Objective Primary ovarian small cell carcinoma of pulmonary type(SCCOPT)is a rare ovarian tumor with a poor prognosis.The platinum-based chemotherapy is the standard treatment.However,there is little research on the c...Objective Primary ovarian small cell carcinoma of pulmonary type(SCCOPT)is a rare ovarian tumor with a poor prognosis.The platinum-based chemotherapy is the standard treatment.However,there is little research on the clinical characteristics of SCCOPT and the potential benefits of other treatments due to its low incidence.The study aims to investigate clinicopathological characteristics and treatment of SCCOPT.Methods We summarized the clinical,imaging,laboratorical and pathological characteristics of 37 SCCOPT cases,in which 6 cases were admitted to the Gansu Provincial Hospital from the year of 2008 to 2022 and 31 cases reported in 17 English and 3 Chinese literatures.Results The median age of the studied SCCOPT cases(n=37)was 56.00(range,22-80)years.Almost 80%of them had a stageⅢorⅣtumor.All patients underwent an operation and postoperative chemotherapy.Nevertheless,all cases had a poor prognosis,with a median overall survival time of 12 months.Immunohistochemical y,the SCCOPT of all patients showed positive expressions of epithelial markers,such as CD56 and sex-determining region of Y chromosome-related high-mobility-group box 2(SOX-2),and negative expressions of estrogen receptor,progesterone receptor,vimentin,Leu-7,and somatostatin receptor 2.The tumor of above 80%cases expressed synaptophysin.Only a few cases expressed neuron-specific enolase,chromogranin A,and thyroid transcription factor-1.Conclusions SCCOPT had a poor prognosis.SOX-2 could be a biomarker to be used to diagnose SCCOPT.展开更多
Recent developments in acceptor–donor–acceptor(A–D–A) type non-fullerene acceptors have led to substantial improvements in bulk-heterojunction polymer solar cells efficiency. The device performance strongly depend...Recent developments in acceptor–donor–acceptor(A–D–A) type non-fullerene acceptors have led to substantial improvements in bulk-heterojunction polymer solar cells efficiency. The device performance strongly depends on photoactive layer morphology, as the molecular packing, donor–acceptor interface and phase separation significantly affect the charge-transfer states and charge carrier dynamics. In this review, we start with a brief introduction of the techniques most effectively utilized to characterize multiphase morphology. Then, we summarize recent progress in A–D–A type acceptors, with the emphasis on understanding the molecular structure–morphology–performance relationships. Finally, an outlook on correlating morphological characteristics with photovoltage losses is presented for further improving device performance.展开更多
The purpose of this article is to classify the regional economic types and development dynamics of small towns in suburb Beijing by applying the classification methods developed by Nelson's method and Location Quo...The purpose of this article is to classify the regional economic types and development dynamics of small towns in suburb Beijing by applying the classification methods developed by Nelson's method and Location Quotient method into 183 small towns in Beijing.Four types of small towns are thus identified,including urban agriculture dominated towns,manufacturing dominated towns,service industry dominated towns and comprehensive type towns with balanced economic development.Within the environment of geographical information system,the spatial distribution pattern of four types of small towns with their evolution trend is analyzed.The results indicate that four types of small towns have obvious'core-periphery'spatial structure but with different functional orientations and evolution mechanisms.Based on this,the different development strategies for each type of small towns are summarized,providing a scientific reference for the differentiating planning and development strategies of these small towns.展开更多
土壤-表层岩溶带厚度是喀斯特地球关键带的关键指标,明确其空间异质性特征对于理解地球关键带结构演化机理以及评估水源涵养功能具有重要意义。在广西环江木连小流域1.4 km 2范围内,通过高密度电法(ERT)探测45条样线,共获取1731个样点...土壤-表层岩溶带厚度是喀斯特地球关键带的关键指标,明确其空间异质性特征对于理解地球关键带结构演化机理以及评估水源涵养功能具有重要意义。在广西环江木连小流域1.4 km 2范围内,通过高密度电法(ERT)探测45条样线,共获取1731个样点的土壤-表层岩溶带厚度及环境因子数据资料,研究了土壤和表层岩溶带厚度的空间分布格局及其影响因素。结果表明,土壤和表层岩溶带厚度平均值分别为1.15 m和6.44 m,且分别呈现强变异程度和中等变异程度。地统计分析结果表明球状模型和指数模型分别可以反映土壤和表层岩溶带的空间结构特征。土壤厚度呈现中等空间自相关性,变程长,空间连续性好;而表层岩溶带呈现强烈的空间自相关性,变程短,空间依赖性强。土壤厚度受到环境因子(地形湿度指数、垂直曲率、曲率、坡向、坡度、高程、覆盖度、出露基岩率和植被归一化指数)的多重影响,而表层岩溶带厚度受部分环境因子影响的同时,与土壤厚度和植被类型的相关性更高。研究结果有助于喀斯特区土壤-表层岩溶带演化机理认识,并为土壤-表层岩溶带厚度的空间预测提供科学依据。展开更多
AIM:To investigate the effects of the somatostatin analogue,octreotide,on maltose and sucrase activities and expression of glucose transporter type 2(GLUT2) in obese rat intestinal mucosa.METHODS:We divided 49 Sprague...AIM:To investigate the effects of the somatostatin analogue,octreotide,on maltose and sucrase activities and expression of glucose transporter type 2(GLUT2) in obese rat intestinal mucosa.METHODS:We divided 49 Sprague-Dawley rats into a group of 31 high fat diet-induced obese rats and a group of 18 normal controls.The obese rats were separated into an octreotide treated group of 16 rats and an obese group of 15.The intervention group was injected with octreotide at 40μg/kg body weight every 12 h for 8 d.Rat body weight was measured weekly to calculate Lee's index.After euthanization,maltase and sucrase activities in the small intestine were measuredby activity assays,and the fasting plasma glucose level was measured.The expression of GLUT2 in small intestinal mucosa was analyzed by immunohistochem-istry,reverse transcriptase polymerase chain reaction and Western blotting assays.RESULTS:Body weight,Lee's index,fasting plasma glucose level,maltase activity in small intestinal mucosa,mucosa and apical GLUT2,GLUT2 mRNA and protein expression levels were all significantly higher in the obese group than in the normal control group(605.61±141.00 vs 378.54±111.75,337.61 ±10.82 vs 318.73±20.10,8.60±1.38 vs 7.33± 0.70,156.01±58.81 vs 50.43±30.49,390 744.2 ±62 469.21 vs 170 546.50±50 646.14,26 740.18 ±3809.60 vs 354.98±57.19,0.26±0.11 vs 0.07 ±0.02,and 2.08±0.59 vs 1.27±0.38,respectively,all P<0.01).Sucrase activity did not differ between the two groups.Octreotide intervention significantly decreased the body weight and fasting plasma glucose level of obese rats(508.27±94.39 vs 605.61±141.00,7.58±1.51 vs 8.60±1.38,respectively,all P<0.05).The intestinal mucosa and apical GLUT2,expression of GLUT2 mRNA and protein were also significantly lower in the octreotide intervention group than in the obese group(269 975.2 ±53 730.94 vs 390 744.2±62 469.21,3758.06± 364.51 vs 26 740.18±3809.60,0.08±0.02 vs 0.26± 0.11,and 1.31±0.27 vs 2.08±0.59,respectively,all P<0.01).CONCLUSION:High fat dietinduced obesity is associated with elevated intestinal maltase activity,GLUT2 expression,and permanent apical GLUT2 in the small intestinal mucosa of rats.Octreotide can inhibit these effects.展开更多
文摘Objective Primary ovarian small cell carcinoma of pulmonary type(SCCOPT)is a rare ovarian tumor with a poor prognosis.The platinum-based chemotherapy is the standard treatment.However,there is little research on the clinical characteristics of SCCOPT and the potential benefits of other treatments due to its low incidence.The study aims to investigate clinicopathological characteristics and treatment of SCCOPT.Methods We summarized the clinical,imaging,laboratorical and pathological characteristics of 37 SCCOPT cases,in which 6 cases were admitted to the Gansu Provincial Hospital from the year of 2008 to 2022 and 31 cases reported in 17 English and 3 Chinese literatures.Results The median age of the studied SCCOPT cases(n=37)was 56.00(range,22-80)years.Almost 80%of them had a stageⅢorⅣtumor.All patients underwent an operation and postoperative chemotherapy.Nevertheless,all cases had a poor prognosis,with a median overall survival time of 12 months.Immunohistochemical y,the SCCOPT of all patients showed positive expressions of epithelial markers,such as CD56 and sex-determining region of Y chromosome-related high-mobility-group box 2(SOX-2),and negative expressions of estrogen receptor,progesterone receptor,vimentin,Leu-7,and somatostatin receptor 2.The tumor of above 80%cases expressed synaptophysin.Only a few cases expressed neuron-specific enolase,chromogranin A,and thyroid transcription factor-1.Conclusions SCCOPT had a poor prognosis.SOX-2 could be a biomarker to be used to diagnose SCCOPT.
基金support by Research Grants Council of Hong Kong(Grant Nos.15246816 and 15218517)the funding for Project of Strategic Importance provided by the Hong Kong Polytechnic University(Project Code:1-ZE29)the Shenzhen Science and Technology Innovation Commission(Project no.JCYJ20170413154602102)
文摘Recent developments in acceptor–donor–acceptor(A–D–A) type non-fullerene acceptors have led to substantial improvements in bulk-heterojunction polymer solar cells efficiency. The device performance strongly depends on photoactive layer morphology, as the molecular packing, donor–acceptor interface and phase separation significantly affect the charge-transfer states and charge carrier dynamics. In this review, we start with a brief introduction of the techniques most effectively utilized to characterize multiphase morphology. Then, we summarize recent progress in A–D–A type acceptors, with the emphasis on understanding the molecular structure–morphology–performance relationships. Finally, an outlook on correlating morphological characteristics with photovoltage losses is presented for further improving device performance.
基金supported by the National Natural Science Foundation' Urban Agriculture-based Development Pattern and Spatial Reconstruction of Towns/Townships in Periurban Beijing'(Grant no.40971100)the knowledge innovation project of Chinese Academy of Science' Study on spatial structural reorganization and its effect on eco-environment'(Grant no.KZCX2- YW-321-01)
文摘The purpose of this article is to classify the regional economic types and development dynamics of small towns in suburb Beijing by applying the classification methods developed by Nelson's method and Location Quotient method into 183 small towns in Beijing.Four types of small towns are thus identified,including urban agriculture dominated towns,manufacturing dominated towns,service industry dominated towns and comprehensive type towns with balanced economic development.Within the environment of geographical information system,the spatial distribution pattern of four types of small towns with their evolution trend is analyzed.The results indicate that four types of small towns have obvious'core-periphery'spatial structure but with different functional orientations and evolution mechanisms.Based on this,the different development strategies for each type of small towns are summarized,providing a scientific reference for the differentiating planning and development strategies of these small towns.
文摘土壤-表层岩溶带厚度是喀斯特地球关键带的关键指标,明确其空间异质性特征对于理解地球关键带结构演化机理以及评估水源涵养功能具有重要意义。在广西环江木连小流域1.4 km 2范围内,通过高密度电法(ERT)探测45条样线,共获取1731个样点的土壤-表层岩溶带厚度及环境因子数据资料,研究了土壤和表层岩溶带厚度的空间分布格局及其影响因素。结果表明,土壤和表层岩溶带厚度平均值分别为1.15 m和6.44 m,且分别呈现强变异程度和中等变异程度。地统计分析结果表明球状模型和指数模型分别可以反映土壤和表层岩溶带的空间结构特征。土壤厚度呈现中等空间自相关性,变程长,空间连续性好;而表层岩溶带呈现强烈的空间自相关性,变程短,空间依赖性强。土壤厚度受到环境因子(地形湿度指数、垂直曲率、曲率、坡向、坡度、高程、覆盖度、出露基岩率和植被归一化指数)的多重影响,而表层岩溶带厚度受部分环境因子影响的同时,与土壤厚度和植被类型的相关性更高。研究结果有助于喀斯特区土壤-表层岩溶带演化机理认识,并为土壤-表层岩溶带厚度的空间预测提供科学依据。
基金Supported by Grants from the National Natural Sciences Foundation of China,No.30870919Sichuan Provincial Department of Science and Technology,No.2010SZ0176
文摘AIM:To investigate the effects of the somatostatin analogue,octreotide,on maltose and sucrase activities and expression of glucose transporter type 2(GLUT2) in obese rat intestinal mucosa.METHODS:We divided 49 Sprague-Dawley rats into a group of 31 high fat diet-induced obese rats and a group of 18 normal controls.The obese rats were separated into an octreotide treated group of 16 rats and an obese group of 15.The intervention group was injected with octreotide at 40μg/kg body weight every 12 h for 8 d.Rat body weight was measured weekly to calculate Lee's index.After euthanization,maltase and sucrase activities in the small intestine were measuredby activity assays,and the fasting plasma glucose level was measured.The expression of GLUT2 in small intestinal mucosa was analyzed by immunohistochem-istry,reverse transcriptase polymerase chain reaction and Western blotting assays.RESULTS:Body weight,Lee's index,fasting plasma glucose level,maltase activity in small intestinal mucosa,mucosa and apical GLUT2,GLUT2 mRNA and protein expression levels were all significantly higher in the obese group than in the normal control group(605.61±141.00 vs 378.54±111.75,337.61 ±10.82 vs 318.73±20.10,8.60±1.38 vs 7.33± 0.70,156.01±58.81 vs 50.43±30.49,390 744.2 ±62 469.21 vs 170 546.50±50 646.14,26 740.18 ±3809.60 vs 354.98±57.19,0.26±0.11 vs 0.07 ±0.02,and 2.08±0.59 vs 1.27±0.38,respectively,all P<0.01).Sucrase activity did not differ between the two groups.Octreotide intervention significantly decreased the body weight and fasting plasma glucose level of obese rats(508.27±94.39 vs 605.61±141.00,7.58±1.51 vs 8.60±1.38,respectively,all P<0.05).The intestinal mucosa and apical GLUT2,expression of GLUT2 mRNA and protein were also significantly lower in the octreotide intervention group than in the obese group(269 975.2 ±53 730.94 vs 390 744.2±62 469.21,3758.06± 364.51 vs 26 740.18±3809.60,0.08±0.02 vs 0.26± 0.11,and 1.31±0.27 vs 2.08±0.59,respectively,all P<0.01).CONCLUSION:High fat dietinduced obesity is associated with elevated intestinal maltase activity,GLUT2 expression,and permanent apical GLUT2 in the small intestinal mucosa of rats.Octreotide can inhibit these effects.
