We investigate how dynamical behaviours of complex motor networks depend on the Newman-Watts small-world （NWSW） connections. Network elements are described by the permanent magnet synchronous motor （PMSM） with the...We investigate how dynamical behaviours of complex motor networks depend on the Newman-Watts small-world （NWSW） connections. Network elements are described by the permanent magnet synchronous motor （PMSM） with the values of parameters at which each individual PMSM is stable. It is found that with the increase of connection probability p, the motor in networks becomes periodic and falls into chaotic motion as p further increases. These phenomena imply that NWSW connections can induce and enhance chaos in motor networks. The possible mechanism behind the action of NWSW connections is addressed based on stability theory.展开更多
The main objective is to study the role or nitric oxide (NO) in small Intestinal migratingmotor complex (MMC). Rats were implanted with strain gauges in the duobenum and jejunum forrecording the motor action of the sm...The main objective is to study the role or nitric oxide (NO) in small Intestinal migratingmotor complex (MMC). Rats were implanted with strain gauges in the duobenum and jejunum forrecording the motor action of the small intestine in fasting and red states arter intravenous infusionof N'-nitro-L-arginine methyl ester (L-NAME ), L-arginin., D-arglnine, sodium nitropusside(NaNP) and angiotensin 1 respectively. The results showed that intravenous inrusion or L-NAME,a NO synthase inhibitor, induced a fasting-like MMC motor pattern in fed rats. Infusion of NaNP, aNO donor, disrupted small intestinal MMC in fasting rats, inducing a postprandial-like motor pattern. Both fasting and postprandial, infusion of L-NAME shortened the duration or Phase I andphase Ⅱ,but didn't chang. the duration, frequency, amplitude and s,eed or Propogatiou of thephaSe, Ⅲ-argining, not D-arginine infused together with L-NAME, prevented the effect of LNAME infusion. Infusion of L-arginine, D-arginine or angioteusin Ⅰ alone didn't modify the smallintestinal motor pattern. It suggests that an inhibition of NO synthesis may be involved in the initiation of the MMC motor pattern during fasting, whereas an increase of NO output relates to the occurrence of the fed motor pattern展开更多
目的:研究小针刀联合经颅磁刺激(Transcranial Magnetic Stimulation.TMS)在改善脑梗死后遗症期患者上肢痉挛症状中的临床疗效。方法:选取2021年6月~2023年6月在本院就诊的80例脑梗死后遗症期上肢轻至中度痉挛患者,随机将其分为小针刀组...目的:研究小针刀联合经颅磁刺激(Transcranial Magnetic Stimulation.TMS)在改善脑梗死后遗症期患者上肢痉挛症状中的临床疗效。方法:选取2021年6月~2023年6月在本院就诊的80例脑梗死后遗症期上肢轻至中度痉挛患者,随机将其分为小针刀组(n=26)、TMS组(n=27)、联合组(n=27)。所有患者在常规康复训练基础上,小针刀组进行小针刀治疗,TMS组进行经颅磁治疗,联合组进行联合治疗。治疗前后评估患者的Fugl-Meyer量表分数、临床痉挛指数分数,运动诱发电位,和静息运动阈值。结果:三组患者治疗后Fugl-Meyer评分均提高,临床痉挛指数评分均下降(P<0.01),其中联合治疗组的FuglMeyer评分高于单一治疗组,临床痉挛指数评分低于单一治疗组(P<0.01):三组患者治疗后运动诱发电位潜伏期均缩短,波幅增高(P<0.01),其中联合治疗组的运动诱发电位潜伏期短于单一治疗组,波幅高于单一治疗组(P<0.01):三组患者治疗后静息运动阈值均下降(P<0.01),其中联合治疗组的静息运动阈值低于单一治疗组(P<0.01)。结论:小针刀联合经颅磁刺激治疗能有效缓解脑梗死后上肢功能痉挛患者的上肢痉挛、中枢神经系统功能及大脑皮层兴奋性,疗效优于单一治疗方法。展开更多
A previous study by our group found that inhibition of nischarin promotes neurite outgrowth and neuronal regeneration in Neuro-2 a cells and primary cortical neurons.In recent years,more and more studies have shown th...A previous study by our group found that inhibition of nischarin promotes neurite outgrowth and neuronal regeneration in Neuro-2 a cells and primary cortical neurons.In recent years,more and more studies have shown that nanomaterials have good prospects in treatment of spinal cord injury.We proposed that small interfering RNA targeting nischarin（Nis-si RNA） delivered by polyethyleneimine-alginate（PEIALG） nanoparticles promoted motor function recovery in rats with spinal cord injury.Direct microinjection of 5 μL PEI-ALG/Nis-si RNA into the spinal cord lesion area of spinal cord injury rats was performed.From day 7 after surgery,Basso,Beattie and Bresnahan score was significantly higher in rats from the PEI-ALG/Nis-si RNA group compared with the spinal cord injury group and PEI-ALG/Control-si RNA group.On day 21 after injection,hematoxylin-eosin staining showed that the necrotic area was reduced in the PEI-ALG/Nis-si RNA group.Immunohistochemistry and western blot assay results confirmed successful inhibition of nischarin expression and increased protein expression of growth-associated protein-43 in the PEI-ALG/Nis-si RNA group.These findings suggest that a complex of PEI-ALG nanoparticles and Nis-si RNA effectively suppresses nischarin expression,induces expression of growth-associated protein-43,and accelerates motor function recovery after spinal cord injury.展开更多
The inverter-fed induction motor drive system may become unstable at low frequencies and light load, and phase current and speed of the induction motor may oscillate periodically, which will threaten safety and reliab...The inverter-fed induction motor drive system may become unstable at low frequencies and light load, and phase current and speed of the induction motor may oscillate periodically, which will threaten safety and reliability of the system. This paper chooses nine-phase induction motor simulated propulsion system as the research object, small disturbance model of three-phase induction motor is built, and average equivalent model of the converter is built by introducing switch function. On the basis above, small disturbance mathematic model of the whole system is obtained. As for the limitation of parameters adjustment method of restrain low-frequency oscillation, the restrain method combining current close-loop with dead-time compensation is put forward. Finally, the proposed restrain method is verified respectively on the built simulation and experimental analogue platform. And the simulation and experimental results indicate that the proposed method can not only satisfy the requirement of low-frequency oscillation restraining, but also be expanded widely, and the stability of the system can get improved greatly.展开更多
基金Project supported by the Key Program of the National Natural Science Foundation of China (Grant No. 50937001)the National Natural Science Foundation of China (Grant Nos. 10862001 and 10947011)the Construction of Key Laboratories in Universities of Guangxi,China (Grant No. 200912)
文摘We investigate how dynamical behaviours of complex motor networks depend on the Newman-Watts small-world （NWSW） connections. Network elements are described by the permanent magnet synchronous motor （PMSM） with the values of parameters at which each individual PMSM is stable. It is found that with the increase of connection probability p, the motor in networks becomes periodic and falls into chaotic motion as p further increases. These phenomena imply that NWSW connections can induce and enhance chaos in motor networks. The possible mechanism behind the action of NWSW connections is addressed based on stability theory.
文摘The main objective is to study the role or nitric oxide (NO) in small Intestinal migratingmotor complex (MMC). Rats were implanted with strain gauges in the duobenum and jejunum forrecording the motor action of the small intestine in fasting and red states arter intravenous infusionof N'-nitro-L-arginine methyl ester (L-NAME ), L-arginin., D-arglnine, sodium nitropusside(NaNP) and angiotensin 1 respectively. The results showed that intravenous inrusion or L-NAME,a NO synthase inhibitor, induced a fasting-like MMC motor pattern in fed rats. Infusion of NaNP, aNO donor, disrupted small intestinal MMC in fasting rats, inducing a postprandial-like motor pattern. Both fasting and postprandial, infusion of L-NAME shortened the duration or Phase I andphase Ⅱ,but didn't chang. the duration, frequency, amplitude and s,eed or Propogatiou of thephaSe, Ⅲ-argining, not D-arginine infused together with L-NAME, prevented the effect of LNAME infusion. Infusion of L-arginine, D-arginine or angioteusin Ⅰ alone didn't modify the smallintestinal motor pattern. It suggests that an inhibition of NO synthesis may be involved in the initiation of the MMC motor pattern during fasting, whereas an increase of NO output relates to the occurrence of the fed motor pattern
文摘目的:研究小针刀联合经颅磁刺激(Transcranial Magnetic Stimulation.TMS)在改善脑梗死后遗症期患者上肢痉挛症状中的临床疗效。方法:选取2021年6月~2023年6月在本院就诊的80例脑梗死后遗症期上肢轻至中度痉挛患者,随机将其分为小针刀组(n=26)、TMS组(n=27)、联合组(n=27)。所有患者在常规康复训练基础上,小针刀组进行小针刀治疗,TMS组进行经颅磁治疗,联合组进行联合治疗。治疗前后评估患者的Fugl-Meyer量表分数、临床痉挛指数分数,运动诱发电位,和静息运动阈值。结果:三组患者治疗后Fugl-Meyer评分均提高,临床痉挛指数评分均下降(P<0.01),其中联合治疗组的FuglMeyer评分高于单一治疗组,临床痉挛指数评分低于单一治疗组(P<0.01):三组患者治疗后运动诱发电位潜伏期均缩短,波幅增高(P<0.01),其中联合治疗组的运动诱发电位潜伏期短于单一治疗组,波幅高于单一治疗组(P<0.01):三组患者治疗后静息运动阈值均下降(P<0.01),其中联合治疗组的静息运动阈值低于单一治疗组(P<0.01)。结论:小针刀联合经颅磁刺激治疗能有效缓解脑梗死后上肢功能痉挛患者的上肢痉挛、中枢神经系统功能及大脑皮层兴奋性,疗效优于单一治疗方法。
基金supported by the Natural Science Foundation of Zhejiang Province of China,No.LY15H250001 and LY14H090002the National Natural Science Foundation of China,No.81000535 and 81402872+1 种基金the Medical Science and Technology Project Foundation of Zhejiang Province of China,No.2014KYA166the Science and Technology Innovation Talents Development Plan Foundation for High School Students in Zhejiang Province of China,No.2014R401186
文摘A previous study by our group found that inhibition of nischarin promotes neurite outgrowth and neuronal regeneration in Neuro-2 a cells and primary cortical neurons.In recent years,more and more studies have shown that nanomaterials have good prospects in treatment of spinal cord injury.We proposed that small interfering RNA targeting nischarin（Nis-si RNA） delivered by polyethyleneimine-alginate（PEIALG） nanoparticles promoted motor function recovery in rats with spinal cord injury.Direct microinjection of 5 μL PEI-ALG/Nis-si RNA into the spinal cord lesion area of spinal cord injury rats was performed.From day 7 after surgery,Basso,Beattie and Bresnahan score was significantly higher in rats from the PEI-ALG/Nis-si RNA group compared with the spinal cord injury group and PEI-ALG/Control-si RNA group.On day 21 after injection,hematoxylin-eosin staining showed that the necrotic area was reduced in the PEI-ALG/Nis-si RNA group.Immunohistochemistry and western blot assay results confirmed successful inhibition of nischarin expression and increased protein expression of growth-associated protein-43 in the PEI-ALG/Nis-si RNA group.These findings suggest that a complex of PEI-ALG nanoparticles and Nis-si RNA effectively suppresses nischarin expression,induces expression of growth-associated protein-43,and accelerates motor function recovery after spinal cord injury.
文摘The inverter-fed induction motor drive system may become unstable at low frequencies and light load, and phase current and speed of the induction motor may oscillate periodically, which will threaten safety and reliability of the system. This paper chooses nine-phase induction motor simulated propulsion system as the research object, small disturbance model of three-phase induction motor is built, and average equivalent model of the converter is built by introducing switch function. On the basis above, small disturbance mathematic model of the whole system is obtained. As for the limitation of parameters adjustment method of restrain low-frequency oscillation, the restrain method combining current close-loop with dead-time compensation is put forward. Finally, the proposed restrain method is verified respectively on the built simulation and experimental analogue platform. And the simulation and experimental results indicate that the proposed method can not only satisfy the requirement of low-frequency oscillation restraining, but also be expanded widely, and the stability of the system can get improved greatly.
