Influencing factors and preventive measures of infectious complications after intestinal resection for Crohn’s disease

The incidence of Crohn’s disease(CD)has increased in recent years,with most patients requiring intestinal resection.Complications after intestinal resection for CD can lead to poor prognosis and recurrence,among which infectious complic-ations are the most common.This study aimed to investigate the common risk factors,including medications,preoperative nutritional status,surgery-related factors,microorganisms,lesion location and type,and so forth,causing infectious complications after intestinal resection for CD,and to propose corresponding preventive measures.The findings provided guidance for identifying suscept-ibility factors and the early intervention and prevention of infectious complic-ations after intestinal resection for CD in clinical practice.

Recent emergence and outbreak of rotavirus gastroenteritis in Samoa:A scoping review of risk factors,containment measures and public health preparedness

Diarrheal diseases have been known to cause death in many children below the age of five years,and rotavirus infection represents a major health problem in the world today,particularly in developing countries.The recent outbreak of rotavirus gastroenteritis in Samoa led to the introduction of her debut national immunization program on rotavirus vaccination for infants.Despite the introduction of anti-viral and anti-emetic drugs as of the containment approaches towards the virus,risk factors,preventive measures and public health preparedness against rotavirus infection are poorly understood in Samoa.This review aims to use available evidence on rotavirus literature to elucidate and map preventive strategies for the recently emerged rotavirus infections in Samoa.We conducted a search strategy using online medical literature databases and retrieval systems.A designated set of keywords such as rotavirus,gastroenteritis,outbreak,risk factors,containment measures,vaccination and Samoa were inserted in electronic databases to retrieve articles.The databases included Pub Med,Google Scholar,MEDLINE,Scinapse,and EBSCO host.Findings from this review addressed the impact of rotavirus infection,associated threats and other preventive measures.Introducing useful health frameworks in pursuing possible methods such as improved water quality,exclusive breast feeding,improved laboratory diagnostics and outbreak surveillance,may be essential in addressing alternate approaches towards containment of the disease in Samoa and other Pacific Island Countries and Territories.

Interpretation of diagnosis and treatment scheme of COVID-19 in Hunan province (the third trial version) based on three factors and measures

The similarities and differences between"Novel Coronavirus Infected pneumonia in Hunan province(trial second edition)"and"Novel Coronavirus Infected pneumonia(Trial seventh edition)"released by the National Health Commission and their ideas were interpreted based on"suiting measures to three factors".①In Hunan program,the third version of the trial adjustment more suitable for local characteristics of the disease;②The prevention program population classification is clear,support,eliminate pathogenic factors of the primary and secondary distinct;③The cause of disease is prominent,damp and toxin are mixed with dryness,and the treatment is mainly to moisten the lung and clear away heat,and the prescription is mostly Xinliang light agent.

Impact factors and improvement measures of enviroment quality in cleaning operating room

Objective To analyze the factors that impact the environment quality of cleaning operating room and to discuss improvement measurement. Methods Environment bacteria testing results and prevalence of surgical incision infection in cleaning operating room were retro-

Analysis of the mechanical property of mudstone/shale in paralic coal measures and its influence factors

The mechanical property of mudstone/shale in coal measures is a key factor of engineering mechanics that influences the development of shale gas. A rock mechanics test was performed in order to analyze the complete stress-strain mechanic characteristics and influence factors of mudstone/shale in paralic coal measures, from the Carboniferous-Permian periods in a coal field of Northern China. The relationship between the mechanical properties of mudstone/shale in coal measures, and its chemical component, water content are established, and their models are constructed. Research results show that mud- stone/shale has low mechanical strength, low elastic modulus and a high Poisson＇s ratio. The complete stress-strain curve has apparent elastoplastic deformation characteristics, and after reaching peak strength, it exhibits obvious strain softening characteristics. The uniaxial compressive strength of mudstone/shale and its elastic modulus increases exponentially with the increase of SiO2 content, and as the ignition loss increases, the uniaxial compressive strength and elastic modulus of mudstone/shale will decrease according to the law of power function. The compressive strength of mudstone/shale and its elastic modulus will decrease with the increase of water content in mudstone/shale.

Analysis on the Influencing Factors and Control Measures of "Non-Grain Conversion" of Cultivated Land in Agricultural Land Transfer

Through the method of literature analysis,this paper analyzes the present situation of the"non-grain conversion"of cultivated land in the transfer of agricultural land in China,summarizes the influencing factors and consequences of the phenomenon of"non-grain conversion"of cultivated land in the transfer of agricultural land,and finally puts forward some measures.The study found that costs and benefits are the fundamental factors affecting the"non-grain conversion"of cultivated land in agricultural land transfer,and other main factors include government and policy guidance,industrial and commercial capital to the countryside,labor transfer and so on.The"non-grain conversion"of cultivated land in the transfer of agricultural land is a serious threat to China s food security,leading to the decline of the quality of agricultural land and the destruction of the ecological environment,as well as the risk of breach of contract in"industrial and commercial capital to the countryside".Based on the understanding of the influencing factors of non-grain conversion,this paper puts forward the following measures:strengthening the control of the use of cultivated land in agricultural land transfer;implementing accurate subsidies for grain cultivation and ensuring the benefit of grain growers;adopting grain planting incentive mechanism to increase grain enthusiasm;strengthening media publicity and education to enhance food security awareness.The improvement of the current situation of the"non-grain conversion"of cultivated land in the transfer of agricultural land will be of great significance to the protection of agricultural land and food security in China.

Analysis of Factors Affecting Logging Quality of Dual Lateral Instruments and Measures

In order to effectively improve the application value of equipment,the quality of dual-sided instrument logging is more important,but it has several influencing factors.This paper analyzes the working principle of dual lateral instrument logging,and discusses the factors affecting the logging quality of dual-sided instruments and optimization measures,for reference only.

Analyzing the Factors and Corresponding Measures for English Majors' Writing

As we know,English writing is an important part of communicative competence.But for many English majors,it is hard to express their thoughts clearly.In order to find out the main problems and corresponding measures,the author analyzes many compositions written by English majors.With some academic opinions and the author’s own analysis,some problems existing in students’writing are listed.According to the problems,the author summarizes some influencing factors.Finally,the author gives some relevant solutions.Through analyzing those samples,the author hopes it has some help for English majors’writing.

Research Progress on Self-Efficacy Level of Patients with Type 2 Diabetes Mellitus and Its Influencing Factors

Self-efficacy plays an important role in the management of type 2 diabetes mellitus (T2DM) patients, and it runs through the whole process of diabetes treatment, which is conducive to controlling and delaying the occurrence and development of complications, as well as improving the quality of life of patients. This paper mainly describes the concept of self-efficacy, the current situation of self-efficacy of diabetic patients at home and abroad, the functional aspects and their influencing factors, so as to take relevant measures on how to improve self-efficacy. It aims to provide a theoretical basis for the development of self-efficacy interventions for patients with type 2 diabetes mellitus.

Risk factors and care of early surgical site infection after primary posterior lumbar interbody fusion

Objectives:To explore the risk factors and nursing measures of early surgical site infection(SSI)after posterior lumbar interbody fusion(PLIF).Methods:A total of 468 patients who received PLIF in our hospital from January 2017 to June 2020 were enrolled into this study.According to the occurrence of early SSI,the patients were divided into two groups,and the general data were analyzed by univariate analysis.Multivariate logistic regression analysis was conducted with the dichotomous variable of whether early SSI occurred and other factors as independent variables to identify the risk factors of early SSI and put forward targeted prevention and nursing measures.Results:Among 468 patients with PLIF,18 patients developed early SSI(3.85%).The proportion of female,age,diabetes mellitus and urinary tract infection(UTI),operation segment,operation time,post-operative drainage volume,and drainage time were significantly higher than those in the uninfected group,with statistical significance(P<0.05),whereas the preoperative albumin and hemoglobin in the infected group were significantly lower than those in the uninfected group,with statistical significance(P<0.05).There was no significant difference between the two groups in the American Society of Anesthesiologists(ASA)grading,body mass index(BMI),complications including cardiovascular and cerebrovascular diseases or hypertension(P>0.05).Logistic regression analysis showed that preoperative diabetes mellitus(OR=2.109,P=0.012)/UTI(OR=1.526,P=0.035),prolonged drainage time(OR=1.639,P=0.029)were risk factors for early SSI.Men(OR=0.736,P=0.027)and albumin level(OR=0.526,P=0.004)were protective factors in reducing early SSI.Conclusions:Women,preoperative diabetes/UTI,hypoproteinemia,and prolonged drainage time are risk factors for early SSI after PLIF.Clinical effective preventive measures should be taken in combination with targeted nursing intervention to reduce the risk of early SSI.

Vertex centrality of complex networks based on joint nonnegative matrix factorization and graph embedding

Finding crucial vertices is a key problem for improving the reliability and ensuring the effective operation of networks,solved by approaches based on multiple attribute decision that suffer from ignoring the correlation among each attribute or the heterogeneity between attribute and structure. To overcome these problems, a novel vertex centrality approach, called VCJG, is proposed based on joint nonnegative matrix factorization and graph embedding. The potential attributes with linearly independent and the structure information are captured automatically in light of nonnegative matrix factorization for factorizing the weighted adjacent matrix and the structure matrix, which is generated by graph embedding. And the smoothness strategy is applied to eliminate the heterogeneity between attributes and structure by joint nonnegative matrix factorization. Then VCJG integrates the above steps to formulate an overall objective function, and obtain the ultimately potential attributes fused the structure information of network through optimizing the objective function. Finally, the attributes are combined with neighborhood rules to evaluate vertex's importance. Through comparative analyses with experiments on nine real-world networks, we demonstrate that the proposed approach outperforms nine state-of-the-art algorithms for identification of vital vertices with respect to correlation, monotonicity and accuracy of top-10 vertices ranking.

Dynamic analysis of agricultural green development efficiency in China: Spatiotemporal evolution and influencing factors

Green development of agriculture is important for achieving coordinated and high-quality regional development for China. Using provincial data from 1990 to 2020, this work explored the dynamics of agricultural green development efficiency of 31 provinces in China, its spatiotemporal characteristics, and its driving factors using a super-efficiency slacks-based measure(Super-SBM), the Malmquist productivity index(MPI), spatial autocorrelation, and a geographic detector. Results showed that the overall agricultural green development efficiency showed a U-shaped trend, suggesting a low level of efficiency. Although a gradient difference was visible among eastern, central, and western regions, the efficiency gap narrowed each year. Technological progress and efficiency both promoted agricultural green development efficiency, especially technological progress. Agricultural green development efficiency had significant spatial aggregation characteristics, but Moran’s Ⅰ result showed a downward trend from 2015 to 2020, indicating a risk of spatial dispersion in the later stage. The provinces with high agricultural green development efficiency were mainly concentrated in the eastern region, while those with low efficiency were concentrated in the central and western regions. Agricultural green development efficiency was influenced by various factors, which showed differences according to time and region. The impact of the labor force’s education level and technological progress increased during the study period, and significantly facilitated agricultural green development efficiency in the eastern region, while the central and western regions were still affected by the scale level and environmental regulation, reflecting the advantages of the eastern region in terms of economy and technology. In the future, strengthening agricultural scientific and technological innovation and deepening interprovincial cooperation can help further improve the level of green agricultural development. In addition, local governments should formulate more precise local agricultural support policies based on macro-level policies and local conditions.

MicroRNA-146a Promotes Embryonic Stem Cell Differentiation towards Vascular Smooth Muscle Cells through Regulation of Kruppel-like Factor 4

Objective Vascular smooth muscle cell(VSMC)differentiation from stem cells is one source of the increasing number of VSMCs that are involved in vascular remodeling-related diseases such as hypertension,atherosclerosis,and restenosis.MicroRNA-146a(miR-146a)has been proven to be involved in cell proliferation,migration,and tumor metabolism.However,little is known about the functional role of miR-146a in VSMC differentiation from embryonic stem cells(ESCs).This study aimed to determine the role of miR-146a in VSMC differentiation from ESCs.Methods Mouse ESCs were differentiated into VSMCs,and the cell extracts were analyzed by Western blotting and RT-qPCR.In addition,luciferase reporter assays using ESCs transfected with miR-146a/mimic and plasmids were performed.Finally,C57BL/6J female mice were injected with mimic or miR-146a-overexpressing ESCs,and immunohistochemistry,Western blotting,and RT-qPCR assays were carried out on tissue samples from these mice.Results miR-146a was significantly upregulated during VSMC differentiation,accompanied with the VSMC-specific marker genes smooth muscle-alpha-actin(SMαA),smooth muscle 22(SM22),smooth muscle myosin heavy chain(SMMHC),and h1-calponin.Furthermore,overexpression of miR-146a enhanced the differentiation process in vitro and in vivo.Concurrently,the expression of Kruppel-like factor 4(KLF4),predicted as one of the top targets of miR-146a,was sharply decreased in miR-146a-overexpressing ESCs.Importantly,inhibiting KLF4 expression enhanced the VSMC-specific gene expression induced by miR-146a overexpression in differentiating ESCs.In addition,miR-146a upregulated the mRNA expression levels and transcriptional activity of VSMC differentiation-related transcription factors,including serum response factor(SRF)and myocyte enhancer factor 2c(MEF-2c).Conclusion Our data support that miR-146a promotes ESC-VSMC differentiation through regulating KLF4 and modulating the transcription factor activity of VSMCs.

Factors Influencing the Use of Outcome Measures for Patients with Low Back Pain: A Survey of Nigerian Physiotherapists

Background: Low back pain is one of the important patients’ presenting complain that requires expert management from the physiotherapists. Yet no work was available for reference on the use of outcome measures for its evaluation by Nigeria physiotherapists. Objective: This study, therefore, investigated the outcome measures used by Nigerian physiotherapists to evaluate patients with Low Back Pain and the factors that influenced their use. Methods: A survey questionnaire was posted to 306 randomly selected mem- bers of the Nigeria Society of Physiotherapy (NSP). Data were analyzed using frequency, percentages, mean, ANOVA, and Pearson’s Chi-square. P-value was placed at 0.05. Results: 52.9% of the respondents (221) used a pain visual analog scale. Only 36.1% used LBP-specific clinical outcome measures. The factors that influenced their use were belief, attitude, knowledge, and choice. There was no significant difference between the majority of the factors and the use of clinical outcome measures. The P-values were 0.960, 0.648, 0.760 for belief, attitude and knowledge respectively. The only factor that had a significant difference (P = 0.029) with the use of clinical outcome measures was choice. Gender and postgraduate qualification had no significant influ- ence on the use of clinical outcome measures at the P-value of 0.117 and 0.510 respectively. Conclusion: Pain visual analog scale is the outcome measure frequently used by Nigeria Physiotherapists to evaluate patients with Low Back Pain. Belief, attitude, knowledge, and choice are the factors that influ- enced the use. There is a need to incorporate the use of LBP-specific outcome measures by Nigerian physiotherapists while treating patients with LBP.

Measurement of the cavity-loaded quality factor in superconducting radio-frequency systems with mismatched source impedance

The accurate measurement of parameters such as the cavity-loaded quality factor(Q_(L))and half bandwidth(f_(0.5))is essential for monitoring the performance of superconducting radio-frequency cavities.However,the conventional"field decay method"employed to calibrate these values requires the cavity to satisfy a"zero-input"condition.This can be challenging when the source impedance is mismatched and produce nonzero forward signals(V_(f))that significantly affect the measurement accuracy.To address this limitation,we developed a modified version of the"field decay method"based on the cavity differential equation.The proposed approach enables the precise calibration of f_(0.5) even under mismatch conditions.We tested the proposed approach on the SRF cavities of the Chinese Accelerator-Driven System Front-End Demo Superconducting Linac and compared the results with those obtained from a network analyzer.The two sets of results were consistent,indicating the usefulness of the proposed approach.

Analysis of Influencing Factors of Pine Wood Nematode Disease in Lu an City Based on GIS

[Objectives]The paper was to figure out the distribution of Monochamus alternatus in the stumps of pine wood nematode infected wood in Lu'an City and to provide a theoretical and practical basis for differentiated prevention and control of pine wood nematode disease in the future.[Methods]The factors influencing the number of epidemic small classes and infected plants in all counties and districts of Lu'an City were analyzed by GIS method,and the number of worms and wormholes of M.alternatus inside and outside the stumps of pine wood nematode infected wood in Lu'an City were investigated on the spot.[Results]There were 98,40,54,781,193,268 and 34 epidemic small classes of pine wood nematode disease,and 7241,6099,9532,39161,11079,49876 and 4853 infected plants in Yu'an District,Jin'an District,Yeji District,Shucheng County,Huoshan County,Jinzhai County and Huoqiu County,respectively.Pine wood nematode disease in Lu'an City mostly occurred in Huoshan County,Shucheng County and Jinzhai County,with relatively high altitude,paddy soil,the annual precipitation higher than 2062 mm,and the annual average temperature lower than 16.2℃.The number of diseased plants of pine wood nematode disease was positively correlated with altitude and annual precipitation,and was negatively correlated with annual average temperature.The number of worms and wormholes in pine wood nematode infected wood was very small at different altitudes,stump heights and stump diameters.[Conclusions]The pine wood nematode infected wood can be differentially processed after stump treatment,and stumps can be peeled.The results will provide a theoretical and practical basis for differentiated prevention and control of pine wood nematode disease in the future.

Effects of Main Cultivation Factors on Rapeseed Oil Yield

[Objective] This study aimed to analyze the influence of six cultivation fac- tors： sowing date, plant density, nitrogen fertilizer amount, phosphate fertilizer amount, potash fertilizer amount and boron fertilizer amount on seed oil yield of Brassica napus. [Method] Statistical analysis was carried out based on the data from previous studies and our work. [Result] Oil yield shared a negative correlation with sowing date, a parabolic relationship with plant density mostly, parabolic rela- tionships with amount of applied nitrogen fertilizer and amount of applied boron fer- tilizer, straight-line relationships with amount of applied phosphate fertilizer and amount of applied potash fertilizer. The average amount of applied nitrogen fertilizer required to obtain the highest oil yield was 185.18 kg/hm2 for high-oil rape varieties （with oil content above 44.00%）, and under this condition, the average oil yield of low-oil rape varieties （with oil content below 42.00%） was 1 247.84 kg/hm2, while that of high-oil rape varieties was 1 442.60 kg/hm2, which was 15.61% more than the former. The average amount of applied nitrogen fertilizer required to obtain the highest oil yield for lower-oil rape varieties was 286.28 kg/hm2, and under this con- dition, the average oil yield of the low-oil rape varieties was 1 350.57 kg/hm2, while that of the high-oil varieties was 6.81% higher than it. There was a significant neg- ative correlation between rapeseed oil yield and the amount of applied nitrogen fer- tilizer to obtain the highest oil yield （0.980 0）. The optimum amount of applied ni- trogen, phosphate, potash and boron fertilizer were 187.5-195, 187.5-195, 105-120, 135-150 and 15-22.5 kg/hm2 for high-oil B. napus varieties. [Conclusion] This study determined the influence of sowing date, plant density and amount of applied nitro- gen fertilizer on oil yield of B. napus, and proposed an optimum cultivation pattern for high-oil varieties.

Homocysteine-induced Enhanced Expression of Tissue Factor in Human Vascular Smooth Muscle Cells

The homocysteine （Hcy）-induced tissue factor （TF） expression in human vascular smooth muscle cells （VSMCs） and the effect of Hcy on the activity of nuclear factor-kappaB （NF-кB） and the expression of inducible nitric oxide synthase （iNOS） were investigated. Human umbilical artery VSMCs were cultured by tissue explanting method, identified by α-actin immunohistochemistry, and incubated with different concentrations of Hcy/PTDC （NF-кB inhibitor）. Semi-quantitative RT-PCR was performed to detect the expression of TF mRNA in VSMCs. Flow cytometry was used to assay the expression of TF protein on the surface of VSMCs and the expression of iNOS in VSMCs. Western blot was carried out to detect the expression of NF-кB protein in nuclei. The results showed that Hcy could induce VSMCs expressing TF mRNA significantly after the VSMCs were incubated with Hcy at concentrations of 10, 100, 500 μmol/L respectively. There was low expression level of TF protein on the surface of the resting VSMCs and Hcy could also induce VSMCs expressing TF pro- tein on the cell surface in different concentrations. Additionally, Hcy could rapidly induce the activation of NF-кB and this effect could be significantly inhibited by PDTC. Hcy alone could not induce the expression of iNOS in VSMCs. It was concluded that Hcy could significantly induce the expression of TF in VSMCs and enhance the activation of NF-ΚB, subsequently mediate TF gene expression and protein synthesis. NF-кB-mediated expression of TF in VSMCs might be the important mechanism of atherosclerosis and thrombosis induced by Hcy.

Different distributions of interstitial cells of Cajal and platelet-derived growth factor receptor-α positive cells in colonic smooth muscle cell/interstitial cell of Cajal/plateletderived growth factor receptor-α positive cell syncytium in mice

AIM To investigate the distribution and function of interstitialcells of Cajal(ICCs) and platelet-derived growth factor receptor-α positive(PDGFRα+) cells in the proximal and distal colon.METHODS The comparison of colonic transit in the proximal and distal ends was performed by colonic migrating motor complexes(CMMCs). The tension of the colonic smooth muscle was examined by smooth muscle spontaneous contractile experiments with both ends of the smooth muscle strip tied with a silk thread. Intracellular recordings were used to assess electrical field stimulation(EFS)-induced inhibitory junction potentials(IJP) on the colonic smooth muscle. Western blot analysis was used to examine the expression levels of ICCs and PDGFRα in the colonic smooth muscle.RESULTS Treatment with NG-nitro-L-arginine methyl ester hydrochloride(L-NAME) significantly increased the CMMC frequency and spontaneous contractions, especially in the proximal colon, while treatment with MRS2500 increased only distal CMMC activity and smooth muscle contractions. Both CMMCs and spontaneous contractions were markedly inhibited by NPPB, especially in the proximal colon. Accordingly, CyPPA sharply inhibited the distal contraction of both CMMCs and spontaneous contractions. Additionally, the amplitude of stimulationinduced nitric oxide(NO)/ICC-dependent slow IJPs(sIJPs) by intracellular recordings from the smooth muscles in the proximal colon was larger than that in the distal colon, while the amplitude of electric field stimulationinduced purinergic/PDGFRα-dependent fast IJPs(fIJPs) in the distal colon was larger than that in the proximal colon. Consistently, protein expression levels of c-Kit and anoctamin-1(ANO1) in the proximal colon were much higher, while protein expression levels of PDGFRα and small conductance calcium-activated potassium channel 3(SK3) in the distal colon were much higher.CONCLUSION The ICCs are mainly distributed in the proximal colon and there are more PDGFRα+ cells are in the distal colon, which generates a pressure gradient between the two ends of the colon to propel the feces to the anus.

Pre-evaluation on stability of proposed expressway embankment with existing geothermal regulation measures in permafrost regions

Embankment stability is the primary problem for the expressway construction in permafrost regions.The proposed Qinghai-Tibet Expressway(QTE)is planned to construct along the Qinghai-Tibet Project Corridor.Confronted with harsh environmental condition and intense heat exchange between earth and atmosphere,it is necessary to predict and evaluate the stability of the proposed QTE.In this study,the factors affecting the embankment stability are analyzed firstly.And then,a scheme for the stability evaluation of the embankment is established.Finally,the evaluation scheme is used for the pre-evaluation of the stability for the proposed QTE with different geothermal regulation measures(GRMs).The results indicate that the influencing factors include climatic environment,permafrost property,engineering condition and geological condition,and among them,engineering condition and permafrost property are the main influence factors for embankment stability.The stability of the proposed QTE varies greatly in the different geomorphological regions.The application effect and contribution to embankment stability of the existing GRMs are different,and using GRMs cannot completely overcome the influence of various factors on expressway stability.In the construction process,different GRMs should be adopted depending on the geomorphological environment where the embankment is located to ensure the embankment stability.