGF23,CHI3L1,endocan,SLPI,and TNFR1 showed a negative correlation with estimated glomerular filtration rate(eGFR),while they had a positive correlation with 24 h urine protein.After adjusting for age,gender,diabetes duration,body mass index(BMI),hemoglobin,glucose,uric acid,24 h urine protein,cholesterol,triglyceride,low-density lipoprotein,and hemoglobin A1c(HbA1c),the multiple regression analysis showed that FGF23,endocan,TNFR1,and SLPI significantly correlated with eGFR.Conclusions:FGF23,endocan,TNFR1,and SLPI are elevated in advanced DKD compared with early stage,and they may take part in the pathogenesis and progression of DKD.Our study provides useful biomarkers for predicting the appearance of damp-heat syndrome,including FGF23,endocan,TNFR1,and SLPI.展开更多
目的 探析联合治疗(1064nm/1320nm复合激光溶脂技术+可吸收线雕)对下面部轻度脂肪堆积伴皮肤松弛(cutis laxa,CL)患者的临床效果。方法:回顾性分析本院2021年7月-2023年7月收治的94例下面部脂肪堆积伴CL患者,根据治疗策略差异分为对照组...目的 探析联合治疗(1064nm/1320nm复合激光溶脂技术+可吸收线雕)对下面部轻度脂肪堆积伴皮肤松弛(cutis laxa,CL)患者的临床效果。方法:回顾性分析本院2021年7月-2023年7月收治的94例下面部脂肪堆积伴CL患者,根据治疗策略差异分为对照组(单一可吸收线雕,n=40例)、观察组(1064nm/1320nm复合激光溶脂技术+可吸收线雕,n=54例)。对比两组术后1月、6月患者主观满意度、观察者总体美容改善评分(improvement based on global aesthetic improvement scale,IGAIS)、术后1月不良反应率。结果:观察组术后1月、6月患者满意度评价(94.44%、87.04%)均高于对照组(72.50%、65.00%),差异有统计学意义(P<0.05)。术后1月、6月观察组IGAIS评分均高于对照组,差异有统计学意义(P<0.05)。两组患者均未发生神经损伤、感染、血肿、皮下出血等严重并发症,术后7d患者术区基本消肿。两组术后不良反应发生率(9.26%、7.50%)对比,差异无统计学意义(P> 0.05)。结论:联合治疗(1064nm/1320nm复合激光溶脂技术+可吸收线雕)应用于下面部脂肪堆积伴CL患者中改善效果显著,可有效提高患者满意度,且不良反应发生率较低,值得临床推广。展开更多
目的:观察湿疹2号方治疗亚急性期湿热蕴肤证湿疹的临床疗效。方法:将102例湿疹患者按照随机数字表法分为治疗组和对照组,每组各51例。对照组采用防风通圣颗粒联合复方倍氯米松樟脑乳膏治疗,观察组采用湿疹2号方联合复方倍氯米松樟脑乳...目的:观察湿疹2号方治疗亚急性期湿热蕴肤证湿疹的临床疗效。方法:将102例湿疹患者按照随机数字表法分为治疗组和对照组,每组各51例。对照组采用防风通圣颗粒联合复方倍氯米松樟脑乳膏治疗,观察组采用湿疹2号方联合复方倍氯米松樟脑乳膏治疗。比较两组患者的临床疗效、瘙痒消退时间及治疗前后瘙痒程度评分、临床症状评分、湿疹面积及严重指数(eczema area and severity index,EASI)评分、实验室指标[血清总IgE、嗜酸性粒细胞(eosinophil,EOS)]变化情况。结果:对照组有效率为74.5%,观察组有效率为94.1%,两组患者有效率比较,差异具有统计学意义(P<0.05)。观察组瘙痒消退时间短于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后皮肤瘙痒程度评分、临床症状评分及EASI评分低于本组治疗前,且治疗后观察组低于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后血清EOS、IgE低于本组治疗前,且治疗后观察组低于对照组,差异具有统计学意义(P<0.05)。结论:湿疹2号方治疗亚急性湿热蕴肤型湿疹,可改善患者的临床症状,缩小湿疹面积,加速皮疹消退,缓解皮疹瘙痒程度。展开更多
文摘Advanced Glycation End-Products (AGEs), play a crucial part in advancing the process of cellular skin aging and its link to chronological age was re-assessed. AGEs accumulation alters cell structure and function of most types of skin cells, affecting skin’s mechanical and physiological properties, following the molecular transformations. Slowdown AGEs accumulation rate in skin, although a potent anti-aging strategy, is difficult and tricky. The lack of working methods for <span style="white-space:nowrap;"><i>In-Vitro</i></span> and <span style="white-space:nowrap;"><i>In-Vitro</i></span> measuring AGEs level complicates the evaluation and prediction of active ingredients’ ability to affect cellular AGEs accumulation. A two-step <span style="white-space:nowrap;"><i>In-Vitro</i></span> systematic screening method is proposed and three different cosmetic active ingredients were selected for its demonstration, using BSA-Glucose and Collagen-Glucose predicting models. Candidates’ effects on AGEs accumulation were evaluated as standalone, and when formulated in a blend. Additionally, the potency of non-invasive auto-fluorescence in-vivo measurement to detect AGEs levels among subjects of different ages was demonstrated. The results are presented in this work and the potential contribution of the proposed system to assist the desired inhibition of AGEs accumulation in skin is discussed.
基金The Project Supported by National Natural Science Foundation of China
文摘Studies show that 235UO2F2 was chiefly localized in kidneys, then in skeleton and liver. Its radioactivity in skeleton rose steadily while the concentration in kidneys and liver droped. 235UO2F2 was difficult to pass through the blood- testes barrier. With 1 to 6 h contact period, only 1.4-1.6 % 235UO2F2 was found in the intact skin, but 41-54 % in the abrasive skin. The dynamic retention of 235UO2F2 through intact or abrasive skins was also dominantly localized in kidneys, skeleton and liver. Accumulation of insoluble 235U3O8 in gastrointestinal tract was well described by a double- exponential- term expression. Values of retention were estimated for fast component T1= 0.34 d, and for relatively long term component T2= 4.05 d.
基金This project was supported by the Fundamental Research Funds for the Central Universities(2017-JYB-JS-075)National Key Project for Drug Discovery(2017ZX09304019).
文摘Objective:To explore the role of endothelial biomarkers in predicting damp-heat syndrome in diabetic kidney disease(DKD).Methods:A total of 183 patients with DKD were divided into 3 groups:the early DKD group,established DKD group,and advanced DKD group.All patients were classified according to traditional Chinese medicine(TCM)syndrome type,and clinical indexes were collected for statistical analysis.Results:A total of 183 DKD patients were included in this study.Fibroblast growth factor 23(FGF23),chitinase-3-like protein 1(CHI3L1),endocan,tumor necrosis factor receptor 1(TNFR1),secretory leukocyte protease inhibitor(SLPI),and vascular endothelial growth factor A(VEGF-A)were increased in advanced DKD.FGF23,CHI3L1,endocan,SLPI,and TNFR1 showed a negative correlation with estimated glomerular filtration rate(eGFR),while they had a positive correlation with 24 h urine protein.After adjusting for age,gender,diabetes duration,body mass index(BMI),hemoglobin,glucose,uric acid,24 h urine protein,cholesterol,triglyceride,low-density lipoprotein,and hemoglobin A1c(HbA1c),the multiple regression analysis showed that FGF23,endocan,TNFR1,and SLPI significantly correlated with eGFR.Conclusions:FGF23,endocan,TNFR1,and SLPI are elevated in advanced DKD compared with early stage,and they may take part in the pathogenesis and progression of DKD.Our study provides useful biomarkers for predicting the appearance of damp-heat syndrome,including FGF23,endocan,TNFR1,and SLPI.
文摘目的 探析联合治疗(1064nm/1320nm复合激光溶脂技术+可吸收线雕)对下面部轻度脂肪堆积伴皮肤松弛(cutis laxa,CL)患者的临床效果。方法:回顾性分析本院2021年7月-2023年7月收治的94例下面部脂肪堆积伴CL患者,根据治疗策略差异分为对照组(单一可吸收线雕,n=40例)、观察组(1064nm/1320nm复合激光溶脂技术+可吸收线雕,n=54例)。对比两组术后1月、6月患者主观满意度、观察者总体美容改善评分(improvement based on global aesthetic improvement scale,IGAIS)、术后1月不良反应率。结果:观察组术后1月、6月患者满意度评价(94.44%、87.04%)均高于对照组(72.50%、65.00%),差异有统计学意义(P<0.05)。术后1月、6月观察组IGAIS评分均高于对照组,差异有统计学意义(P<0.05)。两组患者均未发生神经损伤、感染、血肿、皮下出血等严重并发症,术后7d患者术区基本消肿。两组术后不良反应发生率(9.26%、7.50%)对比,差异无统计学意义(P> 0.05)。结论:联合治疗(1064nm/1320nm复合激光溶脂技术+可吸收线雕)应用于下面部脂肪堆积伴CL患者中改善效果显著,可有效提高患者满意度,且不良反应发生率较低,值得临床推广。
文摘目的:观察湿疹2号方治疗亚急性期湿热蕴肤证湿疹的临床疗效。方法:将102例湿疹患者按照随机数字表法分为治疗组和对照组,每组各51例。对照组采用防风通圣颗粒联合复方倍氯米松樟脑乳膏治疗,观察组采用湿疹2号方联合复方倍氯米松樟脑乳膏治疗。比较两组患者的临床疗效、瘙痒消退时间及治疗前后瘙痒程度评分、临床症状评分、湿疹面积及严重指数(eczema area and severity index,EASI)评分、实验室指标[血清总IgE、嗜酸性粒细胞(eosinophil,EOS)]变化情况。结果:对照组有效率为74.5%,观察组有效率为94.1%,两组患者有效率比较,差异具有统计学意义(P<0.05)。观察组瘙痒消退时间短于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后皮肤瘙痒程度评分、临床症状评分及EASI评分低于本组治疗前,且治疗后观察组低于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后血清EOS、IgE低于本组治疗前,且治疗后观察组低于对照组,差异具有统计学意义(P<0.05)。结论:湿疹2号方治疗亚急性湿热蕴肤型湿疹,可改善患者的临床症状,缩小湿疹面积,加速皮疹消退,缓解皮疹瘙痒程度。
