A water absorption biomaterial, sodium carboxymethylation-functiona- lized chitosan fibers （Na-NOCC fibers） were prepared, applied for cutaneous wound repair, and characterized by FTIR and NMR. The water absorption ...A water absorption biomaterial, sodium carboxymethylation-functiona- lized chitosan fibers （Na-NOCC fibers） were prepared, applied for cutaneous wound repair, and characterized by FTIR and NMR. The water absorption of Na-NOCC fibers increased significantly with substitution degree rising, from 3.2 to 6.8 g/g, and higher than that of chitosan fibers （2.2 g/g） confirmed by swelling behavior. In the antibacterial action, the high degree of substitution of Na-NOCC fibers exhibited stronger antibacterial activities against E. co//（from 66.54% up to 88.86%）. The inhibition of Na-NOCC fibers against S. aureus were above 90%, and more effective than E. coli. The cytotoxicity assay demonstrated that Na-NOCC2 fibers were no obvious cytotoxicity to mouse fibroblasts. Wound healing test and histological examination showed that significantly advanced granulation tissue and capillary formation in the healing-impaired wounds treated with Na-NOCC fibers, as compared to those treated with gauze, which demonstrated that Na- NOCC fibers could promote skin repair and might have great application for wound healing.展开更多
Based on results of single factor experiments,analytical levels for three additives were established and experimental scheme was designed by central composite of response surface methodology(RSM) with the software of ...Based on results of single factor experiments,analytical levels for three additives were established and experimental scheme was designed by central composite of response surface methodology(RSM) with the software of Design-Expert 7.1.6.Funnily,we got the SA-CS blending fiber with a strength of 13.56 cN/tex,should be spun at the conditiongs as follows: The mass dosage of SA to the polysaccharide was 48.89%,the temperature of the water bath was 58.57℃,and the response time was 29.31 minutes.,and in the predict model,the result shows as 13.5688cN/tex,compared the later with the former,it has the error of 0.064%.展开更多
文摘A water absorption biomaterial, sodium carboxymethylation-functiona- lized chitosan fibers （Na-NOCC fibers） were prepared, applied for cutaneous wound repair, and characterized by FTIR and NMR. The water absorption of Na-NOCC fibers increased significantly with substitution degree rising, from 3.2 to 6.8 g/g, and higher than that of chitosan fibers （2.2 g/g） confirmed by swelling behavior. In the antibacterial action, the high degree of substitution of Na-NOCC fibers exhibited stronger antibacterial activities against E. co//（from 66.54% up to 88.86%）. The inhibition of Na-NOCC fibers against S. aureus were above 90%, and more effective than E. coli. The cytotoxicity assay demonstrated that Na-NOCC2 fibers were no obvious cytotoxicity to mouse fibroblasts. Wound healing test and histological examination showed that significantly advanced granulation tissue and capillary formation in the healing-impaired wounds treated with Na-NOCC fibers, as compared to those treated with gauze, which demonstrated that Na- NOCC fibers could promote skin repair and might have great application for wound healing.
文摘Based on results of single factor experiments,analytical levels for three additives were established and experimental scheme was designed by central composite of response surface methodology(RSM) with the software of Design-Expert 7.1.6.Funnily,we got the SA-CS blending fiber with a strength of 13.56 cN/tex,should be spun at the conditiongs as follows: The mass dosage of SA to the polysaccharide was 48.89%,the temperature of the water bath was 58.57℃,and the response time was 29.31 minutes.,and in the predict model,the result shows as 13.5688cN/tex,compared the later with the former,it has the error of 0.064%.
