Red-cell membrane sodium-lithium countertransport (Na+-Li+CT) and sodium sensitivity (SS) were measured in 300 children in Hanzhong.By comparison and retrospective study, the results showed:①In children with higher b...Red-cell membrane sodium-lithium countertransport (Na+-Li+CT) and sodium sensitivity (SS) were measured in 300 children in Hanzhong.By comparison and retrospective study, the results showed:①In children with higher blood pressure(HBP) and positive rainily history (FH+),Na+-Li+ CT rate was signiricantly higher than that in controls (P<0. 01).②6-year retrospective review of blood pressure evolution, the blood pressure increased degree (ASBP) in children with higher Na+-Li+ CT rate was much greater than that in those with lower one (P<0.05), and at the same time,the percentiles of systolic blood pressure (PSBP) for children with higher countertransport mostly kept rising or kept higher levels during this period.③In children with SS, Na+-Li+ CT rate was increased than that in SR group (P<0. 01),and was correlated to the concentration of intra-erythrocytic Na+ (P= 0.004).These suggest that, as intermediate phenotype of essential hypertension, red-cell membrane sodium-lithium countertransport defect could participate in the regulation of blood pressure and pathogensis or hypertension development in children.展开更多
To study the relationship between plasma insulin level, sodium sensitivity and blood pressure, 150 children aged from 10 to 15 years with higher blood pressure (HBP) and 150 children matched for age and sex but with n...To study the relationship between plasma insulin level, sodium sensitivity and blood pressure, 150 children aged from 10 to 15 years with higher blood pressure (HBP) and 150 children matched for age and sex but with normal blood pressure were measured for plasma insulin with radioimmunoassay and sodium sensitivity with the tests of oral saline load and furosemide sodium volume depletion and followed for 5 years. The results showed that: ①In children with HBP and positive family history of hypertension (FH +), the plasma insulin level was significantly higher than that in the respective control group (P<0 01);②In children with high plasma insulin level, the percentiles of systolic blood pressure kept high and had a rising tendency during the follow up period; ③In children with sodium sensitivity, the plasma insulin level was higher than that in children with sodium resistance (P<0 01) and the plasma insulin level correlated positively with blood pressure increasing rate of post load (P<0 05). It is suggested that insulin mediated salt and water retention may be a basic pathogenic mechanism in sodium sensitivity, and involved in the development of essential hypertension.展开更多
文摘Red-cell membrane sodium-lithium countertransport (Na+-Li+CT) and sodium sensitivity (SS) were measured in 300 children in Hanzhong.By comparison and retrospective study, the results showed:①In children with higher blood pressure(HBP) and positive rainily history (FH+),Na+-Li+ CT rate was signiricantly higher than that in controls (P<0. 01).②6-year retrospective review of blood pressure evolution, the blood pressure increased degree (ASBP) in children with higher Na+-Li+ CT rate was much greater than that in those with lower one (P<0.05), and at the same time,the percentiles of systolic blood pressure (PSBP) for children with higher countertransport mostly kept rising or kept higher levels during this period.③In children with SS, Na+-Li+ CT rate was increased than that in SR group (P<0. 01),and was correlated to the concentration of intra-erythrocytic Na+ (P= 0.004).These suggest that, as intermediate phenotype of essential hypertension, red-cell membrane sodium-lithium countertransport defect could participate in the regulation of blood pressure and pathogensis or hypertension development in children.
文摘To study the relationship between plasma insulin level, sodium sensitivity and blood pressure, 150 children aged from 10 to 15 years with higher blood pressure (HBP) and 150 children matched for age and sex but with normal blood pressure were measured for plasma insulin with radioimmunoassay and sodium sensitivity with the tests of oral saline load and furosemide sodium volume depletion and followed for 5 years. The results showed that: ①In children with HBP and positive family history of hypertension (FH +), the plasma insulin level was significantly higher than that in the respective control group (P<0 01);②In children with high plasma insulin level, the percentiles of systolic blood pressure kept high and had a rising tendency during the follow up period; ③In children with sodium sensitivity, the plasma insulin level was higher than that in children with sodium resistance (P<0 01) and the plasma insulin level correlated positively with blood pressure increasing rate of post load (P<0 05). It is suggested that insulin mediated salt and water retention may be a basic pathogenic mechanism in sodium sensitivity, and involved in the development of essential hypertension.
