Smart agriculture modifies traditional farming practices,and offers innovative approaches to boost production and sustainability by leveraging contemporary technologies.In today’s world where technology is everything...Smart agriculture modifies traditional farming practices,and offers innovative approaches to boost production and sustainability by leveraging contemporary technologies.In today’s world where technology is everything,these technologies are utilized to streamline regular tasks and procedures in agriculture,one of the largest and most significant industries in every nation.This research paper stands out from existing literature on smart agriculture security by providing a comprehensive analysis and examination of security issues within smart agriculture systems.Divided into three main sections-security analysis,system architecture and design and risk assessment of Cyber-Physical Systems(CPS)applications-the study delves into various elements crucial for smart farming,such as data sources,infrastructure components,communication protocols,and the roles of different stakeholders such as farmers,agricultural scientists and researchers,technology providers,government agencies,consumers and many others.In contrast to earlier research,this work analyzes the resilience of smart agriculture systems using approaches such as threat modeling,penetration testing,and vulnerability assessments.Important discoveries highlight the concerns connected to unsecured communication protocols,possible threats from malevolent actors,and vulnerabilities in IoT devices.Furthermore,the study suggests enhancements for CPS applications,such as strong access controls,intrusion detection systems,and encryption protocols.In addition,risk assessment techniques are applied to prioritize mitigation tactics and detect potential hazards,addressing issues like data breaches,system outages,and automated farming process sabotage.The research sets itself apart even more by presenting a prototype CPS application that makes use of a digital temperature sensor.This application was first created using a Tinkercad simulator and then using actual hardware with Arduino boards.The CPS application’s defenses against potential threats and vulnerabilities are strengthened by this integrated approach,which distinguishes this research for its depth and usefulness in the field of smart agriculture security.展开更多
The healthcare data requires accurate disease detection analysis,real-timemonitoring,and advancements to ensure proper treatment for patients.Consequently,Machine Learning methods are widely utilized in Smart Healthca...The healthcare data requires accurate disease detection analysis,real-timemonitoring,and advancements to ensure proper treatment for patients.Consequently,Machine Learning methods are widely utilized in Smart Healthcare Systems(SHS)to extract valuable features fromheterogeneous and high-dimensional healthcare data for predicting various diseases and monitoring patient activities.These methods are employed across different domains that are susceptible to adversarial attacks,necessitating careful consideration.Hence,this paper proposes a crossover-based Multilayer Perceptron(CMLP)model.The collected samples are pre-processed and fed into the crossover-based multilayer perceptron neural network to detect adversarial attacks on themedical records of patients.Once an attack is detected,healthcare professionals are promptly alerted to prevent data leakage.The paper utilizes two datasets,namely the synthetic dataset and the University of Queensland Vital Signs(UQVS)dataset,from which numerous samples are collected.Experimental results are conducted to evaluate the performance of the proposed CMLP model,utilizing various performancemeasures such as Recall,Precision,Accuracy,and F1-score to predict patient activities.Comparing the proposed method with existing approaches,it achieves the highest accuracy,precision,recall,and F1-score.Specifically,the proposedmethod achieves a precision of 93%,an accuracy of 97%,an F1-score of 92%,and a recall of 92%.展开更多
The governmental electric utility and the private sector are joining hands to meet the target of electrifying all households by 2024.However,the aforementioned goal is challenged by households that are scattered in re...The governmental electric utility and the private sector are joining hands to meet the target of electrifying all households by 2024.However,the aforementioned goal is challenged by households that are scattered in remote areas.So far,Solar Home Systems(SHS)have mostly been applied to increase electricity access in rural areas.SHSs have continuous constraints to meet electricity demands and cannot run income-generating activities.The current research presents the feasibility study of electrifying Remera village with the smart microgrid as a case study.The renewable energy resources available in Remera are the key sources of electricity in that village.The generation capacity is estimated based on the load profile.The microgrid configurations are simulated with HOMER,and the genetic algorithm is used to analyze the optimum cost.By analyzing the impact of operation and maintenance costs,the results show that the absence of subsidies increases the levelized cost of electricity(COE)five times greater than the electricity price from the public utility.The microgrid made up of PV,diesel generator,and batteries proved to be the most viable solution and ensured continuous power supply to customers.By considering the subsidies,COE reaches 0.186$/kWh,a competitive price with electricity from public utilities in Rwanda.展开更多
Energy management is an inspiring domain in developing of renewable energy sources.However,the growth of decentralized energy production is revealing an increased complexity for power grid managers,inferring more qual...Energy management is an inspiring domain in developing of renewable energy sources.However,the growth of decentralized energy production is revealing an increased complexity for power grid managers,inferring more quality and reliability to regulate electricity flows and less imbalance between electricity production and demand.The major objective of an energy management system is to achieve optimum energy procurement and utilization throughout the organization,minimize energy costs without affecting production,and minimize environmental effects.Modern energy management is an essential and complex subject because of the excessive consumption in residential buildings,which necessitates energy optimization and increased user comfort.To address the issue of energy management,many researchers have developed various frameworks;while the objective of each framework was to sustain a balance between user comfort and energy consumption,this problem hasn’t been fully solved because of how difficult it is to solve it.An inclusive and Intelligent Energy Management System(IEMS)aims to provide overall energy efficiency regarding increased power generation,increase flexibility,increase renewable generation systems,improve energy consumption,reduce carbon dioxide emissions,improve stability,and reduce energy costs.Machine Learning(ML)is an emerging approach that may be beneficial to predict energy efficiency in a better way with the assistance of the Internet of Energy(IoE)network.The IoE network is playing a vital role in the energy sector for collecting effective data and usage,resulting in smart resource management.In this research work,an IEMS is proposed for Smart Cities(SC)using the ML technique to better resolve the energy management problem.The proposed system minimized the energy consumption with its intelligent nature and provided better outcomes than the previous approaches in terms of 92.11% accuracy,and 7.89% miss-rate.展开更多
In the groundbreaking study “The Contribution of AI-powered Mobile Apps to Smart City Ecosystems,” authored by Zaki Ali Bayashot, the transformative role of artificial intelligence (AI) in urban development is metic...In the groundbreaking study “The Contribution of AI-powered Mobile Apps to Smart City Ecosystems,” authored by Zaki Ali Bayashot, the transformative role of artificial intelligence (AI) in urban development is meticulously examined. This comprehensive research delineates the multifaceted ways in which AI-powered mobile applications can significantly enhance the efficiency, sustainability, and livability of urban environments, marking a pivotal step towards the realization of smart cities globally. Bayashot meticulously outlines the critical areas where AI-powered apps offer unprecedented advantages, including urban mobility, public safety, energy management, and environmental monitoring. By leveraging AI’s capabilities, these applications not only streamline city operations but also foster a more sustainable interaction between city dwellers and their environment. The paper emphasizes the importance of data-driven decision-making in urban planning, showcasing how AI analytics can predict and mitigate traffic congestion, optimize energy consumption, and enhance emergency response strategies. The author also explores the social implications of AI in urban settings, highlighting the potential for these technologies to bridge the gap between government entities and citizens. Through engaging case studies, Bayashot demonstrates how participatory governance models, enabled by AI apps, can promote transparency, accountability, and citizen engagement in urban management. A significant contribution of this research is its focus on the challenges and opportunities presented by the integration of AI into smart city ecosystems. Bayashot discusses the technical, ethical, and privacy concerns associated with AI applications, advocating for a balanced approach that ensures technological advancements do not come at the expense of civil liberties. The study calls for robust regulatory frameworks to govern the use of AI in public spaces, emphasizing the need for ethical AI practices that respect privacy and promote inclusivity. Furthermore, Bayashot’s research underscores the necessity of cross-disciplinary collaboration in the development and implementation of AI technologies in urban contexts. By bringing together experts from information technology, urban planning, environmental science, and social sciences, the author argues for a holistic approach to smart city development. This interdisciplinary strategy ensures that AI applications are not only technologically sound but also socially and environmentally responsible. The paper concludes with a visionary outlook on the future of smart cities, posited on the seamless integration of AI technologies. Bayashot envisions a world where AI-powered mobile apps not only facilitate smoother urban operations but also empower citizens to actively participate in the shaping of their urban environments. This research serves as a critical call to action for policymakers, technologists, and urban planners to embrace AI as a tool for creating more sustainable, efficient, and inclusive cities. By presenting a detailed analysis of the current state of AI in urban development, coupled with practical insights and forward-looking recommendations, “The Contribution of AI-powered Mobile Apps to Smart City Ecosystems” stands as a seminal work that is poised to inspire and guide the evolution of urban landscapes worldwide. Its comprehensive exploration of the subject matter, combined with its impactful conclusions, make it a must-read for anyone involved in the field of smart city development, AI technology, or urban policy-making.展开更多
Smart energy monitoring and management system lays a foundation for the application and development of smart energy. However, in recent years, the work efficiency of smart energy development enterprises has generally ...Smart energy monitoring and management system lays a foundation for the application and development of smart energy. However, in recent years, the work efficiency of smart energy development enterprises has generally been low, and there is an urgent need to improve the application efficiency, resilience and sustainability of smart energy monitoring and management system. Digital twin technology provides a data-centric solution to improve smart energy monitoring and management system, bringing an opportunity to transform passive infrastructure assets into data-centric systems. This paper expounds on the concept and key technologies of digital twin, and designs a smart energy monitoring and management system based on digital twin technology, which has dual significance for promoting the development of smart energy field and promoting the application of digital twin.展开更多
Automated Guided Vehicles(AGVs)have been introduced into various applications,such as automated warehouse systems,flexible manufacturing systems,and container terminal systems.However,few publications have outlined pr...Automated Guided Vehicles(AGVs)have been introduced into various applications,such as automated warehouse systems,flexible manufacturing systems,and container terminal systems.However,few publications have outlined problems in need of attention in AGV applications comprehensively.In this paper,several key issues and essential models are presented.First,the advantages and disadvantages of centralized and decentralized AGVs systems were compared;second,warehouse layout and operation optimization were introduced,including some omitted areas,such as AGVs fleet size and electrical energy management;third,AGVs scheduling algorithms in chessboardlike environments were analyzed;fourth,the classical route-planning algorithms for single AGV and multiple AGVs were presented,and some Artificial Intelligence(AI)-based decision-making algorithms were reviewed.Furthermore,a novel idea for accelerating route planning by combining Reinforcement Learning(RL)andDijkstra’s algorithm was presented,and a novel idea of the multi-AGV route-planning method of combining dynamic programming and Monte-Carlo tree search was proposed to reduce the energy cost of systems.展开更多
Cancer immunotherapy,a therapeutic approach that inhibits tumors by activating or strengthening anti-tumor immunity,is currently an important clinical strategy for cancer treatment;however,tumors can develop drug resi...Cancer immunotherapy,a therapeutic approach that inhibits tumors by activating or strengthening anti-tumor immunity,is currently an important clinical strategy for cancer treatment;however,tumors can develop drug resistance to immune surveillance,resulting in poor response rates and low therapeutic efficacy.In addition,changes in genes and signaling pathways in tumor cells prevent susceptibility to immunotherapeutic agents.Furthermore,tumors create an immunosuppressive microenvironment via immunosuppressive cells and secrete molecules that hinder immune cell and immune modulator infiltration or induce immune cell malfunction.To address these challenges,smart drug delivery systems(SDDSs)have been developed to overcome tumor cell resistance to immunomodulators,restore or boost immune cell activity,and magnify immune responses.To combat resistance to small molecules and monoclonal antibodies,SDDSs are used to co-deliver numerous therapeutic agents to tumor cells or immunosuppressive cells,thus increasing the drug concentration at the target site and improving efficacy.Herein,we discuss how SDDSs overcome drug resistance during cancer immunotherapy,with a focus on recent SDDS advances in thwarting drug resistance in immunotherapy by combining immunogenic cell death with immunotherapy and reversing the tumor immunosuppressive microenvironment.SDDSs that modulate the interferon signaling pathway and improve the efficacy of cell therapies are also presented.Finally,we discuss potential future SDDS perspectives in overcoming drug resistance in cancer immunotherapy.We believe that this review will contribute to the rational design of SDDSs and development of novel techniques to overcome immunotherapy resistance.展开更多
Electric smart grids enable a bidirectional flow of electricity and information among power system assets.For proper monitoring and con-trolling of power quality,reliability,scalability and flexibility,there is a need...Electric smart grids enable a bidirectional flow of electricity and information among power system assets.For proper monitoring and con-trolling of power quality,reliability,scalability and flexibility,there is a need for an environmentally friendly system that is transparent,sustainable,cost-saving,energy-efficient,agile and secure.This paper provides an overview of the emerging technologies behind smart grids and the internet of things.The dependent variables are identified by analyzing the electricity consumption patterns for optimal utilization and planning preventive maintenance of their legacy assets like power distribution transformers with real-time parameters to ensure an uninterrupted and reliable power supply.In addition,the paper sorts out challenges in the traditional or legacy electricity grid,power generation,transmission,distribution,and revenue management challenges such as reduc-ing aggregate technical and commercial loss by reforming the existing manual or semi-automatic techniques to fully smart or automatic systems.This article represents a concise review of research works in creating components of the smart grid like smart metering infrastructure for postpaid as well as in prepaid mode,internal structure comparison of advanced metering methods in present scenarios,and communication systems.展开更多
Due to excessive car usage,pollution and traffic have increased.In urban cities in Saudi Arabia,such as Riyadh and Jeddah,drivers and air quality suffer from traffic congestion.Although the government has implemented ...Due to excessive car usage,pollution and traffic have increased.In urban cities in Saudi Arabia,such as Riyadh and Jeddah,drivers and air quality suffer from traffic congestion.Although the government has implemented numerous solutions to resolve this issue or reduce its effect on the environment and residents,it still exists and is getting worse.This paper proposes an intelligent,adaptive,practical,and feasible deep learning method for intelligent traffic control.It uses an Internet of Things(IoT)sensor,a camera,and a Convolutional Neural Network(CNN)tool to control traffic in real time.An image segmentation algorithm analyzes inputs from the cameras installed in designated areas.This study considered whether CNNs and IoT technologies could ensure smooth traffic flow in high-speed,high-congestion situations.The presented algorithm calculates traffic density and cars’speeds to determine which lane gets high priority first.A real case study has been conducted on MATLAB to verify and validate the results of this approach.This algorithm estimates the reduced average waiting time during the red light and the suggested time for the green and red lights.An assessment between some literature works and the presented algorithm is also provided.In contrast to traditional traffic management methods,this intelligent and adaptive algorithm reduces traffic congestion,automobile waiting times,and accidents.展开更多
People’s lives have become easier and simpler as technology has proliferated.This is especially true with the Internet of Things(IoT).The biggest problem for blind people is figuring out how to get where they want to...People’s lives have become easier and simpler as technology has proliferated.This is especially true with the Internet of Things(IoT).The biggest problem for blind people is figuring out how to get where they want to go.People with good eyesight need to help these people.Smart shoes are a technique that helps blind people find their way when they walk.So,a special shoe has been made to help blind people walk safely without worrying about running into other people or solid objects.In this research,we are making a new safety system and a smart shoe for blind people.The system is based on Internet of Things(IoT)technology and uses three ultrasonic sensors to allow users to hear and react to barriers.It has ultrasonic sensors and a microprocessor that can tell how far away something is and if there are any obstacles.Water and flame sensors were used,and a sound was used to let the person know if an obstacle was near him.The sensors use Global Positioning System(GPS)technology to detect motion from almost every side to keep an eye on them and ensure they are safe.To test our proposal,we gave a questionnaire to 100 people.The questionnaire has eleven questions,and 99.1%of the people who filled it out said that the product meets their needs.展开更多
文摘Smart agriculture modifies traditional farming practices,and offers innovative approaches to boost production and sustainability by leveraging contemporary technologies.In today’s world where technology is everything,these technologies are utilized to streamline regular tasks and procedures in agriculture,one of the largest and most significant industries in every nation.This research paper stands out from existing literature on smart agriculture security by providing a comprehensive analysis and examination of security issues within smart agriculture systems.Divided into three main sections-security analysis,system architecture and design and risk assessment of Cyber-Physical Systems(CPS)applications-the study delves into various elements crucial for smart farming,such as data sources,infrastructure components,communication protocols,and the roles of different stakeholders such as farmers,agricultural scientists and researchers,technology providers,government agencies,consumers and many others.In contrast to earlier research,this work analyzes the resilience of smart agriculture systems using approaches such as threat modeling,penetration testing,and vulnerability assessments.Important discoveries highlight the concerns connected to unsecured communication protocols,possible threats from malevolent actors,and vulnerabilities in IoT devices.Furthermore,the study suggests enhancements for CPS applications,such as strong access controls,intrusion detection systems,and encryption protocols.In addition,risk assessment techniques are applied to prioritize mitigation tactics and detect potential hazards,addressing issues like data breaches,system outages,and automated farming process sabotage.The research sets itself apart even more by presenting a prototype CPS application that makes use of a digital temperature sensor.This application was first created using a Tinkercad simulator and then using actual hardware with Arduino boards.The CPS application’s defenses against potential threats and vulnerabilities are strengthened by this integrated approach,which distinguishes this research for its depth and usefulness in the field of smart agriculture security.
基金funded by King Saud University through Researchers Supporting Program Number (RSP2024R499).
文摘The healthcare data requires accurate disease detection analysis,real-timemonitoring,and advancements to ensure proper treatment for patients.Consequently,Machine Learning methods are widely utilized in Smart Healthcare Systems(SHS)to extract valuable features fromheterogeneous and high-dimensional healthcare data for predicting various diseases and monitoring patient activities.These methods are employed across different domains that are susceptible to adversarial attacks,necessitating careful consideration.Hence,this paper proposes a crossover-based Multilayer Perceptron(CMLP)model.The collected samples are pre-processed and fed into the crossover-based multilayer perceptron neural network to detect adversarial attacks on themedical records of patients.Once an attack is detected,healthcare professionals are promptly alerted to prevent data leakage.The paper utilizes two datasets,namely the synthetic dataset and the University of Queensland Vital Signs(UQVS)dataset,from which numerous samples are collected.Experimental results are conducted to evaluate the performance of the proposed CMLP model,utilizing various performancemeasures such as Recall,Precision,Accuracy,and F1-score to predict patient activities.Comparing the proposed method with existing approaches,it achieves the highest accuracy,precision,recall,and F1-score.Specifically,the proposedmethod achieves a precision of 93%,an accuracy of 97%,an F1-score of 92%,and a recall of 92%.
文摘The governmental electric utility and the private sector are joining hands to meet the target of electrifying all households by 2024.However,the aforementioned goal is challenged by households that are scattered in remote areas.So far,Solar Home Systems(SHS)have mostly been applied to increase electricity access in rural areas.SHSs have continuous constraints to meet electricity demands and cannot run income-generating activities.The current research presents the feasibility study of electrifying Remera village with the smart microgrid as a case study.The renewable energy resources available in Remera are the key sources of electricity in that village.The generation capacity is estimated based on the load profile.The microgrid configurations are simulated with HOMER,and the genetic algorithm is used to analyze the optimum cost.By analyzing the impact of operation and maintenance costs,the results show that the absence of subsidies increases the levelized cost of electricity(COE)five times greater than the electricity price from the public utility.The microgrid made up of PV,diesel generator,and batteries proved to be the most viable solution and ensured continuous power supply to customers.By considering the subsidies,COE reaches 0.186$/kWh,a competitive price with electricity from public utilities in Rwanda.
文摘Energy management is an inspiring domain in developing of renewable energy sources.However,the growth of decentralized energy production is revealing an increased complexity for power grid managers,inferring more quality and reliability to regulate electricity flows and less imbalance between electricity production and demand.The major objective of an energy management system is to achieve optimum energy procurement and utilization throughout the organization,minimize energy costs without affecting production,and minimize environmental effects.Modern energy management is an essential and complex subject because of the excessive consumption in residential buildings,which necessitates energy optimization and increased user comfort.To address the issue of energy management,many researchers have developed various frameworks;while the objective of each framework was to sustain a balance between user comfort and energy consumption,this problem hasn’t been fully solved because of how difficult it is to solve it.An inclusive and Intelligent Energy Management System(IEMS)aims to provide overall energy efficiency regarding increased power generation,increase flexibility,increase renewable generation systems,improve energy consumption,reduce carbon dioxide emissions,improve stability,and reduce energy costs.Machine Learning(ML)is an emerging approach that may be beneficial to predict energy efficiency in a better way with the assistance of the Internet of Energy(IoE)network.The IoE network is playing a vital role in the energy sector for collecting effective data and usage,resulting in smart resource management.In this research work,an IEMS is proposed for Smart Cities(SC)using the ML technique to better resolve the energy management problem.The proposed system minimized the energy consumption with its intelligent nature and provided better outcomes than the previous approaches in terms of 92.11% accuracy,and 7.89% miss-rate.
文摘In the groundbreaking study “The Contribution of AI-powered Mobile Apps to Smart City Ecosystems,” authored by Zaki Ali Bayashot, the transformative role of artificial intelligence (AI) in urban development is meticulously examined. This comprehensive research delineates the multifaceted ways in which AI-powered mobile applications can significantly enhance the efficiency, sustainability, and livability of urban environments, marking a pivotal step towards the realization of smart cities globally. Bayashot meticulously outlines the critical areas where AI-powered apps offer unprecedented advantages, including urban mobility, public safety, energy management, and environmental monitoring. By leveraging AI’s capabilities, these applications not only streamline city operations but also foster a more sustainable interaction between city dwellers and their environment. The paper emphasizes the importance of data-driven decision-making in urban planning, showcasing how AI analytics can predict and mitigate traffic congestion, optimize energy consumption, and enhance emergency response strategies. The author also explores the social implications of AI in urban settings, highlighting the potential for these technologies to bridge the gap between government entities and citizens. Through engaging case studies, Bayashot demonstrates how participatory governance models, enabled by AI apps, can promote transparency, accountability, and citizen engagement in urban management. A significant contribution of this research is its focus on the challenges and opportunities presented by the integration of AI into smart city ecosystems. Bayashot discusses the technical, ethical, and privacy concerns associated with AI applications, advocating for a balanced approach that ensures technological advancements do not come at the expense of civil liberties. The study calls for robust regulatory frameworks to govern the use of AI in public spaces, emphasizing the need for ethical AI practices that respect privacy and promote inclusivity. Furthermore, Bayashot’s research underscores the necessity of cross-disciplinary collaboration in the development and implementation of AI technologies in urban contexts. By bringing together experts from information technology, urban planning, environmental science, and social sciences, the author argues for a holistic approach to smart city development. This interdisciplinary strategy ensures that AI applications are not only technologically sound but also socially and environmentally responsible. The paper concludes with a visionary outlook on the future of smart cities, posited on the seamless integration of AI technologies. Bayashot envisions a world where AI-powered mobile apps not only facilitate smoother urban operations but also empower citizens to actively participate in the shaping of their urban environments. This research serves as a critical call to action for policymakers, technologists, and urban planners to embrace AI as a tool for creating more sustainable, efficient, and inclusive cities. By presenting a detailed analysis of the current state of AI in urban development, coupled with practical insights and forward-looking recommendations, “The Contribution of AI-powered Mobile Apps to Smart City Ecosystems” stands as a seminal work that is poised to inspire and guide the evolution of urban landscapes worldwide. Its comprehensive exploration of the subject matter, combined with its impactful conclusions, make it a must-read for anyone involved in the field of smart city development, AI technology, or urban policy-making.
文摘Smart energy monitoring and management system lays a foundation for the application and development of smart energy. However, in recent years, the work efficiency of smart energy development enterprises has generally been low, and there is an urgent need to improve the application efficiency, resilience and sustainability of smart energy monitoring and management system. Digital twin technology provides a data-centric solution to improve smart energy monitoring and management system, bringing an opportunity to transform passive infrastructure assets into data-centric systems. This paper expounds on the concept and key technologies of digital twin, and designs a smart energy monitoring and management system based on digital twin technology, which has dual significance for promoting the development of smart energy field and promoting the application of digital twin.
文摘Automated Guided Vehicles(AGVs)have been introduced into various applications,such as automated warehouse systems,flexible manufacturing systems,and container terminal systems.However,few publications have outlined problems in need of attention in AGV applications comprehensively.In this paper,several key issues and essential models are presented.First,the advantages and disadvantages of centralized and decentralized AGVs systems were compared;second,warehouse layout and operation optimization were introduced,including some omitted areas,such as AGVs fleet size and electrical energy management;third,AGVs scheduling algorithms in chessboardlike environments were analyzed;fourth,the classical route-planning algorithms for single AGV and multiple AGVs were presented,and some Artificial Intelligence(AI)-based decision-making algorithms were reviewed.Furthermore,a novel idea for accelerating route planning by combining Reinforcement Learning(RL)andDijkstra’s algorithm was presented,and a novel idea of the multi-AGV route-planning method of combining dynamic programming and Monte-Carlo tree search was proposed to reduce the energy cost of systems.
基金supported by the National Key R&D Program of China(Grant No.2022YFC3401404)the National Natural Science Foundation of China(Grant Nos.32170935 and 31930066).
文摘Cancer immunotherapy,a therapeutic approach that inhibits tumors by activating or strengthening anti-tumor immunity,is currently an important clinical strategy for cancer treatment;however,tumors can develop drug resistance to immune surveillance,resulting in poor response rates and low therapeutic efficacy.In addition,changes in genes and signaling pathways in tumor cells prevent susceptibility to immunotherapeutic agents.Furthermore,tumors create an immunosuppressive microenvironment via immunosuppressive cells and secrete molecules that hinder immune cell and immune modulator infiltration or induce immune cell malfunction.To address these challenges,smart drug delivery systems(SDDSs)have been developed to overcome tumor cell resistance to immunomodulators,restore or boost immune cell activity,and magnify immune responses.To combat resistance to small molecules and monoclonal antibodies,SDDSs are used to co-deliver numerous therapeutic agents to tumor cells or immunosuppressive cells,thus increasing the drug concentration at the target site and improving efficacy.Herein,we discuss how SDDSs overcome drug resistance during cancer immunotherapy,with a focus on recent SDDS advances in thwarting drug resistance in immunotherapy by combining immunogenic cell death with immunotherapy and reversing the tumor immunosuppressive microenvironment.SDDSs that modulate the interferon signaling pathway and improve the efficacy of cell therapies are also presented.Finally,we discuss potential future SDDS perspectives in overcoming drug resistance in cancer immunotherapy.We believe that this review will contribute to the rational design of SDDSs and development of novel techniques to overcome immunotherapy resistance.
基金supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(2021R1A6A1A03043144)Woosong University Academic Research in 2022.
文摘Electric smart grids enable a bidirectional flow of electricity and information among power system assets.For proper monitoring and con-trolling of power quality,reliability,scalability and flexibility,there is a need for an environmentally friendly system that is transparent,sustainable,cost-saving,energy-efficient,agile and secure.This paper provides an overview of the emerging technologies behind smart grids and the internet of things.The dependent variables are identified by analyzing the electricity consumption patterns for optimal utilization and planning preventive maintenance of their legacy assets like power distribution transformers with real-time parameters to ensure an uninterrupted and reliable power supply.In addition,the paper sorts out challenges in the traditional or legacy electricity grid,power generation,transmission,distribution,and revenue management challenges such as reduc-ing aggregate technical and commercial loss by reforming the existing manual or semi-automatic techniques to fully smart or automatic systems.This article represents a concise review of research works in creating components of the smart grid like smart metering infrastructure for postpaid as well as in prepaid mode,internal structure comparison of advanced metering methods in present scenarios,and communication systems.
基金This research work was funded by Institutional Fund Projects under Grant No.(IFPIP:707-829-1443)The authors gratefully acknowledge technical and financial support provided by theMinistry of Education and King Abdulaziz University,DSR,Jeddah,Saudi Arabia.
文摘Due to excessive car usage,pollution and traffic have increased.In urban cities in Saudi Arabia,such as Riyadh and Jeddah,drivers and air quality suffer from traffic congestion.Although the government has implemented numerous solutions to resolve this issue or reduce its effect on the environment and residents,it still exists and is getting worse.This paper proposes an intelligent,adaptive,practical,and feasible deep learning method for intelligent traffic control.It uses an Internet of Things(IoT)sensor,a camera,and a Convolutional Neural Network(CNN)tool to control traffic in real time.An image segmentation algorithm analyzes inputs from the cameras installed in designated areas.This study considered whether CNNs and IoT technologies could ensure smooth traffic flow in high-speed,high-congestion situations.The presented algorithm calculates traffic density and cars’speeds to determine which lane gets high priority first.A real case study has been conducted on MATLAB to verify and validate the results of this approach.This algorithm estimates the reduced average waiting time during the red light and the suggested time for the green and red lights.An assessment between some literature works and the presented algorithm is also provided.In contrast to traditional traffic management methods,this intelligent and adaptive algorithm reduces traffic congestion,automobile waiting times,and accidents.
文摘People’s lives have become easier and simpler as technology has proliferated.This is especially true with the Internet of Things(IoT).The biggest problem for blind people is figuring out how to get where they want to go.People with good eyesight need to help these people.Smart shoes are a technique that helps blind people find their way when they walk.So,a special shoe has been made to help blind people walk safely without worrying about running into other people or solid objects.In this research,we are making a new safety system and a smart shoe for blind people.The system is based on Internet of Things(IoT)technology and uses three ultrasonic sensors to allow users to hear and react to barriers.It has ultrasonic sensors and a microprocessor that can tell how far away something is and if there are any obstacles.Water and flame sensors were used,and a sound was used to let the person know if an obstacle was near him.The sensors use Global Positioning System(GPS)technology to detect motion from almost every side to keep an eye on them and ensure they are safe.To test our proposal,we gave a questionnaire to 100 people.The questionnaire has eleven questions,and 99.1%of the people who filled it out said that the product meets their needs.
