To track the nonlinear,non-Gaussian bearings-only maneuvering target accurately online,the constrained auxiliary particle filtering(CAPF)algorithm is presented.To restrict the samples into the feasible area,the soft m...To track the nonlinear,non-Gaussian bearings-only maneuvering target accurately online,the constrained auxiliary particle filtering(CAPF)algorithm is presented.To restrict the samples into the feasible area,the soft measurement constraints are implemented into the update routine via the1 regularization.Meanwhile,to enhance the sampling diversity and efficiency,the target kinetic features and the latest observations are involved into the evolution.To take advantage of the past and the current measurement information simultaneously,the sub-optimal importance distribution is constructed as a Gaussian mixture consisting of the original and modified priors with the fuzzy weighted factors.As a result,the corresponding weights are more evenly distributed,and the posterior distribution of interest is approximated well with a heavier tailor.Simulation results demonstrate the validity and superiority of the CAPF algorithm in terms of efficiency and robustness.展开更多
A laser-produced plasma(LPP) source was built using liquid as target and a Nd:YAG laser as the irradiation laser, and the LPP source's radiation with ethanol and acetone target respectively was measured by an AXUV...A laser-produced plasma(LPP) source was built using liquid as target and a Nd:YAG laser as the irradiation laser, and the LPP source's radiation with ethanol and acetone target respectively was measured by an AXUV100 silicon photodiode combined with a McPHERSON model 247 grazing incidence monochromator of the resolution Δλ≤0.075 nm and the wavelength scanning interval 0.5 nm. Both ethanol and acetone target LPP source had EUV emission at 11～20 nm wavelength. The comparison between the spectra of the two kinds of target materials shows that all the two kinds of target source's spectra are the result of oxygen ions' transitions under current source's parameters, but the spectrum intensity from different target sources is different. The spectra intensity from the ethanol target is higher than that from the acetone target. In addition, the target liquid is forced into the vacuum chamber by the background pressure supported by the connected external high pressure gas, and the influence of the background pressure on the source's intensity is investigated.展开更多
Soft tissue sarcoma are rare tumors arising mostly from embryonic mesoderm, that can affect almost any part of the human body, including the gastrointestinal tract. The prognosis associated with soft tissue sarcoma is...Soft tissue sarcoma are rare tumors arising mostly from embryonic mesoderm, that can affect almost any part of the human body, including the gastrointestinal tract. The prognosis associated with soft tissue sarcoma is still poor, mainly because of the low efficacy of traditional approaches based on surgery and chemotherapy. As a result of genetic and molecular analysis, several new target therapies have been developed, leading to a significant improvement in the survival of patients affected by advanced disease. In this review we aim to explore the therapeutic potential and benefit of target therapy in the management of gastrointestinal soft tissue sarcoma and the possible complications or pitfalls of such an approach.展开更多
【目的】探究文心兰miR168的分子进化特性,揭示文心兰miR168a及其候选靶基因响应软腐病菌侵染的表达模式。【方法】以文心兰miRNA文库、转录组数据库及miRbase数据库获取的植物miR168前体和成熟体序列为研究对象,利用生物信息学方法对...【目的】探究文心兰miR168的分子进化特性,揭示文心兰miR168a及其候选靶基因响应软腐病菌侵染的表达模式。【方法】以文心兰miRNA文库、转录组数据库及miRbase数据库获取的植物miR168前体和成熟体序列为研究对象,利用生物信息学方法对其进行系统进化树构建、保守性分析、前体二级结构分析及靶基因预测;通过PCR技术克隆文心兰miR168a前体,采用qRT-PCR技术分析miR168a及其候选靶基因在文心兰不同组织(根、叶、假鳞茎)和感染软腐病(0,12,24,36和48 h)不同时间的表达模式。【结果】植物miR168序列保守性较高,来源于miR168前体的5p臂保守性高于3p臂,miR168前体分歧较大,茎序列的保守性高于环序列;从文心兰中克隆得到93 bp miR168a前体序列,包含21 nt miR168a成熟体序列。进化分析表明,物种亲缘关系对其前体和成熟体序列的形成影响较小;二级结构显示,文心兰miR168a前体能形成典型的发卡结构,其成熟体位于前体的5p臂;随着软腐病侵染时间延长,文心兰miR168a与其候选靶标RNA剪切复合体核心蛋白(AGO1)、RPM1互作蛋白(RIN4)、羧酸酯酶(CXE8)的表达趋势基本呈负相关,而与其候选靶标RNA解旋酶(PRH47A)、泛素羧基末端水解酶(UCH)的表达趋势呈正相关,说明可能存在其他miR168家族成员或miRNAs同时调控。【结论】文心兰miR168与其他植物miR168进化上兼具保守性和特异性,miR168a上调表达可能会增强文心兰的抗病性。展开更多
随着枪械武器的更新换代,弹体的侵彻能力逐渐增强,软体防弹装甲成为现代战场上不可或缺的装备之一。通过ANSYS/LS-DYNA建立了软体防弹靶板的冲击有限元模型,搭建了普通弹侵彻UHMWPE纤维层合板的冲击试验平台,验证了模拟方法的有效性,确...随着枪械武器的更新换代,弹体的侵彻能力逐渐增强,软体防弹装甲成为现代战场上不可或缺的装备之一。通过ANSYS/LS-DYNA建立了软体防弹靶板的冲击有限元模型,搭建了普通弹侵彻UHMWPE纤维层合板的冲击试验平台,验证了模拟方法的有效性,确定了多层软体靶板抗冲击性能较佳的铺层方式,采用遗传算法优化了软体防弹靶板结构。结果表明:纤维层合板采用[0°/30°/60°/90°/120°]_n铺层方式,碳纤维层合板置于迎弹面,UHMWPE纤维层合板置于背弹面,且UHMWPE纤维层合板占比较高时,靶板的防弹性能更好;优化后的0.6 mm面层阻尼/5.1 mm CF层合板/9.4 mm UHMWPE纤维层合板结构靶板可有效抵抗7.62 mm普通弹的侵彻,在相同防弹性能条件下,与装甲钢结构靶板相比,该靶板面密度降低超过53.4%。展开更多
基金supported by the National Natural Science Foundation of China(61773267)the Shenzhen Fundamental Research Project(JCYJ2017030214551952420170818102503604)
文摘To track the nonlinear,non-Gaussian bearings-only maneuvering target accurately online,the constrained auxiliary particle filtering(CAPF)algorithm is presented.To restrict the samples into the feasible area,the soft measurement constraints are implemented into the update routine via the1 regularization.Meanwhile,to enhance the sampling diversity and efficiency,the target kinetic features and the latest observations are involved into the evolution.To take advantage of the past and the current measurement information simultaneously,the sub-optimal importance distribution is constructed as a Gaussian mixture consisting of the original and modified priors with the fuzzy weighted factors.As a result,the corresponding weights are more evenly distributed,and the posterior distribution of interest is approximated well with a heavier tailor.Simulation results demonstrate the validity and superiority of the CAPF algorithm in terms of efficiency and robustness.
文摘A laser-produced plasma(LPP) source was built using liquid as target and a Nd:YAG laser as the irradiation laser, and the LPP source's radiation with ethanol and acetone target respectively was measured by an AXUV100 silicon photodiode combined with a McPHERSON model 247 grazing incidence monochromator of the resolution Δλ≤0.075 nm and the wavelength scanning interval 0.5 nm. Both ethanol and acetone target LPP source had EUV emission at 11～20 nm wavelength. The comparison between the spectra of the two kinds of target materials shows that all the two kinds of target source's spectra are the result of oxygen ions' transitions under current source's parameters, but the spectrum intensity from different target sources is different. The spectra intensity from the ethanol target is higher than that from the acetone target. In addition, the target liquid is forced into the vacuum chamber by the background pressure supported by the connected external high pressure gas, and the influence of the background pressure on the source's intensity is investigated.
文摘Soft tissue sarcoma are rare tumors arising mostly from embryonic mesoderm, that can affect almost any part of the human body, including the gastrointestinal tract. The prognosis associated with soft tissue sarcoma is still poor, mainly because of the low efficacy of traditional approaches based on surgery and chemotherapy. As a result of genetic and molecular analysis, several new target therapies have been developed, leading to a significant improvement in the survival of patients affected by advanced disease. In this review we aim to explore the therapeutic potential and benefit of target therapy in the management of gastrointestinal soft tissue sarcoma and the possible complications or pitfalls of such an approach.
文摘【目的】探究文心兰miR168的分子进化特性,揭示文心兰miR168a及其候选靶基因响应软腐病菌侵染的表达模式。【方法】以文心兰miRNA文库、转录组数据库及miRbase数据库获取的植物miR168前体和成熟体序列为研究对象,利用生物信息学方法对其进行系统进化树构建、保守性分析、前体二级结构分析及靶基因预测;通过PCR技术克隆文心兰miR168a前体,采用qRT-PCR技术分析miR168a及其候选靶基因在文心兰不同组织(根、叶、假鳞茎)和感染软腐病(0,12,24,36和48 h)不同时间的表达模式。【结果】植物miR168序列保守性较高,来源于miR168前体的5p臂保守性高于3p臂,miR168前体分歧较大,茎序列的保守性高于环序列;从文心兰中克隆得到93 bp miR168a前体序列,包含21 nt miR168a成熟体序列。进化分析表明,物种亲缘关系对其前体和成熟体序列的形成影响较小;二级结构显示,文心兰miR168a前体能形成典型的发卡结构,其成熟体位于前体的5p臂;随着软腐病侵染时间延长,文心兰miR168a与其候选靶标RNA剪切复合体核心蛋白(AGO1)、RPM1互作蛋白(RIN4)、羧酸酯酶(CXE8)的表达趋势基本呈负相关,而与其候选靶标RNA解旋酶(PRH47A)、泛素羧基末端水解酶(UCH)的表达趋势呈正相关,说明可能存在其他miR168家族成员或miRNAs同时调控。【结论】文心兰miR168与其他植物miR168进化上兼具保守性和特异性,miR168a上调表达可能会增强文心兰的抗病性。
文摘随着枪械武器的更新换代,弹体的侵彻能力逐渐增强,软体防弹装甲成为现代战场上不可或缺的装备之一。通过ANSYS/LS-DYNA建立了软体防弹靶板的冲击有限元模型,搭建了普通弹侵彻UHMWPE纤维层合板的冲击试验平台,验证了模拟方法的有效性,确定了多层软体靶板抗冲击性能较佳的铺层方式,采用遗传算法优化了软体防弹靶板结构。结果表明:纤维层合板采用[0°/30°/60°/90°/120°]_n铺层方式,碳纤维层合板置于迎弹面,UHMWPE纤维层合板置于背弹面,且UHMWPE纤维层合板占比较高时,靶板的防弹性能更好;优化后的0.6 mm面层阻尼/5.1 mm CF层合板/9.4 mm UHMWPE纤维层合板结构靶板可有效抵抗7.62 mm普通弹的侵彻,在相同防弹性能条件下,与装甲钢结构靶板相比,该靶板面密度降低超过53.4%。
