Red-cell membrane sodium-lithium countertransport (Na+-Li+CT) and sodium sensitivity (SS) were measured in 300 children in Hanzhong.By comparison and retrospective study, the results showed:①In children with higher b...Red-cell membrane sodium-lithium countertransport (Na+-Li+CT) and sodium sensitivity (SS) were measured in 300 children in Hanzhong.By comparison and retrospective study, the results showed:①In children with higher blood pressure(HBP) and positive rainily history (FH+),Na+-Li+ CT rate was signiricantly higher than that in controls (P<0. 01).②6-year retrospective review of blood pressure evolution, the blood pressure increased degree (ASBP) in children with higher Na+-Li+ CT rate was much greater than that in those with lower one (P<0.05), and at the same time,the percentiles of systolic blood pressure (PSBP) for children with higher countertransport mostly kept rising or kept higher levels during this period.③In children with SS, Na+-Li+ CT rate was increased than that in SR group (P<0. 01),and was correlated to the concentration of intra-erythrocytic Na+ (P= 0.004).These suggest that, as intermediate phenotype of essential hypertension, red-cell membrane sodium-lithium countertransport defect could participate in the regulation of blood pressure and pathogensis or hypertension development in children.展开更多
文摘Red-cell membrane sodium-lithium countertransport (Na+-Li+CT) and sodium sensitivity (SS) were measured in 300 children in Hanzhong.By comparison and retrospective study, the results showed:①In children with higher blood pressure(HBP) and positive rainily history (FH+),Na+-Li+ CT rate was signiricantly higher than that in controls (P<0. 01).②6-year retrospective review of blood pressure evolution, the blood pressure increased degree (ASBP) in children with higher Na+-Li+ CT rate was much greater than that in those with lower one (P<0.05), and at the same time,the percentiles of systolic blood pressure (PSBP) for children with higher countertransport mostly kept rising or kept higher levels during this period.③In children with SS, Na+-Li+ CT rate was increased than that in SR group (P<0. 01),and was correlated to the concentration of intra-erythrocytic Na+ (P= 0.004).These suggest that, as intermediate phenotype of essential hypertension, red-cell membrane sodium-lithium countertransport defect could participate in the regulation of blood pressure and pathogensis or hypertension development in children.
