Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative disease.Although the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and therapy.The induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease therapies.The current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem cells.The benefits of induced pluripotent stem cell-based research are highlighted.Various dopaminergic neuron differentiation protocols from induced pluripotent stem cells are compared.The emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are evaluated.Finally,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

Enhancing perianal disease management with integrated physical and psychological approaches

This article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal diseases.The study sheds light on how illness perception,anxiety,and depression significantly influence recovery outcomes.Hou et al developed a predictive model that demonstrated high accuracy in identifying patients at risk of poor recovery.The article explores the critical role of pre-operative psychological assessment,highlighting the need for mental health support and personalized recovery plans in enhancing POR quality.A multidisciplinary approach,integrating mental health professionals with surgeons,anesthesiologists,and other specialists,is emphasized to ensure comprehensive care for patients.The study’s findings serve as a call to integrate psychological care into surgical practice to optimize outcomes for patients with perianal diseases.

Gastrointestinal tuberculosis:Diagnostic approaches for this uncommon pathology

A case report entitled“Primary gastroduodenal tuberculosis presenting as gastric outlet obstruction”recently published in the World Journal of Clinical Cases presented a rare cause of gastric outlet obstruction and highlighted the atypical manner in which gastrointestinal tuberculosis(TB)can present.The literature with regards to this rare pathology is limited to case reports and case series with the largest being published using data from between 2003 and 2013.However,since then the diagnostic tools available have significantly changed with more modern and increasingly accurate tests now available.This editorial reviews the current state of the art with regards to diagnosis in gastrointestinal TB.

Chemical structures,analytical approaches and toxicological effects of oxidative derivatives of triglycerides as potential hazards in lipid thermal processing:A review

There is an increasing attention on oxidative derivatives of triglycerides,a group of potential thermal processing induced food toxicants,which are formed during the thermal processing of food lipids.This review aims to summarize current knowledge about their formation mechanisms,detection approaches,and toxicology impacts.Oxidative derivatives of triglycerides are generated through the oxidation,cyclization,polymerization,and hydrolysis of triglycerides under high-temperature and abundant oxygen.The analytical techniques,including GC,HPSEC,MS,^(1)H-NMR were discussed in analyzing these components.In addition,their toxic effects on human health,including effects on the liver,intestines,cardiovascular system,immune system,and metabolism were elucidated.Information in this review could be used to improve the understanding of oxidative derivatives of triglycerides and ultimately improve academic and industrial strategies for eliminating these compounds in thermal processing food systems.

Contemporary strategies and approaches for characterizing composition and enhancing biofilm penetration targeting bacterial extracellular polymeric substances

Extracellular polymeric substances(EPS)constitutes crucial elements within bacterial biofilms,facili-tating accelerated antimicrobial resistance and conferring defense against the host's immune cells.Developing precise and effective antibiofilm approaches and strategies,tailored to the specific charac-teristics of EPS composition,can offer valuable insights for the creation of novel antimicrobial drugs.This,in turn,holds the potential to mitigate the alarming issue of bacterial drug resistance.Current analysis of EPS compositions relies heavily on colorimetric approaches with a significant bias,which is likely due to the selection of a standard compound and the cross-interference of various EPS compounds.Considering the pivotal role of EPS in biofilm functionality,it is imperative for EPS research to delve deeper into the analysis of intricate compositions,moving beyond the current focus on polymeric materials.This ne-cessitates a shift from heavy reliance on colorimetric analytic methods to more comprehensive and nuanced analytical approaches.In this study,we have provided a comprehensive summary of existing analytical methods utilized in the characterization of EPS compositions.Additionally,novel strategies aimed at targeting EPS to enhance biofilm penetration were explored,with a specific focus on high-lighting the limitations associated with colorimetric methods.Furthermore,we have outlined the challenges faced in identifying additional components of EPS and propose a prospective research plan to address these challenges.This review has the potential to guide future researchers in the search for novel compounds capable of suppressing EPS,thereby inhibiting biofilm formation.This insight opens up a new avenue for exploration within this research domain.

Optimizing a Transportation System Using Metaheuristics Approaches (EGD/GA/ACO): A Forest Vehicle Routing Case Study

The large-scale optimization problem requires some optimization techniques, and the Metaheuristics approach is highly useful for solving difficult optimization problems in practice. The purpose of the research is to optimize the transportation system with the help of this approach. We selected forest vehicle routing data as the case study to minimize the total cost and the distance of the forest transportation system. Matlab software helps us find the best solution for this case by applying three algorithms of Metaheuristics: Genetic Algorithm (GA), Ant Colony Optimization (ACO), and Extended Great Deluge (EGD). The results show that GA, compared to ACO and EGD, provides the best solution for the cost and the length of our case study. EGD is the second preferred approach, and ACO offers the last solution.

The Model of Open and Distance Learning for Teaching Indonesian Through Socio-Cultural Approach and Psychological Aspects to Students of Indonesian for Foreign

This study aims to find out the effect of the model of ODL （Open and Distance Learning） for teaching Indonesian for foreign and whether this model of ODL implements socio-cultural and psychological approaches. The students＇ learning of Indonesian for foreign is in so many aspects that it must be considered from both psychological aspects of students＇ language and cultural aspects. The research was carried out on foreign students＇ studying Indonesian language. The research method used action research. ODL model developed this concerning how the students are anxious in foreign language learning and language use in accordance with Indonesian culture. The model of ODL for teaching foreign Indonesian uses the Internet facilities such as email, Skype, VolP, Google Talk, circulating document with comments, chat, forum, CD, audio-video, stream media player, and e-learning system. Based on the results of this study which is that students study the model ODL for teaching Indonesian through socio-cultural approach and psychological aspects and students of Indonesian for foreign improve their ability to use the Indonesian language, students are able to converse fluently in Indonesian in accordance with Indonesian culture

Exploring Ester Prodrugs: A Comprehensive Review of Approaches, Applications, and Methods

The review provides an overview of the approaches, applications, and methods for ester prodrugs. Ester prodrugs are pharmacologically inactive compounds in their original form but become active drugs on biotransformation within the body, which offers advantages concerning the solubility, stability, and targeted delivery of the active drug. Several approaches of ester prodrugs have been reviewed in this review, including simple ester prodrugs, amino acid ester prodrugs, sugar ester prodrugs, lipid ester prodrugs, and polymeric ester prodrugs. This review incorporates in vitro and in vivo methods as well as the characterization of physical and chemical properties for ester prodrugs, cell culture systems, enzymatic assays, and animal models—all of these having a very important bearing on the evaluation of stability, bioavailability, and efficacy for ester prodrugs. While the benefits of using ester prodrugs are significant, there are also disadvantages like instability, poor or variable enzymatic hydrolysis, and toxicity from released promoieties or by-products. This review discusses solutions to the various limitations that include enhancing stability with ionizable promoieties and using physiologically-based pharmacokinetic modeling. The review also highlights the application of ester prodrugs in neurological disorders, such as Parkinson’s disease, and the ongoing efforts to address the critical limitations in treatment efficacy. Future prodrug strategies are poised to advance significantly by harnessing diverse transport mechanisms across the blood-brain barrier and integrating nanotechnology.

Objectives of and Approaches to Ecological City Construction

It has become a trend of the city development in the world to build up the ecological city with an ecological system that is balanced in structure,high-efficient in service function.Taking Suzhou as a case,the authors believe that the construction of an ecological city is a process of the progressive and well-organized systematic development and of the ecological function consummation,which will require five stages to complete,including ecological hygiene,ecological security,ecological industry,ecological landscape,and ecological culture.The problems presently encountered in the construction of ecological city in Suzhou can be solved through the following approaches:(1) To rebuild the relationship between man and nature when the planning is worked out;(2) To observe the principle of ecology in city design;(3) To choose the local plant species in city afforestation;(4) To choose those plantlets with vigorous growth,good shape,and high survival rate,observing the growth rule of plant and paying much attention to forest landscape,ecological system and biological diversity,rationally allocating the plant species resources;(5) To aim at the implementation of the less-labor management even the zero-labor management.

Approaches for Improvement of Competitiveness of Bama Rural Health-caring Tourism from the Deep Perspective of Tourism,China

After analysis of characteristics of Bama rural health-caring tourism,it had highlighted monopolisticness of longevity culture,diversity of tourist resources,and harmony between human and nature.The paper pointed out that,to accelerate new countryside construction of Bama rural health-caring tourism,it should realize nearby employment and increase farmers' income;complete construction of rural basic facilities;ameliorate rural sanitary condition and transform villagers' thought;promote adjustment of rural industrial structure;and establish protection mechanism of longevous people.After survey on development of Bama rural tourism,it concluded bottlenecks restricting Bama rural tourism development,which were that environment at longevity area had suffered pollution;that the development was disordered and lacked of management;and that basic facilities waited for improvement.On this basis,approaches for improvement of competitiveness of Bama health-caring tourism had been proposed.It emphasized that it should enhance protection of longevity tourist resources,build farmhouse inn demonstration base,implement admittance system,establish community health-care system,beneficial to realizing economic,social and ecological benefits,and further manifesting its exuberant vitality.

Low-carbon Landscape Construction Approaches Based on Human Behavior

After the analysis of connotations of human behavior and low-carbon landscape,according to relevant theories of behavioral science and psychology,the internal relation between behavior and lowcarbon landscape has been discussed.They relate to,interact on and are the precondition of each other.Reasonable landscape environment has carried people's expectation for nature,and different landscapes give people different feelings and present to be of different behavior features.Finally,the paper has proposed constructing low-carbon landscape in the perspective of landscape design idea,design methods,construction process and later management,providing a theoretical basis for advocating energy saving and environmental protection,and creating green ecology.

On the Study of Translation Approaches of Culture-loaded Words in Literary Works

Culture-loaded words refer to expressions and idioms that carry typically culture messages. The peculiarity of one culture cannot be understood or accepted by readers from another culture. The uniqueness very likely makes misunderstanding and may lead to cultural vacancy in other cultures. Due to the culture differences between Chinese and English, it is hard for a translator to achieve complete equivalence at the level of word. This paper discusses the translation approaches of Chinese cultureloaded words in literary works.

Functional Orientation and Practice of Inductive and Deductive Approaches to Grammar Teaching in EFL

To solve the ambiguous understanding of Grammar Teaching position,based on explicit grammatical knowledge,this paper discusses the grammar position in EFL,compares both its pros and cons between deductive and inductive approaches,and indicates that grammar teaching by either approach alone has disadvantages,should adopt a combination technique.

Theoretical Approaches to Error Analysis

Contrast Analysis (CA), Interlanguage(IL),cognitive approach are considered as three aspects closely related to Error Analysis (EA).Originated from CA, EA takes IL as its linguistic basis and cognitive approach as its psychological support.Comparing with CA, EA pays more attention to the learner himself rather than the linguistic forms, and error is therefore shifted from what should be avoided to the crucial approach to the exploration of the learner’s cognitive process.

On the Options of EFL Methodological Approaches

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The Development of Meta-functional Approaches in Translation Studies

Functional linguistics has exerted an increasing impact on modern linguistic studies.Functional approaches,especially metafunctions have undergone a process of development and improvement.The affirmation of the metafunctions of language has aroused more and more scholars'concern on the"functional"facet of language,especially in Translation studies.The formation and improvement of functional approaches are introduced separately.

Major Problems in American Education: From a Socio-Cultural Perspective

American intellectuals of different generations and in various eras,with a strong sense of social responsibility and a critical mind,have dedicated themselves in revealing some major problems existing in American education,namely educational inequality,declining academic performance,inadequate funding,and school violence.By describing and probing into these problems from a socio-cultural perspective,they offer a solution of eliminating the socio-economic inequality in America,which is fundamental and essential.

Humanistic Approaches to Foreign Language Teaching

Some educators and teachers stated that the reason of the major failures in foreign language teaching was that teachers could not help their students to discover the personal meaning of the information they provided. To deal with the problem that students were regarded as containers and classroom learning was dull, humanistic approaches were put forward.

An application of Genre-based Teaching Approaches into the teaching of English reading and writing

There are several teaching approaches being used to instruct the reading and writing teaching, such as the product approach, the process approach and the genre approach. In a long period, the product approach and the process approach dominate the field of writing teaching. With the development of genre and genre-analysis theory, we begin to realize that genre-based approach is effective in improving students ’ reading comprehension and writing. Based on the analysis of the theory and on the present situations of college English teaching and personal teaching experience, the genre-based teaching approach is introduced to the writing and reading comprehension teaching.

INTEGRATED ANALYSIS APPROACHES TO ROCK MECHANICS PROBLEMS

In order to effectively cope with exponent increase of the complexity faced to the rock mechanics analysis problems and the large incompatibility existing between the information level required to model the rock mass and engineering and our obtainable information level at hand,the integrated approaches with intelligent characters are proposed. Many previous standard methods,such as precedent type analysis,rock classification,analytic method stress-based,basic numerical methods (BEM,FEM,DEM,hybrid),and their extended numerical methods (fully coupled) to be developed,can be selected respectively or integrated accordingly. It is alternative to develop basic/fully integrated system,and internet-based approaches. These novel methods can also be selected or integrated each other or with the standard methods to perform rock mechanics analysis. Some key techniques to develop these alternative methods are discussed. It may focus in future on developing fully integrated systems and internet-based approaches. Developing an environmental,virtual facility/space shall be firstly done for this collaborative research on internet.