Smart responsive staple for dynamic promotion of anastomotic stoma healing

The precise combination of conflicting biological properties through sophisticated structural and functional design to meet all the requirements of anastomotic healing is of great demand but remains challenging.Here,we develop a smart responsive anastomotic staple(Ti–OH-MC)by integrating porous titanium anastomotic staple with multifunctional polytannic acid/tannic acid coating.This design achieves dynamic sequential regulation of antibacterial,anti-inflammatory,and cell proliferation properties.During the inflammatory phase of the anastomotic stoma,our Ti–OH-MC can release tannic acid to provide antibacterial and anti-inflammatory properties,together with immune microenvironment regulation function.At the same time,as the healing progresses,the multifunctional coating gradually falls off to expose the porous structure of the titanium anastomotic staple,which promotes cell adhesion and proliferation during the later proliferative and remodeling phases.As a result,our Ti–OH-MC exceeds the properties of clinically used titanium anastomotic staple,and can effectively promote the healing.The staple’s preparation strategy is simple and biocompatible,promising for industrialisation and clinical application.This work provides an effective anastomotic staple for anastomotic stoma healing and serve as a reference for the functional design and preparation of other types of titanium-based tissue repair materials.

A novel triple responsive smart fluid for tight oil fracturing-oil expulsion integration

The traditional multi-process to enhance tight oil recovery based on fracturing and huff-n-puff has obvious deficiencies,such as low recovery efficiency,rapid production decline,high cost,and complexity,etc.Therefore,a new technology,the so-called fracturing-oil expulsion integration,which does not need flowback after fracturing while making full use of the fracturing energy and gel breaking fluids,are needed to enable efficient exploitation of tight oil.A novel triple-responsive smart fluid based on“pseudo-Gemini”zwitterionic viscoelastic surfactant(VES)consisting of N-erucylamidopropyl-N,N-dimethyl-3-ammonio-2-hydroxy-1-propane-sulfonate(EHSB),N,N,N′,N′-tetramethyl-1,3-propanediamine(TMEDA)and sodium p-toluenesulfonate(NaPts),is developed.Then,the rheology of smart fluid is systematically studied at varying conditions(CO_(2),temperature and pressure).Moreover,the mechanism of triple-response is discussed in detail.Finally,a series of fracturing and spontaneous imbibition performances are systematically investigated.The smart fluid shows excellent CO_(2)-,thermal-,and pressure-triple responsive behavior.It can meet the technical requirement of tight oil fracturing construction at 140°C in the presence of 3.5 MPa CO_(2).The gel breaking fluid shows excellent spontaneous imbibition oil expulsion(∼40%),salt resistance(1.2×104 mg/L Na+),temperature resistance(140°C)and aging stability(30 days).

Some Hotspots Concerned with Smart Grid

The smart grid has been such a hot topic recently.In this paper the hot topics in this field,such as the definition and features of smart grid,key technical problems to be addressed such as new system components,new types of transducers and measurement technologies,advanced interfaces,event-driven fast-simulated decision-making and coordination,and adaptive control,etc.,and diff iculties are analyzed and discussed.

How Does the Government Facilitate the Co-Production of Digital Public Safety Services?——Based on Empirical Evidence from Shenzhen

The application of big data technology provides support for the co-production of public safety services.Existing research often focuses on how technology influences co-production,but lacks attention to the key actors that drive co-production and the mechanisms that facilitate it.This study examines the role of government in the digital co-production of public safety services,using the practice of Shenzhen as a case study.Shenzhen has built 125 information systems based on over 100 billion pieces of big data,forming a model of digital safety service co-production.The study reveals three types of digital co-production,characterized by"government-business joint planning,passive participation of businesses and the public,and active cooperation among government,businesses,and the public"in the"design-production-application"stages.The study shows that the government is not only a co-producer but also a proactive actor in activating the willingness of non-governmental entities to participate.Local governments mobilize non-governmental participation through three mechanisms:empowerment,profit enhancement,and value co-creation.The"power-interest-value"paradigm is applicable for analyzing the co-production of public services and helps to explain the transformation mechanisms of co-production behavior.