Trends in oxycodone and oxycodone-containing analgesics administration for back pain in emergency departments in the USA(2007–2018)

BACKGROUND:To describe trends in oxycodone and oxycodone-containing analgesic prescribing for the treatment of back pain among adults in emergency departments(EDs) in the USA from 2007 to 2018.METHODS:Data were gathered from the National Hospital Ambulatory Medical Care Survey(NHAMCS) from 2007 to 2018.The study population included individuals of all ages presenting to USA EDs.The NHAMCS reasons for visit and oxycodone drug ID codes were used to isolate patients with back pain.The main outcome was the proportion of oxycodone and oxycodone-containing analgesics prescribed for back pain in the EDs over the specified time period.RESULTS:There was a relative decrease in the overall administration of oxycodone for back pain in the EDs by 62.3% from 2007(244,000 visits) to 2018(92,000 visits).The proportion of ED patients prescribed with oxycodone-containing analgesics for back pain increased among patients aged 45 years and older(from 43.8% to 57.6%),female patients(from 54.5% to 62.0%),black patients(from 22.5% to 30.4%),and Hispanic/Latino patients(from 9.4% to 19.6%).Oxycodone/acetaminophen was most prescribed and accounted for 90.2% of all oxycodone-containing analgesics in 2007,with a decrease to 68.5% in 2018.Pure oxycodone was the second most prescribed medication,accounting for 6.1% in 2007 and 31.5% in 2018.CONCLUSION:The overall number of oxycodone-containing analgesics decreased significantly from 2007 to 2018.However,that number trended upward in 45-year-old and older,female,black,or Hispanic/Latino patients from 2007 to 2018.The total amount of pure oxycodone increased significantly from 2007 to 2008.

Effects of Slow-release Nitrogen on Dry Matter Accumulation,Translocation and Yield of Summer Maize

[Objectives]This study was conducted to investigate the effects of slow-release nitrogen fertilizer on dry matter accumulation and translocation of summer maize.[Methods]With Zhoudan 9 as the test variety,six different treatment were set up:blank control(CK1),slow-release urea 75 kg/hm^(2)(C1),slow-release urea 150 kg/hm^(2)(C2),slow-release urea 225 kg/hm^(2)(C3),slow-release urea 300 kg/hm^(2)(C4)and ordinary urea 300 kg/hm^(2)(CK2),to study the change law of dry matter accumulation and translocation in summer maize.[Results]Treatment slow-release urea 225 kg/hm^(2)(C4)showed summer maize yield,dry matter translocation between organs,grain contribution rate and proportion of grain dry matter in the full ripe stage higher than other treatments.Considering the weight loss and cost factors,slow-release urea 225 kg/hm^(2)(C3)could be recommended as the fertilizing amount for summer maize.[Conclusions]This study provides theoretical reference for rational selection of fertilizers for reducing fertilizer application and increasing fertilizer efficiency,and for production of summer maize in Shajiang black soil region.

Effects of Slow-release Nitrogen Fertilizer on Yield and Nitrogen Accumulation of Summer Maize in Shajiang Black Soil Area

[Objectives] This study was conducted to verify the field application effect of slow-release nitrogen fertilizer on summer maize in Shajiang black soil area by simultaneous sowing and fertilization, and explore the application scope and nitrogen metabolism mechanism, so as to lay a foundation for fertilizer reduction and efficiency improvement. [Methods] With maize variety Beiqing 340 and sulfur-coated urea as experimental materials, five nitrogen application levels were set, namely, control (C0), slow-release nitrogen 70 kg/hm^(2) (C70), slow-release nitrogen 140 kg/hm^(2) (C140), slow-release nitrogen 210 kg/hm^(2) (C210) and slow-release nitrogen 280 kg/hm^(2) (C280). The phosphorus and potassium fertilizers were all in accordance with the unified standard. [Results] With the application rate of slow-release nitrogen increasing, the nitrogen accumulation in organs increased first and then decreased after tasseling stage of maize. In order to reduce the fertilizing amount and increase efficiency, 210 kg/hm^(2) of slow-release nitrogen fertilizer was the best fertilizing amount for summer maize in Shajiang black soil area. [Conclusions] This study provides reference for fertilizer reduction, efficiency improvement and sustainable development of summer maize in Shajiang black soil area.

Effects of Slow-release Fertilizer and Balanced Fertilization on Nitrogen, Phosphorus and Potassium Uptake in Peppers

Field plot experiment was conducted to study the effects of two slow-re- lease fertilizers and balanced fertilization on dry matter accumulation, yield, fertilizer use efficiency, nitrogen, phosphorus and potassium uptake of peppers at Jiangna Town, Yanshan County, Yunnan Province in 2011. The results showed that the dry matter accumulation in dried pepper plant, pepper yield, nitrogen, phosphorus, potassium uptake in peppers were significantly increased in all the fertilizer treat- ments, compared with those in control （no fertilizer）. Compared with conventional fertilization, balanced fertilization, slow-release compound fertilizer and slow-release urea fertilizer significantly increased dried pepper economic output by 20.94%, 17.5% and 14.54%, nitrogen uptake in dried peppers by 21.53%,18.46% and 13.19%, phosphorus uptake in dried peppers by 14.08%, 15.76% and 10.44%, potassium uptake in dried peppers by 22.66%, 15.73% and 16.28%; they also in- creased nitrogen and potassium use efficiency, but reduced potassium use efficiency due to the increased potassium addition. In treatments with balanced fertilization, slow-release compound fertilizer and slow-release urea fertilizer, the nitrogen utiliza- tion was 5.84%, 7.14% and 8.33% higher and the phosphorus utilization was 3.32%, 3.27% and 2.47% higher than those in treatment with conventional fertiliza- tion. In addition, the nitrogen application could be reduced by 20%-50% by bal- anced fertilization and the two slow-release fertilizers, thereby reducing environmen- tal pollution. Slow-release fertilizers could also reduce the frequency of fertilization and labor costs.

Effects of Soil Nitrate Nitrogen Residues and Leaching for Different Kinds of Slow-release Nitrogen Fertilizers in Tall-fescue Soil

ObjectiveThe aim was to explore the movement of nitrate nitrogen in tall-fescue soils by different kinds of slow release nitrogen fertilizers. MethodBased on infiltration-tanks and test plots, a new and environment friendly fertilizer was explored. ResultThe results show that compared with urea treatment, slow-release nitrogen fertilizer treatments could reduce nitrate nitrogen content and leaching amount in soils. Compared with PCU30 and IU treatments, the PCU60 treatment became more efficient in reducing nitrate content and leaching amount in 0-90 cm soil layer. ConclusionIn summary, slow-release nitrogen fertilizer, which can reduce soil nitrate content and leaching losses, is a kind of novel fertilizer with high environmental benefit and promising application.

Preliminary Report on Application Effects of Slow-release Formula Fertilizer in Tea Plants

In order to accelerate the construction of green production mode for tea in Hubei Province, improve the yield of tea and use efficiency of fertilizers, and improve the quality of tea, application effects of special slow-release formula fertilizer in tea plants were investigated in Wuhan. The results showed that compared with conventional fertilization, application of tea plant-specific slow-release formula fertilizer improved the yield of tea by more than 30%. The amino acid content in tea was increased by 21.05% and 30.82%, respectively, and the income was increased 27 696 （33.88%） and 27 624 （33.79%） yuan/hm2, respectively.

Comparison of Nutrient Release Characteristics from Coated Controlled/Slow-release Fertilizers

[Objective] The study aimed at comparing the characteristics of nutrient release from coated controlled/slow-release fertilizers,so as to provide theoretical reference for improving the farming practice and fertilizer application,reducing pollution in Baiyangdian Lake and the surrounding area.[Method] Soil column leaching method was used to study NH4-N and NO3-N leaching characteristics from five kinds of nitrogen fertilizers including three coated controlled/slow-release fertilizers.[Result] Resin and sulfur coated controlled/slow-release urea decreased NH4-N concentration obviously,controlled NO3-N release in early term of experiment,while increased the content of NH4-N ＋ NO3-N in middle-late periods.Compared with that of common urea,the NH4-N of resin and sulfur coated controlled/slow-release urea decreased by 98.5%,98.7% in early period,96.5%,97.4% in middle period,and 59.1%,81.75% in last period.[Conclusion] Resin and sulfur coated controlled/slow-release urea significantly reduced the NH4-N concentration,effectively controlled the NO3-N release in early stage and increased the supply of NO3-N in last period.

Efficacy and safety of controlled-release oxycodone/naloxone versus controlled-release oxycodone in Korean patients with cancer-related pain: a randomized controlled trial

Background: Controlled-release oxycodone/naloxone(OXN-CR) maintains the effect of opioid-induced analgesia through oxycodone while reducing the occurrence rate of opioid-induced constipation through naloxone. The present study was designed to assess the non-inferiority of OXN-CR to controlled-release oxycodone(OX-CR) for the control of cancer-related pain in Korean patients.Methods: In this randomized, open-labeled, parallel-group, phase IV study, we enrolled patients aged 20 years or older with moderate to severe cancer-related pain [numeric rating scale(NRS) pain score ≥4] from seven Korean oncology/hematology centers. Patients in the intention-to-treat(ITT) population were randomized(1:1) to OXNCR or OX-CR groups. OXN-CR was administered starting at 20 mg/10 mg per day and up-titrated to a maximum of80 mg/40 mg per day for 4 weeks, and OX-CR was administered starting at 20 mg/day and up-titrated to a maximum of 80 mg/day for 4 weeks.The primary efficacy endpoint was the change in NRS pain score from baseline to week4, with non-inferiority margin of-1.5. Secondary endpoints included analgesic rescue medication intake, patientreported change in bowel habits, laxative intake, quality of life(QoL), and safety assessments.Results: Of the ITT population comprising 128 patients, 7 with missing primary efficacy data and 4 who violated the eligibility criteria were excluded from the efficacy analysis. At week 4, the mean change in NRS pain scores was not significantly different between the OXN-CR group(n = 58) and the OX-CR group(n = 59)(-1.586 vs.-1.559,P = 0.948). The lower limit of the one-sided 95% confidence interval(-0.776 to 0.830) for the difference exceeded the non-inferiority margin(P < 0.001). The OXN-CR and OX-CR groups did not differ significantly in terms of analgesic rescue medication intake, change in bowel habits, laxative intake, QoL, and safety assessments.Conclusions: OXN-CR was non-inferior to OX-CR in terms of pain reduction after 4 weeks of treatment and had a similar safety profile. Studies in larger populations of Korean patients with cancer-related pain are needed to further investigate the effectiveness of OXN-CR for long-term pain control and constipation alleviation.Trial registration ClinicalTrials.gov NCT01313780, registered March 8。

Advances in the clinical application of oxycodone in the perioperative period

To review the research progress of pure opioid receptor agonist oxycodone.The research progress of oxycodone in terms of pharmacokinetics,pharmacodynamics,adverse reactions,clinical application,combined medication and new progress in clinical application was summarized by referring to the literature.Oxycodone is a semi-synthetic thebaine derivative of opioid alkaloids,and is a pure opioidμandκreceptor agonist.The main action sites are the central nervous system and visceral smooth muscle.Due to its advantages of low adverse reactions,good analgesic effects,and a wide range of safe doses,the drug has been widely used in the control of acute and chronic postoperative pain,as well as malignant and non-malignant pain.Since the end of the 20^(th) century,researchers have begun to formulate antipyretic analgesics,opioid receptor agonists,opioid receptor antagonists,dopamine receptor antagonists and other drugs with oxycodone in different proportions to enhance the analgesic effect.At the same time,it can reduce the dosage of oxycodone and reduce its adverse reactions,so as to achieve the purpose of limiting opioid abuse.With the continuous research on the efficacy and safety of oxycodone in the perioperative period at home and abroad,oxycodone has become the only dual-opioid potent analgesic that can be used in clinical work.

Effect of commercial slow-release urea product on in vitro rumen fermentation and ruminal microbial community using RUSITEC technique

Background:The objectives of this study were to determine the effect of commercial slow-release urea(SRU)on in vitro fermentation characteristics,nutrient digestibility,gas production,microbial protein synthesis and bacterial community using a rumen simulation technique(RUSITEC).The experiment was a completely randomized design with four treatments and four replications of each treatment.Treatments were:control diet(no SRU addition),control diet plus 0.28%SRU(U28),or plus 0.56%SRU(U56),and control diet that was modified substituting a part of soybean meal equivalent to 0.35%SRU(MU35;dry matter[DM]basis).The experiment consisted of 8 d of adaptation and 7 d of data and sample collection.Rumen inoculum was obtained from three ruminally fistulated Angus cows fed the same diet to the substrate incubated.Results:Digestibility of DM,organic matter(OM),crude protein(CP),fibre and starch was not affected,but daily production of gas(P<0.07)and methane(P<0.05)was quadratically increased with increasing SRU supplementation.The increase of SRU addition did not affect fermentation pH and total volatile fatty acid(VFA)production,whereas linearly(P<0.01)decreased proportion of propionate,and linearly(P<0.01)increased acetate to propionate ratio and ammonia nitrogen(N)concentration.The microbial N efficiency was also linearly(P<0.03)improved with increasing supplementation of SRU.In comparison with control diet,the dietary substitution of SRU for part of soybean meal increased(P<0.05)the digestibility of DM,OM and CP and decreased(P<0.02)the total gas production.The total VFA production and acetate to propionate ratio did not differ between control and MU35,whereas the proportion of butyrate was lower(P<0.05)and that of branched-chain VFA was greater(P<0.05)with MU35 than control diet.Total and liquid-associated microbial N production as well as ammonia N concentration were greater(P<0.03)with MU35 than control diet.Observed operational taxonomic units(OTUs),Shannon diversity index,and beta diversity of the microbial community did not differ among treatments.Taxonomic analysis revealed no effect of adding SRU on the relative abundance of bacteria at the phylum level,while at the genus level,the beneficial impact of SRU on relative abundance of Rikenellaceae and Prevotellaceae in feed particleassociated bacteria,and the abundance of Roseburia in liquid associate bacteria was greater(P<0.05)with MU35.Conclusions:Supplementation of a dairy cow diet with SRU showed potential of increase in ammonia N concentration and microbial protein production,and change fermentation pattern to more acetate production.Adding SRU in dairy cow diet also showed beneficial effect on improving digestibility of OM and fibre.The results suggest that SRU can partially substitute soybean meal in dairy cow diet to increase microbial protein production without impairing rumen fermentation.

Simultaneous determination of acetaminophen and oxycodone in human plasma by LC–MS/MS and its application to a pharmacokinetic study

A simple and rapid liquid chromatography-tandem mass spectrometry （LC-MS/MS） method was de- veloped and validated for simultaneous determination of acetaminophen and oxycodone in human plasma. Acetaminophen-d4 and oxycodone-d3 were used as internal standards. The challenge en- countered in the method development that the high plasma concentration level of acetaminophen made the MS response saturated while the desired lower limit of quantification （LLOQ,） for oxycodone was hard to reach was well solved. The analytes were extracted by protein precipitation using acetonitrile. The matrix effect of the analytes was avoided by chromatographic separation using a hydrophilic C18 column coupled with gradient elution. Multiple reaction monitoring in positive ion mode was performed on tandem mass spectrometer employing electrospray ion source. The calibration curves were linear over the concentration ranges of 40.0-8000 ng/mL and 0.200-40.0 ng/mL for acetaminophen and oxycodone, respectively. This method, which could contribute to high throughput analysis and better clinical drug monitoring, was successfully applied to a pharmacokinetic study in healthy Chinese volunteers.

Effective remediation of cadmium and lead contaminated soils by a novel slow-release phosphate amendment

Phosphate is widely used to immobilize cadmium(Cd)and lead(Pb)in soils through the insoluble metal phosphate precipitation.However,an increase in the phosphorus content of the environment can cause new pollution.In this study,five slow-release phosphate amendments(SRPAs)were synthesized and their characteristics including BET,SEM,FTIR,swelling ratio,and thephosphorus release were determined.The results show that SRPA was a sphere with a network structure with a specific surface area of 5 to 7.18 m^(2)/g andcontained phosphate,hydroxyl,carboxyl and other functional groups.Among five SRPAs,S3 sample showed good performance for phosphate release.Phosphate release from SRPA was well fitted with Ritger-Peppas model with constant n between 0.45 and 0.85,indicating that the phosphate release was in accordance with non-Fickian diffusion.As compared with monocalcium phosphate(MCP),SRPA application led to a lower concentration of water-soluble phosphorus in the soil sample and higher remediation efficiencies of Cd and Pb.The remediation efficiencies of water-soluble Cd and Pb in soil with SRPA were 97.1%and 97.9%,respectively.The remediation efficiencies of bioavailable Cd and Pb were 71.85%and 76.47%,respectively.The results of Tessier extraction showed that the exchangeable and carbonatebound fractions of Cd and Pb in the soil sample after SRPA application significantly reduced,while the residual fraction increased,indicating the stability of heavy metals increased.

THE EFFECT OF BASIC FIBROBLAST GROWTH FACTOR SLOW-RELEASE MICROCAPSULES ON ANGIOGENESIS IN INFARCTED RABBIT MYOCARDIUM

Objectives To observe the effect of basic fibroblast growth factor (bFGF) slow-release microcapsules on angiogenesis in infarcted myocardial regions. Methods.Myocardial infarction was induced in 24 New Zealand rabbits by ligating the root of left anterior descending coronary artery.Group Ⅰ(n=8) served as control, group Ⅱ(n=8) as a blank microcapsule group, group Ⅲ(n=8, each microcapsule contains 1μg bFGF) as micrpcapsule group.In group Ⅱ and Ⅲ, 5 blank microcapsules or bFGF slow-release microcapsules were implanted into myocardium underneath the epicardium between the left anterior descending coronary artery and left circumflex artery.Infarct size was evaluated by infarcted weight/left ventricle weight ratio and angiogenesis was evaluated by immunohistochemical examinations 5 weeks later. [WT5”BX] Results.As compared with group Ⅰ and Ⅱ, rabbits treated with bFGF slow-release microcapsules showed higher microvessel counts (group Ⅰ3775±450, group Ⅱ3837±498,vs.group Ⅲ 13550±481,P<0001) and less infarcted weight /left ventricle weight (group Ⅰ168%±04%,group Ⅱ167%±05%,vs.group Ⅲ 70%±02%,P<0001). Conclusions.Subepicardial administration of bFGF slow-release microcapsule in the infarcted rabbit model results in effective angiogenesis and reduction in infarct size.

Hybrid rice yield response to potted-seedling machine transplanting and slow-release nitrogen fertilizer application combined with urea topdressing

Machine transplanting and the application of slow-release nitrogen(N) fertilizer(SRNF) have played vital roles in the modernization of rice production. We aimed to determine the effects of potted-seedling transplanting—a new machine-transplanting method—and SRNF on hybrid rice yields. A 2-year splitplot experiment(2016–2017) was conducted in Meishan, Sichuan province, China, using two machinetransplanting methods(potted-seedling and blanket-seedling) and three N treatments. Total green leaf area, high-effective leaf area and its rate at heading, net photosynthetic rate of flag leaves 7 days after heading, glutamate synthase(GOGAT) and glutamine synthase(GS) activity after heading, dry matter production, and N accumulation at heading and maturity increased under the potted-seedling method or 70% SRNF as a base + 30% urea application at the panicle initiation stage(SBUP). Stem diameter and number of small and of all vascular bundles at the neck–panicle node in potted-seedling plants increased as a result of increasing numbers of effective panicles, secondary branches, and spikelets. In pottedseedling plants, treatment with SBUP increased the number of large and total vascular bundles at the panicle–neck internode and the number of differentiated and surviving secondary branches and spikelets and decreased the number of ineffective tillers and degenerated secondary branches and spikelets. We conclude that the potted-seedling machine transplanting method and SRNF combined with urea topdressing can strengthen the source–sink relationship in rice, resulting in higher yields.

Effects of Slow-release Fertilizers and Sugarcane-specific Fertilizers on Yield and Quality of Sugarcane

The effects of slow-release fertilizers and sugarcane-specific fertilizers on the growth and quality of sugarcane were studied to provide a theoretical basis for cultivation of sugarcane with lower costs but higher efficiency. Field experiments were carried out in two major sugarcane areas in Guangxi and three fertilization treatments were studied: single application of compound fertilizers( treatment I),compound fertilizers + slow-release fertilizers( treatment II) and sugarcane-specific base fertilizers + sugarcane-specific topdressing( treatment III). Effects of equal fertilization conditions of treatment I,II and III on growth,yield and sugar of sugarcane were studied. The three fertilization treatments had little effects on emergence,tillering,and effective stems of sugarcane,but compared with the treatment of compound fertilizer( treatment I) with a ratio of N,P,and K of 1∶1∶1,treatment II using slow-release fertilizers as topdressing had better growth,higher plant height and stem diameter,so the yield was higher. Treatment III designed sugarcane-specific fertilizers with proper ratio according to fertilizer demands of sugarcane. Besides,the treatment III sugarcane-specific base fertilizers,containing certain amount of organic matters,could promote the sugar accumulation of sugarcane. Therefore,the sugarcane yield of treatment III was higher than that of treatment II. In conclusion,slow-release fertilizers and sugarcane-specific fertilizers can significantly increase sugarcane yield,especially sugarcane-specific fertilizers. Sugarcane-specific fertilizers have reasonable ratio and contain certain amount of organic matters,and can increase sugar content,obtain significant economic benefits,so it is worth popularization in large areas.

Effect of slow-release iron fertilizer on iron-deficiency chlorosis, yield and quality of Lilium davidii var.unicolor in a two-year field experiment

Iron deficiency chlorosis of Lilium davidii var. unicolor is often the case in practice in alkaline soils of northwest region of China. It is difficult to control iron chlorosis because of high cost and short effective work time of conventional iron fertilizers. In this study, a 2-year field experiment was conducted to evaluate the effects of two slow-release fertilizers on the suppression of iron deficiency chlorosis, soil chemical properties, and the yield and quality of L. davidii var. unicolor. Results show that both coated slow-release iron fertilizers and embedded slow-release iron fertilizer effectively controlled iron-deficiency chlorosis. The application of slow-release iron fertilizers significantly increased plant height and chlorophyll content of L. davidii var. unicolor at different growth stages. Furthermore, coated iron fertilizer application significantly increased starch, protein, soluble sugar and vitamin C content of L. davidii var. unicolor, and it also significantly improved total amino acid content, with increases in essential amino acids(Trp, Leu, Lys, Phe, Val, and Thr contents) and in nonessential amino acids(Asp, Glu, Cit, Ihs, Acc, Ala, Pro, and Cys contents). It was concluded that application of coated slow-release iron fertilizer could be a promising option for suppression of iron deficiency chlorosis and deserves further study.

The clinical observation of slow-released morphine tablets by rectum in the treatment of the patients with moderate to severe cancer pain

Objective: To observe the effect of slow-released morphine tablets by rectum in treating the patients of moderate to severe cancer pain with server nausea and vomiting or dysphagia. Methods: 54 cases of cancer patients with server nau- sea and vomiting symptoms or dysphagia were treated with slow-released morphine tablets by rectum, 30-90 mg/time, once every 12 hours. The drug dose was titrated by degree of pain, and the effects and adverse effects were observed. Results: The total effective rate was 81.48%, complete response rate was 51.85% (28/54), and the partial response rate was 29.63% (16/54); there were no obvious toxicities, and the common adverse symptoms included nausea (16.7%) and vomiting (9.3%). Conclusion: The treatment of slow-released morphine tablet by rectum could effectively control cancer pain, the adverse effects were slight than that by mouth. It is safe and effective to be worthy of the adhibition in clinic.

Delaying application time of slow-release fertilizer increases soil rhizosphere nitrogen content,root activity,and grain yield of spring maize

Application of slow-release fertilizer(SF)is a nutrient-management measure aimed at improving maize nutrient use and yield and saving labor cost.One-time application of SF at sowing usually results in nutrient deficiency during the post-silking stage,owing to the long growth period of spring maize.This study was conducted to investigate the effects on spring maize of SF application stage(zero,three-,and six-leaf stages,designated as SF0,SF3,and SF6,respectively)on grain yield,total soil rhizosphere nitrogen(N)content,and root activity,in comparison with the conventional fertilization mode(CF,application of compound fertilizer at sowing time,and topdressing urea at six-leaf and tasseling stages)at the same fertilization level as the control.Compared with no fertilization(F0)and CF,SF increased grain number and weight.The maize cultivars Suyu 30(SY30)and Jiangyu 877(JY877)produced the highest grain yield and net return under SF6 treatment over the three years.SF6 increased enzymatic activities including oxidoreductase,hydrolase,transferase,and lyase in rhizosphere soil at silking(R1)and milking stages(R3).SF6 increased the total N contents of rhizosphere soil by 7.1%at R1 and 9.2%R3 stages compared with SF0.The activities of antioxidant enzymes in roots were increased under SF6 treatments at R1and R3.The mean root activities of SF0,SF3,and SF6 increased by 7.1%,12.8%,and 20.5%compared with CF at R1 and by 8.8%,13.0%,and 23.5%at R3.Delaying the application time of SF could increase grain yield by increasing total N content of rhizosphere soil,delaying root senescence,and increasing root activity at the late reproductive stage.Applying SF at the six-leaf stage is recommended as an effective fertilization strategy for the sustainable production of spring maize in southern China.

Candelilla Wax as Natural Slow-Release Matrix for Fertilizers Encapsulated by Spray Chilling

Efforts to improve crop yields with efficient use of fertilizers are needed to guarantee global food security.Enhanced slow-release fertilizer systems(SRFs)encapsulated in biodegradable matrices are being developed to address this global concern.From a wide range of strategies for SRFs development,we explored a natureinspired solution based on the plant cuticle model and its function as a membrane for water and nutrient transport control.Here,Candelilla wax,extracted from Candelilla wild plants(Euphorbia antisyphilitica),is studied as a renewable slow-release matrix for fertilizers encapsulated by a modified spray chilling process.From this process,microencapsulates containing 40 wt%of phosphorus fertilizer are obtained with distinctive sizes and chemical characteristics,presenting a slow-release behavior.Considering the abovementioned features,novel insights into fertilizer release mechanisms based on plant cuticle models are discussed.

Control Effect of Slow-release, Long-acting and Multi-functional New Pesticides on Sugarcane Borders and Woolly Aphids

In order to select the long-acting,low toxic,low-risk and multi-functional new pesticides for the control of sugarcane borders and woolly aphids and precise and efficient application technology,the control effect of 10% monosultap · thiamethoxam granular formulation and 1% Bt · clothianidin granular formulation on sugarcane borders and woolly aphids were studied.The results showed that 10% monosultap·thiamethoxam GR and 1% Bt·clothianidin GR had good control effects on sugarcane borders and woolly aphids.They were ideal slow-release,long-acting,low toxic and multi-functional new pesticides used to control sugarcane borders and woolly aphids.They could be used alternately with other pesticides to delay the emergence and development of pest resistance to pesticides.The best dosage of the two pesticides in the field was 45 kg/hm^2.They could be mixed with fertilizer( 1200-1800 kg/hm^2),scattered in sugarcane ditches or at the base of sugarcane plants,and covered with soil or film from January to July.The control effect on dead heart seedlings damaged by borers could be up to above 79.2%,and the control effect on sugarcane woolly aphids could reach more than 98.8%.In comparison with the control group,the actual yield and sugar content of sugarcane increased by above 41 555 kg/hm^2 and 6.5% respectively.The application of slow-release,long-acting,strong systemic and multi-functional new agents with fertilizer around roots is convenient,precise and efficient,labor-saving,time-saving and environmentally friendly,and is worthy of being widely applied in sugarcane areas.