Solar ultraviolet B(UVB)radiation is a major skin cancer-causing agent.Initiation,promotion,and progression are the diverse phases of UVB-induced carcinogenesis.Exposure to UVB causes abnormalities in a series of bioc...Solar ultraviolet B(UVB)radiation is a major skin cancer-causing agent.Initiation,promotion,and progression are the diverse phases of UVB-induced carcinogenesis.Exposure to UVB causes abnormalities in a series of biochemical and molecular pathways:thymine dimer formation,DNA damage,oxidative stress,inflammatory responses,and altered cell signaling,eventually resulting in tumor formation.The increased skin cancer rates urge researchers to develop more efficient drugs,but synthetic chemotherapeutic drugs have more contrary effects and drug resistance issues,which have been reported recently.The current review focuses on the relationship between microbes and cancer.Human skin acts as a barrier against the external environment and serves as a protective shield for its inhabitant microbiota,collectively called skin microbes.The gut microbiome plays a vital role in cancer therapy.Production of short-chain fatty acids(SCFAs)such as butyrate,acetate,and propionate by intestinal microbes has anti-cancer properties against various cancer cell lines.Yet,the knowledge of SCFAs produced by skin microbes remains yet to be elucidated exhaustively.In this review,we strive to summarize the findings of studies performed to date regarding the anti-cancer properties of SCFA against various cancer cell lines and provide insight into future directions in the skin microbiome field.展开更多
Software Defined Satellite Networks(SDSN) are proposed to solve the problems in traditional satellite networks, such as time-consuming configuration and inflexible traffic scheduling. The emerging application of small...Software Defined Satellite Networks(SDSN) are proposed to solve the problems in traditional satellite networks, such as time-consuming configuration and inflexible traffic scheduling. The emerging application of small satellite and research of SDSN make it possible for satellite networks to provide flexible network services. Service Function Chain(SFC) can satisfy this need. In this paper, we are motivated to investigate applying SFC in the small satellite-based SDSN for service delivery. We introduce the structure of the multi-layer constellation-based SDSN. Then, we describe two deployment patterns of SFC in SDSN, the Multi-Domain(MD) pattern and the Satellite Formation(SF) pattern. We propose two algorithms, SFP-MD, and SFP-SF, to calculate the Service Function Path(SFP). We implement the algorithms and conduct contrast experiments in our prototype. Finally, we summarize the applicable conditions of two deployment patterns according to the experimental results in terms of hops, delay, and packet loss rate.展开更多
RNA interference(RNAi),which causes the degradation of any RNA in a sequence specific manner,is a posttranscriptional gene silencing mechanism.Targeting the invariant chain(Ii)in DCs has been used as an approach to en...RNA interference(RNAi),which causes the degradation of any RNA in a sequence specific manner,is a posttranscriptional gene silencing mechanism.Targeting the invariant chain(Ii)in DCs has been used as an approach to enhance antitumor immunity.It is demonstrated in this article that transfection of H-2(K)DCs with siRNA specific for Ii gene can significantly knock down Ii.When exposed to TNF-alpha,immature DCs transfected with Ii siRNA can differentiate into mature DCs without reducing viability or IL-12p70 production.Ii siRNA-treated H-2(K)DCs exhibited an increased allostimulatory capacity in a lymphocyte proliferation assay.Furthermore,Ii siRNA-transfected H-2(K)DCs enhanced Th1 responses by increasing IFN-gamma and decreasing IL-4 production,and much stronger cytotoxic activity was observed when DCs were co-transfected with Ii siRNA and an endogenous tumor antigen in vitro.Our findings indicate that silencing the Ii gene in DCs with siRNA may offer a potential approach to enhancing antitumor immunotherapy.展开更多
As the rapid development of the national small characteristic town,some problems began to show through.For example,the spatial structure is not reasonable,the industrial is not harmonious,and the industrial cluster is...As the rapid development of the national small characteristic town,some problems began to show through.For example,the spatial structure is not reasonable,the industrial is not harmonious,and the industrial cluster is not obvious and so on.In order to solve these uncoordinated problems and arrange industrial structure properly,to build the industrial ecologic chain construction according to local conditions appears to be critical.Therefore,constructing industrial ecological chain is of importance in academic aspect and practical significance to sustainable development.According to the theory of industrial ecology,this article researches on industrial ecological chain construction of Gui-An New District's VR town.Otherwise,with the principles of vertical supply-demand chain,horizontal collaboration chain,energy utilization chain,material circulation chain and water cycle chain,on the basis of five elements including public environment,service bake up,demand-supply collaboration,management system in a cloud and resource reuse,this paper put forward the industrial ecological chain model of VR town in Gui-An New District and analyze each links detailedly.The purpose is to explore and analyze the industrial ecological chain construction of VR town in Gui-An New District to abundant domestic related theory about small town and play a certain reference significance on other new-type of characteristic urbanization in mountainous region.展开更多
The experimental investigation on the conformation of a thermotropic main-chain nematic polymer by small-angle X-ray scattering (SAXS) has been carried out. The average radius of gyration of the polymer has been deter...The experimental investigation on the conformation of a thermotropic main-chain nematic polymer by small-angle X-ray scattering (SAXS) has been carried out. The average radius of gyration of the polymer has been determined in nematic and isotropic state respectively. The experiment shows that the boundary between domains is not sharp but diffuse, and the diffuse-boundary thickness of the polymer as a function of temperature has been given.展开更多
The kinetics of I-->N transition of a side chain nematic polymethacrylate has been studied by small angle depolarized light scattering intensity measurements using a charge coupled device linear image sensor. The p...The kinetics of I-->N transition of a side chain nematic polymethacrylate has been studied by small angle depolarized light scattering intensity measurements using a charge coupled device linear image sensor. The polymer shows the transition temperatures K52N79I in degreesC, The H-v scattering intensity T(q,t) during the transition I (at 80.2degreesC)-->N (at 75.8degreesC) shows that T(q) is independent of q for all t, and during the initial stage (in 6 s) T(t) increases exponentially with t. In the later stage of the transition T(t) approaches a saturation value in 2 min. This experimental result indicates that the I-->N transition of a liquid crystalline polymer is a spinodal type of phase transition mediated by orientation fluctuation.展开更多
文摘Solar ultraviolet B(UVB)radiation is a major skin cancer-causing agent.Initiation,promotion,and progression are the diverse phases of UVB-induced carcinogenesis.Exposure to UVB causes abnormalities in a series of biochemical and molecular pathways:thymine dimer formation,DNA damage,oxidative stress,inflammatory responses,and altered cell signaling,eventually resulting in tumor formation.The increased skin cancer rates urge researchers to develop more efficient drugs,but synthetic chemotherapeutic drugs have more contrary effects and drug resistance issues,which have been reported recently.The current review focuses on the relationship between microbes and cancer.Human skin acts as a barrier against the external environment and serves as a protective shield for its inhabitant microbiota,collectively called skin microbes.The gut microbiome plays a vital role in cancer therapy.Production of short-chain fatty acids(SCFAs)such as butyrate,acetate,and propionate by intestinal microbes has anti-cancer properties against various cancer cell lines.Yet,the knowledge of SCFAs produced by skin microbes remains yet to be elucidated exhaustively.In this review,we strive to summarize the findings of studies performed to date regarding the anti-cancer properties of SCFA against various cancer cell lines and provide insight into future directions in the skin microbiome field.
基金supported in part by NSFC of China under Grant No.61232017National Basic Research Program of China(“973 program”)under Grant No.2013CB329101+1 种基金Fundamental Research Funds for the Central Universities under Grant No.2016YJS026NSAF of China under Grant No.U1530118
文摘Software Defined Satellite Networks(SDSN) are proposed to solve the problems in traditional satellite networks, such as time-consuming configuration and inflexible traffic scheduling. The emerging application of small satellite and research of SDSN make it possible for satellite networks to provide flexible network services. Service Function Chain(SFC) can satisfy this need. In this paper, we are motivated to investigate applying SFC in the small satellite-based SDSN for service delivery. We introduce the structure of the multi-layer constellation-based SDSN. Then, we describe two deployment patterns of SFC in SDSN, the Multi-Domain(MD) pattern and the Satellite Formation(SF) pattern. We propose two algorithms, SFP-MD, and SFP-SF, to calculate the Service Function Path(SFP). We implement the algorithms and conduct contrast experiments in our prototype. Finally, we summarize the applicable conditions of two deployment patterns according to the experimental results in terms of hops, delay, and packet loss rate.
基金National Nature Science Foundation of China(30570828,30471961,30170915).
文摘RNA interference(RNAi),which causes the degradation of any RNA in a sequence specific manner,is a posttranscriptional gene silencing mechanism.Targeting the invariant chain(Ii)in DCs has been used as an approach to enhance antitumor immunity.It is demonstrated in this article that transfection of H-2(K)DCs with siRNA specific for Ii gene can significantly knock down Ii.When exposed to TNF-alpha,immature DCs transfected with Ii siRNA can differentiate into mature DCs without reducing viability or IL-12p70 production.Ii siRNA-treated H-2(K)DCs exhibited an increased allostimulatory capacity in a lymphocyte proliferation assay.Furthermore,Ii siRNA-transfected H-2(K)DCs enhanced Th1 responses by increasing IFN-gamma and decreasing IL-4 production,and much stronger cytotoxic activity was observed when DCs were co-transfected with Ii siRNA and an endogenous tumor antigen in vitro.Our findings indicate that silencing the Ii gene in DCs with siRNA may offer a potential approach to enhancing antitumor immunotherapy.
文摘As the rapid development of the national small characteristic town,some problems began to show through.For example,the spatial structure is not reasonable,the industrial is not harmonious,and the industrial cluster is not obvious and so on.In order to solve these uncoordinated problems and arrange industrial structure properly,to build the industrial ecologic chain construction according to local conditions appears to be critical.Therefore,constructing industrial ecological chain is of importance in academic aspect and practical significance to sustainable development.According to the theory of industrial ecology,this article researches on industrial ecological chain construction of Gui-An New District's VR town.Otherwise,with the principles of vertical supply-demand chain,horizontal collaboration chain,energy utilization chain,material circulation chain and water cycle chain,on the basis of five elements including public environment,service bake up,demand-supply collaboration,management system in a cloud and resource reuse,this paper put forward the industrial ecological chain model of VR town in Gui-An New District and analyze each links detailedly.The purpose is to explore and analyze the industrial ecological chain construction of VR town in Gui-An New District to abundant domestic related theory about small town and play a certain reference significance on other new-type of characteristic urbanization in mountainous region.
文摘The experimental investigation on the conformation of a thermotropic main-chain nematic polymer by small-angle X-ray scattering (SAXS) has been carried out. The average radius of gyration of the polymer has been determined in nematic and isotropic state respectively. The experiment shows that the boundary between domains is not sharp but diffuse, and the diffuse-boundary thickness of the polymer as a function of temperature has been given.
基金This work was supported by the National Key Projects for Fundamental Research, "Macromolecular Condensed State" of Ministry of Science and Technology of China.
文摘The kinetics of I-->N transition of a side chain nematic polymethacrylate has been studied by small angle depolarized light scattering intensity measurements using a charge coupled device linear image sensor. The polymer shows the transition temperatures K52N79I in degreesC, The H-v scattering intensity T(q,t) during the transition I (at 80.2degreesC)-->N (at 75.8degreesC) shows that T(q) is independent of q for all t, and during the initial stage (in 6 s) T(t) increases exponentially with t. In the later stage of the transition T(t) approaches a saturation value in 2 min. This experimental result indicates that the I-->N transition of a liquid crystalline polymer is a spinodal type of phase transition mediated by orientation fluctuation.
