This paper presents an accurate small-signal model for multi-gate GaAs pHEMTs in switching-mode.The extraction method for the proposed model is developed.A 2-gate switch structure is fabricated on a commercial 0.5μm ...This paper presents an accurate small-signal model for multi-gate GaAs pHEMTs in switching-mode.The extraction method for the proposed model is developed.A 2-gate switch structure is fabricated on a commercial 0.5μm AlGaAs/GaAs pHEMT technology to verify the proposed model.Excellent agreement has been obtained between the measured and simulated results over a wide frequency range.展开更多
According to the physiological and anatomical characteristics of small intestine,neglecting the effect of its motility on the distribution and absorption of drug and nutrient,Y.Miyamoto et al.proposed a model of two-d...According to the physiological and anatomical characteristics of small intestine,neglecting the effect of its motility on the distribution and absorption of drug and nutrient,Y.Miyamoto et al.proposed a model of two-dimensional laminar flow in a circular porous tube with permeable wall and calculated the concentration profile of drugby numerical analysis.In this paper,we give a steady-state analytical solution of the above model including deactivationterm.The obtained results are in agreement with the results of their numerical analysis. Moreover the analytical solution presented in this paper reveals the relation among the physiological parameters of the model and describes the basic absorption rule of drug and nutrient through the intestinal wall and hence pro- vides a theoretical basis for determining the permeability and reflection coefficient through in situ experiments.展开更多
AIM: To evaluate the safety and effectiveness of laparoscopy compared with laparotomy for diagnosing and treating small bowel injuries (SBIs) in a porcine model. METHODS: Twenty-eight female pigs were anesthetized and...AIM: To evaluate the safety and effectiveness of laparoscopy compared with laparotomy for diagnosing and treating small bowel injuries (SBIs) in a porcine model. METHODS: Twenty-eight female pigs were anesthetized and laid in the left recumbent position. The SBI model was established by shooting at the right lower quadrant of the abdomen. The pigs were then randomized into either the laparotomy group or the laparoscopy group. All pigs underwent routine exploratory laparotomy or laparoscopy to evaluate the abdominal injuries, particularly the types, sites, and numbers of SBIs. Traditional open surgery or therapeutic laparoscopy was then performed. All pigs were kept alive within the observational period (postoperative 72 h). The postoperative recovery of each pig was carefully observed. RESULTS: The vital signs of all pigs were stable within 1-2 h after shooting and none of the pigs died from gunshot wounds or SBIs immediately. The SBI model was successfully established in all pigs and definitively diagnosed with single or multiple SBIs either by exploratory laparotomy or laparoscopy. Compared with exploratory laparotomy, laparoscopy took a significantly longer time for diagnosis (41.27 ± 12.04 min vs 27.64 ± 13.32 min, P = 0.02), but the time for therapeutic laparoscopy was similar to that of open surgery. The length of incision was significantly reduced in the laparoscopy group compared with the laparotomy group (5.27 ± 1.86 cm vs 15.73 ± 1.06 cm, P < 0.01). In the final post-mortem examination 72 h after surgery, both laparotomy and laparoscopy offered a definitive diagnosis with no missed injuries. Postoperative complications occurred in four cases (three following laparotomy and one following laparoscopy, P = 0.326). The average recovery period for bowel function, vital appearance, and food re-intake after laparoscopy was 10.36 ± 4.72 h, 14.91 ± 3.14 h, and 15.00 ± 7.11 h, respectively. All of these were significantly shorter than after laparotomy (21.27 ± 10.17 h, P = 0.004; 27.82 ± 9.61 h, P < 0.001; and 24.55 ± 9.72 h, respectively, P = 0.016). CONCLUSION: Compared with laparotomy, laparoscopy offers equivalent efficacy for diagnosing and treating SBIs, and reduces postoperative complications as well as recovery period.展开更多
We present a multifractal detrended fluctuation analysis (MFDFA) of the time series of return generated by our recently-proposed Ising financial market model with underlying small world topology. The result of the M...We present a multifractal detrended fluctuation analysis (MFDFA) of the time series of return generated by our recently-proposed Ising financial market model with underlying small world topology. The result of the MFDFA shows that there exists obvious multifractal scaling behavior in produced time series. We compare the MFDFA results for original time series with those for shuffled series, and find that its multifractal nature is due to two factors: broadness of probability density function of the series and different correlations in small- and large-scale fluctuations. This may provide new insight to the problem of the origin of multifractality in financial time series.展开更多
The small-scale drilling technique can be a fast and reliable method to estimate rock strength parameters. It needs to link the operational drilling parameters and strength properties of rock. The parameters such as b...The small-scale drilling technique can be a fast and reliable method to estimate rock strength parameters. It needs to link the operational drilling parameters and strength properties of rock. The parameters such as bit geometry, bit movement, contact frictions and crushed zone affect the estimated parameters.An analytical model considering operational drilling data and effective parameters can be used for these purposes. In this research, an analytical model was developed based on limit equilibrium of forces in a Tshaped drag bit considering the effective parameters such as bit geometry, crushed zone and contact frictions in drilling process. Based on the model, a method was used to estimate rock strength parameters such as cohesion, internal friction angle and uniaxial compressive strength of different rock types from operational drilling data. Some drilling tests were conducted by a portable and powerful drilling machine which was developed for this work. The obtained results for strength properties of different rock types from the drilling experiments based on the proposed model are in good agreement with the results of standard tests. Experimental results show that the contact friction between the cutting face and rock is close to that between bit end wearing face and rock due to the same bit material. In this case,the strength parameters, especially internal friction angle and cohesion, are estimated only by using a blunt bit drilling data and the bit bluntness does not affect the estimated results.展开更多
Software engineering's lifecycle models havc proven to be very important for traditional software development. However, can these models be applied to the development of Web-based applications as well? In recent yea...Software engineering's lifecycle models havc proven to be very important for traditional software development. However, can these models be applied to the development of Web-based applications as well? In recent years, Web-based applications have become more and more complicated and a lot of efforts have been placed on introducing new technologies such as J2EE, PhP, and .NET, etc., which have been universally accepted as the development technologies for Web-based applications. However, there is no universally accepted process model for the development of Web-based applications. Moreover, shaping the process model for small medium-sized enterprises (SMEs), which have limited resources, has been relatively neglected. Based on our previous work, this paper presents an expanded lifecycle process model for the development of Web-based applications in SMEs. It consists of three sets of processes, i.e., requirement processes, development processes, and evolution processes. Particularly, the post-delivery evolution processes are important to SMEs to develop and maintain quality web applications with limited resources and time.展开更多
On small-meso scale, the sea ice dynamic characteristics are quite different from that on large scale. To model the sea ice dynamics on small-meso scale, a new elastic-viscous-plastic (EVP) constitutive model and a ...On small-meso scale, the sea ice dynamic characteristics are quite different from that on large scale. To model the sea ice dynamics on small-meso scale, a new elastic-viscous-plastic (EVP) constitutive model and a hybrid Lagrangian- Eulerian (HLE) numerical method are developed based on continuum theory. While a modified discrete element model (DEM) is introduced to model the ice cover at discrete state. With the EVP constitutive model, the numerical simulation for ice ridging in an idealized rectangular basin is carried out and the results are comparable with the analytical solution of jam theory. Adopting the HLE numerical model, the sea ice dynamic process is simulated in a vortex wind field. The furthering application of DEM is discussed in details for modeling the discrete distribution of sea ice. With this study, the mechanical and numerical models for sea ice dynamics can be improved with high precision and computational efficiency.展开更多
An accurate and broad-band method for hetero-junction bipolar transistors(HBT) small-signal model parameters-extraction is presented in this paper. An equivalent circuit forthe HBT under a forward-bias condition is pr...An accurate and broad-band method for hetero-junction bipolar transistors(HBT) small-signal model parameters-extraction is presented in this paper. An equivalent circuit forthe HBT under a forward-bias condition is proposed for extraction of accessresistance and parasiticinductance. This method differs from previous ones by extracting the c-quivalent circuit parameterswithout using special test structure or global numerical optimization techniques. The mainadvantage of this method is that a unique and physically meaningful set of intrinsic parameters isextracted from impedance and admittance representation of the measured S-pa-rameters in thefrequency range of 1-12 GHz under different bias conditions. The method yields a deviation of lessthan 5% between measured and modeled S-parameters.展开更多
The voltage source converter based high voltage direct current(VSC-HVDC)system is based on voltage source converter,and its control system is more complex.Also affected by the fast control of power electronics,oscilla...The voltage source converter based high voltage direct current(VSC-HVDC)system is based on voltage source converter,and its control system is more complex.Also affected by the fast control of power electronics,oscillation phenomenon in wide frequency domain may occur.To address the problem of small signal stability of the VSCHVDC system,a converter control strategy is designed to improve its small signal stability,and the risk of system oscillation is reduced by attaching a damping controller and optimizing the control parameters.Based on the modeling of the VSC-HVDC system,the general architecture of the inner and outer loop control of the VSCHVDC converter is established;and the damping controllers for DC control and AC control are designed in the phase-locked loop and the inner and outer loop control parts respectively;the state-space statemodel of the control system is established to analyze its performance.And the electromagnetic transient simulation model is built on the PSCAD/EMTDC simulation platform to verify the accuracy of the small signal model.The influence of the parameters of each control part on the stability of the system is summarized.The main control parts affecting stability are optimized for the phenomenon of oscillation due to changes in operation mode occurring on the AC side due to faults and other reasons,which effectively eliminates system oscillation and improves system small signal stability,providing a certain reference for engineering design.展开更多
We introduce a modified small-world network adding new links with nonlinearly preferential connectioninstead of adding randomly,then we apply Bak-Sneppen(BS)evolution model on this network.We study severalimportant st...We introduce a modified small-world network adding new links with nonlinearly preferential connectioninstead of adding randomly,then we apply Bak-Sneppen(BS)evolution model on this network.We study severalimportant structural properties of our network such as the distribution of link-degree,the maximum link-degree,and thegth of the shortest path.We further argue several dynamical characteristics of the model such as the important criticalvalue f_c,the f_0 avalanche,and the mutating condition,and find that those characteristics show panticular behaviors.展开更多
Objective: Several predictors of survival have been identified in EGFR-positive non-small cell lung cancer(NSCLC) patients treated with first generation EGFR inhibitors. Prognostic models of survival outcomes with afa...Objective: Several predictors of survival have been identified in EGFR-positive non-small cell lung cancer(NSCLC) patients treated with first generation EGFR inhibitors. Prognostic models of survival outcomes with afatinib have not been evaluated.Methods: A prognostic tool for overall survival(OS)/progression free survival(PFS) based on pre-treatment clinicopathological factors was developed for EGFR-positive advanced NSCLC patients treated with first-line afatinib using penalised regression of individual-participant data from LUX-Lung 3 and 6(n = 468). Favourable, intermediate and poor risk groups were identified and externally validated using LUX-Lung 1(n = 390) and LUX-Lung 2(n = 129) trials that initiated afatinib following previous chemotherapy or EGFR inhibitor treatment.Results: Discriminative performance was good in the development and validation cohorts. For patients treated with first-line afatinib, the median OS for the favourable, intermediate and poor risk groups were > 47.7, 29.3 and 16.4 months, respectively, and the median PFS were 17.3, 13.2 and 8.3 months, respectively. The improvement in median OS with afatinib use compared to chemotherapy was > 12.4 months for the favourable risk group, whereas no OS benefit was apparent for the poor risk group. The improvement in median PFS with afatinib use compared to chemotherapy was 10.2 months for the favourable risk group and 3.2 months for the poor risk group.Conclusions: A prognostic tool was developed and validated to identify favourable, intermediate and poor risk groups for OS/PFS in EGFR-positive advanced NSCLC patients treated with afatinib. The prognostic groups can inform the likely absolute OS/PFS benefit expected from afatinib compared to chemotherapy in first-line treatment.展开更多
The paper applies multi-dimension to lower technology-projection pursuit evaluation model in the conservation of water and soil discipline domain, optimizes the projection direction using the improved acceleration gen...The paper applies multi-dimension to lower technology-projection pursuit evaluation model in the conservation of water and soil discipline domain, optimizes the projection direction using the improved acceleration genetic algorithms, transforms the multi-dimensional data target to lower sub-space, and values soil adaptability of Dongdagou basin in Keshan County by searching the optimal projection direction and the projection function data. The paper provides a new notion and method for the conservation of water and soil in small basin.展开更多
Further to the investigation of the critical properties of the Potts model with <em>q</em> = 3 and 8 states in one dimension (1D) on directed small-world networks reported by Aquino and Lima, which present...Further to the investigation of the critical properties of the Potts model with <em>q</em> = 3 and 8 states in one dimension (1D) on directed small-world networks reported by Aquino and Lima, which presents, in fact, a second-order phase transition with a new set of critical exponents, in addition to what was reported in Sumour and Lima in studying Ising model on non-local directed small-world for several values of probability 0 < <em>P</em> < 1. In this paper the behavior of two models discussed previously, will be re-examined to study differences between their behavior on directed small-world networks for networks of different values of probability <em>P</em> = 0.1, 0.2, 0.3, 0.4 and 0.5 with different lattice sizes <em>L</em> = 10, 20, 30, 40, and 50 to compare between the important physical variables between Ising and Potts models on the directed small-world networks. We found in our paper that is a phase transitions in both Ising and Potts models depending essentially on the probability <em>P</em>.展开更多
The Lagrangian equations of motion of small particle in turbulent boundary layer flows, taking into account the effects of the drug force caused by the wall presence, the Saffman and the Magus lift forces et al., is s...The Lagrangian equations of motion of small particle in turbulent boundary layer flows, taking into account the effects of the drug force caused by the wall presence, the Saffman and the Magus lift forces et al., is studied. Using the spectral method, analytical expression relating to the Lagrangian power spectra of particle velocity to that of the fluid are developed and the results are used to evaluate various responses statistics. In this paper, the results clearly show that the turbulent diffusivity of the particle may be larger than that of the fluid for a period of long-time.展开更多
Purpose: To evaluate the quality of three-dimensional (3D) CT angiography images of the abdominal viscera with small focal spot, low tube voltage, and iterative model reconstruction technique (IMR). Materials and Meth...Purpose: To evaluate the quality of three-dimensional (3D) CT angiography images of the abdominal viscera with small focal spot, low tube voltage, and iterative model reconstruction technique (IMR). Materials and Methods: Seven patients with suspected disease of the pancreatobiliary system had undergone CT with high-quality CTA protocol in the present study. There were 5 men and 2 women, ranging in age from 52 to 80 years (mean: 64 years). Results: Depiction of abdominal small artery, small portal vein was possible in all cases. In two cases that we were able to compare, it was superior to standard CTA in small vascular depiction in CTA made clearly in high quality protocol. Conclusions: Although the use of small focal spot, low tube voltage, and IMR can produce higher-quality images of abdominal vessels than standard CTA, this improvement is not significant at elevated radiation doses.展开更多
The present work deals with a detailed analysis of the small-angle X-ray scattering of nanoporous atomistic models for amorphous germanium. Structures with spherical nanovoids, others with arbitrarily oriented ellipso...The present work deals with a detailed analysis of the small-angle X-ray scattering of nanoporous atomistic models for amorphous germanium. Structures with spherical nanovoids, others with arbitrarily oriented ellipsoidal ones, with monodisperse and polydisperse size distributions, were first generated. After relaxing the as-generated structure, we compute its radial distribution function, and then we deduce by the Fourier transform technique its X-ray scattering pattern. Using a smoothing procedure, the computed small-angle X-ray scattering patterns are corrected for the termination errors due to the finite size of the model, allowing so, for the first time at our best knowledge, a rigorous quantitative analysis of this scattering. The Guinier’s law is found to be valid irrespective of size and shape of the nanovoids over a scattering vector-range extending beyond the expected limit. A weighted combination of the Guinier’s forms accounts for well the nanovoid size distribution in the amorphous structure. The invariance of the Q-factor and its relationship to the void volume fraction are also confirmed. Our findings support then the quantitative analyses of available small-angle X-ray scattering data for amorphous germanium.展开更多
文摘This paper presents an accurate small-signal model for multi-gate GaAs pHEMTs in switching-mode.The extraction method for the proposed model is developed.A 2-gate switch structure is fabricated on a commercial 0.5μm AlGaAs/GaAs pHEMT technology to verify the proposed model.Excellent agreement has been obtained between the measured and simulated results over a wide frequency range.
基金The project supported by NSF of Shandong Province
文摘According to the physiological and anatomical characteristics of small intestine,neglecting the effect of its motility on the distribution and absorption of drug and nutrient,Y.Miyamoto et al.proposed a model of two-dimensional laminar flow in a circular porous tube with permeable wall and calculated the concentration profile of drugby numerical analysis.In this paper,we give a steady-state analytical solution of the above model including deactivationterm.The obtained results are in agreement with the results of their numerical analysis. Moreover the analytical solution presented in this paper reveals the relation among the physiological parameters of the model and describes the basic absorption rule of drug and nutrient through the intestinal wall and hence pro- vides a theoretical basis for determining the permeability and reflection coefficient through in situ experiments.
文摘AIM: To evaluate the safety and effectiveness of laparoscopy compared with laparotomy for diagnosing and treating small bowel injuries (SBIs) in a porcine model. METHODS: Twenty-eight female pigs were anesthetized and laid in the left recumbent position. The SBI model was established by shooting at the right lower quadrant of the abdomen. The pigs were then randomized into either the laparotomy group or the laparoscopy group. All pigs underwent routine exploratory laparotomy or laparoscopy to evaluate the abdominal injuries, particularly the types, sites, and numbers of SBIs. Traditional open surgery or therapeutic laparoscopy was then performed. All pigs were kept alive within the observational period (postoperative 72 h). The postoperative recovery of each pig was carefully observed. RESULTS: The vital signs of all pigs were stable within 1-2 h after shooting and none of the pigs died from gunshot wounds or SBIs immediately. The SBI model was successfully established in all pigs and definitively diagnosed with single or multiple SBIs either by exploratory laparotomy or laparoscopy. Compared with exploratory laparotomy, laparoscopy took a significantly longer time for diagnosis (41.27 ± 12.04 min vs 27.64 ± 13.32 min, P = 0.02), but the time for therapeutic laparoscopy was similar to that of open surgery. The length of incision was significantly reduced in the laparoscopy group compared with the laparotomy group (5.27 ± 1.86 cm vs 15.73 ± 1.06 cm, P < 0.01). In the final post-mortem examination 72 h after surgery, both laparotomy and laparoscopy offered a definitive diagnosis with no missed injuries. Postoperative complications occurred in four cases (three following laparotomy and one following laparoscopy, P = 0.326). The average recovery period for bowel function, vital appearance, and food re-intake after laparoscopy was 10.36 ± 4.72 h, 14.91 ± 3.14 h, and 15.00 ± 7.11 h, respectively. All of these were significantly shorter than after laparotomy (21.27 ± 10.17 h, P = 0.004; 27.82 ± 9.61 h, P < 0.001; and 24.55 ± 9.72 h, respectively, P = 0.016). CONCLUSION: Compared with laparotomy, laparoscopy offers equivalent efficacy for diagnosing and treating SBIs, and reduces postoperative complications as well as recovery period.
基金Supported by the Scientific Research Foundation for the Returned Overseas Chinese Scholars of State Education Ministry
文摘We present a multifractal detrended fluctuation analysis (MFDFA) of the time series of return generated by our recently-proposed Ising financial market model with underlying small world topology. The result of the MFDFA shows that there exists obvious multifractal scaling behavior in produced time series. We compare the MFDFA results for original time series with those for shuffled series, and find that its multifractal nature is due to two factors: broadness of probability density function of the series and different correlations in small- and large-scale fluctuations. This may provide new insight to the problem of the origin of multifractality in financial time series.
文摘The small-scale drilling technique can be a fast and reliable method to estimate rock strength parameters. It needs to link the operational drilling parameters and strength properties of rock. The parameters such as bit geometry, bit movement, contact frictions and crushed zone affect the estimated parameters.An analytical model considering operational drilling data and effective parameters can be used for these purposes. In this research, an analytical model was developed based on limit equilibrium of forces in a Tshaped drag bit considering the effective parameters such as bit geometry, crushed zone and contact frictions in drilling process. Based on the model, a method was used to estimate rock strength parameters such as cohesion, internal friction angle and uniaxial compressive strength of different rock types from operational drilling data. Some drilling tests were conducted by a portable and powerful drilling machine which was developed for this work. The obtained results for strength properties of different rock types from the drilling experiments based on the proposed model are in good agreement with the results of standard tests. Experimental results show that the contact friction between the cutting face and rock is close to that between bit end wearing face and rock due to the same bit material. In this case,the strength parameters, especially internal friction angle and cohesion, are estimated only by using a blunt bit drilling data and the bit bluntness does not affect the estimated results.
文摘Software engineering's lifecycle models havc proven to be very important for traditional software development. However, can these models be applied to the development of Web-based applications as well? In recent years, Web-based applications have become more and more complicated and a lot of efforts have been placed on introducing new technologies such as J2EE, PhP, and .NET, etc., which have been universally accepted as the development technologies for Web-based applications. However, there is no universally accepted process model for the development of Web-based applications. Moreover, shaping the process model for small medium-sized enterprises (SMEs), which have limited resources, has been relatively neglected. Based on our previous work, this paper presents an expanded lifecycle process model for the development of Web-based applications in SMEs. It consists of three sets of processes, i.e., requirement processes, development processes, and evolution processes. Particularly, the post-delivery evolution processes are important to SMEs to develop and maintain quality web applications with limited resources and time.
基金supported by the National Natural Science Foundation of China(Grant No.40206004)partly by the open foundation of Key Laboratory of Polar Science of Science of the State Oceanic Administration,China(Grant No.KP2007004).
文摘On small-meso scale, the sea ice dynamic characteristics are quite different from that on large scale. To model the sea ice dynamics on small-meso scale, a new elastic-viscous-plastic (EVP) constitutive model and a hybrid Lagrangian- Eulerian (HLE) numerical method are developed based on continuum theory. While a modified discrete element model (DEM) is introduced to model the ice cover at discrete state. With the EVP constitutive model, the numerical simulation for ice ridging in an idealized rectangular basin is carried out and the results are comparable with the analytical solution of jam theory. Adopting the HLE numerical model, the sea ice dynamic process is simulated in a vortex wind field. The furthering application of DEM is discussed in details for modeling the discrete distribution of sea ice. With this study, the mechanical and numerical models for sea ice dynamics can be improved with high precision and computational efficiency.
基金Supported by the National Natural Science Foun dation of China(60444004) and the AM Foundation of Shanghai Mu nicipal Science and Technology Commission of China (0109)
文摘An accurate and broad-band method for hetero-junction bipolar transistors(HBT) small-signal model parameters-extraction is presented in this paper. An equivalent circuit forthe HBT under a forward-bias condition is proposed for extraction of accessresistance and parasiticinductance. This method differs from previous ones by extracting the c-quivalent circuit parameterswithout using special test structure or global numerical optimization techniques. The mainadvantage of this method is that a unique and physically meaningful set of intrinsic parameters isextracted from impedance and admittance representation of the measured S-pa-rameters in thefrequency range of 1-12 GHz under different bias conditions. The method yields a deviation of lessthan 5% between measured and modeled S-parameters.
基金supported by Research on the Oscillation Mechanism and Suppression Strategy of Yu-E MMC-HVDC Equipment and System(2021Yudian Technology 33#).
文摘The voltage source converter based high voltage direct current(VSC-HVDC)system is based on voltage source converter,and its control system is more complex.Also affected by the fast control of power electronics,oscillation phenomenon in wide frequency domain may occur.To address the problem of small signal stability of the VSCHVDC system,a converter control strategy is designed to improve its small signal stability,and the risk of system oscillation is reduced by attaching a damping controller and optimizing the control parameters.Based on the modeling of the VSC-HVDC system,the general architecture of the inner and outer loop control of the VSCHVDC converter is established;and the damping controllers for DC control and AC control are designed in the phase-locked loop and the inner and outer loop control parts respectively;the state-space statemodel of the control system is established to analyze its performance.And the electromagnetic transient simulation model is built on the PSCAD/EMTDC simulation platform to verify the accuracy of the small signal model.The influence of the parameters of each control part on the stability of the system is summarized.The main control parts affecting stability are optimized for the phenomenon of oscillation due to changes in operation mode occurring on the AC side due to faults and other reasons,which effectively eliminates system oscillation and improves system small signal stability,providing a certain reference for engineering design.
基金National Natural Science Foundation of China under Grant No.10675060the Doctoral Foundation of the Ministry of Education of China under Grant No.2002055009
文摘We introduce a modified small-world network adding new links with nonlinearly preferential connectioninstead of adding randomly,then we apply Bak-Sneppen(BS)evolution model on this network.We study severalimportant structural properties of our network such as the distribution of link-degree,the maximum link-degree,and thegth of the shortest path.We further argue several dynamical characteristics of the model such as the important criticalvalue f_c,the f_0 avalanche,and the mutating condition,and find that those characteristics show panticular behaviors.
基金supported by a grant from Cancer Council South Australia’s Beat Cancer Project on behalf of its donors and the State Government through the Department of Health (Grant No.1159924 and 1127220)funded by a Postdoctoral Fellowship from the National Breast Cancer Foundation, Australia (Grant No.PF-17-007)
文摘Objective: Several predictors of survival have been identified in EGFR-positive non-small cell lung cancer(NSCLC) patients treated with first generation EGFR inhibitors. Prognostic models of survival outcomes with afatinib have not been evaluated.Methods: A prognostic tool for overall survival(OS)/progression free survival(PFS) based on pre-treatment clinicopathological factors was developed for EGFR-positive advanced NSCLC patients treated with first-line afatinib using penalised regression of individual-participant data from LUX-Lung 3 and 6(n = 468). Favourable, intermediate and poor risk groups were identified and externally validated using LUX-Lung 1(n = 390) and LUX-Lung 2(n = 129) trials that initiated afatinib following previous chemotherapy or EGFR inhibitor treatment.Results: Discriminative performance was good in the development and validation cohorts. For patients treated with first-line afatinib, the median OS for the favourable, intermediate and poor risk groups were > 47.7, 29.3 and 16.4 months, respectively, and the median PFS were 17.3, 13.2 and 8.3 months, respectively. The improvement in median OS with afatinib use compared to chemotherapy was > 12.4 months for the favourable risk group, whereas no OS benefit was apparent for the poor risk group. The improvement in median PFS with afatinib use compared to chemotherapy was 10.2 months for the favourable risk group and 3.2 months for the poor risk group.Conclusions: A prognostic tool was developed and validated to identify favourable, intermediate and poor risk groups for OS/PFS in EGFR-positive advanced NSCLC patients treated with afatinib. The prognostic groups can inform the likely absolute OS/PFS benefit expected from afatinib compared to chemotherapy in first-line treatment.
文摘The paper applies multi-dimension to lower technology-projection pursuit evaluation model in the conservation of water and soil discipline domain, optimizes the projection direction using the improved acceleration genetic algorithms, transforms the multi-dimensional data target to lower sub-space, and values soil adaptability of Dongdagou basin in Keshan County by searching the optimal projection direction and the projection function data. The paper provides a new notion and method for the conservation of water and soil in small basin.
文摘Further to the investigation of the critical properties of the Potts model with <em>q</em> = 3 and 8 states in one dimension (1D) on directed small-world networks reported by Aquino and Lima, which presents, in fact, a second-order phase transition with a new set of critical exponents, in addition to what was reported in Sumour and Lima in studying Ising model on non-local directed small-world for several values of probability 0 < <em>P</em> < 1. In this paper the behavior of two models discussed previously, will be re-examined to study differences between their behavior on directed small-world networks for networks of different values of probability <em>P</em> = 0.1, 0.2, 0.3, 0.4 and 0.5 with different lattice sizes <em>L</em> = 10, 20, 30, 40, and 50 to compare between the important physical variables between Ising and Potts models on the directed small-world networks. We found in our paper that is a phase transitions in both Ising and Potts models depending essentially on the probability <em>P</em>.
文摘The Lagrangian equations of motion of small particle in turbulent boundary layer flows, taking into account the effects of the drug force caused by the wall presence, the Saffman and the Magus lift forces et al., is studied. Using the spectral method, analytical expression relating to the Lagrangian power spectra of particle velocity to that of the fluid are developed and the results are used to evaluate various responses statistics. In this paper, the results clearly show that the turbulent diffusivity of the particle may be larger than that of the fluid for a period of long-time.
文摘Purpose: To evaluate the quality of three-dimensional (3D) CT angiography images of the abdominal viscera with small focal spot, low tube voltage, and iterative model reconstruction technique (IMR). Materials and Methods: Seven patients with suspected disease of the pancreatobiliary system had undergone CT with high-quality CTA protocol in the present study. There were 5 men and 2 women, ranging in age from 52 to 80 years (mean: 64 years). Results: Depiction of abdominal small artery, small portal vein was possible in all cases. In two cases that we were able to compare, it was superior to standard CTA in small vascular depiction in CTA made clearly in high quality protocol. Conclusions: Although the use of small focal spot, low tube voltage, and IMR can produce higher-quality images of abdominal vessels than standard CTA, this improvement is not significant at elevated radiation doses.
文摘The present work deals with a detailed analysis of the small-angle X-ray scattering of nanoporous atomistic models for amorphous germanium. Structures with spherical nanovoids, others with arbitrarily oriented ellipsoidal ones, with monodisperse and polydisperse size distributions, were first generated. After relaxing the as-generated structure, we compute its radial distribution function, and then we deduce by the Fourier transform technique its X-ray scattering pattern. Using a smoothing procedure, the computed small-angle X-ray scattering patterns are corrected for the termination errors due to the finite size of the model, allowing so, for the first time at our best knowledge, a rigorous quantitative analysis of this scattering. The Guinier’s law is found to be valid irrespective of size and shape of the nanovoids over a scattering vector-range extending beyond the expected limit. A weighted combination of the Guinier’s forms accounts for well the nanovoid size distribution in the amorphous structure. The invariance of the Q-factor and its relationship to the void volume fraction are also confirmed. Our findings support then the quantitative analyses of available small-angle X-ray scattering data for amorphous germanium.