Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral response.Recent studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and hippocampus.Determining how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress psychopathology.In this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of depression.We focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine circuit.We determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic system.Therefore,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

Empirical analysis of carbon tariff's effect on the export structure of China's manufacturing industry and social welfare based on the GTAP model

In recent years,carbon emissions have gradually evolved from an environment issue into a political and economic one.Carbon tariff has brought about new trade barriers of developed countries,and in order to enhance the industrial competitiveness of developed countries,it will produce unfavorable impact on developing countries.Concentrated on the manufacturing industry,which is the most intensive high-carbon industry in China's export structure,this article studies the relationship between carbon tariff policy and industry structure of export trade and builds up a relation between climate change and international trade.First,by means of establishing a partial equilibrium model,it applies geometric analysis and mathematical analysis to compute the impact on China's manufacturing export trade and the consequences of the introduction of the US carbon tariff to China's manufacturing industry that has already imposed a domestic shipping carbon tax.Furthermore,with the application of the GTAP model,it estimates the overall economic and welfare effects on China's manufacturing industry if the US and Europe introduce carbon tariff by means of four ways,and then analyzes the influence on China's manufacturing industry export structure and social welfare as well.The result shows that the introduction of the US carbon import tariff lowers China's export price and export volume,and the implementation of a domestic carbon tax justifies a higher export price and a lower export volume for China.However,the degree of export reduction is smaller than that under the effect of the US carbon tariff.In the case of developed countries imposing carbon tariff on China's energy-intensive industries,such as chemical rubber products,oil and coal-processing industry and paper industry,whose export would be reduced,the negative impact on the paper industry is the severest,which will decrease the paper industry's export ranging from 1.79%to 6.05%,whereas the other industries' export will increase.Anyhow,it will promote China's manufacturing industry to adjust the export structure to a certain extent.In addition,it will lead to a decrease in China's welfare,with a decrease between $2,134 billion and $8,347 billion.Finally,this paper provides information on international coordination,export structure adjustment and green manufacturing adjustment as a reference for the development of China's manufacturing industry.

Social Marketing:An Advocacy Empirical Analysis of Service Objects of Public Welfare Organizations

The ultimate goal of social marketing is to change the behavior,attitude,concept,and so on of target audiences.For the public welfare organization,the basis of its service project design is the organization's mission and location.The key to achieve the organizational mission is to be able to lock the service objects and respond to the needs of service objects effectively.This research is based on the theoretical framework of social marketing and based on the questionnaire survey and analysis of the advocacy effectiveness and problems of service objects of the 327 public service organizations in China.Using the Delphi method and the entropy method,the 6P model of social marketing for service objects advocacy in the field of domestic public welfare practice is concise,and a new operational mechanism for service objects advocacy of public welfare organizations is proposed to implement the mission and value of public welfare organizations and contribute to the change of service objects.

Optimal social welfare:A many-to-many data transaction mechanism based on double auctions

With the development of Big Data and the Internet of Things(IoT),the data value is more significant in both academia and industry.Trading can achieve maximal data value and prepare data for smart city services.Due to data's unique characteristics,such as dispersion,heterogeneity and distributed storage,an unbiased platform is necessary for the data trading market with rational trading entities.Meanwhile,there are multiple buyers and sellers in a practical data trading market,and this makes it challenging to maximize social welfare.To solve these problems,this paper proposes a Social-Welfare-Oriented Many-to-Many Trading Mechanism(SOMTM),which integrates three entities,a trading process and an algorithm named Many-to-Many Trading Algorithm(MMTA).Based on the market scale,market dominated-side and market fixed-side,simulations verify the convergency,economic properties and efficiency of SOMTM.

Multi-objective Programming and Social Welfare Analysis of Rural–urban Land Conversion Decision-making

Rural-urban land conversion is an inevitable phenomenon in urbanization arid industrialization. And the decision-making issue about this conversion is multi-objective because the social decision maker （the whole of central government and local authority） has to integrate the requirements of different interest groups （rural collective economic organizations, peasants, urban land users and the ones affected indirectly） and harmonize the sub-objects （economic, social and ecological outcomes） of this land allocation process. This paper established a multi-objective programming model for rural-urban land conversion decision-making and made some social welfare analysis correspondingly. Result shows that the general object of rural-urban land conversion decision-making is to reach the optimal level of social welfare in a certain state of resources allocation, while the preference of social decision makers and the value judgment of interest groups are two crucial factors which determine the realization of the rural-urban land conversion decision-making objects.

The social welfare effect of forest certification under environmental spillovers

Forest certification has positive environmental spillovers.Considering environmental spillovers,this study ana‐lyzed the social welfare effects of forest certification using partial and general equilibrium methods.The re‐sults of the partial equilibrium analysis showed that social welfare in producing countries tended to increase under the market expansion of certified forest products.The general equilibrium analysis results indicated that,in autarky,or economic independence,the production amount of certified forest products could increase.If conventional forest products are imported and certified forest products are exported,then the level of utility in free trade condition is greater than that in autarky.If conventional forest products are exported and certi‐fied forest products are imported,then the price of imported products must be compared with the price of the autarky domestic market to determine the utility level of free trade and autarky.If the price of certified prod‐ucts is less than the price at the time of autarky,then the total utility level increases;otherwise,it decreases.The social welfare effect of forest certification can be increased through expanding the market demand of cer‐tified products and giving these products subsidies in production and price incentives in importing.

Notions of Free Market and Social Welfare in Islamic Economics

Trading and business in Islam has been identified as the second best profession after agriculture and Prophet Muhammad （PBUH） himself has been engaged in trading. The Islamic theory of market aims to provide optimization of returns and satisfaction for all stakeholders. It also seeks to make ＂free market＂ an instrument of promoting equity and social justice for the welfare of society. It combines tenants from the free market model as well as those in command market economy. Islamic economics identifies certain functional parameters for the efficient functioning of the market to achieve the optimization of returns and social welfare like absence of middle men, prohibition of hoarding, mode of finance free from interest and usury, taxation and other wealth redistribution instruments like Zakat and Khums, asset-based and risk-sharing partnerships and stakes, etc.. It essentially creates conditions for proper functioning of a competitive market as an instrument of economic progress and social equity. In Islamic economics, the role accorded to the state is to ensure that institutions are set up and vigilance officers are appointed which create the specified condition for the proper and fair functioning of the market and hence preventing what is identified as ＂market failure＂. The role of the state is to improve the functioning of the market as opposed to that of systematic intervention. This paper tries to examine the Islamic notions of ＂free market＂ in the traditional sources like Qur＇an, Hadees, the early texts of Islamic Jurisprudence, and contemporary writings on Islamic economic system and to make a comparative analysis with theories of market in capitalist and socialist frameworks. The paper will examine the extent to which Islamic notions of free market offer an alternative model to resolve the problems of growth, inequity, and risk management.

Changes in social welfare party leadership since the reform and opening up

The planned economy period after the founding of New China, there are a number of defects caused by the social welfare system of the country arranged the comprehensive safeguards, cannot meet the needs of the members of the community welfare. Since the reform and opening up, under the leadership of the Communist Party of China, China＇s social welfare undertakings made progress in the reform, old-age benefits, disability benefits, women＇s welfare, child welfare and so on can be further developed. In aging relatively serious today, social pension needs of rapid growth, the urgent need to support the people＇s participation and social forces, to promote the socialization of social welfare, accelerate the development of social welfare, the early establishment of an appropriate type social welfare undertakings Pratt ＆ Whitney.

Social Welfare Transformation and Community Governance Model for the Aging Generation:Rural Community Care in Chiayi County as a Case Study

Over the past two decades,Taiwan’s welfare policies for the elderly have prepared for the arrival of an aged society with the aim of facilitating aging in place(AIP).The Long-Term Care Services Act passed by the Legislative Yuan in 2015 set regulations for long-term care personnel,thereby improving the welfare system for the elderly.The government’s AIP policies focus on providing welfare institutions or service units and do not sufficiently explore key factors such as the relationship between care services and community governance models.Since the basic focus of elderly welfare policies is AIP,it is important to actively empower grassroots community organizations and consider the elderly as important subjects of community participation.AIP policies emphasize providing long-term care and nurturing the elderly until death;such policies will be more proactive and innovative if coproduction is incorporated.This study briefly discusses theories related to coproduction using the case study of Chiayi County’s Dingcaiyian Community Development Association,which links six communities in remote rural villages and establishes a community care network based on the coproduction concept.Follow-up issues related to community care are considered and potential practices and ideas to guide social welfare transformation and community governance in the future are discussed.

Key sources of SOE profitability and their implications for social welfare

An analysis of the sources of profit growth for China's state-owned industry since 1999 indicates that the key source of profit growth is not the high productivity of state-owned enterprises (SOEs) but rather their monopoly position and pricing power in some basic industries. From an overall social perspective, such high profitability means an inefficient allocation of industrial resources and a potential loss of social welfare. Therefore, further expanding and deepening the reform of SOE property rights, encouraging the development of non-SOEs and boosting the competitiveness of basic industries will significantly improve the resource allocation efficiency of the Chinese industry and enhance overall social welfare.

Social Work and Social Welfare from a Multidisciplinary Perspective -- A Challenge for Researchers

In 2008, a deep economic crisis started in the US and rapidly spread around the world. The financial and economic crisis, called “The Great Recession”, continues in many countries today and has been considered as the most severe recession in the history of US (after “The Great Depression”). The crisis brought very fast growth in unemployment and it is foreseeable that it will be long lasting and that recovery will be very slow. Hence, such economic change obviously had a significant impact on workers worldwide.

Analysis of Intermediate Product Price and Social Welfare in the Vertical Merger of Enterprises

According to the different products that two upper enterprises produce, this paper analyzes the transfer pricing of intermediate product and the effect of social welfare of vertical merger under imperfect competition market. The conclusions are: the transfer pricing of intermediate product is equal to marginal cost; the perfect outputs that upper enterprises sell to the market before and after the vertical merger of enterprises are the same; the product price in the integrated enterprises may be higher, lower or equal to the price in non-integrated enterprises.

Research on features and questions of Korean social welfare model

In the second half of the 1990s, South Korea has undergone dramatic changes called fetal movement of welfare state. However, after the foreign exchange crisis, members of the South Korean society are faced with unstable employment and income instability, where the degree of risk of unemployment is higher than ever before. Deepening of globalization has a complex influence on social welfare development. Despite social welfare developing, the reasons of income inequality and more serious poverty are diverse. Developmentalism strategy since the 1960s in Korea has obvious limitations, which cannot continue to play an effective function according to changing internal and external conditions. In order to get rid of this situation, it should create a virtuous cycle of welfare and growth, and materialize the development strategy of the social welfare in the macro-economic and social development stratezv.

Integrated ribosome and proteome analyses reveal insights into sevoflurane-induced long-term social behavior and cognitive dysfunctions through ADNP inhibition in neonatal mice

A growing number of studies have demonstrated that repeated exposure to sevoflurane during development results in persistent social abnormalities and cognitive impairment.Davunetide,an active fragment of the activity-dependent neuroprotective protein(ADNP),has been implicated in social and cognitive protection.However,the potential of davunetide to attenuate social deficits following sevoflurane exposure and the underlying developmental mechanisms remain poorly understood.In this study,ribosome and proteome profiles were analyzed to investigate the molecular basis of sevoflurane-induced social deficits in neonatal mice.The neuropathological basis was also explored using Golgi staining,morphological analysis,western blotting,electrophysiological analysis,and behavioral analysis.Results indicated that ADNP was significantly down-regulated following developmental exposure to sevoflurane.In adulthood,anterior cingulate cortex(ACC)neurons exposed to sevoflurane exhibited a decrease in dendrite number,total dendrite length,and spine density.Furthermore,the expression levels of Homer,PSD95,synaptophysin,and vglut2 were significantly reduced in the sevoflurane group.Patch-clamp recordings indicated reductions in both the frequency and amplitude of miniature excitatory postsynaptic currents(mEPSCs).Notably,davunetide significantly ameliorated the synaptic defects,social behavior deficits,and cognitive impairments induced by sevoflurane.Mechanistic analysis revealed that loss of ADNP led to dysregulation of Ca^(2+)activity via the Wnt/β-catenin signaling,resulting in decreased expression of synaptic proteins.Suppression of Wnt signaling was restored in the davunetide-treated group.Thus,ADNP was identified as a promising therapeutic target for the prevention and treatment of neurodevelopmental toxicity caused by general anesthetics.This study provides important insights into the mechanisms underlying social and cognitive disturbances caused by sevoflurane exposure in neonatal mice and elucidates the regulatory pathways involved.

Mapping and measuring urban-rural inequalities in accessibility to social infrastructures

Equal access to social infrastructures is a fundamental prerequisite for sustainable development,but has long been a great challenge worldwide.Previous studies have primarily focused on the accessibility to social infras-tructures in urban areas across various scales,with less attention to rural areas,where inequality can be more severe.Particularly,few have investigated the disparities of accessibility to social infrastructures between urban and rural areas.Here,using the Changsha-Zhuzhou-Xiangtan urban agglomeration,China,as an example,we investigated the inequality of accessibility in both urban and rural areas,and further compared the urban-rural difference.Accessibility was measured by travel time of residents to infrastructures.We selected four types of social infrastructures including supermarkets,bus stops,primary schools,and health care,which were funda-mentally important to both urban and rural residents.We found large disparities in accessibility between urban and rural areas,ranging from 20 min to 2 h.Rural residents had to spend one to two more hours to bus stops than urban residents,and 20 min more to the other three types of infrastructures.Furthermore,accessibility to multiple infrastructures showed greater urban-rural differences.Rural residents in more than half of the towns had no access to any infrastructure within 15 min,while more than 60%of the urban residents could access to all infrastructures within 15 min.Our results revealed quantitative accessibility gap between urban and rural areas and underscored the necessity of social infrastructures planning to address such disparities.

Dysfunctional attitudes,social support,negative life events,and depressive symptoms in Chinese adolescents:A moderated mediation model

BACKGROUND Depression is a prevalent psychological issue in adolescents that is significantly related to negative life events(NLEs)and dysfunctional attitudes.High levels of social support can significantly buffer NLEs’effect on depression.Currently,there is limited research on how social support moderates the relationship between NLEs,dysfunctional attitudes,and depression in adolescents in China.It is imperative to investigate this moderating effect to mitigate dysfunctional attitudes in adolescent undergoing depressive mood,ultimately enhancing their overall mental health.AIM To investigate the relationship and underlying mechanisms between specific dysfunctional attitudes,social support,and depression among Chinese adolescents.METHODS This is a cross-sectional study which selected five middle schools in Shandong Province for investigation in March 2022.Participants included 795 adolescents(49.87%male,mage=15.15,SD=1.84,age range=11-18 years old).All participants completed the Dysfunctional Attitude Scale,Adolescent Life Event Scale,Beck Depression Inventory,and Social Support Rating Scale.A moderated mediation model was conducted to examine the relationship between specific dysfunctional attitudes,social support,and depression.RESULTS Results indicated that NLEs affected depression through the mediating role of specific dysfunctional attitudes(autonomy attitudesβ=0.21;perfectionismβ=0.25).Moreover,social support was found to moderate the mediating effect between NLEs,specific dysfunctional attitudes,and depressive symptoms(autonomy attitudes b2=-0.08;perfectionism b2=-0.09).CONCLUSION Dysfunctional attitudes mediated and social support moderated the relationship between NLEs and depression.Social support can buffer depression symptoms among adolescents with autonomy attitudes and perfectionism.

Comparative analyses of mitogenomes in the social bees with insights into evolution of long inverted repeats in the Meliponini

The insect mitogenome is typically a compact circular molecule with highly conserved gene contents.Nonetheless,mitogenome structural variations have been reported in specific taxa,and gene rearrangements,usually the tRNAs,occur in different lineages.Because synapomorphies of mitogenome organizations can provide information for phylogenetic inferences,comparative analyses of mitogenomes have been given increasing attention.However,most studies use a very few species to represent the whole genus,tribe,family,or even order,overlooking potential variations at lower taxonomic levels,which might lead to some incorrect inferences.To provide new insights into mitogenome organizations and their implications for phylogenetic inference,this study conducted comparative analyses for mitogenomes of three social bee tribes(Meliponini,Bombini,and Apini)based on the phylogenetic framework with denser taxonomic sampling at the species and population levels.Comparative analyses revealed that mitogenomes of Apini and Bombini are the typical type,while those of Meliponini show diverse variations in mitogenome sizes and organizations.Large inverted repeats(IRs)cause significant gene rearrangements of protein coding genes(PCGs)and rRNAs in Indo-Malay/Australian stingless bee species.Molecular evolution analyses showed that the lineage with IRs have lower dN/dS ratios for PCGs than lineages without IRs,indicating potential effects of IRs on the evolution of mitochondrial genes.The finding of IRs and different patterns of gene rearrangements suggested that Meliponini is a hotspot in mitogenome evolution.Unlike conserved PCGs and rRNAs whose rearrangements were found only in the mentioned lineages within Meliponini,tRNA rearrangements are common across all three tribes of social bees,and are significant even at the species level,indicating that comprehensive sampling is needed to fully understand the patterns of tRNA rearrangements,and their implications for phylogenetic inference.

Adolescent suicide risk factors and the integration of socialemotional skills in school-based prevention programs

Adolescents are considered one of the most vulnerable groups affected by suicide.Rapid changes in adolescents’physical and mental states,as well as in their lives,significantly and undeniably increase the risk of suicide.Psychological,social,family,individual,and environmental factors are important risk factors for suicidal behavior among teenagers and may contribute to suicide risk through various direct,indirect,or combined pathways.Social-emotional learning is considered a powerful intervention measure for addressing the crisis of adolescent suicide.When deliberately cultivated,fostered,and enhanced,selfawareness,self-management,social awareness,interpersonal skills,and responsible decision-making,as the five core competencies of social-emotional learning,can be used to effectively target various risk factors for adolescent suicide and provide necessary mental and interpersonal support.Among numerous suicide intervention methods,school-based interventions based on social-emotional competence have shown great potential in preventing and addressing suicide risk factors in adolescents.The characteristics of school-based interventions based on social-emotional competence,including their appropriateness,necessity,cost-effectiveness,comprehensiveness,and effectiveness,make these interventions an important means of addressing the crisis of adolescent suicide.To further determine the potential of school-based interventions based on social-emotional competence and better address the issue of adolescent suicide,additional financial support should be provided,the combination of socialemotional learning and other suicide prevention programs within schools should be fully leveraged,and cooperation between schools and families,society,and other environments should be maximized.These efforts should be considered future research directions.

Making the case for the evolving role of social media in health professions education and a literature review on the application of some in ophthalmology

Background and Objective:Social media(SoMe)has emerged as a tool in health professions education(HPE),particularly amidst the challenges posed by the coronavirus disease 2019(COVID-19)pandemic.Despite the academia’s initial skepticism SoMe has been gaining traction in supporting learning communities,and offering opportunities for innovation in HPE.Our study aims to explore the integration of SoMe in HPE.Four key components were outlined as necessary for a successful integration,and include designing learning experiences,defining educator roles,selecting appropriate platforms,and establishing educational objectives.Methods:This article stemmed from the online Teaching Skills Series module on SoMe in education from the Ophthalmology Foundation,and drew upon evidence supporting learning theories relevant to SoMe integration and models of education.Additionally,we conducted a literature review considering Englishlanguage articles on the application of SoMe in ophthalmology from PubMed over the past decade.Key Content and Findings:Early adopters of SoMe platforms in HPE have leveraged these tools to enhance learning experiences through interaction,dialogue,content sharing,and active learning strategies.By integrating SoMe into educational programs,both online and in-person,educators can overcome time and geographical constraints,fostering more diverse and inclusive learning communities.Careful consideration is,however,necessary to address potential limitations within HPE.Conclusions:This article lays groundwork for expanding SoMe integration in HPE design,emphasizing the supportive scaffold of various learning theories,and the need of furthering robust research on examining its advantages over traditional educational formats.Our literature review underscores an ongoing multifaceted,random application of SoMe platforms in ophthalmology education.We advocate for an effective incorporation of SoMe in HPE education,with the need to comply with good educational practice.

Spatiotemporal dynamics of the social structure of Indo-Pacific humpback dolphins(Sousa chinensis)in Xiamen waters from 2007 to 2019

As highly social animals,Indo-Pacific humpback dolphins(Sousa chinensis)exhibit community differentiation.Nevertheless,our understanding of the external and internal factors influencing these dynamics,as well as their spatiotemporal variations,is still limited.In the present study,variations in the social structure of an endangered Indo-Pacific humpback dolphin population in Xiamen Bay,China,were monitored over two distinct periods(2007–2010 and 2017–2019)to analyze the effects of habitat utilization and the composition of individuals within the population.In both periods,the population demonstrated a strikingly similar pattern of social differentiation,characterized by the division of individuals into two main clusters and one small cluster.Spatially,the two primary clusters occupied the eastern and western waters,respectively,although the core distribution area of the eastern cluster shifted further eastward between the two periods.Despite this distribution shift,the temporal stability of the social structure and inter-associations within the eastern cluster remained unaffected.A subset of 16individuals observed in both periods,comprising 51.6%and 43.2%of the population in each respective period,emerged as a foundational element of the social structure and may be responsible for sustaining social structure stability,especially during the 2007–2010 period.These observations suggest that the composition of dominant individuals,an internal factor,had a more substantial influence on the formation of the social network than changes in habitat use,an external factor.Consequently,the study proposes distinct conservation measures tailored to each of the two main clusters.