Each biological system possesses a widely unrecognized buffer system to maintain acid-base balance to a specific pH. The skin pH is crucial for physiological skin function. In aged or diseased skin, pH increase is obs...Each biological system possesses a widely unrecognized buffer system to maintain acid-base balance to a specific pH. The skin pH is crucial for physiological skin function. In aged or diseased skin, pH increase is observed and may negatively affect skin health. Skin care products with a pH that is slightly more acidic than the average normal skin pH and have an adequate buffering capacity, are considered beneficial for the skin. However, the buffer capacity of these products also plays an important role. In the present study, a possible normalization or acidification of skin surface pH and influence on skin hydration and skin barrier function was assessed via application of buffered skin care products that are formulated with pH ≤ 4.5. 48 subjects aged above 50 were treated with three different skin care products (Vitamin C Spheres, Collagen Spray, and Collagen Mask) and skin surface pH, skin hydration and barrier integrity were assessed before treatment start and after 4 weeks. The results show that after 4-week treatment with Vitamin C, the skin pH is acidified. Treatment with Collagen Spray and Collagen Mask showed maintenance of a physiological skin pH. Subgroup analysis of subjects that had a higher than average skin pH at study start demonstrated that all three tested skin care products were able to acidify the skin surface. In addition, skin hydration was also increased for two of the three tested products, whereas skin barrier is not significantly changed. This demonstrates that buffered skin care products formulated to a pH ≤ 4.5 are able to acidify and maintain physiological skin pH and may contribute to a physiological skin function.展开更多
The physiological skin surface pH is just below 5. With age the skin surface pH increases up to 6. An increased pH correlates with reduced barrier integrity/cohesion. The present pilot study assesses possible normaliz...The physiological skin surface pH is just below 5. With age the skin surface pH increases up to 6. An increased pH correlates with reduced barrier integrity/cohesion. The present pilot study assesses possible normalization of an increased skin surface pH of the elderly and improvement of barrier function via application of ≈pH 4.0 skin care products. Baseline skin surface pH was determined in elderly (80+ years old;n = 15) compared to middle aged adults (31 - 50 years old;n = 15). The effect of o/w emulsions at pH-values of 3.5, 4.0, 4.5 and 5.5 on the skin surface pH was determined in both groups. Further, the effect of a 4-week treatment with a pH 4.0 skin care product on the skin surface pH, skin hydration and barrier integrity was assessed. Thirteen elderly females were involved in this home-in-use test. Increased baseline skin surface pH of the elderly normalizes to the physiological pH of 4.5 - 5.0 over 7 hours after single application of o/w-emulsions with a given pH of 3.5 or 4.0. A 4 week treatment employing the pH 4.0 skin care product improves the epidermal barrier integrity of the elderly significantly (p = 0.005). Reduction of the increased baseline skin surface pH of the elderly is accompanied by improved epidermal barrier integrity. Skin care products for the elderly have to be adjusted in the pH range of 3.5 to 4.0.展开更多
Purpose: Demodex folliculorum is a transparent mite, 0.3 - 0.4 mm long, which asymptomatically parasitizes the human pilosebaceous follicles. D. folliculorum is observed in normal skin with a prevalence of 100% and a ...Purpose: Demodex folliculorum is a transparent mite, 0.3 - 0.4 mm long, which asymptomatically parasitizes the human pilosebaceous follicles. D. folliculorum is observed in normal skin with a prevalence of 100% and a density of ≤ 5 D/cm2 in the adult population. Materials and Methods: This study evaluated the differences in pH on the five facial sites between the two populations with and without D. folliculorum. The relationship between pH and skin surface oil was analyzed in populations with and without Demodex mites. Mongolian 750 subjects (370 males and 380 females) aged 16 - 84 years, who lived in Ulaanbaatar city, were enrolled in this study. The eligibility criteria included a minimum age of 16 and no physical and dermatologic illness, no cosmetic. Results: Skin surface oil among the five facial areas differed significantly in both subjects with and without Demodex folliculorum (P < 0.001). When the skin surface oil on the T-zone, U-zone was compared, those on the T-zone were significantly higher than those of the U-zone (P < 0.001) in both populations (P< 0.01). The pH levels on the five facial sites, and U-zone, T-zone and MFpH differed significantly in among both subjects with and without Demodex folliculorum (P < 0.001). In both groups, the pH levels of the U-zone were significantly lower than the pH of the T-zone (P Conclusions: Among the five facial sites in subjects with Demodex folliculorum, there were significant negative correlations between skin surface oil and pH on the forehead (p < 0.001, r = 652), cheek (P < 0.001, r = 0.656), nose (P < 0.001, r = 0.754), chin (P < 0.001, r = 0.679), and T-zone (P < 0.001, r = 0.698), MFSE-MFpH (P < 0.001, r = 0.483). In contrast, among the five sites in subjects without Demodex folliculorum, a significant negative correlation between skin surface oil and pH was observed on the forehead (p < 0.001, r = 766), cheek (P < 0.001, r = 0.798), nose (P < 0.001, r = 0.706), chin (P < 0.001, r = 0.823), and T-zone (P < 0.001, r = 0.602), U-zone (P < 0.001, r = -0.550)展开更多
Research in dermatology is exploring bio-compatible materials like alginate and calcium sulphate for use in skincare products, such as facial sheet masks. Alginate (from seaweed) has wound healing and hydration proper...Research in dermatology is exploring bio-compatible materials like alginate and calcium sulphate for use in skincare products, such as facial sheet masks. Alginate (from seaweed) has wound healing and hydration properties, while calcium assists in maintaining skin balance and protection. In this study we explore the effects of an algae-calcium based sheet mask on skin. Materials and Methods: In-vitro studies investigated the purpose, process and effectiveness of an algae-calcium dry sheet mask (Algae Mask-MedSkin Solutions Dr. Suwelack). The mask is made from brown algae and undergoes a lyophilization and stabilization process to form its final structure. The mask’s properties were tested using scanning electron microscopy (SEM) and its performance was assessed on human skin biopsies. Various tests were performed, such as measuring the release of ionic constituents and concentration of calcium ions, and the fibroblast cell-activating effect. Clinical evaluations and skin microbiome assessment were conducted on healthy volunteers to assess the mask’s effect on the skin. Results and Conclusion: The study validates the benefits of macro algae-based sheet masks for skincare, with significant cosmetic effects and high tolerance due to its composition. Notably, the algae based mask releases substantial calcium ions, hydrates, minimizes skin roughness and wrinkles, regulates pH levels, and maintains skin microbiome diversity. It also decreases Corynebacterium species found on the skin, suggesting potential to modify skin microbiome. .展开更多
文摘Each biological system possesses a widely unrecognized buffer system to maintain acid-base balance to a specific pH. The skin pH is crucial for physiological skin function. In aged or diseased skin, pH increase is observed and may negatively affect skin health. Skin care products with a pH that is slightly more acidic than the average normal skin pH and have an adequate buffering capacity, are considered beneficial for the skin. However, the buffer capacity of these products also plays an important role. In the present study, a possible normalization or acidification of skin surface pH and influence on skin hydration and skin barrier function was assessed via application of buffered skin care products that are formulated with pH ≤ 4.5. 48 subjects aged above 50 were treated with three different skin care products (Vitamin C Spheres, Collagen Spray, and Collagen Mask) and skin surface pH, skin hydration and barrier integrity were assessed before treatment start and after 4 weeks. The results show that after 4-week treatment with Vitamin C, the skin pH is acidified. Treatment with Collagen Spray and Collagen Mask showed maintenance of a physiological skin pH. Subgroup analysis of subjects that had a higher than average skin pH at study start demonstrated that all three tested skin care products were able to acidify the skin surface. In addition, skin hydration was also increased for two of the three tested products, whereas skin barrier is not significantly changed. This demonstrates that buffered skin care products formulated to a pH ≤ 4.5 are able to acidify and maintain physiological skin pH and may contribute to a physiological skin function.
文摘The physiological skin surface pH is just below 5. With age the skin surface pH increases up to 6. An increased pH correlates with reduced barrier integrity/cohesion. The present pilot study assesses possible normalization of an increased skin surface pH of the elderly and improvement of barrier function via application of ≈pH 4.0 skin care products. Baseline skin surface pH was determined in elderly (80+ years old;n = 15) compared to middle aged adults (31 - 50 years old;n = 15). The effect of o/w emulsions at pH-values of 3.5, 4.0, 4.5 and 5.5 on the skin surface pH was determined in both groups. Further, the effect of a 4-week treatment with a pH 4.0 skin care product on the skin surface pH, skin hydration and barrier integrity was assessed. Thirteen elderly females were involved in this home-in-use test. Increased baseline skin surface pH of the elderly normalizes to the physiological pH of 4.5 - 5.0 over 7 hours after single application of o/w-emulsions with a given pH of 3.5 or 4.0. A 4 week treatment employing the pH 4.0 skin care product improves the epidermal barrier integrity of the elderly significantly (p = 0.005). Reduction of the increased baseline skin surface pH of the elderly is accompanied by improved epidermal barrier integrity. Skin care products for the elderly have to be adjusted in the pH range of 3.5 to 4.0.
文摘Purpose: Demodex folliculorum is a transparent mite, 0.3 - 0.4 mm long, which asymptomatically parasitizes the human pilosebaceous follicles. D. folliculorum is observed in normal skin with a prevalence of 100% and a density of ≤ 5 D/cm2 in the adult population. Materials and Methods: This study evaluated the differences in pH on the five facial sites between the two populations with and without D. folliculorum. The relationship between pH and skin surface oil was analyzed in populations with and without Demodex mites. Mongolian 750 subjects (370 males and 380 females) aged 16 - 84 years, who lived in Ulaanbaatar city, were enrolled in this study. The eligibility criteria included a minimum age of 16 and no physical and dermatologic illness, no cosmetic. Results: Skin surface oil among the five facial areas differed significantly in both subjects with and without Demodex folliculorum (P < 0.001). When the skin surface oil on the T-zone, U-zone was compared, those on the T-zone were significantly higher than those of the U-zone (P < 0.001) in both populations (P< 0.01). The pH levels on the five facial sites, and U-zone, T-zone and MFpH differed significantly in among both subjects with and without Demodex folliculorum (P < 0.001). In both groups, the pH levels of the U-zone were significantly lower than the pH of the T-zone (P Conclusions: Among the five facial sites in subjects with Demodex folliculorum, there were significant negative correlations between skin surface oil and pH on the forehead (p < 0.001, r = 652), cheek (P < 0.001, r = 0.656), nose (P < 0.001, r = 0.754), chin (P < 0.001, r = 0.679), and T-zone (P < 0.001, r = 0.698), MFSE-MFpH (P < 0.001, r = 0.483). In contrast, among the five sites in subjects without Demodex folliculorum, a significant negative correlation between skin surface oil and pH was observed on the forehead (p < 0.001, r = 766), cheek (P < 0.001, r = 0.798), nose (P < 0.001, r = 0.706), chin (P < 0.001, r = 0.823), and T-zone (P < 0.001, r = 0.602), U-zone (P < 0.001, r = -0.550)
文摘Research in dermatology is exploring bio-compatible materials like alginate and calcium sulphate for use in skincare products, such as facial sheet masks. Alginate (from seaweed) has wound healing and hydration properties, while calcium assists in maintaining skin balance and protection. In this study we explore the effects of an algae-calcium based sheet mask on skin. Materials and Methods: In-vitro studies investigated the purpose, process and effectiveness of an algae-calcium dry sheet mask (Algae Mask-MedSkin Solutions Dr. Suwelack). The mask is made from brown algae and undergoes a lyophilization and stabilization process to form its final structure. The mask’s properties were tested using scanning electron microscopy (SEM) and its performance was assessed on human skin biopsies. Various tests were performed, such as measuring the release of ionic constituents and concentration of calcium ions, and the fibroblast cell-activating effect. Clinical evaluations and skin microbiome assessment were conducted on healthy volunteers to assess the mask’s effect on the skin. Results and Conclusion: The study validates the benefits of macro algae-based sheet masks for skincare, with significant cosmetic effects and high tolerance due to its composition. Notably, the algae based mask releases substantial calcium ions, hydrates, minimizes skin roughness and wrinkles, regulates pH levels, and maintains skin microbiome diversity. It also decreases Corynebacterium species found on the skin, suggesting potential to modify skin microbiome. .
文摘为探讨香瓜(Cucumis melo L.)皮作为沼气发酵原料资源化利用的可行性,以香瓜皮为发酵原料,在30℃下进行批量式沼气发酵试验,测定发酵过程中的TS产气潜力、VS产气潜力、日产气量、产气速率、p H等指标。结果表明,发酵历时48 d,当发酵体系出现酸化时,在微生物的调节下p H能够很快恢复,产气未受到任何影响。整个发酵过程香瓜皮总产气量3 274 m L,TS产气潜力为726 m L/g(TS),VS产气潜力为777 m L/g(VS),且发酵前后p H变化不大,维持在沼气发酵的较佳范围内。
