As an exploration of electromagnetic induction effects on homeostatic regulation of sleep wake cycle, a magnetic flux term coupled with membrane current is proposed as an equivalent induction current act on a physiolo...As an exploration of electromagnetic induction effects on homeostatic regulation of sleep wake cycle, a magnetic flux term coupled with membrane current is proposed as an equivalent induction current act on a physiologically-motivated mathematical model, to study the effects of electromagnetic induction and its noise on the sleep wake cycle. The basic model includes 2 simplified Hodgkin-Huxley type neurons connected via glutamate(Glu) synapses, one of which additionally contains hypocretin/orexin(Hcrt/ox) as the functionally relevant co-transmitter. The numerical results suggest that when a constant current(DC) stimulus is applied to the model, the average fire frequency of the Hcrt/ox neuron could be modified from gamma to delta frequency with increased the intensity of electromagnetic induction, but the local Glu neuron transforms active into sleep state.Additionally, the homeostatic regulation function has better robustness to electromagnetic induction and its noise than the current or conductance noise, even there is a similar stochastic resonance phenomenon. For the circadian current input case, the time of wake up is delayed and fall asleep is advanced when the electromagnetic induction and its noise is considered. Furthermore, the effects of electromagnetic noise on the regulation is not significant, but only to inhibit the neuronal discharge activities and change the time of wake up and fall asleep of the Glu neuron, characterized by the sleep duration is slightly prolonged with increasing the strength of noise intensity.展开更多
The neuropeptide orexin is synthesized by neurons exclusively located in the hypothalamus. However, these neurons send axons over virtually the entire brain and spinal cord and therefore constitute a unique central or...The neuropeptide orexin is synthesized by neurons exclusively located in the hypothalamus. However, these neurons send axons over virtually the entire brain and spinal cord and therefore constitute a unique central orexinergic system. It is well known that central orexin plays a crucial role in the regulation of various basic non-somatic and somatic physiological functions, including feeding, energy homeostasis, the sleep/wake cycle, reward, addiction, and neuroendocrine, as well as motor control. Moreover, the absence of orexin results in narcolepsy-cataplexy, a simultaneous somatic and non-somatic dysfunction. In this review, we summarize these central functions of the orexinergic system and associated diseases, and suggest that this system may hold a key position in somatic-non-somatic integration.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.11372122&11072099)
文摘As an exploration of electromagnetic induction effects on homeostatic regulation of sleep wake cycle, a magnetic flux term coupled with membrane current is proposed as an equivalent induction current act on a physiologically-motivated mathematical model, to study the effects of electromagnetic induction and its noise on the sleep wake cycle. The basic model includes 2 simplified Hodgkin-Huxley type neurons connected via glutamate(Glu) synapses, one of which additionally contains hypocretin/orexin(Hcrt/ox) as the functionally relevant co-transmitter. The numerical results suggest that when a constant current(DC) stimulus is applied to the model, the average fire frequency of the Hcrt/ox neuron could be modified from gamma to delta frequency with increased the intensity of electromagnetic induction, but the local Glu neuron transforms active into sleep state.Additionally, the homeostatic regulation function has better robustness to electromagnetic induction and its noise than the current or conductance noise, even there is a similar stochastic resonance phenomenon. For the circadian current input case, the time of wake up is delayed and fall asleep is advanced when the electromagnetic induction and its noise is considered. Furthermore, the effects of electromagnetic noise on the regulation is not significant, but only to inhibit the neuronal discharge activities and change the time of wake up and fall asleep of the Glu neuron, characterized by the sleep duration is slightly prolonged with increasing the strength of noise intensity.
基金supported by the National Natural Science Foundation of China (30700201, 31070959, 31071021, 31171050)the National Natural Science Foundation of China/Research Grants Council of Hong Kong Joint Research Scheme (30931160433)+2 种基金the Research Fund for the Doctoral Program of Higher Education, Ministry of Education, China (20070284057 and 20100091110016)Program for New Century Excellent Talents in University, Fundamental Research Funds for the Central Universities, Ministry of Education, China (1094020806 and 1095020821)the Natural Science Foundation of Jiangsu Province, China (BK2011014)
文摘The neuropeptide orexin is synthesized by neurons exclusively located in the hypothalamus. However, these neurons send axons over virtually the entire brain and spinal cord and therefore constitute a unique central orexinergic system. It is well known that central orexin plays a crucial role in the regulation of various basic non-somatic and somatic physiological functions, including feeding, energy homeostasis, the sleep/wake cycle, reward, addiction, and neuroendocrine, as well as motor control. Moreover, the absence of orexin results in narcolepsy-cataplexy, a simultaneous somatic and non-somatic dysfunction. In this review, we summarize these central functions of the orexinergic system and associated diseases, and suggest that this system may hold a key position in somatic-non-somatic integration.
