Characteristics of brainstem auditory evoked potentials of students studying folk dance

BACKGROUND: Previous experiments have demonstrated that brainstem auditory evoked potential is affected by exercise,exercise duration,and frequency. OBJECTIVE: Comparing the brainstem auditory evoked potential of students studying folk dance to students studying other subjects. DESIGN: Observational contrast study. SETTING: Physical Education College,Shandong Normal University PARTICIPANTS: Fifty-five female students were enrolled at Shandong Normal University between September and December in 2005,including 21 students that studied folk dance and 34 students that studied other subjects. The age of the folk dance students averaged (19 ± 1) years and dance training length was (6.0 ± 1.5) years. The students that studied other subjects had never taken part in dance training or other physical training,and their age averaged (22 ± 1) years,body height averaged (162 ± 5) cm,body mass averaged (51 ± 6) kg. All subjects had no prior ear disease or history of other neurological disorders. All students provided informed consent for the experimental project. METHODS: The neural electricity tester,NDI-200 (Shanghai Poseidon Medical Electronic Instrument Factory) was used to examine and record Brainstem Auditory Evoked Potential values of the subjects during silence,as well as to transversally analyze the Brainstem Auditory Evoked Potential values. The electrode positions were cleaned and degreased with soapy water,followed by ethanol. The selected bipolar electrodes were situated on the head: recording electrodes were placed at the Baihui acupoint,and the reference electrode was placed at the mastoid of the measured ear,with grounding electrodes in the center of the forehead. Brainstem Auditory Evoked Potential values were elicited by monaural stimulation of a "click" though an earphone; the other ear was sheltered by the white noise. The click intensity was 102 db,the stimulation frequency was 30 Hz,the bandpass filters were 1 000-3 000 Hz,the sensitivity was 5 μV,and a total of 2 000 sweeps were averaged. Waveform identification and analysis: various components of the Brainstem Auditory Evoked Potential values were identified,and the peak latencies and peak-peak values were analyzed. MAIN OUTCOME MEASURES: Latency of Ⅰ,Ⅱ,Ⅲ,Ⅳ,Ⅴ and Peak-Peak Value of Ⅰ,Ⅲ,Ⅴ were measured. RESULTS: Fifty-five subjects were enrolled in the final analysis,without any loss. Compared to the students who studied other subjects ①Ⅰ-Ⅴ peak latencies (PL): Ⅳ PL of the right ear of the folk dance students was obviously longer (P < 0.05); ②Ⅰ,Ⅲ,Ⅴ peak-peak values: Ⅰ peak-peak values of the right ear were obviously higher (P < 0.05). CONCUSION: ① PL of the right ear of the folk dance students was obviously longer,which indicates that dancing results in a stronger sensibility to auditory stimuli. ②P?eak-peak values were obviously higher,which indicates that long-term exercise enhances the music senses and synchrony of auditory nerve impulses.

Brainstem auditory evoked potentials in patients with delayed encephalopathy after acute carbon monoxide poisoning

Objective:To evaluate the changes of brainstem auditory evoked potential (BAEP) in patients with delayed encephalopathy after acute carbon monoxide poisoning. Methods: BAEPs were performed in 32 controls and 40 patients. Wave Ⅰ , Ⅱ , Ⅲ ,Ⅳ, Ⅴ latencies and Ⅰ-Ⅲ , Ⅲ-Ⅴ , Ⅰ-Ⅴ interpeak latencies were measured, respectively. Results: Abnormalities of BAEPs in 13 patients (13/40, 32 ％). Among the13 abnormal BAEPs, 3 displayed prolongation of latency to waves in one side, no potential in another side; 5 displayed a similar abnormality which was bilateral prolongation of latency to waves ;and another 5 displayed unilateral latency delay. Compared wave Ⅰ , Ⅱ , Ⅲ , Ⅳ, Ⅴ latencies and Ⅰ-Ⅲ , Ⅲ-Ⅴ , Ⅰ-Ⅴ interpeak latencies in the patients and the controls, there were no significant differences (P＞0.05). Conclusion: BAEPs can be used for evaluating the diagnostic and prognostic values in the cases of delayed encephalopathy after acute carbon monoxide poisoning.

Characteristics of brainstem auditory evoked potential of neonates with mild or moderate hyperbilirubinemia

BACKGROUND:Brainstem auditory evoked potential(BAEP) has been widely used to evaluate the functional integrity and development of injured auditory system and brain,especially to objectively evaluate the function of auditory system and brain stem of very young babies,such as neonates and sick babies. OBJECTIVE:To observe the changes of BAEP of neonates with hyperbilirubinemia,and to investigate the relationship of bilirubin concentration and BAEP. DESIGN:An observation experiment. SETTING:Department of Pediatrics,the 309 Clinical Division,General Hospital of Chinese PLA. PARTICIPANTS:Fifty-eight neonates with mild or moderate hyperbilirubinemia exhibiting jaundice within 24 hours after born,who received the treatment in the Department of Pediatrics,the 309 Clinical Division,General Hospital of Chinese PLA between January 2004 and May 2007,were recruited in this study. The involved neonates,31 boys and 27 girls,had gestational age of 37 to 46 weeks. They had no history of birth asphyxia,and were scored 8 to 10 points when born. Written informed consents of examination and treatment were obtained from the guardians of the neonates. This study was approved by the Hospital Ethics Committee. According to serum total bilirubin value,the neonates were assigned into 3 groups:low-concentration bilirubin group(n =16),moderate-concentration bilirubin group(n =27) and high-concentration bilirubin group(n =15). According to mean daily bilirubin increase,the subjects were sub-assigned into bilirubin rapid increase group(n =39) and bilirubin slow increase group(n =19). METHODS:After admission,all the neonates received drug treatment. Meanwhile,their 116 ears were examined with a myoelectricity evoked potential equipment(KEYPOINT) in latency,wave duration,amplitude and wave shape differentiation of each wave of BAEP. BAEP abnormal type was observed and abnormal rate of BAEP was calculated. MAIN OUTCOME MEASURES:① Abnormal rate and abnormal type of BAEP. ② Latency of waves Ⅰ,Ⅲ and Ⅴ,and wave duration of waves Ⅰ to Ⅲ,Ⅲ to Ⅴ,and Ⅰ to Ⅴ. RESULTS:Fifty-eight neonates with mild or moderate hyperbilirubinemia were involved in the final analysis. ①Abnormal type and abnormal rate of BAEP of neonates with hyperbilirubinemia:Among the 116 ears,unilateral or bilateral waves Ⅰ,Ⅲ,Ⅴ still existed. The latency of waves Ⅰ,Ⅲ and Ⅴ was +2.5 s longer than the normal level in 8,4 and 15 ears,respectively. The wave duration of waves Ⅰ to Ⅲ and waves Ⅲ to Ⅴ was +2.5 s longer than the normal level in 6 and 14 ears,respectively. The wave duration of waves Ⅲ to Ⅴ was longer than that of ipsilateral waves Ⅰ to Ⅲ in 24 ears. The latency difference of wave Ⅴ between two ears was larger than 0.4 ms in 31 neonates with hyperbilirubinemia;The amplitude of wave Ⅴ to that of ipsilateral wave I was lower than 0.5 in 29 neonates. Totally 52 ears were abnormal,and the abnormal rate was 44.8%. One to two months later,98% abnormal neonates with hyperbilirubinemia recovered. The abnormal rate in the low-,moderate-,and high-concentration bilirubin groups was 37.5%,44.4% and 53.3%,respectively. ② Comparison of latency and wave duration of each wave of BAEP:Latency of waves Ⅰ,Ⅲ and Ⅴ,and wave duration of waves Ⅰ to Ⅲ and Ⅲ to Ⅴ were gradually prolonged in low-,moderate-,and high-concentration bilirubin groups,but significant difference did not exist between two groups(P > 0.05). ③ There were no significant differences in latency of waves Ⅰ,Ⅲ and Ⅴ,and wave duration of waves Ⅰ to Ⅲ,Ⅲ to Ⅴ and Ⅰ to Ⅴ between bilirubin rapid increase group and bilirubin slow increase group(P > 0.05). CONCLUSION:Auditory acuity and brainstem of neonates with mild or moderate hyperbilirubinemia are damaged to some extent. High-concentration bilirubin causes BAEP abnormality easily. Bilirubin increase and its concentration change are not consistent with nervous lesion degree.

Electroencephalogram and brainstem auditory evoked potential in 539 patients with central coordination disorder

BACKGROUND: Electroencephalogram (EEG) and brainstem auditory evoked potential (BAEP) are objective non-invasive means of measuring brain electrophysiology. OBJECTIVE: To analyze the value of EEG and BAEP in early diagnosis, treatment and prognostic evaluation of central coordination disorder. DESIGN, TIME AND SETTING: This case analysis study was performed at the Rehabilitation Center of Hunan Children’s Hospital from January 2002 to January 2006. PARTICIPANTS: A total of 593 patients with severe central coordination disorder, comprising 455 boys and 138 girls, aged 1–6 months were enrolled for this study. METHODS: EEG was monitored using electroencephalography. BAEP was recorded using a Keypoint electromyogram device. Intelligence was tested by professionals using the Gesell scale. MAIN OUTCOME MEASURES: (1) The rate of abnormal EEG and BAEP, (2) correlation of abnormalities of EEG and BAEP with associated injuries, (3) correlation of abnormalities of EEG and BAEP with high risk factors. RESULTS: The rate of abnormal EEG was 68.6% (407/593 patients), and was increased in patients who also had mental retardation (P < 0.05). The rate of abnormal BAEP was 21.4% (127/593 patients). These 127 patients included 67 patients (52.8%) with peripheral auditory damage and 60 patients (47.2%) with central and mixed auditory damage. The rate of abnormal BAEP was significantly increased in patients who also had mental retardation (P < 0.01). Logistic regression analysis showed that asphyxia (P < 0.05), jaundice, preterm delivery, low birth weight and the umbilical cord around the neck were closely correlated with abnormal EEG in patients with central coordination disorder. Intracranial hemorrhage, jaundice (P < 0.05), low birth weight and intrauterine infection (P < 0.05) were closely correlated with abnormal BAEP in patients with central coordination disorder. CONCLUSION: Central coordination disorder is often associated with abnormal EEG and BAEP. The rate of EEG or BAEP abnormality is positively associated with the size of the brain injury. Asphyxia is a high risk factor for abnormal EEG in central coordination disorder. Jaundice and intrauterine infection are high risk factors for abnormal BAEP in central coordination disorder.

Otoacoustic Emissions and Evoked Potentials in Infants after Breast-Feeding Jaundice——Hearing Dysfunction in Breast-Feeding Jaundice

We study hearing in a group of infants with Breast-feeding jaundice (BFJ) by means of Transient-evoked otoacoustic emissions (T-EOE) and Brainstem auditory evoked potentials (BAEP) searching for relationship between bilirubin serum levels and auditory dysfunction. Eleven infants born at-term with BFJ were selected for the study. We studied also 11 control age- and gender matched healthy at-term infants without signs of jaundice. T-EOAE studies were performed between 5-7 days after birth, and 3 months later. BAEP studies were performed once. BFJ group infants exhibited lower amplitudes in T-EOE than infants in the control group. These differences disappear at the 3-month evaluation. In BAEP, we observed a significant latency delay of waves I and V in Breast-feeding jaundice group infants. All infants in both groups demonstrated reproducible wave V response at 30 decibels. No significant correlation values were observed between bilirubin serum levels and T-EOE and BAEP variables. Our data suggest that BFJ can result in transient peripheral and central auditory dysfunction. Dysfunction is reversible after treatment of infants with BFJ.

Dysfunction of the peripheral and central auditory pathway in patients with type 1 diabetes mellitus

Although auditory alterations are not a typical symptom of diabetes mellitus (DM), they can occur in patients with type 1 DM. The findings of previous studies are controversial, because the frequency and degree of hearing loss varies, and quite often alterations are still subclinical. The typical test used to detect and manage hearing loss is the audiogram, but this test alone is only capable of detecting alterations due to injury of the inner hair cells and/or alterations in the central auditory pathway. However, auditory alterations resulting from a dysfunction that is still subclinical are only able to be detected through electrophysiological auditory tests, such as the otoacoustic emissions (OAE) and the auditory brainstem response (ABR) tests. Thus, the purpose of this paper is to review the studies that utilize the OAE and ABR tests, and to verify if the dysfunction is cochlear and/or neural in patients with type 1 DM. The findings of this review demonstrate that patients with type 1 DM can have auditory alterations stemming from a central cochlear origin. Following this finding, early diagnosis is very important in order to implement preventative treatments and initiate therapy.

The effect of lead on brainstem auditory evoked potentials in children

To determine whether lead affects brainstem auditory evoked potentials (BAEPs) in low-to-moderate lead exposed children Methods BAEPs were recorded from 114 asymptomatic children aged 1-6 years Average values were calculated for peak latency (PL) and amplitude (Amp) Whole blood lead (PbB) levels were assessed by graphite furnace atomic absorption spectroscopy Based on their PbB levels, subjects were divided into low lead (PbB<100 μg/L) and high lead subgroups (PbB ≥100 μg/L) Results The PbB levels of the 114 subjects ranged from 32 0 to 380 0 μg/L in a positively skewed distribution The median of PbB levels was 90 0 μg/L while the arithmetic average was 88 0 μg/L Of the subjects, 43 0% (49/114) had levels equal to or greater than 100 μg/L Bilateral PLs Ⅰ, Ⅴ, and Ⅲ of the left ear in the high lead subgroup were significantly longer than those in the low lead subgroup (P<0 05) A positive correlation was found between PbB levels and bilateral PLs Ⅰ, Ⅴ and Ⅲ of the left ear (P<0 05), after controlling for age and gender as confounding factors A significant and positive correlation between PbB levels and PL Ⅰ of the left ear, even when PbB levels were lower than 100 μg/L, in the low subgroup (r=0 295, P=0 019) was also found Conclusions Lead poisoning in children younger than 6 years old is a very serious problem to which close attention should be paid The indications that lead prolongs partial PLs may imply that lead, even at PbB levels lower than 100 μg/L, impairs both the peripheral and the central portions of the auditory system BAEPs may be a sensitive detector of subclinical lead exposure effects on the nervous system in

脑电图结果和脑干听觉诱发电位与急性脑干梗死患者吞咽功能障碍的关系探讨

目的:探讨急性脑干梗死患者吞咽功能障碍与脑电图结果和脑干听觉诱发电位之间的关系。方法:将2021年1月—2023年4月在厦门市仙岳医院接受治疗的80例急性脑干梗死患者纳入为观察组,并选取同期健康体检者80例纳入为对照组,纳入的160例研究对象均接受脑电图及脑干听觉诱发电位检查。分析两组脑干听觉诱发电位、脑电图检查异常率并进行组间比较;比较不同脑干听觉诱发电位表现的脑梗死患者吞咽困难及预后情况;比较不同脑电图表现的脑梗死患者吞咽困难及预后情况;比较不同预后情况的脑梗死患者脑干听觉诱发电位检查Ⅰ波、Ⅲ波、Ⅴ波、Ⅰ-Ⅲ波、Ⅲ-Ⅴ波。结果:观察组脑电图和脑干听觉诱发电位异常率均高于对照组(P<0.05)。与脑干听觉诱发电位异常患者比较,正常患者改良Rankin量表问卷(mRS)预后良好、吞咽困难情况较轻(P<0.05);与脑电图异常患者比较,正常患者吞咽困难情况较轻(P<0.05)。脑干听觉诱发电位检查预后良好患者Ⅰ波、Ⅲ波、Ⅴ波、Ⅰ-Ⅲ波、Ⅲ-Ⅴ波均低于预后不良患者(P<0.05)。结论:脑电图和脑干听觉诱发电位检查异常患者的预后情况较差,吞咽功能障碍情况较为严重。

脑干听觉诱发电位在孤独症谱系障碍患儿中的特征分析

目的:分析脑干听觉诱发电位(BAEP)在孤独症谱系障碍(ASD)患儿中的特征。方法:选取2020年1月—2023年1月厦门市仙岳医院收治的100例ASD患儿为观察组,另取同期体检健康儿童26例为对照组,对其BAEP检测结果进行统计。对观察组实施听觉统合训练,观察干预效果。结果:两组Ⅰ波与Ⅲ波潜伏期比较,差异无统计学意义(P>0.05),观察组Ⅴ波潜伏期长于对照组,差异有统计学意义(P<0.05)。两组Ⅰ波、Ⅲ波波间差比较,差异无统计学意义(P>0.05),观察组Ⅲ波、Ⅴ波,Ⅰ波、Ⅴ波波间差均大于对照组,差异有统计学意义(P<0.05)。治疗后2周、1个月,异常组孤独症治疗评定量表(ATEC)评分均低于非异常组,差异有统计学意义(P<0.05)。治疗前和治疗后2周,异常组儿童孤独症评定量表(CARS)评分均低于非异常组,差异有统计学意义(P<0.05);异常组治疗前和治疗后2周CARS评分差值均大于非异常组,差异有统计学意义(P<0.05)。结论:BAEP检测能够为ASD患儿诊断提供依据,且听觉统合训练对于BAEP异常患儿症状改善更为显著。

Combined monitoring of evoked potentials during microsurgery for lesions adjacent to the brainstem and intracranial aneurysms

在外科期间监视的背景 Neurophysiologic 是阻止永久神经病学的损害源于外科的操作。改进 intraoperative neuromonitoring 的精确性和敏感， transcranial 监视电的刺激马达联合唤起了潜力( TES-MEPs )， somatosensory 唤起了潜力( SSEP )和 brainstem 听觉的唤起的潜力( BAEP )为邻近与 SSEP 联合 TES-MEPs 监视的 brainstem 和 intracranial aneurysms.Methods 的损害在 microsurgery 被尝试象 intracranial 一样与邻近 brainstem 的损害在 68 个连续病人被尝试一在他们之中， 31 个病人(31 个手术， 28 个以后的头部的窝肿瘤， 3 个以后的发行量动脉瘤) 也受到 BAEP 监视。监视结果和临床的结果的关联是 68 个病人的唤起的潜力(EP ) 监视联合在 64 被做的学习 prospectively.Results (94.1%) 。监视的 MEP 为 4 个病人(5.9%) 是不可能的。没有复杂并发症在在所有病人监视联合期间被观察。(66.2%) 在 45， 68 个病人，， EP 是稳定的，并且他们是神经病学地未经触动的。马达机能障碍被 MEP 在 4 在 8 个病人，在 5 的 SSEP ，和 BAEP 检测， respectively.Conclusions A 结束关系在手术后的马达功能之间存在， TES-MEPs monitoring.TES-MEPs 的结果在检测马达机能障碍，而是联合 EP 比 SSEP 和 BAEP 优异用作一只保险箱，为马达神经系统的功能监视的 intraoperative 的有效、侵略的方法。为邻近 brainstem 和 intracranial 动脉瘤的损害在 microsurgery 期间联合 EP 监视可以检测潜在地危险的演习并且改进随后的过程的安全。

Brainstem auditory evoked potential combined with high resolution cranial base CT can optimize the diagnosis of auditory nerve injury

Purpose:Auditory nerve injury is one of the most common nerve injury complications of skull base fractures.However,there is currently a lack of auxiliary examination methods for its direct diagnosis.The purpose of this study was to find a more efficient and accurate means of diagnosis for auditory nerve injury.Methods:Through retrospectively analyzing the results of brainstem auditory evoked potential(BAEP)and high-resolution CT(HRCT)in 37 patients with hearing impairment following trauma from January 1,2018 to July 31,2020,the role of the two inspection methods in the diagnosis of auditory nerve injury was studied.Inclusion criteria were patient had a clear history of trauma and unilateral hearing impairment after trauma;while exclusion criteria were:(1)severe patient with a Glasgow coma scale score<5 because these patients were classified as severe head injury and admitted to the intensive care unit,(2)patient in the subacute stage admitted 72 h after trauma,and(3)patient with prior hearing impairment before trauma.According to Goodman's classification of hearing impairment,the patients were divided into low/medium/severe injury groups.In addition,patients were divided into HRCT-positive and negative groups for further investigation with their BAEP results.The positive rates of BEAP for each group were observed,and the results were analyzed by Chi-square test(p<0.05,regarded as statistical difference).Results:A total of 37 patients were included,including 21 males and 16 females.All of them were hospitalized patients with GCS score of 6-15 at the time of admission.The BAEP positive rate in the medium and severe injury group was 100%,which was significantly higher than that in the low injury group(27.27%)(p<0.01).The rate of BEAP positivity was significantly higher in the HRCT-positive group(20/30,66.7%)than in the HRCT-negative group(1/7,14.3%)(p<0.05).Twenty patients(54.05%)were both positive for BEAP and HRCT test,and considered to have auditory nerve damage.Six patients(16.22%)were both negative for BEAP and HRCT test,and 10 patients(27.03%)were BAEP-negative but HRCT-positive:all the 16 patients were considered as non-neurological injury.The rest 1 case(2.70%)was BAEP-positive but HRCT-negative,which we speculate may have auditory nerve concussion.Conclusion:By way of BAEP combining with skull base HRCT,we may improve the accuracy of the diagnosis of auditory nerve injury.Such a diagnostic strategy may be beneficial to guiding treatment plans and evaluating prognosis.

电生理测试在力声特人工耳蜗调试中的应用

目的分析电镫骨肌反射阈值(electrically evoked stapedius reflex threshold,ESRT)、电刺激听性脑干反应(electrically evoked auditory brainstem response,EABR)阈值、电刺激听神经复合动作电位(electrically evoked auditory nerve compound action potentials,ECAP)阈值与人工耳蜗心理物理量测试中的最大舒适阈值(maximum comfort threshold,C值)及最小反应阈值(minimum response threshold,T值)之间的关系,为力声特人工耳蜗植入者调试时参数设置提供参考。方法选择14例具有一定响度辨别经验及言语交流能力且配合良好的语后聋力声特人工耳蜗植入者,平均年龄22.47±13.37岁,植入体型号为LCI-20PI。在每个患者开机后6±1个月时,选取人工耳蜗低频(1号)、中频(11号)、高频(19号)区域电极各一个,分别测试其T值、C值、ESRT、EABR及ECAP阈值,并进行相关性分析。结果1、11及19号电极ESRT引出率均为100%;EABR阈值引出率分别为100%、100%、78.57%;ECAP阈值引出率分别为100%、100%、71.43%。各电极ESRT与C值均存在显著相关性(P<0.05),相关系数分别为0.76、0.73、0.70,与T值均没有显著相关性(P>0.05)。各电极EABR阈值、ECAP阈值与T值、C值均无显著相关性(P>0.05)。结论ESRT可以作为力声特人工耳蜗植入者调试中C值设置的首选参考指标。

恢复期脑干听觉诱发电位对儿童严重意识障碍预后的预测价值研究

目的探讨恢复期脑干听觉诱发电位(BAEP)对各种获得性脑损伤(创伤、感染、缺氧等)所致的儿童严重意识障碍(DOC)预后的预测价值。方法对2013年7月至2021年12月在该院首次接受康复治疗并完成BAEP检查的228例DOC患儿的预后进行回顾性研究。结果缺氧缺血性脑损伤组患儿BAEP的Ⅴ波均保留;在创伤性脑损伤、颅内感染、其他病因组中,双侧V波存在的患儿病程3个月时的意识恢复率和1年时的功能结局良好率并未高于单/双侧V波缺失患儿,差异均无统计学意义(P>0.05);多因素logistic回归分析显示,V波存在与否对病程1年时功能结局的影响差异无统计学意义(OR=0.916,95%CI 0.542~1.549,P>0.05)。结论恢复期BAEP并未显示对各种获得性病因所致的DOC患儿近期(病程3个月)及远期(病程1年)预后预测的价值。

A research on the largest Lyapunov exponent of BAEP time series

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新生儿ABO血型不合溶血病和G6PD致高胆红素血症患儿脑干听觉诱发电位筛查及其临床意义

目的探讨新生儿ABO血型不合溶血病和红细胞内葡萄糖-6-磷酸脱氢酶缺乏症(G6PD)致高胆红素血症患儿脑干听觉诱发电位筛查的临床意义。方法选取2017年4月—2022年3月海南省人民医院收治的151例ABO血型不合溶血病和G6PD致高胆红素血症患儿为研究对象。所有患儿入院后均行脑干听觉诱发电位筛查,记录其Ⅴ波潜伏期耳间差值(ILD)。分析研究组不同病情严重程度患儿Ⅴ波ILD情况,分析影响ABO血型不合溶血病和G6PD致高胆红素血症患儿听力损伤的因素,Ⅴ波ILD诊断ABO血型不合溶血病和G6PD致高胆红素血症患儿听力情况的价值。结果重症组脑干听觉诱发电位Ⅴ波ILD高于轻症组(P<0.05)。多因素Logistic回归分析显示:酸中毒[O^R=4.943(95%CI:2.034,12.013)]、TSB[O^R=5.078(95%CI:2.090,12.342)]、UCB[O^R=5.109(95%CI:2.102,12.417)]、Ⅴ波ILD[O^R=4.614(95%CI:1.898,11.212)]是影响ABO血型不合溶血病和G6PD致高胆红素血症患儿听力的影响因素(P<0.05)。ROC曲线分析结果显示,脑干听觉诱发电位Ⅴ波ILD诊断ABO血型不合溶血病和G6PD致高胆红素血症患儿听力损伤的敏感性为73.33%(95%CI:0.538,0.870),特异性为84.30%(95%CI:0.763,0.901),AUC为0.820(95%CI:0.725,0.915)。结论ABO血型不合溶血病和G6PD致高胆红素血症患儿病情与脑干听觉诱发电位筛查的Ⅴ波ILD有关,Ⅴ波ILD诊断患儿听力损伤效能良好。

脑干听觉诱发电位在孤独症谱系障碍患儿早期诊断中的应用

目的 探讨脑干听觉诱发电位(BAEP)在孤独症谱系障碍(ASD)患儿中的特征。方法 回顾性分析20例2~5岁诊断为ASD的患儿(ASD组)的BAEP检测结果,与20例同龄正常儿童(对照组)的BEAP结果相比较。结果 BAEP结果显示,ASD组患儿Ⅰ波、Ⅲ波潜伏时与对照组相比,差异无统计学意义(P>0.05),Ⅴ波潜伏时较对照组延长,差异有统计学意义(P<0.05);ASD组患儿Ⅰ~Ⅲ波间差与对照组相比,差异无统计学意义(P>0.05),Ⅲ~Ⅴ波间差及Ⅰ~Ⅴ波间差较对照组延长,差异有统计学意义(P<0.05)。结论 ASD患儿较正常儿童V波潜伏时延长,Ⅲ~Ⅴ波间差及Ⅰ~Ⅴ波间差延长,表明ASD患儿存在脑干传导通路异常,BAEP在ASD患儿的早期诊断中有一定意义,可能适合作为ASD患儿早期诊断的一项客观检查指标。

脑梗死继发癫痫患者脑干听觉诱发电位与脑血流量相关性及意义

目的 探究脑梗死继发癫痫患者脑干听觉诱发电位(brainstem auditory e-voked potential,BAEP)与脑血流量(cerebral blood flow,CBF)相关性及意义。方法 选取脑梗死继发癫痫患者80例作为研究组,另选同期脑梗死未继发癫痫患者80例作为对照组。比较2组入院时一般资料、CBF、血清脂蛋白相关磷脂酶A2(lipoprotein-associated phospholipase A2,Lp-PLA2)、神经元烯醇化酶(neuronal-specific enolase,NSE)水平及BAEP评分,分析脑梗死继发癫痫患者BAEP评分与CBF、血清Lp-PLA2、NSE水平的相关性,并比较研究组不同癫痫特征(发作类型、放电类型、放电部位)患者BAEP评分,分析BAEP评分与脑梗死继发癫痫发作特征的相关性,通过受试者工作特征(receiver operating characteristic,ROC)曲线分析BAEP评分、CBF、Lp-PLA2、NSE预测脑梗死继发癫痫的价值。结果 研究组CBF低于对照组,血清Lp-PLA2、NSE水平及BAEP评分均高于对照组(P<0.05);研究组BAEP评分与CBF呈负相关,与血清Lp-PLA2、NSE水平呈正相关(P<0.05);研究组癫痫全面发作患者BAEP评分高于部分发作患者,多灶性放电患者BAEP评分高于局灶性放电患者(P<0.05);BAEP评分与脑梗死继发癫痫发作类型、放电类型呈正相关(P<0.05);BAEP评分、CBF、Lp-PLA2、NSE预测脑梗死继发癫痫的曲线下面积(area under the curve,AUC)均>0.7,其中BAEP评分联合CBF、Lp-PLA2、NSE预测的AUC最大,为0.928(95%CI:0.876~0.963)。结论 脑梗死继发癫痫患者BAEP与CBF及血清Lp-PLA2、NSE水平密切相关,各指标联合在预测脑梗死继发癫痫方面具有较高预测效能。

重复经颅磁刺激结合舌压抗阻反馈训练对脑出血术后吞咽功能障碍患者脑干听觉诱发电位及误吸风险的影响

目的探讨重复经颅磁刺激结合舌压抗阻反馈训练在脑出血术后吞咽功能障碍患者中的应用效果。方法选择2019年7月至2021年8月我院收治的80例脑出血术后吞咽功能障碍患者,根据干预方案不同将其分为对照组、观察组,各40例。对照组接受舌压抗阻反馈训练,观察组在对照组干预方案基础上加施重复经颅磁刺激。比较两组的干预效果。结果干预后,观察组的脑干听觉诱发电位(BAEP)Ⅰ波、Ⅲ波、Ⅴ波潜伏期均短于对照组(P<0.05)。干预后,观察组的渗透-误吸量表(PAS)等级分布优于对照组(P<0.05)。干预后,观察组的功能性经口摄食量表(FOIS)评分高于对照组,标准吞咽功能评估量表(SSA)评分低于对照组(P<0.05)。结论重复经颅磁刺激结合舌压抗阻反馈训练可改善脑出血术后吞咽功能障碍患者BAEP及吞咽功能,减少误吸的发生风险。

语言发育迟缓儿童听力评估模式的探讨

目的探讨自动听性脑干反应(AABR)与畸变产物耳声发射(DPOAE)联合检测模式在语言发育迟缓儿童听力评估中的应用价值。方法2022年1~10月在上海市儿童医院初诊为语言发育迟缓的470例儿童,随机分为诊断组与筛查组。诊断组235例患儿,应用听性脑干反应(ABR)行听力诊断评估。筛查组235例患儿,应用DPOAE+AABR先行听力筛查评估,后行ABR检测。将两组听力评估的结果及测试时间进行比较分析。结果筛查组235例(470耳)患儿中,听力筛查阳性率为7.45%(35/470)。确诊听力障碍16例(31耳),听力诊断阳性率为6.60%(31/470)。以ABR结果为标准,AABR联合DPOAE的灵敏度为100%(31/31),特异度为99.01%(435/439)。在诊断组235例(470耳)患儿中,听力诊断阳性率为5.53%(26/470)。将两组评估模式结果进行比较,组间筛查阳性率与诊断阳性率无显著差异性(χ^(2)=1.420,P=0.233)。将两组测试时间比较,诊断组ABR测试时间(39.02±3.52)min显著高于筛查组DPOAE和AABR(8.40±2.03)min(P<0.001)。结论AABR+DPOAE联合筛查模式能可靠的评估语言发育迟缓儿童的听觉能力,可高效筛选出需进入诊断程序的患儿,进一步优化语言发育迟缓患儿的听力评估流程,使患儿尽早明确病因,早期康复。

脑干听觉诱发电位在意识障碍康复中应用的研究进展

脑干听觉诱发电位(brain-stem auditory evoked potentials,BAEP)可用于无法主动进行检查的患者,给无法交流的意识障碍(disorders of consciousness,DOC)患者提出较为客观的检查依据,并评估患者的意识水平。单独用BAEP预测DOC患者的预后有一定局限性。利用BAEP预测DOC患者的预后应考虑病变部位及致病因素的影响,且联合多模态的评估手段可提高预测的准确性。BAEP因操作简单、可重复性强,相较于影像学检查无电离辐射,可作为一种疗效评估手段动态监测DOC患者的意识变化,还能评估DOC患者的康复效果,尤其是与行为学评估、血清标记物、其他神经电生理技术联合使用其准确性更高,可靠性更好,是DOC诊断及预后评估的一种补充手段。