AIM: To compare the risk of cutaneous infections and tumours in kidney transplant recipients with data recently published about this topic.METHODS: In the present work, we evaluated the incidence of bacterial, fungal ...AIM: To compare the risk of cutaneous infections and tumours in kidney transplant recipients with data recently published about this topic.METHODS: In the present work, we evaluated the incidence of bacterial, fungal and viral cutaneous infectious diseases and the development of skin cancers in a cohort of 436 patients who underwent a renal transplantation. The median age at transplantation of our patients was 50 years and the median duration of the immunosuppression was of 7.2 years. Data obtainedfrom our cohort were compared with those obtained by a systematic review of the literature of the last 20 years about the same topic.RESULTS: Infectious diseases were the most frequent dermatological disorders that were diagnosed after transplantation, affecting about the 16.5% of patients. Herpes virus reactivation occurs in about the 35% of patients and is more common within 6 mo from transplantation, whereas when the immunosuppression is reduced, skin infections are mainly represented by Human Papilloma Virus infections and localized mycosis, such as pityriasis versicolor and superficial candidiasis. Bacterial infections were relatively rare and occur mainly in the first months after transplantation. The cumulative risk to develop skin cancer enhance significantly over the time, as consequence of longterm immunosuppressive regiments. Endogenous and exogenous risk factors, as well as the schedule of immunosuppression can play a role and justify the different incidence of skin cancer in the various series. CONCLUSION: Skin infections and cancer, commonly diagnosed in transplanted patients, impact on survival and life-quality, justifying the realization of follow-up programs for the early diagnosis and treatment.展开更多
Tumour Lysis Syndrome (TLS) is an important oncological emergency case which is often found together with haematological malignities and, much less often, with solid tumours. While TLS seen in solid tumour cases usual...Tumour Lysis Syndrome (TLS) is an important oncological emergency case which is often found together with haematological malignities and, much less often, with solid tumours. While TLS seen in solid tumour cases usually develops following a cytotoxic chemotherapy and its prognosis is poor. We present the case of a 60-year-old man with gastric adenocarcinoma with diffuse liver metastases (image shows diffuse liver metastatic lesions) and high serum LDH levels, who developed TLS after systemic chemotherapy. With urgent and proper supportive treatment (intravenous intensive hydration, sodium bicarbonate, diuretic, calcium gluconate, allopurinol and haemodialysis), an impressive recovery from TLS was achieved in the patient with an advanced stage gastric cancer. The purpose of this report is to emphasize that although the present case was a rare, high physician attention is required because significant morbidity or mortality may occur when the syndrome is not duly considered during the pre-cytotoxic evaluation of the patient, when preventive measures are not taken, or if the appropriate treatment is not applied immediately once the syndrome appears, especially in patients who have high tumour burden solid cancer.展开更多
This paper compared various correlation of IMRA for CA19-9 and CA50 in the digestive system tumour antigen, such as linearity, sensitivity, analytical range, precision as well as storage and stability and so on. And i...This paper compared various correlation of IMRA for CA19-9 and CA50 in the digestive system tumour antigen, such as linearity, sensitivity, analytical range, precision as well as storage and stability and so on. And it also determined serum level of CA19- 9 and CA50 of patients with different tumours. The results showed it was well correlated to CA19- 9 and CA50 as a marker of digestive system tumour. Particularly high levels of both markers were found in patients with pancreastic colonic cancer. Therefore it is possible to obtain a higher sensitivity and acceptable specificity by combination with CA19-9 and CA50.展开更多
Brain metastases from solid tumours are associated with poor prognosis despite aggressive treatment. Temozolomide can be used for the treatment of glioblastoma multiforme as well as melanoma. It has also been shown to...Brain metastases from solid tumours are associated with poor prognosis despite aggressive treatment. Temozolomide can be used for the treatment of glioblastoma multiforme as well as melanoma. It has also been shown to have activity in patients with brain metastases from various malignancies, since it can cross the blood-brain barrier. To better understand the efficacy of temozolomide in the treatment of brain metastases, we carried out a review of 21 published clinical trials to determine whether temozolomide would benefit patients with brain metastases from solid tumours. Information regarding complete response, partial response, stable disease, objective response and objective response rate were collected to assess clinical outcomes. A modest therapeutic effect was observed when temozolomide was used as a single agent, however, the combination of temozolomide with whole-brain radiotherapy and/or other anticancer drugs exhibited encouraging activity. Thus, future high quality studies are warranted to confirm our findings.展开更多
目的探讨3.0 T MRI对胰腺实性肿瘤的诊断价值。方法回顾性分析经病理或临床证实的49例胰腺实性肿瘤的病例资料,其中胰腺癌30例,神经内分泌肿瘤5例,实性假乳头状瘤7例,转移瘤7例。49例均行MRI平扫和增强扫描,23例行MRCP。总结各种肿瘤的...目的探讨3.0 T MRI对胰腺实性肿瘤的诊断价值。方法回顾性分析经病理或临床证实的49例胰腺实性肿瘤的病例资料,其中胰腺癌30例,神经内分泌肿瘤5例,实性假乳头状瘤7例,转移瘤7例。49例均行MRI平扫和增强扫描,23例行MRCP。总结各种肿瘤的MRI表现。结果胰腺癌形态不规则,T_1WI低信号11例,略低信号18例,等信号1例;增强动脉期轻度强化16例,无强化14例,实质期及延迟期呈延迟强化;18例MRCP见"双管征",1例远端胰管扩张。5例神经内分泌肿瘤中,4例高分化者边界清晰,1例神经内分泌癌边界不清;增强扫描,动脉期明显强化4例,1例三期强化程度均低于正常胰腺组织。实性假乳头状瘤肿块平均直径6.2cm,实性部分T_1WI呈稍低信号,T_2WI呈稍高信号,动态增强扫描呈渐进性强化;6例肿瘤有完整包膜,包膜T_1WI、T_2WI均呈低信号,增强扫描可见延迟强化。7例胰腺转移瘤,单发结节3例,多发结节2例,局部胰腺肿大2例;T_1WI呈稍低信号6例,1例伴出血呈高信号;增强扫描三期均呈轻度不均匀强化5例,环形强化1例,动脉期明显强化、延迟期及门静脉期强化减退1例;3例MRCP可见"双管征"。结论 MRI对于胰腺实性肿块的诊断及鉴别具有重要价值。展开更多
文摘AIM: To compare the risk of cutaneous infections and tumours in kidney transplant recipients with data recently published about this topic.METHODS: In the present work, we evaluated the incidence of bacterial, fungal and viral cutaneous infectious diseases and the development of skin cancers in a cohort of 436 patients who underwent a renal transplantation. The median age at transplantation of our patients was 50 years and the median duration of the immunosuppression was of 7.2 years. Data obtainedfrom our cohort were compared with those obtained by a systematic review of the literature of the last 20 years about the same topic.RESULTS: Infectious diseases were the most frequent dermatological disorders that were diagnosed after transplantation, affecting about the 16.5% of patients. Herpes virus reactivation occurs in about the 35% of patients and is more common within 6 mo from transplantation, whereas when the immunosuppression is reduced, skin infections are mainly represented by Human Papilloma Virus infections and localized mycosis, such as pityriasis versicolor and superficial candidiasis. Bacterial infections were relatively rare and occur mainly in the first months after transplantation. The cumulative risk to develop skin cancer enhance significantly over the time, as consequence of longterm immunosuppressive regiments. Endogenous and exogenous risk factors, as well as the schedule of immunosuppression can play a role and justify the different incidence of skin cancer in the various series. CONCLUSION: Skin infections and cancer, commonly diagnosed in transplanted patients, impact on survival and life-quality, justifying the realization of follow-up programs for the early diagnosis and treatment.
文摘Tumour Lysis Syndrome (TLS) is an important oncological emergency case which is often found together with haematological malignities and, much less often, with solid tumours. While TLS seen in solid tumour cases usually develops following a cytotoxic chemotherapy and its prognosis is poor. We present the case of a 60-year-old man with gastric adenocarcinoma with diffuse liver metastases (image shows diffuse liver metastatic lesions) and high serum LDH levels, who developed TLS after systemic chemotherapy. With urgent and proper supportive treatment (intravenous intensive hydration, sodium bicarbonate, diuretic, calcium gluconate, allopurinol and haemodialysis), an impressive recovery from TLS was achieved in the patient with an advanced stage gastric cancer. The purpose of this report is to emphasize that although the present case was a rare, high physician attention is required because significant morbidity or mortality may occur when the syndrome is not duly considered during the pre-cytotoxic evaluation of the patient, when preventive measures are not taken, or if the appropriate treatment is not applied immediately once the syndrome appears, especially in patients who have high tumour burden solid cancer.
文摘This paper compared various correlation of IMRA for CA19-9 and CA50 in the digestive system tumour antigen, such as linearity, sensitivity, analytical range, precision as well as storage and stability and so on. And it also determined serum level of CA19- 9 and CA50 of patients with different tumours. The results showed it was well correlated to CA19- 9 and CA50 as a marker of digestive system tumour. Particularly high levels of both markers were found in patients with pancreastic colonic cancer. Therefore it is possible to obtain a higher sensitivity and acceptable specificity by combination with CA19-9 and CA50.
文摘Brain metastases from solid tumours are associated with poor prognosis despite aggressive treatment. Temozolomide can be used for the treatment of glioblastoma multiforme as well as melanoma. It has also been shown to have activity in patients with brain metastases from various malignancies, since it can cross the blood-brain barrier. To better understand the efficacy of temozolomide in the treatment of brain metastases, we carried out a review of 21 published clinical trials to determine whether temozolomide would benefit patients with brain metastases from solid tumours. Information regarding complete response, partial response, stable disease, objective response and objective response rate were collected to assess clinical outcomes. A modest therapeutic effect was observed when temozolomide was used as a single agent, however, the combination of temozolomide with whole-brain radiotherapy and/or other anticancer drugs exhibited encouraging activity. Thus, future high quality studies are warranted to confirm our findings.
文摘目的探讨3.0 T MRI对胰腺实性肿瘤的诊断价值。方法回顾性分析经病理或临床证实的49例胰腺实性肿瘤的病例资料,其中胰腺癌30例,神经内分泌肿瘤5例,实性假乳头状瘤7例,转移瘤7例。49例均行MRI平扫和增强扫描,23例行MRCP。总结各种肿瘤的MRI表现。结果胰腺癌形态不规则,T_1WI低信号11例,略低信号18例,等信号1例;增强动脉期轻度强化16例,无强化14例,实质期及延迟期呈延迟强化;18例MRCP见"双管征",1例远端胰管扩张。5例神经内分泌肿瘤中,4例高分化者边界清晰,1例神经内分泌癌边界不清;增强扫描,动脉期明显强化4例,1例三期强化程度均低于正常胰腺组织。实性假乳头状瘤肿块平均直径6.2cm,实性部分T_1WI呈稍低信号,T_2WI呈稍高信号,动态增强扫描呈渐进性强化;6例肿瘤有完整包膜,包膜T_1WI、T_2WI均呈低信号,增强扫描可见延迟强化。7例胰腺转移瘤,单发结节3例,多发结节2例,局部胰腺肿大2例;T_1WI呈稍低信号6例,1例伴出血呈高信号;增强扫描三期均呈轻度不均匀强化5例,环形强化1例,动脉期明显强化、延迟期及门静脉期强化减退1例;3例MRCP可见"双管征"。结论 MRI对于胰腺实性肿块的诊断及鉴别具有重要价值。
