A metabolic profile of plasma samples from patients undergoing heart surgery with the use of cardiopulmonary bypass （CPB） and concurrent administration of tranexamic acid was determined. Direct immersion solid phase...A metabolic profile of plasma samples from patients undergoing heart surgery with the use of cardiopulmonary bypass （CPB） and concurrent administration of tranexamic acid was determined. Direct immersion solid phase microextraction （DI-SPME）, a new sampling and sample preparation tool for metabolomics, was used in this study for the first time to investigate clinical samples. The results showed alteration of diverse compounds involved in different biochemical pathways. The most significant contribution in changes induced by surgery and applied pharmacotherapy was noticed in metabolic profile of lysophospholipids, triacylglycerols, mediators of platelet aggregation, and linoleic acid metabolites. Two cases of individual response to treatment were also reported.展开更多
Lithium-sulfur(Li-S)batteries are regarded as one of the most promising next-generation energy storage systems due to their high theoretical energy density and low material cost.However,the conventional ether-based el...Lithium-sulfur(Li-S)batteries are regarded as one of the most promising next-generation energy storage systems due to their high theoretical energy density and low material cost.However,the conventional ether-based electrolytes of Li-S batteries are extremely flammable and have high solubility of lithium polysulfides(LiPS),resulting in a high safety risk and a poor life cycle.Herein,we report an ether/carbonate co-solvent fluorinated electrolyte with a special solvation sheath of Li^(+),which can prevent the formation of dissoluble long-chain LiPS of the sulfur cathode,restrict Li dendrite growth at the anode side,and show fire resistance in combustion experiments.As a result,the proposed Li-S batteries with 70 wt%sulfur content in its cathode deliver stable life cycle,low self-discharge ratio,and intrinsic safety.Therefore,the unique passivation characteristics of the designed fluorinated electrolyte break several critical limitations of the traditional“liquid phase”-based Li-S batteries,offering a facile and promising way to develop long-life and high-safety Li-S batteries.展开更多
基金the Natural Sciences and Engineering Research Council of Canada Industrial Research Chairs (NSERC IRC) and the Canada Research Chairs (CRC) for financial support of the project
文摘A metabolic profile of plasma samples from patients undergoing heart surgery with the use of cardiopulmonary bypass （CPB） and concurrent administration of tranexamic acid was determined. Direct immersion solid phase microextraction （DI-SPME）, a new sampling and sample preparation tool for metabolomics, was used in this study for the first time to investigate clinical samples. The results showed alteration of diverse compounds involved in different biochemical pathways. The most significant contribution in changes induced by surgery and applied pharmacotherapy was noticed in metabolic profile of lysophospholipids, triacylglycerols, mediators of platelet aggregation, and linoleic acid metabolites. Two cases of individual response to treatment were also reported.
基金financially supported by the National Key R&D Program of China (2018YFB0905400)the National Natural Science Foundation of China (51972131 and 51632001)
文摘Lithium-sulfur(Li-S)batteries are regarded as one of the most promising next-generation energy storage systems due to their high theoretical energy density and low material cost.However,the conventional ether-based electrolytes of Li-S batteries are extremely flammable and have high solubility of lithium polysulfides(LiPS),resulting in a high safety risk and a poor life cycle.Herein,we report an ether/carbonate co-solvent fluorinated electrolyte with a special solvation sheath of Li^(+),which can prevent the formation of dissoluble long-chain LiPS of the sulfur cathode,restrict Li dendrite growth at the anode side,and show fire resistance in combustion experiments.As a result,the proposed Li-S batteries with 70 wt%sulfur content in its cathode deliver stable life cycle,low self-discharge ratio,and intrinsic safety.Therefore,the unique passivation characteristics of the designed fluorinated electrolyte break several critical limitations of the traditional“liquid phase”-based Li-S batteries,offering a facile and promising way to develop long-life and high-safety Li-S batteries.
