Two-phase flow pressure drop measurements were made during the phase change heat transfer process of R22 in a small horizontal smooth tube with 2.5 mm inside diameter. Conclusions can be drawn that the quality corresp...Two-phase flow pressure drop measurements were made during the phase change heat transfer process of R22 in a small horizontal smooth tube with 2.5 mm inside diameter. Conclusions can be drawn that the quality corresponding to the pressure gradient peak value of small tubes became higher than that of large tubes. The effect of quality to pressure drop becomes weak as the mass flux increases. The experiment data were compared with the predicated values of the state-of-the-art correlations from the open literature. The comparisons between the data and the predictions indicate that most of the state-of-the-art correlations fails to predict the experimental data. Chisholm model shows a relatively better predictive ability than the other empirical correlations although it has a mean deviation of 26.7%. But the predicated values of Chisholm model are lower by 50% than the experimental data when the quality becomes larger.展开更多
Objective To investigate the placement of a long tube into the small intestine under fluoroscopic guidance and to evaluate its decompression effect on early postoperative small bowel obstruction(EPSBO).Methods Fifty-f...Objective To investigate the placement of a long tube into the small intestine under fluoroscopic guidance and to evaluate its decompression effect on early postoperative small bowel obstruction(EPSBO).Methods Fifty-four patients with EPSBO requiring decompression between April 2010 and July 2014 were enrolled in the study.Insertion of a long tube was guided by fluoroscopy.We first used the guide wire to pass the pylorus and then used the 10 Fr feeding tube as an exchangeable tube to put the superstiff wire into the duodenum.Finally the long tube could be passed over the guide wire through the pylorus into the intestine.The total procedure time,the radiation exposure time,and the incidence of complications were evaluated.Results The long tubes passed into the jejunum on initial insertion for all patients,so the success rate of this technique was 100%.The long tube was inserted into ileum in 18 patients.The mean total procedure time was 34.4±8.6 minutes,and the mean radiation exposure time 18.9±6.8 minutes.A total of 47 patients(87%) experienced full recovery following long-tube decompression and without the need for surgical intervention.Conclusions Using the wire-exchange technique,it is easy to place a long tube into the small bowel under fluoroscopic guidance.This decompression method is safe and effective for management of EPSBO.展开更多
Currently requirements of thin-walled tube with small bending radius cause the defects such as wrinkling, overthinning and cross-section distortion more prone to occur in bending process. Based on the analysis of the ...Currently requirements of thin-walled tube with small bending radius cause the defects such as wrinkling, overthinning and cross-section distortion more prone to occur in bending process. Based on the analysis of the forming characteristics by analytical and experimental methods, a complete 3D elastic-plastic FEM model of the process was developed using ABAQUS/Explicit code, including bending process, balls retracting and unloading process, and thus the plastic deformation characteristics with small bending radius were investigated. The main results show that: 1) The utmost deformation feature of the NC bending process is its continuous progressive deformation. 2) The occurring conditions of the defects such as wrinkling and tension instability in the process are obtained. The wrinkling is traditional on the double compressive stresses state and the tension instability is on the double tension stresses state. 3) The enhanced non-uniform deformation in thin-walled tube with small bending radius is demonstrated by comparing the stress/ strains distributions under the 1.5D and 1D bending conditions. 4) For ID small bending process, a new method-'stepped mandrel retraction' is proposed to improve the bending quality in experiment according to the FE simulation. The simulation results are verified by experiment.展开更多
Purpose: To evaluate the quality of three-dimensional (3D) CT angiography images of the abdominal viscera with small focal spot, low tube voltage, and iterative model reconstruction technique (IMR). Materials and Meth...Purpose: To evaluate the quality of three-dimensional (3D) CT angiography images of the abdominal viscera with small focal spot, low tube voltage, and iterative model reconstruction technique (IMR). Materials and Methods: Seven patients with suspected disease of the pancreatobiliary system had undergone CT with high-quality CTA protocol in the present study. There were 5 men and 2 women, ranging in age from 52 to 80 years (mean: 64 years). Results: Depiction of abdominal small artery, small portal vein was possible in all cases. In two cases that we were able to compare, it was superior to standard CTA in small vascular depiction in CTA made clearly in high quality protocol. Conclusions: Although the use of small focal spot, low tube voltage, and IMR can produce higher-quality images of abdominal vessels than standard CTA, this improvement is not significant at elevated radiation doses.展开更多
The welding temperature field and deformation of parallel arrangement small-section rectangular tubes is calculated by using a non-contact model. After comparing the computed results with the experimentally measured r...The welding temperature field and deformation of parallel arrangement small-section rectangular tubes is calculated by using a non-contact model. After comparing the computed results with the experimentally measured results, it shows that there exist big errors when applying this model to the numerical simulation of small-section rectangular tube' s welding temperature field and deformation. Based on a simple analysis of the errors, a contact model is presented. The heat transfer and stress analysis between small-section rectangular tubes and clamping fixture are simulated by using direct constraints method, and then the laws of the temperature distribution, which coincide with experiment, are obtained. A further numerical analysis of the stress and deformation are made, it shows that a "T" shaped stress-field is formed in the vicinity of the weld. As the stress-field departs from the centroid of tubes', this leads to the small rectangular tubes not only have a longitudinal deflection, but also have a transverse bending and deformation.展开更多
AIMTo determine whether small interfering RNA (siRNA) of PGC-1α could inhibit vascular endothelial growth factor (VEGF) expression and tube formation in human retinal vascular endothelial cells (hRVECs).ME...AIMTo determine whether small interfering RNA (siRNA) of PGC-1α could inhibit vascular endothelial growth factor (VEGF) expression and tube formation in human retinal vascular endothelial cells (hRVECs).METHODShRVECs transfected with peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) siRNA were incubated for 24h and then placed into a normoxic (20%, O<sub>2</sub>) or hypoxic (1%, O<sub>2</sub>) environment for another 16h. PGC-1α mRNA and protein levels were detected by real-time PCR and Western blot. VEGF mRNA and protein levels were detected by real-time PCR and ELISA. Cell proliferation was evaluated by BrdU incorporation assay. Forty-eight hours after siRNA transfection, hRVECs were planted into Matrigel-coated plates and cultured under normoxic (20%, O<sub>2</sub>) or hypoxic (1%, O<sub>2</sub>) conditions for another 48h. The tube formation of hRVECs was observed under an optical microscope and quantified by counting the number of branch points and calculating the total tube length.RESULTSPGC-1α mRNA and protein levels were significantly reduced by PGC-1α siRNA, and VEGF mRNA and protein levels also decreased significantly. The percentage of BrdU-labeled cells in siPGC-1α groups were significantly decreased compared with control siRNA groups under normoxia and hypoxia in cell proliferation assay. In the tube formation assay, PGC-1α siRNA treated cells formed significantly fewer tubes.CONCLUSIONBlocking PGC-1α expression can inhibit VEGF expression in hRVECs and inhibit their ability to form tubes under both normoxic and hypoxic conditions.展开更多
Background: Surveys of pediatric endotracheal tube (ETT) management previously reported that specialists in pediatric anesthesia and intensive care medicine preferred to use uncuffed ETTs for children younger than 8 t...Background: Surveys of pediatric endotracheal tube (ETT) management previously reported that specialists in pediatric anesthesia and intensive care medicine preferred to use uncuffed ETTs for children younger than 8 to 10 years of age. The aim of this study was to reveal the most recent attitudes and clinical practices of pediatric ETT management in Japan. Methods: The attitudes and clinical practices of pediatric ETT management were investigated using the data sheets of each institution and each patient. The data sheets contained information on patient characteristics and type of hospital, surgical procedures, devices used for intubation, and ETT information including types, size, depth, intracuff pressure (ICP), interval of ICP measurement, laryngeal packing, ETT exchange, airway complications, and reintubations. Results: The response rate of this survey was 66.7%. More than half of children older than 2 years of age were intubated with cuffed ETTs;83.5% of cuffed ETTs were used with the cuffs inflated, and ICP was measured in 80.7% of cuffed ETTs. More than half of ICP measurements were only taken at the time of intubation. Post-extubation stridor was rarely observed in cuffed (0.4%) or uncuffed ETTs (1.2%). The pediatric ETT management questionnaire revealed age-based size selection, differences in pressure of air leakage between cuffed (15 - 20 cmH2O) and uncuffed ETTs (20 - 30 cmH2O) of different sizes, the depthmarking method of insertion length. Continuous measurement of ICP was not common. Conclusion: This study revealed widespread use of cuffed ETTs in children older than 2 years of age, rarely occurrence of post-extubation stridor, inflation of cuffs, and practice of ICP measurement.展开更多
Two-phase flow pressure drop measurements are made during phase change heat transfer process of R-22 in small horizontal smooth tubes with 2.5 mm inside diameter. Conclusions are drawn that the quality corresponding t...Two-phase flow pressure drop measurements are made during phase change heat transfer process of R-22 in small horizontal smooth tubes with 2.5 mm inside diameter. Conclusions are drawn that the quality corresponding to pressure gradient peak value of small tubes became higher than that of large tubes and that effects of quality on pressure drop become weak as the increase of mass flux. The experiment data are compared with predicted values of the state-of-the-art correlations from the open literature, which indicates that most of the state-of-the-art correlations fail to predict the present experimental data. Chisholm model shows a relatively better predictive ability than the other empirical correlations because it has the lowest mean deviation of 26.7%. But the predicted values of Chisholm model are 50% lower than experimental data when quality becomes higher. In this regard, an new empirical correlation based on Chisholm model is developed and this modified Chisholm correlation can describe 95% of the present data with ±20% mean deviations.展开更多
Numerical control(NC) bending experiments with different process parameters were carried out for 5052O aluminum alloy tubes with outer diameter of 70 mm, wall thickness of 1.5 mm, and centerline bending radius of 105 ...Numerical control(NC) bending experiments with different process parameters were carried out for 5052O aluminum alloy tubes with outer diameter of 70 mm, wall thickness of 1.5 mm, and centerline bending radius of 105 mm. And the effects of process parameters on tube wall thinning and cross section distortion were investigated. Meanwhile, acceptable bending of the 5052O aluminum tubes was accomplished based on the above experiments. The results show that the effects of process parameters on bending process for large diameter thin-walled aluminum alloy tubes are similar to those for small diameter thin-walled tubes, but the forming quality of the large diameter thin-walled aluminum alloy tubes is much more sensitive to the process parameters and thus it is more difficult to form.展开更多
Intussusception is quite uncommon in adults.We report a rare case of a 76-year-old man with small bowel intussusception induced by two indwelling bowel tubes,the first a jejunal feeding tube and the second an ileus tu...Intussusception is quite uncommon in adults.We report a rare case of a 76-year-old man with small bowel intussusception induced by two indwelling bowel tubes,the first a jejunal feeding tube and the second an ileus tube.After complete reduction of the first intussusception caused by the jejunal feeding tube and adhesion,reintussusception occurred due to the postoperative adhesion and ileus tube inserted into the bowel after the previous operation for intussusception.Finally,the part of the jejunum with re-intussusception and adhesion,including the place where the previous reduced intussusception had occurred,was resected.This case is a reminder that when there is no mucosal lesion other than an indwelling bowel tube or a hard adhesion/ inflammation around intussusception,the patient should be operated on without delay for resection of the intussusception to prevent re-intussusception,even if the resected bowel is predicted to be long.展开更多
Background: Accurate determination of the optimal insertion depth of a pediatric endotracheal tube (ETT) is quite important. The aim of this study was to create an easily available formula that can be used to determin...Background: Accurate determination of the optimal insertion depth of a pediatric endotracheal tube (ETT) is quite important. The aim of this study was to create an easily available formula that can be used to determine the optimal insertion depth for a cuffed ETT even without depth marking with clear definitions of the upper and lower limits for the tip of ETT in the trachea in clinical practice. Methods: Eighty children under 12 years of age were enrolled. The depth marking of the cuffed ETT was placed at the vocal cords and both lungs were then auscultated using a stethoscope. The upper limit was radiographically defined as the position of the tip of the cuffed ETT being between the clavicles. The lower limit was defined as a distance of 5 mm above the carina. The relationship between the insertion depth and patient characteristics was analyzed to create a formula for optimal ETT insertion depth. Results: Sixty-nine ETTs were optimally placed in the trachea. There were good correlations between the optimal insertion depth of ETTs and patients characteristics (height (R = 0.92);BSA (R = 0.92);weight (R = 0.91);age (R = 0.88)). Using these patient characteristics, we created the following three formulas for calculation of the optimal insertion depth for pediatric cuffed ETTs: insertion depth (cm) = height (cm)/11 + 5.5, weight (kg)/3 + 9.5 or 11 + 3/4 × age (years). The rates of appropriate tube placement of both pediatric cuffed ETTs were 87.5% (Hi-Contour) and 85.0% (Microcuff). Conclusions: Our formula and graphs may be easy to determine the optimal insertion depth of cuffed ETT even without depth marking in clinical practice.展开更多
文摘Two-phase flow pressure drop measurements were made during the phase change heat transfer process of R22 in a small horizontal smooth tube with 2.5 mm inside diameter. Conclusions can be drawn that the quality corresponding to the pressure gradient peak value of small tubes became higher than that of large tubes. The effect of quality to pressure drop becomes weak as the mass flux increases. The experiment data were compared with the predicated values of the state-of-the-art correlations from the open literature. The comparisons between the data and the predictions indicate that most of the state-of-the-art correlations fails to predict the experimental data. Chisholm model shows a relatively better predictive ability than the other empirical correlations although it has a mean deviation of 26.7%. But the predicated values of Chisholm model are lower by 50% than the experimental data when the quality becomes larger.
文摘Objective To investigate the placement of a long tube into the small intestine under fluoroscopic guidance and to evaluate its decompression effect on early postoperative small bowel obstruction(EPSBO).Methods Fifty-four patients with EPSBO requiring decompression between April 2010 and July 2014 were enrolled in the study.Insertion of a long tube was guided by fluoroscopy.We first used the guide wire to pass the pylorus and then used the 10 Fr feeding tube as an exchangeable tube to put the superstiff wire into the duodenum.Finally the long tube could be passed over the guide wire through the pylorus into the intestine.The total procedure time,the radiation exposure time,and the incidence of complications were evaluated.Results The long tubes passed into the jejunum on initial insertion for all patients,so the success rate of this technique was 100%.The long tube was inserted into ileum in 18 patients.The mean total procedure time was 34.4±8.6 minutes,and the mean radiation exposure time 18.9±6.8 minutes.A total of 47 patients(87%) experienced full recovery following long-tube decompression and without the need for surgical intervention.Conclusions Using the wire-exchange technique,it is easy to place a long tube into the small bowel under fluoroscopic guidance.This decompression method is safe and effective for management of EPSBO.
基金Projects(59975076, 50175092) supported by the National Natural Science Foundation of China Project(50225518) by the National Science Found of China for Distinguished Young Scholars Project by the Teaching and Research Award Program for Outstanding Young Teachers in Higher Education Institutions of MOE, PRC Project(20020699002) by the Specialized Research Fund for the Doctoral Program of Higher Education of MOE, PRC Project (04H53057) by Aviation Science Foundation
文摘Currently requirements of thin-walled tube with small bending radius cause the defects such as wrinkling, overthinning and cross-section distortion more prone to occur in bending process. Based on the analysis of the forming characteristics by analytical and experimental methods, a complete 3D elastic-plastic FEM model of the process was developed using ABAQUS/Explicit code, including bending process, balls retracting and unloading process, and thus the plastic deformation characteristics with small bending radius were investigated. The main results show that: 1) The utmost deformation feature of the NC bending process is its continuous progressive deformation. 2) The occurring conditions of the defects such as wrinkling and tension instability in the process are obtained. The wrinkling is traditional on the double compressive stresses state and the tension instability is on the double tension stresses state. 3) The enhanced non-uniform deformation in thin-walled tube with small bending radius is demonstrated by comparing the stress/ strains distributions under the 1.5D and 1D bending conditions. 4) For ID small bending process, a new method-'stepped mandrel retraction' is proposed to improve the bending quality in experiment according to the FE simulation. The simulation results are verified by experiment.
文摘Purpose: To evaluate the quality of three-dimensional (3D) CT angiography images of the abdominal viscera with small focal spot, low tube voltage, and iterative model reconstruction technique (IMR). Materials and Methods: Seven patients with suspected disease of the pancreatobiliary system had undergone CT with high-quality CTA protocol in the present study. There were 5 men and 2 women, ranging in age from 52 to 80 years (mean: 64 years). Results: Depiction of abdominal small artery, small portal vein was possible in all cases. In two cases that we were able to compare, it was superior to standard CTA in small vascular depiction in CTA made clearly in high quality protocol. Conclusions: Although the use of small focal spot, low tube voltage, and IMR can produce higher-quality images of abdominal vessels than standard CTA, this improvement is not significant at elevated radiation doses.
文摘The welding temperature field and deformation of parallel arrangement small-section rectangular tubes is calculated by using a non-contact model. After comparing the computed results with the experimentally measured results, it shows that there exist big errors when applying this model to the numerical simulation of small-section rectangular tube' s welding temperature field and deformation. Based on a simple analysis of the errors, a contact model is presented. The heat transfer and stress analysis between small-section rectangular tubes and clamping fixture are simulated by using direct constraints method, and then the laws of the temperature distribution, which coincide with experiment, are obtained. A further numerical analysis of the stress and deformation are made, it shows that a "T" shaped stress-field is formed in the vicinity of the weld. As the stress-field departs from the centroid of tubes', this leads to the small rectangular tubes not only have a longitudinal deflection, but also have a transverse bending and deformation.
基金Supported by National Natural Science Fundation of China(No.81000387)
文摘AIMTo determine whether small interfering RNA (siRNA) of PGC-1α could inhibit vascular endothelial growth factor (VEGF) expression and tube formation in human retinal vascular endothelial cells (hRVECs).METHODShRVECs transfected with peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) siRNA were incubated for 24h and then placed into a normoxic (20%, O<sub>2</sub>) or hypoxic (1%, O<sub>2</sub>) environment for another 16h. PGC-1α mRNA and protein levels were detected by real-time PCR and Western blot. VEGF mRNA and protein levels were detected by real-time PCR and ELISA. Cell proliferation was evaluated by BrdU incorporation assay. Forty-eight hours after siRNA transfection, hRVECs were planted into Matrigel-coated plates and cultured under normoxic (20%, O<sub>2</sub>) or hypoxic (1%, O<sub>2</sub>) conditions for another 48h. The tube formation of hRVECs was observed under an optical microscope and quantified by counting the number of branch points and calculating the total tube length.RESULTSPGC-1α mRNA and protein levels were significantly reduced by PGC-1α siRNA, and VEGF mRNA and protein levels also decreased significantly. The percentage of BrdU-labeled cells in siPGC-1α groups were significantly decreased compared with control siRNA groups under normoxia and hypoxia in cell proliferation assay. In the tube formation assay, PGC-1α siRNA treated cells formed significantly fewer tubes.CONCLUSIONBlocking PGC-1α expression can inhibit VEGF expression in hRVECs and inhibit their ability to form tubes under both normoxic and hypoxic conditions.
文摘Background: Surveys of pediatric endotracheal tube (ETT) management previously reported that specialists in pediatric anesthesia and intensive care medicine preferred to use uncuffed ETTs for children younger than 8 to 10 years of age. The aim of this study was to reveal the most recent attitudes and clinical practices of pediatric ETT management in Japan. Methods: The attitudes and clinical practices of pediatric ETT management were investigated using the data sheets of each institution and each patient. The data sheets contained information on patient characteristics and type of hospital, surgical procedures, devices used for intubation, and ETT information including types, size, depth, intracuff pressure (ICP), interval of ICP measurement, laryngeal packing, ETT exchange, airway complications, and reintubations. Results: The response rate of this survey was 66.7%. More than half of children older than 2 years of age were intubated with cuffed ETTs;83.5% of cuffed ETTs were used with the cuffs inflated, and ICP was measured in 80.7% of cuffed ETTs. More than half of ICP measurements were only taken at the time of intubation. Post-extubation stridor was rarely observed in cuffed (0.4%) or uncuffed ETTs (1.2%). The pediatric ETT management questionnaire revealed age-based size selection, differences in pressure of air leakage between cuffed (15 - 20 cmH2O) and uncuffed ETTs (20 - 30 cmH2O) of different sizes, the depthmarking method of insertion length. Continuous measurement of ICP was not common. Conclusion: This study revealed widespread use of cuffed ETTs in children older than 2 years of age, rarely occurrence of post-extubation stridor, inflation of cuffs, and practice of ICP measurement.
文摘Two-phase flow pressure drop measurements are made during phase change heat transfer process of R-22 in small horizontal smooth tubes with 2.5 mm inside diameter. Conclusions are drawn that the quality corresponding to pressure gradient peak value of small tubes became higher than that of large tubes and that effects of quality on pressure drop become weak as the increase of mass flux. The experiment data are compared with predicted values of the state-of-the-art correlations from the open literature, which indicates that most of the state-of-the-art correlations fail to predict the present experimental data. Chisholm model shows a relatively better predictive ability than the other empirical correlations because it has the lowest mean deviation of 26.7%. But the predicted values of Chisholm model are 50% lower than experimental data when quality becomes higher. In this regard, an new empirical correlation based on Chisholm model is developed and this modified Chisholm correlation can describe 95% of the present data with ±20% mean deviations.
基金Project(50225518) supported by the National Science Foundation of China for Distinguished Young ScholarsProject(59975076, 50175092) supported by the National Natural Science Foundation of ChinaProject(04H53057) supported by the Aviation Science Foundation of China
文摘Numerical control(NC) bending experiments with different process parameters were carried out for 5052O aluminum alloy tubes with outer diameter of 70 mm, wall thickness of 1.5 mm, and centerline bending radius of 105 mm. And the effects of process parameters on tube wall thinning and cross section distortion were investigated. Meanwhile, acceptable bending of the 5052O aluminum tubes was accomplished based on the above experiments. The results show that the effects of process parameters on bending process for large diameter thin-walled aluminum alloy tubes are similar to those for small diameter thin-walled tubes, but the forming quality of the large diameter thin-walled aluminum alloy tubes is much more sensitive to the process parameters and thus it is more difficult to form.
文摘Intussusception is quite uncommon in adults.We report a rare case of a 76-year-old man with small bowel intussusception induced by two indwelling bowel tubes,the first a jejunal feeding tube and the second an ileus tube.After complete reduction of the first intussusception caused by the jejunal feeding tube and adhesion,reintussusception occurred due to the postoperative adhesion and ileus tube inserted into the bowel after the previous operation for intussusception.Finally,the part of the jejunum with re-intussusception and adhesion,including the place where the previous reduced intussusception had occurred,was resected.This case is a reminder that when there is no mucosal lesion other than an indwelling bowel tube or a hard adhesion/ inflammation around intussusception,the patient should be operated on without delay for resection of the intussusception to prevent re-intussusception,even if the resected bowel is predicted to be long.
文摘Background: Accurate determination of the optimal insertion depth of a pediatric endotracheal tube (ETT) is quite important. The aim of this study was to create an easily available formula that can be used to determine the optimal insertion depth for a cuffed ETT even without depth marking with clear definitions of the upper and lower limits for the tip of ETT in the trachea in clinical practice. Methods: Eighty children under 12 years of age were enrolled. The depth marking of the cuffed ETT was placed at the vocal cords and both lungs were then auscultated using a stethoscope. The upper limit was radiographically defined as the position of the tip of the cuffed ETT being between the clavicles. The lower limit was defined as a distance of 5 mm above the carina. The relationship between the insertion depth and patient characteristics was analyzed to create a formula for optimal ETT insertion depth. Results: Sixty-nine ETTs were optimally placed in the trachea. There were good correlations between the optimal insertion depth of ETTs and patients characteristics (height (R = 0.92);BSA (R = 0.92);weight (R = 0.91);age (R = 0.88)). Using these patient characteristics, we created the following three formulas for calculation of the optimal insertion depth for pediatric cuffed ETTs: insertion depth (cm) = height (cm)/11 + 5.5, weight (kg)/3 + 9.5 or 11 + 3/4 × age (years). The rates of appropriate tube placement of both pediatric cuffed ETTs were 87.5% (Hi-Contour) and 85.0% (Microcuff). Conclusions: Our formula and graphs may be easy to determine the optimal insertion depth of cuffed ETT even without depth marking in clinical practice.