Suppression of Tumorigenicity 2 （ST2） is a member of the interleukin （IL）-1 receptor family The ST2 receptor exists in two isoforms - ST2 ligand （ST2L） and soluble ST2 （sST2）.ST2L is a membrane receptor and sS...Suppression of Tumorigenicity 2 （ST2） is a member of the interleukin （IL）-1 receptor family The ST2 receptor exists in two isoforms - ST2 ligand （ST2L） and soluble ST2 （sST2）.ST2L is a membrane receptor and sST2 is a trun- cated receptor which is soluble in the blood, allowing it to be detected in serum. IL-33 is a member of the IL-1 family of ligand and is the fimctional ligand of ST2L receptor. It binds to the ST2L, thereby mediating its immune function.展开更多
BACKGROUND Acute pancreatitis(AP)is an inflammatory disease in which the regulatory pathway is complex and not well understood.Soluble suppression of tumorigenicity 2(sST2)protein receptor functions as a decoy recepto...BACKGROUND Acute pancreatitis(AP)is an inflammatory disease in which the regulatory pathway is complex and not well understood.Soluble suppression of tumorigenicity 2(sST2)protein receptor functions as a decoy receptor for interleukin(IL)-33 to prevent IL-33/suppression of tumorigenicity 2L(ST2L)-pathwaymediated T helper(Th)2 immune responses.AIM To investigate the role of sST2 in AP.METHODS We assessed the association between sST2 and severity of AP in 123 patients enrolled in this study.The serum levels of sST2,C-reactive protein(CRP)and Th1-and Th2-related cytokines,including interferon(IFN)-γ,tumor necrosis factor(TNF)-α,IL-2,IL-4,IL-5 and IL-13,were measured by highly sensitive ELISA,and the severity of AP in patients was evaluated by the 2012 Atlanta Classification Criteria.RESULTS Serum sST2 levels were significantly increased in AP patients,and further,these levels were significantly elevated in severe AP(SAP)patients compared to moderately severe AP(MSAP)and mild AP(MAP)patients.Logistic regression showed sST2 was a predictor of SAP[odds ratio(OR):1.003(1.001–1.006),P=0.000].sST2 cutoff point was 1190 pg/mL,and sST2 above this cutoff was associated with SAP.sST2 was also a predictor of any organ failure and mortality during AP[OR:1.006(1.003–1.009),P=0.000,OR:1.002(1.001–1.004),P=0.012,respectively].Additionally,the Th1-related cytokines IFN-γand TNF-αin the SAP group were higher and the Th2-related cytokine IL-4 in the SAP group was significantly lower than those in MSAP and MAP groups.CONCLUSION sST2 may be used as a novel inflammatory marker in predicting AP severity and may regulate the function and differentiation of IL-33/ST2-mediated Th1 and Th2 Lymphocytes in AP homeostasis.展开更多
Background：Many studies have explored the diagnostic performance of soluble suppression of tumorigenicity-2 （sST2） for heart failure （HF）,but the results are inconsistent.Here,we performed a meta-analysis to asse...Background：Many studies have explored the diagnostic performance of soluble suppression of tumorigenicity-2 （sST2） for heart failure （HF）,but the results are inconsistent.Here,we performed a meta-analysis to assess the role of sST2 in the diagnosis of HF.Methods：We searched PubMed,Web of Science,Cochrane Library,China National Knowledge Infrastructure,and Wanfang Database from inception to April 2015.Studies that investigated the diagnostic role of sST2 for HF were reviewed.The numbers of true-positive,false-positive,false-negative,and true-negative results were extracted to calculate pooled diagnostic odds ratio （DOR） with 95% confidence interval （CI） and the summary receiver operating characteristic curve and area under the curve （AUC）.The Spearman correlation coefficient was used to check the threshold effect.The Cochran Q statistic （P 〈 0.05） and the inconsistency index （I2 〉 50%） were used to assess the nonthreshold effect.Meta-regression was conducted to explore the source of heterogeneity;subgroup analysis showed the results in different subgroups.Finally,the Deeks＇ test was performed to assess the publication bias.Results：Nine articles including 10 studies were included in the meta-analysis.The pooled sensitivity was 0.84 （95% CI：0.81-0.86）,and pooled specificity was 0.74 （95% CI：0.72-0.76）.The summary DOR was 8.49 （95% CI：4.54-15.86）,and AUC was 0.81 （standard error：0.03）.The Spearman correlation coefficient identified the nonsignificant threshold effect （coefficient =0.49,P =0.148）,but the nonthreshold effect heterogeneity was significant （Cochran Q =58.52,P 〈 0.0001;I2 =84.6%）.Meta-regression found that characteristics of controls might be the suggestive source ofnonthreshold effect heterogeneity （P =0.095）.Subgroup analysis found that DOR was 5.65 and 7.86,respectively for the controls of hospital patients and healthy populations.Deeks＇ test demonstrated that there was no publication bias （P =0.616）.Conclusion：The meta-analysis illustrated that sST2 might play a role in diagnosing HF.展开更多
文摘Suppression of Tumorigenicity 2 （ST2） is a member of the interleukin （IL）-1 receptor family The ST2 receptor exists in two isoforms - ST2 ligand （ST2L） and soluble ST2 （sST2）.ST2L is a membrane receptor and sST2 is a trun- cated receptor which is soluble in the blood, allowing it to be detected in serum. IL-33 is a member of the IL-1 family of ligand and is the fimctional ligand of ST2L receptor. It binds to the ST2L, thereby mediating its immune function.
基金Supported by Henan Province Education Department for Henan Province University Key Scientific Research Project,No.20A320018 and No.20A320064。
文摘BACKGROUND Acute pancreatitis(AP)is an inflammatory disease in which the regulatory pathway is complex and not well understood.Soluble suppression of tumorigenicity 2(sST2)protein receptor functions as a decoy receptor for interleukin(IL)-33 to prevent IL-33/suppression of tumorigenicity 2L(ST2L)-pathwaymediated T helper(Th)2 immune responses.AIM To investigate the role of sST2 in AP.METHODS We assessed the association between sST2 and severity of AP in 123 patients enrolled in this study.The serum levels of sST2,C-reactive protein(CRP)and Th1-and Th2-related cytokines,including interferon(IFN)-γ,tumor necrosis factor(TNF)-α,IL-2,IL-4,IL-5 and IL-13,were measured by highly sensitive ELISA,and the severity of AP in patients was evaluated by the 2012 Atlanta Classification Criteria.RESULTS Serum sST2 levels were significantly increased in AP patients,and further,these levels were significantly elevated in severe AP(SAP)patients compared to moderately severe AP(MSAP)and mild AP(MAP)patients.Logistic regression showed sST2 was a predictor of SAP[odds ratio(OR):1.003(1.001–1.006),P=0.000].sST2 cutoff point was 1190 pg/mL,and sST2 above this cutoff was associated with SAP.sST2 was also a predictor of any organ failure and mortality during AP[OR:1.006(1.003–1.009),P=0.000,OR:1.002(1.001–1.004),P=0.012,respectively].Additionally,the Th1-related cytokines IFN-γand TNF-αin the SAP group were higher and the Th2-related cytokine IL-4 in the SAP group was significantly lower than those in MSAP and MAP groups.CONCLUSION sST2 may be used as a novel inflammatory marker in predicting AP severity and may regulate the function and differentiation of IL-33/ST2-mediated Th1 and Th2 Lymphocytes in AP homeostasis.
文摘Background：Many studies have explored the diagnostic performance of soluble suppression of tumorigenicity-2 （sST2） for heart failure （HF）,but the results are inconsistent.Here,we performed a meta-analysis to assess the role of sST2 in the diagnosis of HF.Methods：We searched PubMed,Web of Science,Cochrane Library,China National Knowledge Infrastructure,and Wanfang Database from inception to April 2015.Studies that investigated the diagnostic role of sST2 for HF were reviewed.The numbers of true-positive,false-positive,false-negative,and true-negative results were extracted to calculate pooled diagnostic odds ratio （DOR） with 95% confidence interval （CI） and the summary receiver operating characteristic curve and area under the curve （AUC）.The Spearman correlation coefficient was used to check the threshold effect.The Cochran Q statistic （P 〈 0.05） and the inconsistency index （I2 〉 50%） were used to assess the nonthreshold effect.Meta-regression was conducted to explore the source of heterogeneity;subgroup analysis showed the results in different subgroups.Finally,the Deeks＇ test was performed to assess the publication bias.Results：Nine articles including 10 studies were included in the meta-analysis.The pooled sensitivity was 0.84 （95% CI：0.81-0.86）,and pooled specificity was 0.74 （95% CI：0.72-0.76）.The summary DOR was 8.49 （95% CI：4.54-15.86）,and AUC was 0.81 （standard error：0.03）.The Spearman correlation coefficient identified the nonsignificant threshold effect （coefficient =0.49,P =0.148）,but the nonthreshold effect heterogeneity was significant （Cochran Q =58.52,P 〈 0.0001;I2 =84.6%）.Meta-regression found that characteristics of controls might be the suggestive source ofnonthreshold effect heterogeneity （P =0.095）.Subgroup analysis found that DOR was 5.65 and 7.86,respectively for the controls of hospital patients and healthy populations.Deeks＇ test demonstrated that there was no publication bias （P =0.616）.Conclusion：The meta-analysis illustrated that sST2 might play a role in diagnosing HF.
